{"id":"https://openalex.org/W2024151828","doi":"https://doi.org/10.1093/nar/gkf395","title":"Studies on the synthesis of a G-rich octaoligoisonucleotide (isoT)2(isoG)4(isoT)2 by the phosphotriester approach and its formation of G-quartet structure","display_name":"Studies on the synthesis of a G-rich octaoligoisonucleotide (isoT)2(isoG)4(isoT)2 by the phosphotriester approach and its formation of G-quartet structure","publication_year":2002,"publication_date":"2002-07-01","ids":{"openalex":"https://openalex.org/W2024151828","doi":"https://doi.org/10.1093/nar/gkf395","mag":"2024151828","pmid":"https://pubmed.ncbi.nlm.nih.gov/12087187"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkf395","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkf395","pdf_url":"https://academic.oup.com/nar/article-pdf/30/13/3005/7040756/gkf395.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/nar/article-pdf/30/13/3005/7040756/gkf395.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100394911","display_name":"Jing Chen","orcid":"https://orcid.org/0000-0002-6640-7140"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"J. Chen","raw_affiliation_strings":["National Research Laboratory of Natural and Biomimetic Drugs, Peking University, 38 Xueyuan Road, Beijing 100083, People's Republic of China","National Research Laboratory of Natural and Biomimetic Drugs, Peking University, 38 Xueyuan Road, Beijing\u00a0100083, People\u2019s Republic of China"],"affiliations":[{"raw_affiliation_string":"National Research Laboratory of Natural and Biomimetic Drugs, Peking University, 38 Xueyuan Road, Beijing 100083, People's Republic of China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"National Research Laboratory of Natural and Biomimetic Drugs, Peking University, 38 Xueyuan Road, Beijing\u00a0100083, People\u2019s Republic of China","institution_ids":["https://openalex.org/I20231570"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100394911"],"corresponding_institution_ids":["https://openalex.org/I20231570"],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":null,"fwci":0.5729,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.64627496,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"30","issue":"13","first_page":"3005","last_page":"3014"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oligomer","display_name":"Oligomer","score":0.7172863483428955},{"id":"https://openalex.org/keywords/nucleobase","display_name":"Nucleobase","score":0.6993613243103027},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5710993409156799},{"id":"https://openalex.org/keywords/intermolecular-force","display_name":"Intermolecular force","score":0.5281733870506287},{"id":"https://openalex.org/keywords/capillary-electrophoresis","display_name":"Capillary electrophoresis","score":0.49674588441848755},{"id":"https://openalex.org/keywords/stereochemistry","display_name":"Stereochemistry","score":0.49415162205696106},{"id":"https://openalex.org/keywords/g-quadruplex","display_name":"G-quadruplex","score":0.46353864669799805},{"id":"https://openalex.org/keywords/phase","display_name":"Phase (matter)","score":0.4162401556968689},{"id":"https://openalex.org/keywords/nucleotide","display_name":"Nucleotide","score":0.41549164056777954},{"id":"https://openalex.org/keywords/crystallography","display_name":"Crystallography","score":0.399404376745224},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.3736805319786072},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.24200230836868286},{"id":"https://openalex.org/keywords/molecule","display_name":"Molecule","score":0.16510796546936035},{"id":"https://openalex.org/keywords/molecular-biology","display_name":"Molecular biology","score":0.13792777061462402},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.12170276045799255},{"id":"https://openalex.org/keywords/organic-chemistry","display_name":"Organic chemistry","score":0.09443682432174683}],"concepts":[{"id":"https://openalex.org/C2780642029","wikidata":"https://www.wikidata.org/wiki/Q726004","display_name":"Oligomer","level":2,"score":0.7172863483428955},{"id":"https://openalex.org/C61234307","wikidata":"https://www.wikidata.org/wiki/Q422960","display_name":"Nucleobase","level":3,"score":0.6993613243103027},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5710993409156799},{"id":"https://openalex.org/C166950319","wikidata":"https://www.wikidata.org/wiki/Q245031","display_name":"Intermolecular force","level":3,"score":0.5281733870506287},{"id":"https://openalex.org/C2900643","wikidata":"https://www.wikidata.org/wiki/Q747468","display_name":"Capillary electrophoresis","level":2,"score":0.49674588441848755},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.49415162205696106},{"id":"https://openalex.org/C83762044","wikidata":"https://www.wikidata.org/wiki/Q411641","display_name":"G-quadruplex","level":3,"score":0.46353864669799805},{"id":"https://openalex.org/C44280652","wikidata":"https://www.wikidata.org/wiki/Q104837","display_name":"Phase (matter)","level":2,"score":0.4162401556968689},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.41549164056777954},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.399404376745224},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3736805319786072},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24200230836868286},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.16510796546936035},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.13792777061462402},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.12170276045799255},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.09443682432174683},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002942","descriptor_name":"Circular Dichroism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002942","descriptor_name":"Circular Dichroism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002942","descriptor_name":"Circular Dichroism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006151","descriptor_name":"Guanosine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006151","descriptor_name":"Guanosine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006151","descriptor_name":"Guanosine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009841","descriptor_name":"Oligonucleotides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D009841","descriptor_name":"Oligonucleotides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D009841","descriptor_name":"Oligonucleotides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D009841","descriptor_name":"Oligonucleotides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009841","descriptor_name":"Oligonucleotides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009841","descriptor_name":"Oligonucleotides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010755","descriptor_name":"Organophosphates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010755","descriptor_name":"Organophosphates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010755","descriptor_name":"Organophosphates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019075","descriptor_name":"Electrophoresis, Capillary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019075","descriptor_name":"Electrophoresis, Capillary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019075","descriptor_name":"Electrophoresis, Capillary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1093/nar/gkf395","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkf395","pdf_url":"https://academic.oup.com/nar/article-pdf/30/13/3005/7040756/gkf395.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmid:12087187","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12087187","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":null},{"id":"pmh:oai:europepmc.org:155325","is_oa":false,"landing_page_url":"http://europepmc.org/pmc/articles/PMC117050","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:155325","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/117050","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:117050","is_oa":true,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/nar/gkf395","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkf395","pdf_url":"https://academic.oup.com/nar/article-pdf/30/13/3005/7040756/gkf395.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.47999998927116394,"display_name":"Clean water and sanitation","id":"https://metadata.un.org/sdg/6"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2024151828.pdf","grobid_xml":"https://content.openalex.org/works/W2024151828.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1970057367","https://openalex.org/W1970602452","https://openalex.org/W1975398188","https://openalex.org/W1978502771","https://openalex.org/W1985649733","https://openalex.org/W1986648841","https://openalex.org/W2001601356","https://openalex.org/W2003481427","https://openalex.org/W2003842226","https://openalex.org/W2005493974","https://openalex.org/W2019142905","https://openalex.org/W2024913717","https://openalex.org/W2030132004","https://openalex.org/W2033526098","https://openalex.org/W2039139749","https://openalex.org/W2043537736","https://openalex.org/W2046422030","https://openalex.org/W2052442164","https://openalex.org/W2060356703","https://openalex.org/W2061464861","https://openalex.org/W2061771534","https://openalex.org/W2062395030","https://openalex.org/W2065459148","https://openalex.org/W2065753344","https://openalex.org/W2073722866","https://openalex.org/W2079991869","https://openalex.org/W2080558085","https://openalex.org/W2087350667","https://openalex.org/W2088047441","https://openalex.org/W2088531081","https://openalex.org/W2091876286","https://openalex.org/W2104713756","https://openalex.org/W2107634357","https://openalex.org/W2116950191","https://openalex.org/W2128598406","https://openalex.org/W2140657452","https://openalex.org/W2325993641","https://openalex.org/W2362851908","https://openalex.org/W2505641105","https://openalex.org/W2949284044"],"related_works":["https://openalex.org/W2078075210","https://openalex.org/W2292512574","https://openalex.org/W1829912350","https://openalex.org/W2531235969","https://openalex.org/W2073618147","https://openalex.org/W2383441779","https://openalex.org/W2043504820","https://openalex.org/W2032787256","https://openalex.org/W2054446568","https://openalex.org/W4214573824"],"abstract_inverted_index":{"The":[0,52],"octaoligoisonucleotide":[1],"(isoT)2(isoG)4(isoT)2":[2],"(I),":[3],"consisting":[4],"of":[5,46,55],"isonucleoside":[6],"units":[7],"6'-O-allyl-4'-deoxy-4'-(nucleobase)-2',5'-anhydro-L-mannitol,":[8],"was":[9,26],"synthesized":[10],"by":[11],"the":[12,44],"phosphotriester":[13],"approach":[14],"in":[15],"solution":[16],"phase.":[17],"Based":[18],"on":[19],"CD":[20],"spectra":[21],"and":[22,40,49],"capillary":[23],"electrophoresis,":[24],"it":[25],"confirmed":[27],"that":[28],"iso-oligomer":[29],"I":[30],"could":[31],"form":[32],"a":[33],"parallel":[34],"intermolecular":[35],"G-quadruplex":[36],"structure.":[37],"K+,":[38],"Na+":[39,61],"Li+":[41],"can":[42],"prompt":[43],"formation":[45],"G-quartet":[47],"structures":[48],"stabilize":[50],"them.":[51],"effective":[53],"order":[54],"these":[56],"cations":[57],"is":[58],"K+":[59],">":[60,62],"Li+.":[63]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}