{"id":"https://openalex.org/W2121149237","doi":"https://doi.org/10.1093/nar/gkg036","title":"RTKdb: database of receptor tyrosine kinase","display_name":"RTKdb: database of receptor tyrosine kinase","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W2121149237","doi":"https://doi.org/10.1093/nar/gkg036","mag":"2121149237","pmid":"https://pubmed.ncbi.nlm.nih.gov/12520021"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkg036","is_oa":false,"landing_page_url":"https://doi.org/10.1093/nar/gkg036","pdf_url":null,"source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/165483","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026665311","display_name":"Julien Grassot","orcid":null},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"J. Grassot","raw_affiliation_strings":["Centre de G\u00e9n\u00e9tique Mol\u00e9culaire et Cellulaire, UMR CNRS 5534, Universit\u00e9 Claude Bernard-Lyon 1, 43 bd. du 11 Novembre 1918, 69622 Villeurbanne Cedex, France. grassot@biomserv.univ-lyon1.fr","Centre de G\u00e9n\u00e9tique Mol\u00e9culaire et Cellulaire, UMR CNRS 5534, Universit\u00e9 Claude Bernard-Lyon 1, 43 bd. du 11 Novembre 1918, 69622 Villeurbanne Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de G\u00e9n\u00e9tique Mol\u00e9culaire et Cellulaire, UMR CNRS 5534, Universit\u00e9 Claude Bernard-Lyon 1, 43 bd. du 11 Novembre 1918, 69622 Villeurbanne Cedex, France. grassot@biomserv.univ-lyon1.fr","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Centre de G\u00e9n\u00e9tique Mol\u00e9culaire et Cellulaire, UMR CNRS 5534, Universit\u00e9 Claude Bernard-Lyon 1, 43 bd. du 11 Novembre 1918, 69622 Villeurbanne Cedex, France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5026665311"],"corresponding_institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590"],"apc_list":{"value":3992,"currency":"USD","value_usd":3992},"apc_paid":null,"fwci":0.9746,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.73368927,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"31","issue":"1","first_page":"353","last_page":"358"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9926000237464905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9926000237464905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9905999898910522,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9901000261306763,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.8776741027832031},{"id":"https://openalex.org/keywords/receptor-tyrosine-kinase","display_name":"Receptor tyrosine kinase","score":0.8150075674057007},{"id":"https://openalex.org/keywords/database","display_name":"Database","score":0.5685620307922363},{"id":"https://openalex.org/keywords/receptor-protein-tyrosine-kinases","display_name":"Receptor Protein-Tyrosine Kinases","score":0.5072050094604492},{"id":"https://openalex.org/keywords/tyrosine-kinase","display_name":"Tyrosine kinase","score":0.4386771619319916},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3665570020675659},{"id":"https://openalex.org/keywords/kinase","display_name":"Kinase","score":0.2895403802394867},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.27008751034736633},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.26232147216796875},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.07336068153381348}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8776741027832031},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.8150075674057007},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.5685620307922363},{"id":"https://openalex.org/C2911166042","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor Protein-Tyrosine Kinases","level":4,"score":0.5072050094604492},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.4386771619319916},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3665570020675659},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.2895403802394867},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.27008751034736633},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.26232147216796875},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.07336068153381348}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020794","descriptor_name":"Receptor Protein-Tyrosine Kinases","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D020794","descriptor_name":"Receptor Protein-Tyrosine Kinases","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D020794","descriptor_name":"Receptor Protein-Tyrosine Kinases","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D020794","descriptor_name":"Receptor Protein-Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020794","descriptor_name":"Receptor Protein-Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020794","descriptor_name":"Receptor Protein-Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020794","descriptor_name":"Receptor Protein-Tyrosine Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020794","descriptor_name":"Receptor Protein-Tyrosine Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020794","descriptor_name":"Receptor Protein-Tyrosine Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/nar/gkg036","is_oa":false,"landing_page_url":"https://doi.org/10.1093/nar/gkg036","pdf_url":null,"source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmid:12520021","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12520021","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:165483","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/165483","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:165483","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/165483","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322892","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1525759724","https://openalex.org/W1575504122","https://openalex.org/W1994025789","https://openalex.org/W1995392323","https://openalex.org/W2003144438","https://openalex.org/W2016000389","https://openalex.org/W2017026835","https://openalex.org/W2028415754","https://openalex.org/W2042575909","https://openalex.org/W2052356760","https://openalex.org/W2057081312","https://openalex.org/W2065172786","https://openalex.org/W2076960251","https://openalex.org/W2085397716","https://openalex.org/W2097706568","https://openalex.org/W2110041134","https://openalex.org/W2121654656","https://openalex.org/W2141885858","https://openalex.org/W2149057166","https://openalex.org/W2149160071","https://openalex.org/W2159620702","https://openalex.org/W2163181687","https://openalex.org/W2166022874","https://openalex.org/W2180005201","https://openalex.org/W4210531204","https://openalex.org/W4211075026","https://openalex.org/W4213149192","https://openalex.org/W4241156921","https://openalex.org/W4252546523"],"related_works":["https://openalex.org/W2061697147","https://openalex.org/W2075091575","https://openalex.org/W2071513467","https://openalex.org/W2198509606","https://openalex.org/W2321063763","https://openalex.org/W2088346679","https://openalex.org/W1991624054","https://openalex.org/W2126073113","https://openalex.org/W2086259825","https://openalex.org/W284991352"],"abstract_inverted_index":{"Receptor":[0,132],"Tyrosine":[1,133],"Kinases":[2],"(RTK)":[3],"are":[4,63,129,158],"transmembrane":[5],"receptors":[6,145],"specifically":[7],"found":[8],"in":[9,22,42,59,71,80,83],"metazoans.":[10],"They":[11],"represent":[12],"an":[13],"excellent":[14],"model":[15,88,115,155],"for":[16,56,116,165],"studying":[17],"evolution":[18],"of":[19,29,38,68,76],"cellular":[20],"processes":[21],"metazoans":[23],"because":[24],"they":[25,62],"encompass":[26],"large":[27],"families":[28],"modular":[30],"proteins":[31],"and":[32,93,118,169],"belong":[33],"to":[34,122],"a":[35,66,84,108,113],"major":[36],"family":[37],"contingency":[39],"generating":[40],"molecules":[41],"eukaryotic":[43],"cells:":[44],"the":[45,131,139,161,166,177,190,197],"protein":[46,151],"kinases.":[47],"Because":[48],"tyrosine":[49,143],"kinases":[50],"have":[51],"been":[52],"under":[53,160],"close":[54],"scrutiny":[55],"many":[57],"years":[58],"various":[60],"species,":[61],"associated":[64],"with":[65],"wealth":[67],"information,":[69],"mainly":[70],"mammals.":[72],"Presently,":[73],"most":[74],"categories":[75],"RTK":[77,104],"were":[78],"identified":[79],"mammals,":[81],"but":[82],"near":[85],"future":[86],"other":[87,99],"species":[89,157],"will":[90,94],"be":[91,174],"sequenced,":[92],"bring":[95],"us":[96],"RTKs":[97],"from":[98,153],"metazoan":[100,156],"clades.":[101],"Thus,":[102],"collecting":[103],"sequences":[105,152],"would":[106],"provide":[107],"good":[109],"starting":[110],"point":[111],"as":[112],"new":[114],"comparative":[117],"evolutionary":[119],"studies":[120],"applying":[121],"multigene":[123],"families.":[124],"In":[125,148],"this":[126,149],"context,":[127],"we":[128],"developing":[130],"Kinase":[134],"database":[135,141],"(RTKdb),":[136],"which":[137],"is":[138],"only":[140],"on":[142],"kinase":[144],"presently":[146],"available.":[147],"database,":[150],"eight":[154],"organized":[159],"format":[162],"previously":[163],"used":[164],"HOVERGEN,":[167],"HOBACGEN":[168],"NUREBASE":[170],"systems.":[171],"RTKdb":[172],"can":[173],"accessed":[175],"through":[176,189],"PBIL":[178],"(P\u00f4le":[179],"Bioinformatique":[180],"Lyonnais)":[181],"World":[182],"Wide":[183],"Web":[184],"server":[185],"at":[186,196],"http://pbil.univ-lyon1.fr/RTKdb/,":[187],"or":[188],"FamFetch":[191],"graphical":[192],"user":[193],"interface":[194],"available":[195],"same":[198],"address.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":1}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2025-10-10T00:00:00"}