{"id":"https://openalex.org/W4376872109","doi":"https://doi.org/10.1093/nar/gkad408","title":"SEanalysis 2.0: a comprehensive super-enhancer regulatory network analysis tool for human and mouse","display_name":"SEanalysis 2.0: a comprehensive super-enhancer regulatory network analysis tool for human and mouse","publication_year":2023,"publication_date":"2023-05-17","ids":{"openalex":"https://openalex.org/W4376872109","doi":"https://doi.org/10.1093/nar/gkad408","pmid":"https://pubmed.ncbi.nlm.nih.gov/37194711"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkad408","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkad408","pdf_url":"https://academic.oup.com/nar/advance-article-pdf/doi/10.1093/nar/gkad408/50363635/gkad408.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/advance-article-pdf/doi/10.1093/nar/gkad408/50363635/gkad408.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022537385","display_name":"Fengcui Qian","orcid":"https://orcid.org/0000-0003-3817-4690"},"institutions":[{"id":"https://openalex.org/I4210166238","display_name":"Hunan Provincial Maternal and Child Health Hospital","ror":"https://ror.org/05szwcv45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166238"]},{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feng-Cui Qian","raw_affiliation_strings":["Insititute of Biochemistry and Molecular Biology, Hengyang Medical College, University of South China , Hengyang , Hunan \u00a0421001, China","National Health Commission Key Laboratory of Birth Defect Research and Prevention, Hunan Provincial Maternal and Child Health Care Hospital , Changsha , Hunan \u00a0410008, China","School of Computer, University of South China , Hengyang , Hunan \u00a0421001, China","The First Affiliated Hospital, Cardiovascular Lab of Big Data and Imaging Artificial Intelligence, Hengyang Medical School, University of South China , Hengyang , Hunan \u00a0421001, China","The First Affiliated Hospital, Department of Cardiology, Hengyang Medical School, University of South China , Hengyang , China","The First Affiliated Hospital, Institute of Cardiovascular Disease, Hengyang Medical School, University of South China , Hengyang , Hunan \u00a0421001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Insititute of Biochemistry and Molecular Biology, Hengyang Medical College, University of South China , Hengyang , Hunan \u00a0421001, China","institution_ids":["https://openalex.org/I91935597"]},{"raw_affiliation_string":"National Health Commission Key Laboratory of Birth Defect Research and Prevention, Hunan Provincial Maternal and Child Health Care Hospital , Changsha , Hunan \u00a0410008, China","institution_ids":["https://openalex.org/I4210166238"]},{"raw_affiliation_string":"School of Computer, University of South China , Hengyang , Hunan \u00a0421001, China","institution_ids":["https://openalex.org/I91935597"]},{"raw_affiliation_string":"The First Affiliated Hospital, Cardiovascular Lab of Big Data and Imaging Artificial Intelligence, Hengyang Medical School, University of South China , Hengyang , Hunan \u00a0421001, China","institution_ids":["https://openalex.org/I91935597"]},{"raw_affiliation_string":"The First Affiliated Hospital, Department of Cardiology, Hengyang Medical School, University of South China , Hengyang , China","institution_ids":["https://openalex.org/I91935597"]},{"raw_affiliation_string":"The First Affiliated Hospital, Institute of Cardiovascular Disease, Hengyang Medical School, University of South China , Hengyang , Hunan \u00a0421001, China","institution_ids":["https://openalex.org/I91935597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073809871","display_name":"Li\u2010Wei Zhou","orcid":"https://orcid.org/0000-0002-2851-2839"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li-Wei Zhou","raw_affiliation_strings":["School of Medical Informatics, Daqing Campus, Harbin Medical University , Daqing \u00a0163319, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medical Informatics, Daqing Campus, Harbin Medical University , Daqing \u00a0163319, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101470623","display_name":"Yanyu Li","orcid":"https://orcid.org/0000-0002-1416-9216"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan-Yu Li","raw_affiliation_strings":["School of Medical Informatics, Daqing Campus, Harbin Medical University , Daqing \u00a0163319, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medical Informatics, Daqing Campus, Harbin Medical University , Daqing \u00a0163319, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080189085","display_name":"Zhengmin Yu","orcid":"https://orcid.org/0009-0006-0777-4043"},"institutions":[{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zheng-Min Yu","raw_affiliation_strings":["The First Affiliated Hospital, Cardiovascular Lab of Big Data and Imaging Artificial Intelligence, Hengyang Medical School, University of South China , Hengyang , Hunan \u00a0421001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital, Cardiovascular Lab of Big Data and Imaging Artificial Intelligence, Hengyang Medical School, University of South China , Hengyang , Hunan \u00a0421001, China","institution_ids":["https://openalex.org/I91935597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019531815","display_name":"Lidong Li","orcid":"https://orcid.org/0000-0003-0797-2518"},"institutions":[{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li-Dong Li","raw_affiliation_strings":["School of Computer, University of South China , Hengyang , Hunan \u00a0421001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer, University of South China , Hengyang , Hunan \u00a0421001, China","institution_ids":["https://openalex.org/I91935597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103325466","display_name":"Yuezhu Wang","orcid":"https://orcid.org/0009-0009-4095-6473"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yue-Zhu Wang","raw_affiliation_strings":["School of Medical Informatics, Daqing Campus, Harbin Medical University , Daqing \u00a0163319, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medical Informatics, Daqing Campus, Harbin Medical University , Daqing \u00a0163319, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059646863","display_name":"Mingcong Xu","orcid":null},"institutions":[{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ming-Cong Xu","raw_affiliation_strings":["The First Affiliated Hospital, Cardiovascular Lab of Big Data and Imaging Artificial Intelligence, Hengyang Medical School, University of South China , Hengyang , Hunan \u00a0421001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital, Cardiovascular Lab of Big Data and Imaging Artificial Intelligence, Hengyang Medical School, University of South China , Hengyang , Hunan \u00a0421001, China","institution_ids":["https://openalex.org/I91935597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115694793","display_name":"Qiuyu Wang","orcid":"https://orcid.org/0009-0006-9422-7223"},"institutions":[{"id":"https://openalex.org/I4210166238","display_name":"Hunan Provincial Maternal and Child Health Hospital","ror":"https://ror.org/05szwcv45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166238"]},{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiu-Yu Wang","raw_affiliation_strings":["Insititute of Biochemistry and Molecular Biology, Hengyang Medical College, University of South China , Hengyang , Hunan \u00a0421001, China","National Health Commission Key Laboratory of Birth Defect Research and Prevention, Hunan Provincial Maternal and Child Health Care Hospital , Changsha , Hunan \u00a0410008, China","School of Computer, University of South China , Hengyang , Hunan \u00a0421001, China","The First Affiliated Hospital, Cardiovascular Lab of Big Data and Imaging Artificial Intelligence, Hengyang Medical School, University of South China , Hengyang , Hunan \u00a0421001, China","The First Affiliated Hospital, Department of Cardiology, Hengyang Medical School, University of South China , Hengyang , China","The First Affiliated Hospital, Institute of Cardiovascular Disease, Hengyang Medical School, University of South China , Hengyang , Hunan \u00a0421001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Insititute of Biochemistry and Molecular Biology, Hengyang Medical College, University of South China , Hengyang , Hunan \u00a0421001, China","institution_ids":["https://openalex.org/I91935597"]},{"raw_affiliation_string":"National Health Commission Key Laboratory of Birth Defect Research and Prevention, Hunan Provincial Maternal and Child Health Care Hospital , Changsha , Hunan \u00a0410008, China","institution_ids":["https://openalex.org/I4210166238"]},{"raw_affiliation_string":"School of Computer, University of South China , Hengyang , Hunan \u00a0421001, China","institution_ids":["https://openalex.org/I91935597"]},{"raw_affiliation_string":"The First Affiliated Hospital, Cardiovascular Lab of Big Data and Imaging Artificial Intelligence, Hengyang Medical School, University of South China , Hengyang , Hunan \u00a0421001, China","institution_ids":["https://openalex.org/I91935597"]},{"raw_affiliation_string":"The First Affiliated Hospital, Department of Cardiology, Hengyang Medical School, University of South China , Hengyang , China","institution_ids":["https://openalex.org/I91935597"]},{"raw_affiliation_string":"The First Affiliated Hospital, Institute of Cardiovascular Disease, Hengyang Medical School, University of South China , Hengyang , Hunan \u00a0421001, China","institution_ids":["https://openalex.org/I91935597"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100728506","display_name":"Chunquan Li","orcid":"https://orcid.org/0000-0002-4700-5496"},"institutions":[{"id":"https://openalex.org/I4210166238","display_name":"Hunan Provincial Maternal and Child Health Hospital","ror":"https://ror.org/05szwcv45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166238"]},{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chun-Quan Li","raw_affiliation_strings":["Insititute of Biochemistry and Molecular Biology, Hengyang Medical College, University of South China , Hengyang , Hunan \u00a0421001, China","National Health Commission Key Laboratory of Birth Defect Research and Prevention, Hunan Provincial Maternal and Child Health Care Hospital , Changsha , Hunan \u00a0410008, China","School of Computer, University of South China , Hengyang , Hunan \u00a0421001, China","The First Affiliated Hospital, Cardiovascular Lab of Big Data and Imaging Artificial Intelligence, Hengyang Medical School, University of South China , Hengyang , Hunan \u00a0421001, China","The First Affiliated Hospital, Department of Cardiology, Hengyang Medical School, University of South China , Hengyang , China","The First Affiliated Hospital, Institute of Cardiovascular Disease, Hengyang Medical School, University of South China , Hengyang , Hunan \u00a0421001, China"],"raw_orcid":"https://orcid.org/0000-0002-4700-5496","affiliations":[{"raw_affiliation_string":"Insititute of Biochemistry and Molecular Biology, Hengyang Medical College, University of South China , Hengyang , Hunan \u00a0421001, China","institution_ids":["https://openalex.org/I91935597"]},{"raw_affiliation_string":"National Health Commission Key Laboratory of Birth Defect Research and Prevention, Hunan Provincial Maternal and Child Health Care Hospital , Changsha , Hunan \u00a0410008, China","institution_ids":["https://openalex.org/I4210166238"]},{"raw_affiliation_string":"School of Computer, University of South China , Hengyang , Hunan \u00a0421001, China","institution_ids":["https://openalex.org/I91935597"]},{"raw_affiliation_string":"The First Affiliated Hospital, Cardiovascular Lab of Big Data and Imaging Artificial Intelligence, Hengyang Medical School, University of South China , Hengyang , Hunan \u00a0421001, China","institution_ids":["https://openalex.org/I91935597"]},{"raw_affiliation_string":"The First Affiliated Hospital, Department of Cardiology, Hengyang Medical School, University of South China , Hengyang , China","institution_ids":["https://openalex.org/I91935597"]},{"raw_affiliation_string":"The First Affiliated Hospital, Institute of Cardiovascular Disease, Hengyang Medical School, University of South China , Hengyang , Hunan \u00a0421001, China","institution_ids":["https://openalex.org/I91935597"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":{"value":3630,"currency":"USD","value_usd":3630},"fwci":13.589,"has_fulltext":true,"cited_by_count":101,"citation_normalized_percentile":{"value":0.99282208,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"51","issue":"W1","first_page":"W520","last_page":"W527"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9962999820709229,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10184","display_name":"Plant Molecular Biology Research","score":0.9847000241279602,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.8789133429527283},{"id":"https://openalex.org/keywords/enhancer","display_name":"Enhancer","score":0.694406270980835},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.673485517501831},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6448764204978943},{"id":"https://openalex.org/keywords/regulatory-sequence","display_name":"Regulatory sequence","score":0.5778936743736267},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.5334940552711487},{"id":"https://openalex.org/keywords/annotation","display_name":"Annotation","score":0.46421220898628235},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.44499433040618896},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.42930319905281067},{"id":"https://openalex.org/keywords/regulation-of-gene-expression","display_name":"Regulation of gene expression","score":0.41367074847221375},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3971773684024811},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.18819865584373474}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8789133429527283},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.694406270980835},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.673485517501831},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6448764204978943},{"id":"https://openalex.org/C21592294","wikidata":"https://www.wikidata.org/wiki/Q3238407","display_name":"Regulatory sequence","level":4,"score":0.5778936743736267},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5334940552711487},{"id":"https://openalex.org/C2776321320","wikidata":"https://www.wikidata.org/wiki/Q857525","display_name":"Annotation","level":2,"score":0.46421220898628235},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.44499433040618896},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.42930319905281067},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.41367074847221375},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3971773684024811},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.18819865584373474},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004742","descriptor_name":"Enhancer Elements, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004742","descriptor_name":"Enhancer Elements, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004742","descriptor_name":"Enhancer Elements, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/nar/gkad408","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkad408","pdf_url":"https://academic.oup.com/nar/advance-article-pdf/doi/10.1093/nar/gkad408/50363635/gkad408.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmid:37194711","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37194711","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10320134","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10320134","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10320134/pdf/gkad408.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/nar/gkad408","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkad408","pdf_url":"https://academic.oup.com/nar/advance-article-pdf/doi/10.1093/nar/gkad408/50363635/gkad408.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1224704230","display_name":null,"funder_award_id":"62171166","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6685575456","display_name":null,"funder_award_id":"LH2021F044","funder_id":"https://openalex.org/F4320323085","funder_display_name":"Natural Science Foundation of Heilongjiang Province"},{"id":"https://openalex.org/G7413427463","display_name":null,"funder_award_id":"2021-01","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8961461774","display_name":null,"funder_award_id":"62272212","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320323085","display_name":"Natural Science Foundation of Heilongjiang Province","ror":null},{"id":"https://openalex.org/F4320325572","display_name":"University of South China","ror":"https://ror.org/03mqfn238"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4376872109.pdf"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1964733653","https://openalex.org/W1969466735","https://openalex.org/W1971578941","https://openalex.org/W2010789111","https://openalex.org/W2026690931","https://openalex.org/W2060484997","https://openalex.org/W2080152736","https://openalex.org/W2084160423","https://openalex.org/W2102619694","https://openalex.org/W2118258530","https://openalex.org/W2140952049","https://openalex.org/W2145010689","https://openalex.org/W2146512944","https://openalex.org/W2156627746","https://openalex.org/W2157009395","https://openalex.org/W2167852161","https://openalex.org/W2259938310","https://openalex.org/W2262709833","https://openalex.org/W2341539131","https://openalex.org/W2491676496","https://openalex.org/W2583735774","https://openalex.org/W2702680930","https://openalex.org/W2752211734","https://openalex.org/W2767749844","https://openalex.org/W2901027836","https://openalex.org/W2901303766","https://openalex.org/W2940527079","https://openalex.org/W2941993016","https://openalex.org/W2946657092","https://openalex.org/W2990225395","https://openalex.org/W3014967119","https://openalex.org/W3038319703","https://openalex.org/W3106120778","https://openalex.org/W3108737349","https://openalex.org/W3165593669","https://openalex.org/W3180853053","https://openalex.org/W3212334377","https://openalex.org/W4206759436","https://openalex.org/W4207035071","https://openalex.org/W4214710575","https://openalex.org/W4220784448","https://openalex.org/W4220897536","https://openalex.org/W4221102522","https://openalex.org/W4226021060","https://openalex.org/W4280652009","https://openalex.org/W4309908811","https://openalex.org/W4317037064","https://openalex.org/W4394033564","https://openalex.org/W6863703140"],"related_works":["https://openalex.org/W4221130891","https://openalex.org/W2070964166","https://openalex.org/W2615895636","https://openalex.org/W2167063030","https://openalex.org/W2623141677","https://openalex.org/W2134434282","https://openalex.org/W3048510984","https://openalex.org/W3037778845","https://openalex.org/W2277277196","https://openalex.org/W2043274041"],"abstract_inverted_index":{"Super-enhancers":[0],"(SEs)":[1],"play":[2],"an":[3,30,186],"essential":[4],"regulatory":[5,44,113,132,145,191],"role":[6],"in":[7,87,96,185],"various":[8],"biological":[9],"processes":[10],"and":[11,51,59,76,115,134,177],"diseases":[12],"through":[13],"their":[14],"specific":[15],"interaction":[16],"with":[17],"transcription":[18],"factors":[19],"(TFs).":[20],"Here,":[21],"we":[22,125,167],"present":[23],"the":[24,34,39,62,102,151,157,175,190],"release":[25],"of":[26,33,42,64,104,143,180,189,193],"SEanalysis":[27,35,88,170],"2.0":[28,89,171],"(http://licpathway.net/SEanalysis),":[29],"updated":[31],"version":[32,55,97],"web":[36],"server":[37],"for":[38,119,138],"comprehensive":[40,141],"analyses":[41,108,142],"transcriptional":[43],"networks":[45,146],"formed":[46],"by":[47,148],"SEs,":[48,66,181],"pathways,":[49],"TFs,":[50],"genes.":[52],"The":[53,84],"current":[54],"added":[56],"mouse":[57,79],"SEs":[58,72,80],"further":[60],"expanded":[61,174],"scale":[63],"human":[65,71],"documenting":[67],"1":[68],"167":[69],"518":[70],"from":[73,81],"1739":[74],"samples":[75,86],"550":[77],"226":[78],"931":[82],"samples.":[83],"SE-related":[85,106,163],"were":[90,154],"more":[91,140],"than":[92],"five":[93],"times":[94],"that":[95,169],"1.0,":[98],"which":[99,182],"significantly":[100,173],"improved":[101],"ability":[103],"original":[105],"network":[107],"('pathway":[109],"downstream":[110],"analysis',":[111],"'upstream":[112],"analysis'":[114,133,137],"'genomic":[116],"region":[117],"annotation')":[118],"understanding":[120,188],"context-specific":[121],"gene":[122],"regulation.":[123],"Furthermore,":[124],"designed":[126],"two":[127],"novel":[128],"analysis":[129],"models,":[130],"'TF":[131],"'Sample":[135],"comparative":[136],"supporting":[139],"SE":[144,158],"driven":[147],"TFs.":[149],"Further,":[150],"risk":[152],"SNPs":[153],"annotated":[155],"to":[156,160],"regions":[159],"provide":[161],"potential":[162],"disease/trait":[164],"information.":[165],"Hence,":[166],"believe":[168],"has":[172],"data":[176],"analytical":[178],"capabilities":[179],"helps":[183],"researchers":[184],"in-depth":[187],"mechanisms":[192],"SEs.":[194]},"counts_by_year":[{"year":2026,"cited_by_count":25},{"year":2025,"cited_by_count":59},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":1}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}