{"id":"https://openalex.org/W4379600237","doi":"https://doi.org/10.1093/nar/gkad472","title":"DDMut: predicting effects of mutations on protein stability using deep learning","display_name":"DDMut: predicting effects of mutations on protein stability using deep learning","publication_year":2023,"publication_date":"2023-06-07","ids":{"openalex":"https://openalex.org/W4379600237","doi":"https://doi.org/10.1093/nar/gkad472","pmid":"https://pubmed.ncbi.nlm.nih.gov/37283042"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkad472","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkad472","pdf_url":"https://academic.oup.com/nar/advance-article-pdf/doi/10.1093/nar/gkad472/50527454/gkad472.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/advance-article-pdf/doi/10.1093/nar/gkad472/50527454/gkad472.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032359709","display_name":"Yunzhuo Zhou","orcid":"https://orcid.org/0000-0003-3827-8916"},"institutions":[{"id":"https://openalex.org/I142471025","display_name":"Baker Heart and Diabetes Institute","ror":"https://ror.org/03rke0285","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I142471025"]},{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Yunzhuo Zhou","raw_affiliation_strings":["Computational Biology and Clinical Informatics, Baker Heart and Diabetes Institute , Melbourne , Victoria , Australia","School of Chemistry and Molecular Biosciences, The University of Queensland , Brisbane , Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biology and Clinical Informatics, Baker Heart and Diabetes Institute , Melbourne , Victoria , Australia","institution_ids":["https://openalex.org/I142471025"]},{"raw_affiliation_string":"School of Chemistry and Molecular Biosciences, The University of Queensland , Brisbane , Australia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040267991","display_name":"Qisheng Pan","orcid":"https://orcid.org/0000-0001-8154-4293"},"institutions":[{"id":"https://openalex.org/I142471025","display_name":"Baker Heart and Diabetes Institute","ror":"https://ror.org/03rke0285","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I142471025"]},{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Qisheng Pan","raw_affiliation_strings":["Computational Biology and Clinical Informatics, Baker Heart and Diabetes Institute , Melbourne , Victoria , Australia","School of Chemistry and Molecular Biosciences, The University of Queensland , Brisbane , Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biology and Clinical Informatics, Baker Heart and Diabetes Institute , Melbourne , Victoria , Australia","institution_ids":["https://openalex.org/I142471025"]},{"raw_affiliation_string":"School of Chemistry and Molecular Biosciences, The University of Queensland , Brisbane , Australia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071950872","display_name":"Douglas E. V. Pires","orcid":"https://orcid.org/0000-0002-3004-2119"},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Douglas E V Pires","raw_affiliation_strings":["School of Computing and Information Systems, University of Melbourne , Melbourne , Victoria , Australia"],"raw_orcid":"https://orcid.org/0000-0002-3004-2119","affiliations":[{"raw_affiliation_string":"School of Computing and Information Systems, University of Melbourne , Melbourne , Victoria , Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001797627","display_name":"Carlos H. M. Rodrigues","orcid":"https://orcid.org/0000-0002-4420-6401"},"institutions":[{"id":"https://openalex.org/I142471025","display_name":"Baker Heart and Diabetes Institute","ror":"https://ror.org/03rke0285","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I142471025"]},{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Carlos\u00a0H M Rodrigues","raw_affiliation_strings":["Computational Biology and Clinical Informatics, Baker Heart and Diabetes Institute , Melbourne , Victoria , Australia","School of Chemistry and Molecular Biosciences, The University of Queensland , Brisbane , Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biology and Clinical Informatics, Baker Heart and Diabetes Institute , Melbourne , Victoria , Australia","institution_ids":["https://openalex.org/I142471025"]},{"raw_affiliation_string":"School of Chemistry and Molecular Biosciences, The University of Queensland , Brisbane , Australia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091903225","display_name":"David B. Ascher","orcid":"https://orcid.org/0000-0003-2948-2413"},"institutions":[{"id":"https://openalex.org/I142471025","display_name":"Baker Heart and Diabetes Institute","ror":"https://ror.org/03rke0285","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I142471025"]},{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"David\u00a0B Ascher","raw_affiliation_strings":["Computational Biology and Clinical Informatics, Baker Heart and Diabetes Institute , Melbourne , Victoria , Australia","School of Chemistry and Molecular Biosciences, The University of Queensland , Brisbane , Australia"],"raw_orcid":"https://orcid.org/0000-0003-2948-2413","affiliations":[{"raw_affiliation_string":"Computational Biology and Clinical Informatics, Baker Heart and Diabetes Institute , Melbourne , Victoria , Australia","institution_ids":["https://openalex.org/I142471025"]},{"raw_affiliation_string":"School of Chemistry and Molecular Biosciences, The University of Queensland , Brisbane , Australia","institution_ids":["https://openalex.org/I165143802"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5091903225"],"corresponding_institution_ids":["https://openalex.org/I142471025","https://openalex.org/I165143802"],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":{"value":3630,"currency":"USD","value_usd":3630},"fwci":36.1213,"has_fulltext":true,"cited_by_count":255,"citation_normalized_percentile":{"value":0.99885151,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"51","issue":"W1","first_page":"W122","last_page":"W128"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9883999824523926,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.9446790218353271},{"id":"https://openalex.org/keywords/stability","display_name":"Stability (learning theory)","score":0.567861020565033},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.5487703084945679},{"id":"https://openalex.org/keywords/protein-stability","display_name":"Protein stability","score":0.5328083038330078},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.5261150002479553},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5005753040313721},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2753719091415405},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.16858771443367004},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.16098222136497498}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9446790218353271},{"id":"https://openalex.org/C112972136","wikidata":"https://www.wikidata.org/wiki/Q7595718","display_name":"Stability (learning theory)","level":2,"score":0.567861020565033},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5487703084945679},{"id":"https://openalex.org/C2988375501","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein stability","level":2,"score":0.5328083038330078},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5261150002479553},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5005753040313721},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2753719091415405},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.16858771443367004},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.16098222136497498},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/nar/gkad472","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkad472","pdf_url":"https://academic.oup.com/nar/advance-article-pdf/doi/10.1093/nar/gkad472/50527454/gkad472.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmid:37283042","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37283042","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10320186","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10320186","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10320186/pdf/gkad472.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/nar/gkad472","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkad472","pdf_url":"https://academic.oup.com/nar/advance-article-pdf/doi/10.1093/nar/gkad472/50527454/gkad472.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G6454673195","display_name":null,"funder_award_id":"GNT1174405","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320315885","display_name":"Australian Government","ror":"https://ror.org/0314h5y94"},{"id":"https://openalex.org/F4320322858","display_name":"State Government of Victoria","ror":"https://ror.org/02xvc5r05"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4379600237.pdf"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1984452172","https://openalex.org/W1986522554","https://openalex.org/W2014731953","https://openalex.org/W2023490488","https://openalex.org/W2030071974","https://openalex.org/W2041476324","https://openalex.org/W2060588922","https://openalex.org/W2064488723","https://openalex.org/W2065283382","https://openalex.org/W2089863534","https://openalex.org/W2099672241","https://openalex.org/W2103459989","https://openalex.org/W2112702439","https://openalex.org/W2123400824","https://openalex.org/W2130479394","https://openalex.org/W2172034373","https://openalex.org/W2560264526","https://openalex.org/W2615841538","https://openalex.org/W2743857398","https://openalex.org/W2801491392","https://openalex.org/W2806399642","https://openalex.org/W2912783011","https://openalex.org/W2953906682","https://openalex.org/W3012929814","https://openalex.org/W3045100294","https://openalex.org/W3083008290","https://openalex.org/W3104081477","https://openalex.org/W3136963718","https://openalex.org/W3164662464","https://openalex.org/W3183009512","https://openalex.org/W4206007286","https://openalex.org/W4213345021","https://openalex.org/W4378530277","https://openalex.org/W6678761317"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W1509071637","https://openalex.org/W2065530813","https://openalex.org/W2957509185","https://openalex.org/W1536710881","https://openalex.org/W2137231843","https://openalex.org/W2146849562","https://openalex.org/W2028961943","https://openalex.org/W2012422256","https://openalex.org/W3104156022"],"abstract_inverted_index":{"Understanding":[0],"the":[1,91,105,175],"effects":[2],"of":[3,24,90,121,178],"mutations":[4,75],"on":[5,128,137,158],"protein":[6,15,183],"stability":[7],"is":[8,186],"crucial":[9],"for":[10,78],"variant":[11],"interpretation":[12],"and":[13,17,37,52,65,72,98,114,132,154,161,180,193],"prioritisation,":[14],"engineering,":[16],"biotechnology.":[18],"Despite":[19],"significant":[20],"efforts,":[21],"community":[22],"assessments":[23],"predictive":[25,35],"tools":[26],"have":[27],"highlighted":[28],"ongoing":[29],"limitations,":[30],"including":[31],"computational":[32],"time,":[33],"low":[34],"power,":[36],"biased":[38],"predictions":[39],"towards":[40],"destabilising":[41,160],"mutations.":[42,163],"To":[43],"fill":[44],"this":[45],"gap,":[46],"we":[47],"developed":[48],"DDMut,":[49],"a":[50,169,190],"fast":[51],"accurate":[53],"siamese":[54],"network":[55],"to":[56,76,123,172],"predict":[57],"changes":[58],"in":[59],"Gibbs":[60],"Free":[61],"Energy":[62],"upon":[63],"single":[64,129],"multiple":[66],"point":[67,130],"mutations,":[68,131,179],"leveraging":[69],"both":[70,112,159],"forward":[71],"hypothetical":[73],"reverse":[74],"account":[77],"model":[79],"anti-symmetry.":[80],"Deep":[81],"learning":[82],"models":[83],"were":[84],"built":[85],"by":[86,110],"integrating":[87],"graph-based":[88],"representations":[89],"localised":[92],"3D":[93],"environment,":[94],"with":[95],"convolutional":[96],"layers":[97],"transformer":[99],"encoders.":[100],"This":[101],"combination":[102],"better":[103,173],"captured":[104],"distance":[106],"patterns":[107],"between":[108],"atoms":[109],"extracting":[111],"short-range":[113],"long-range":[115],"interactions.":[116],"DDMut":[117,150,166,185],"achieved":[118],"Pearson's":[119],"correlations":[120],"up":[122],"0.70":[124,133],"(RMSE:":[125,134],"1.37":[126],"kcal/mol)":[127,136],"1.84":[135],"double/triple":[138],"mutants,":[139],"outperforming":[140],"most":[141],"available":[142,188],"methods":[143],"across":[144],"non-redundant":[145],"blind":[146],"test":[147],"sets.":[148],"Importantly,":[149],"was":[151],"highly":[152],"scalable":[153],"demonstrated":[155],"anti-symmetric":[156],"performance":[157],"stabilising":[162],"We":[164],"believe":[165],"will":[167],"be":[168],"useful":[170],"platform":[171],"understand":[174],"functional":[176],"consequences":[177],"guide":[181],"rational":[182],"engineering.":[184],"freely":[187],"as":[189],"web":[191],"server":[192],"API":[194],"at":[195],"https://biosig.lab.uq.edu.au/ddmut.":[196]},"counts_by_year":[{"year":2026,"cited_by_count":43},{"year":2025,"cited_by_count":118},{"year":2024,"cited_by_count":70},{"year":2023,"cited_by_count":24}],"updated_date":"2026-06-16T07:32:37.131356","created_date":"2025-10-10T00:00:00"}
