{"id":"https://openalex.org/W2090335524","doi":"https://doi.org/10.1093/nar/gkh393","title":"RESCUE-ESE identifies candidate exonic splicing enhancers in vertebrate exons","display_name":"RESCUE-ESE identifies candidate exonic splicing enhancers in vertebrate exons","publication_year":2004,"publication_date":"2004-07-01","ids":{"openalex":"https://openalex.org/W2090335524","doi":"https://doi.org/10.1093/nar/gkh393","mag":"2090335524","pmid":"https://pubmed.ncbi.nlm.nih.gov/15215377"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkh393","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkh393","pdf_url":"https://academic.oup.com/nar/article-pdf/32/suppl_2/W187/6208865/gkh393.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/nar/article-pdf/32/suppl_2/W187/6208865/gkh393.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040598548","display_name":"William G. Fairbrother","orcid":"https://orcid.org/0000-0002-6312-5615"},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"W. G. Fairbrother","raw_affiliation_strings":["Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA","Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139 (USA)"],"affiliations":[{"raw_affiliation_string":"Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA","institution_ids":["https://openalex.org/I63966007","https://openalex.org/I4210149717"]},{"raw_affiliation_string":"Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139 (USA)","institution_ids":["https://openalex.org/I63966007","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082310752","display_name":"G Yeo","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. W. Yeo","raw_affiliation_strings":["Department of Biology and"],"affiliations":[{"raw_affiliation_string":"Department of Biology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062873463","display_name":"Ru\u2010Fang Yeh","orcid":null},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Yeh","raw_affiliation_strings":["Department of Epidemiology and Biostatistics, University of California San Francisco, 500 Parnassus Avenue Box 0560, San Francisco, CA 94143-0560, USA and 4 46 Glenbrook Road, W. Hartford, CT 06107, USA"],"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Biostatistics, University of California San Francisco, 500 Parnassus Avenue Box 0560, San Francisco, CA 94143-0560, USA and 4 46 Glenbrook Road, W. Hartford, CT 06107, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082113325","display_name":"Pavel Goldstein","orcid":"https://orcid.org/0000-0002-5224-1725"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. Goldstein","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015990526","display_name":"Matthew Mawson","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Mawson","raw_affiliation_strings":["Department of Biology and"],"affiliations":[{"raw_affiliation_string":"Department of Biology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022945869","display_name":"Phillip A. Sharp","orcid":"https://orcid.org/0000-0003-1465-1691"},"institutions":[{"id":"https://openalex.org/I144112489","display_name":"McGovern Institute for Brain Research","ror":"https://ror.org/05ymca674","country_code":"US","type":"facility","lineage":["https://openalex.org/I144112489","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. A. Sharp","raw_affiliation_strings":["Center for Cancer Research,","Department of Biology and","McGovern Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA,"],"affiliations":[{"raw_affiliation_string":"Center for Cancer Research,","institution_ids":["https://openalex.org/I4210149717"]},{"raw_affiliation_string":"Department of Biology and","institution_ids":[]},{"raw_affiliation_string":"McGovern Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA,","institution_ids":["https://openalex.org/I144112489","https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022755619","display_name":"C. B. Burge","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. B. Burge","raw_affiliation_strings":["Department of Biology and"],"affiliations":[{"raw_affiliation_string":"Department of Biology and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5040598548"],"corresponding_institution_ids":["https://openalex.org/I4210149717","https://openalex.org/I63966007"],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":{"value":3630,"currency":"USD","value_usd":3630},"fwci":8.7709,"has_fulltext":true,"cited_by_count":278,"citation_normalized_percentile":{"value":0.9869865,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"32","issue":"Web Server","first_page":"W187","last_page":"W190"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.8602695465087891},{"id":"https://openalex.org/keywords/exon","display_name":"Exon","score":0.82715904712677},{"id":"https://openalex.org/keywords/rna-splicing","display_name":"RNA splicing","score":0.72371506690979},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.6649678945541382},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"Alternative splicing","score":0.6455684304237366},{"id":"https://openalex.org/keywords/enhancer","display_name":"Enhancer","score":0.643671452999115},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.6347834467887878},{"id":"https://openalex.org/keywords/exonic-splicing-enhancer","display_name":"Exonic splicing enhancer","score":0.4951685965061188},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.48381632566452026},{"id":"https://openalex.org/keywords/zebrafish","display_name":"Zebrafish","score":0.4836234152317047},{"id":"https://openalex.org/keywords/exon-skipping","display_name":"Exon skipping","score":0.4648747742176056},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.25422972440719604},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.10226121544837952}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8602695465087891},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.82715904712677},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.72371506690979},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6649678945541382},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.6455684304237366},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.643671452999115},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6347834467887878},{"id":"https://openalex.org/C42576000","wikidata":"https://www.wikidata.org/wiki/Q5420618","display_name":"Exonic splicing enhancer","level":5,"score":0.4951685965061188},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.48381632566452026},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.4836234152317047},{"id":"https://openalex.org/C2778776201","wikidata":"https://www.wikidata.org/wiki/Q3474283","display_name":"Exon skipping","level":5,"score":0.4648747742176056},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.25422972440719604},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.10226121544837952}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012322","descriptor_name":"RNA Precursors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012322","descriptor_name":"RNA Precursors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012322","descriptor_name":"RNA Precursors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012326","descriptor_name":"RNA Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012326","descriptor_name":"RNA Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012326","descriptor_name":"RNA Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023721","descriptor_name":"Tetraodontiformes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D023721","descriptor_name":"Tetraodontiformes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D023721","descriptor_name":"Tetraodontiformes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D038621","descriptor_name":"Regulatory Sequences, Ribonucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D038621","descriptor_name":"Regulatory Sequences, Ribonucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D038621","descriptor_name":"Regulatory Sequences, Ribonucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/nar/gkh393","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkh393","pdf_url":"https://academic.oup.com/nar/article-pdf/32/suppl_2/W187/6208865/gkh393.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmid:15215377","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15215377","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":null},{"id":"pmh:oai:europepmc.org:162768","is_oa":false,"landing_page_url":"http://europepmc.org/pmc/articles/PMC441531","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:441531","is_oa":true,"landing_page_url":"http://doi.org/10.1093/nar/gkh393","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/nar/gkh393","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkh393","pdf_url":"https://academic.oup.com/nar/article-pdf/32/suppl_2/W187/6208865/gkh393.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Life below water","score":0.6600000262260437,"id":"https://metadata.un.org/sdg/14"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320320290","display_name":"University of Oxford","ror":"https://ror.org/052gg0110"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2090335524.pdf","grobid_xml":"https://content.openalex.org/works/W2090335524.grobid-xml"},"referenced_works_count":11,"referenced_works":["https://openalex.org/W1836860525","https://openalex.org/W1965748552","https://openalex.org/W2023648355","https://openalex.org/W2063318299","https://openalex.org/W2102337459","https://openalex.org/W2125069153","https://openalex.org/W2128614530","https://openalex.org/W2129682060","https://openalex.org/W2141419420","https://openalex.org/W2159864549","https://openalex.org/W4301741990"],"related_works":["https://openalex.org/W2321791250","https://openalex.org/W4213427798","https://openalex.org/W2023199111","https://openalex.org/W2052498125","https://openalex.org/W2564462691","https://openalex.org/W2094867951","https://openalex.org/W2151954452","https://openalex.org/W2168675625","https://openalex.org/W4213165146","https://openalex.org/W1929261690"],"abstract_inverted_index":{"A":[0,59],"typical":[1],"gene":[2,51,57],"contains":[3],"two":[4],"levels":[5],"of":[6,18,28,40,80],"information:":[7],"a":[8,12,16,89],"sequence":[9,41,148],"that":[10,21,49,61,131,150],"encodes":[11],"particular":[13],"protein":[14],"and":[15,120,138],"host":[17],"other":[19],"signals":[20,53],"are":[22],"necessary":[23],"for":[24,68],"the":[25,29,38,44,78,85],"correct":[26],"expression":[27],"transcript.":[30,87],"While":[31],"much":[32],"attention":[33],"has":[34,110],"been":[35,112],"focused":[36],"on":[37,43],"effects":[39],"variation":[42,60],"amino":[45],"acid":[46],"sequence,":[47],"variations":[48],"disrupt":[50,151],"processing":[52],"can":[54,139],"dramatically":[55],"impact":[56],"function.":[58],"disrupts":[62],"an":[63,81,125],"exonic":[64],"splicing":[65,144],"enhancer":[66],"(ESE),":[67],"example,":[69],"could":[70],"cause":[71],"exon":[72,83],"skipping":[73],"which":[74],"would":[75],"result":[76],"in":[77,93,104,114,135],"exclusion":[79],"entire":[82],"from":[84],"mRNA":[86],"RESCUE-ESE,":[88],"computational":[90],"approach":[91],"used":[92,141],"conjunction":[94],"with":[95],"experimental":[96],"validation,":[97],"previously":[98],"identified":[99],"238":[100],"candidate":[101],"ESE":[102,127],"hexamers":[103,134],"human":[105],"genes.":[106],"The":[107],"RESCUE-ESE":[108,133],"method":[109],"recently":[111],"implemented":[113],"three":[115],"additional":[116],"species:":[117],"mouse,":[118],"zebrafish":[119],"pufferfish.":[121],"Here":[122],"we":[123],"describe":[124],"online":[126],"analysis":[128],"tool":[129],"(http://genes.mit.edu/burgelab/rescue-ese/)":[130],"annotates":[132],"vertebrate":[136],"exons":[137],"be":[140],"to":[142],"predict":[143],"phenotypes":[145],"by":[146],"identifying":[147],"changes":[149],"or":[152],"alter":[153],"predicted":[154],"ESEs.":[155]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":16},{"year":2013,"cited_by_count":17},{"year":2012,"cited_by_count":16}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}