{"id":"https://openalex.org/W4308616057","doi":"https://doi.org/10.1093/nar/gkac967","title":"Annotation and evaluation of base editing outcomes in multiple cell types using CRISPRbase","display_name":"Annotation and evaluation of base editing outcomes in multiple cell types using CRISPRbase","publication_year":2022,"publication_date":"2022-11-09","ids":{"openalex":"https://openalex.org/W4308616057","doi":"https://doi.org/10.1093/nar/gkac967","pmid":"https://pubmed.ncbi.nlm.nih.gov/36350608"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkac967","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkac967","pdf_url":"https://academic.oup.com/nar/article-pdf/51/D1/D1249/48441659/gkac967.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/51/D1/D1249/48441659/gkac967.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110722905","display_name":"Jibiao Fan","orcid":null},"institutions":[{"id":"https://openalex.org/I78978612","display_name":"Yangzhou University","ror":"https://ror.org/03tqb8s11","country_code":"CN","type":"education","lineage":["https://openalex.org/I78978612"]},{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]},{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jibiao Fan","raw_affiliation_strings":["College of Animal Science and Technology, Yangzhou University , Yangzhou , Jiangsu Province\u00a0 225009 , China","Institute of Medical Innovation and Research, Peking University Third Hospital , Beijing \u00a0100191, China"],"affiliations":[{"raw_affiliation_string":"College of Animal Science and Technology, Yangzhou University , Yangzhou , Jiangsu Province\u00a0 225009 , China","institution_ids":["https://openalex.org/I78978612"]},{"raw_affiliation_string":"Institute of Medical Innovation and Research, Peking University Third Hospital , Beijing \u00a0100191, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210141942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042185564","display_name":"Leisheng Shi","orcid":"https://orcid.org/0000-0003-3795-3641"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Leisheng Shi","raw_affiliation_strings":["Cancer Center, Peking University Third Hospital , Beijing \u00a0100191, China","Institute of Medical Innovation and Research, Peking University Third Hospital , Beijing \u00a0100191, China"],"affiliations":[{"raw_affiliation_string":"Cancer Center, Peking University Third Hospital , Beijing \u00a0100191, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210141942"]},{"raw_affiliation_string":"Institute of Medical Innovation and Research, Peking University Third Hospital , Beijing \u00a0100191, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210141942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107808966","display_name":"Qi Liu","orcid":"https://orcid.org/0000-0002-8723-9553"},"institutions":[{"id":"https://openalex.org/I4210090603","display_name":"Rice Research Institute","ror":"https://ror.org/00c11v577","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210090603","https://openalex.org/I4210099004"]},{"id":"https://openalex.org/I4210099004","display_name":"Guangdong Academy of Agricultural Sciences","ror":"https://ror.org/01rkwtz72","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210099004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qi Liu","raw_affiliation_strings":["Guangdong Key Laboratory of New Technology in Rice Breeding , Guangzhou \u00a0510640, China","Guangdong Rice Engineering Laboratory , Guangzhou \u00a0510640, China","Rice Research Institute, Guangdong Academy of Agricultural Sciences , Guangzhou \u00a0510640, China"],"affiliations":[{"raw_affiliation_string":"Guangdong Key Laboratory of New Technology in Rice Breeding , Guangzhou \u00a0510640, China","institution_ids":[]},{"raw_affiliation_string":"Guangdong Rice Engineering Laboratory , Guangzhou \u00a0510640, China","institution_ids":["https://openalex.org/I4210090603"]},{"raw_affiliation_string":"Rice Research Institute, Guangdong Academy of Agricultural Sciences , Guangzhou \u00a0510640, China","institution_ids":["https://openalex.org/I4210090603","https://openalex.org/I4210099004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051552011","display_name":"Zhipeng Zhu","orcid":"https://orcid.org/0000-0001-5685-410X"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhipeng Zhu","raw_affiliation_strings":["Cancer Center, Peking University Third Hospital , Beijing \u00a0100191, China","Institute of Medical Innovation and Research, Peking University Third Hospital , Beijing \u00a0100191, China"],"affiliations":[{"raw_affiliation_string":"Cancer Center, Peking University Third Hospital , Beijing \u00a0100191, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210141942"]},{"raw_affiliation_string":"Institute of Medical Innovation and Research, Peking University Third Hospital , Beijing \u00a0100191, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210141942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100380496","display_name":"Fan Wang","orcid":"https://orcid.org/0000-0001-9806-5037"},"institutions":[{"id":"https://openalex.org/I78978612","display_name":"Yangzhou University","ror":"https://ror.org/03tqb8s11","country_code":"CN","type":"education","lineage":["https://openalex.org/I78978612"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fan Wang","raw_affiliation_strings":["College of Animal Science and Technology, Yangzhou University , Yangzhou , Jiangsu Province\u00a0 225009 , China"],"affiliations":[{"raw_affiliation_string":"College of Animal Science and Technology, Yangzhou University , Yangzhou , Jiangsu Province\u00a0 225009 , China","institution_ids":["https://openalex.org/I78978612"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035846199","display_name":"Runxian Song","orcid":"https://orcid.org/0000-0001-9343-194X"},"institutions":[{"id":"https://openalex.org/I4210099004","display_name":"Guangdong Academy of Agricultural Sciences","ror":"https://ror.org/01rkwtz72","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210099004"]},{"id":"https://openalex.org/I47689461","display_name":"Northeast Forestry University","ror":"https://ror.org/02yxnh564","country_code":"CN","type":"education","lineage":["https://openalex.org/I47689461"]},{"id":"https://openalex.org/I4210090603","display_name":"Rice Research Institute","ror":"https://ror.org/00c11v577","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210090603","https://openalex.org/I4210099004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Runxian Song","raw_affiliation_strings":["Rice Research Institute, Guangdong Academy of Agricultural Sciences , Guangzhou \u00a0510640, China","State Key Laboratory of Tree Genetics and Breeding, Forestry College, Northeast Forestry University , Harbin \u00a0150040, China"],"affiliations":[{"raw_affiliation_string":"Rice Research Institute, Guangdong Academy of Agricultural Sciences , Guangzhou \u00a0510640, China","institution_ids":["https://openalex.org/I4210090603","https://openalex.org/I4210099004"]},{"raw_affiliation_string":"State Key Laboratory of Tree Genetics and Breeding, Forestry College, Northeast Forestry University , Harbin \u00a0150040, China","institution_ids":["https://openalex.org/I47689461"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081784653","display_name":"Jimeng Su","orcid":null},"institutions":[{"id":"https://openalex.org/I78978612","display_name":"Yangzhou University","ror":"https://ror.org/03tqb8s11","country_code":"CN","type":"education","lineage":["https://openalex.org/I78978612"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jimeng Su","raw_affiliation_strings":["College of Animal Science and Technology, Yangzhou University , Yangzhou , Jiangsu Province\u00a0 225009 , China"],"affiliations":[{"raw_affiliation_string":"College of Animal Science and Technology, Yangzhou University , Yangzhou , Jiangsu Province\u00a0 225009 , China","institution_ids":["https://openalex.org/I78978612"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025919733","display_name":"Degui Zhou","orcid":"https://orcid.org/0000-0003-1902-7150"},"institutions":[{"id":"https://openalex.org/I4210099004","display_name":"Guangdong Academy of Agricultural Sciences","ror":"https://ror.org/01rkwtz72","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210099004"]},{"id":"https://openalex.org/I4210090603","display_name":"Rice Research Institute","ror":"https://ror.org/00c11v577","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210090603","https://openalex.org/I4210099004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Degui Zhou","raw_affiliation_strings":["Guangdong Key Laboratory of New Technology in Rice Breeding , Guangzhou \u00a0510640, China","Guangdong Rice Engineering Laboratory , Guangzhou \u00a0510640, China","Rice Research Institute, Guangdong Academy of Agricultural Sciences , Guangzhou \u00a0510640, China"],"affiliations":[{"raw_affiliation_string":"Guangdong Key Laboratory of New Technology in Rice Breeding , Guangzhou \u00a0510640, China","institution_ids":[]},{"raw_affiliation_string":"Guangdong Rice Engineering Laboratory , Guangzhou \u00a0510640, China","institution_ids":["https://openalex.org/I4210090603"]},{"raw_affiliation_string":"Rice Research Institute, Guangdong Academy of Agricultural Sciences , Guangzhou \u00a0510640, China","institution_ids":["https://openalex.org/I4210090603","https://openalex.org/I4210099004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061625997","display_name":"Xiao Chen","orcid":"https://orcid.org/0000-0001-5059-8846"},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao Chen","raw_affiliation_strings":["Laboratory of Marine Protozoan Biodiversity & Evolution, Marine College, Shandong University , Weihai \u00a0264209, China"],"affiliations":[{"raw_affiliation_string":"Laboratory of Marine Protozoan Biodiversity & Evolution, Marine College, Shandong University , Weihai \u00a0264209, China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070011755","display_name":"Kailong Li","orcid":"https://orcid.org/0000-0002-3311-5782"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kailong Li","raw_affiliation_strings":["Department of Biochemistry and Biophysics, School of Basic Medical Sciences, Peking University Health Science Center , Beijing \u00a0100191, China"],"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, School of Basic Medical Sciences, Peking University Health Science Center , Beijing \u00a0100191, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019257182","display_name":"Lixiang Xue","orcid":"https://orcid.org/0000-0003-1507-7193"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lixiang Xue","raw_affiliation_strings":["Cancer Center, Peking University Third Hospital , Beijing \u00a0100191, China","Institute of Medical Innovation and Research, Peking University Third Hospital , Beijing \u00a0100191, China"],"affiliations":[{"raw_affiliation_string":"Cancer Center, Peking University Third Hospital , Beijing \u00a0100191, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210141942"]},{"raw_affiliation_string":"Institute of Medical Innovation and Research, Peking University Third Hospital , Beijing \u00a0100191, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210141942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102714473","display_name":"Lichao Sun","orcid":"https://orcid.org/0000-0003-0551-1080"},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lichao Sun","raw_affiliation_strings":["State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing \u00a0100021, China"],"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing \u00a0100021, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046363705","display_name":"Fengbiao Mao","orcid":"https://orcid.org/0000-0003-0852-4266"},"institutions":[{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]},{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Fengbiao Mao","raw_affiliation_strings":["Cancer Center, Peking University Third Hospital , Beijing \u00a0100191, China","Institute of Medical Innovation and Research, Peking University Third Hospital , Beijing \u00a0100191, China"],"affiliations":[{"raw_affiliation_string":"Cancer Center, Peking University Third Hospital , Beijing \u00a0100191, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210141942"]},{"raw_affiliation_string":"Institute of Medical Innovation and Research, Peking University Third Hospital , Beijing \u00a0100191, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210141942"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5019257182","https://openalex.org/A5046363705","https://openalex.org/A5102714473"],"corresponding_institution_ids":["https://openalex.org/I200296433","https://openalex.org/I20231570","https://openalex.org/I4210141942"],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":{"value":3630,"currency":"USD","value_usd":3630},"fwci":0.52,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.62328659,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"51","issue":"D1","first_page":"D1249","last_page":"D1256"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":0.9950000047683716,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9919999837875366,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7311648726463318},{"id":"https://openalex.org/keywords/genome-editing","display_name":"Genome editing","score":0.7032153606414795},{"id":"https://openalex.org/keywords/crispr","display_name":"CRISPR","score":0.6444759964942932},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6256340146064758},{"id":"https://openalex.org/keywords/annotation","display_name":"Annotation","score":0.5691105127334595},{"id":"https://openalex.org/keywords/base","display_name":"Base (topology)","score":0.48619645833969116},{"id":"https://openalex.org/keywords/rna-editing","display_name":"RNA editing","score":0.48392778635025024},{"id":"https://openalex.org/keywords/guide-rna","display_name":"Guide RNA","score":0.47729575634002686},{"id":"https://openalex.org/keywords/scope","display_name":"Scope (computer science)","score":0.4652593731880188},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4639641046524048},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3741830587387085},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.25482919812202454},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.23522061109542847},{"id":"https://openalex.org/keywords/programming-language","display_name":"Programming language","score":0.18796256184577942}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7311648726463318},{"id":"https://openalex.org/C144501496","wikidata":"https://www.wikidata.org/wiki/Q5533489","display_name":"Genome editing","level":4,"score":0.7032153606414795},{"id":"https://openalex.org/C98108389","wikidata":"https://www.wikidata.org/wiki/Q412563","display_name":"CRISPR","level":3,"score":0.6444759964942932},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6256340146064758},{"id":"https://openalex.org/C2776321320","wikidata":"https://www.wikidata.org/wiki/Q857525","display_name":"Annotation","level":2,"score":0.5691105127334595},{"id":"https://openalex.org/C42058472","wikidata":"https://www.wikidata.org/wiki/Q810214","display_name":"Base (topology)","level":2,"score":0.48619645833969116},{"id":"https://openalex.org/C21786251","wikidata":"https://www.wikidata.org/wiki/Q14886350","display_name":"RNA editing","level":4,"score":0.48392778635025024},{"id":"https://openalex.org/C97702854","wikidata":"https://www.wikidata.org/wiki/Q4039747","display_name":"Guide RNA","level":5,"score":0.47729575634002686},{"id":"https://openalex.org/C2778012447","wikidata":"https://www.wikidata.org/wiki/Q1034415","display_name":"Scope (computer science)","level":2,"score":0.4652593731880188},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4639641046524048},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3741830587387085},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.25482919812202454},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.23522061109542847},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.18796256184577942},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000072669","descriptor_name":"Gene Editing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000072669","descriptor_name":"Gene Editing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000072669","descriptor_name":"Gene Editing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D064113","descriptor_name":"CRISPR-Cas Systems","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064113","descriptor_name":"CRISPR-Cas Systems","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064113","descriptor_name":"CRISPR-Cas Systems","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/nar/gkac967","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkac967","pdf_url":"https://academic.oup.com/nar/article-pdf/51/D1/D1249/48441659/gkac967.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmid:36350608","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36350608","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:9825451","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9825451","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/nar/gkac967","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkac967","pdf_url":"https://academic.oup.com/nar/article-pdf/51/D1/D1249/48441659/gkac967.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2382766078","display_name":null,"funder_award_id":"32170656","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4586387842","display_name":null,"funder_award_id":"BYSYYZD2021001","funder_id":"https://openalex.org/F4320325739","funder_display_name":"Peking University Third Hospital"},{"id":"https://openalex.org/G6623560441","display_name":null,"funder_award_id":"Z211100002121039","funder_id":"https://openalex.org/F4320334978","funder_display_name":"Beijing Nova Program"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320325739","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12"},{"id":"https://openalex.org/F4320334978","display_name":"Beijing Nova Program","ror":"https://ror.org/034k14f91"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4308616057.pdf","grobid_xml":"https://content.openalex.org/works/W4308616057.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1984068087","https://openalex.org/W2041877620","https://openalex.org/W2045435533","https://openalex.org/W2104549677","https://openalex.org/W2170551349","https://openalex.org/W2194856653","https://openalex.org/W2336828812","https://openalex.org/W2480829753","https://openalex.org/W2530994846","https://openalex.org/W2560199174","https://openalex.org/W2560407750","https://openalex.org/W2764327284","https://openalex.org/W2767106457","https://openalex.org/W2767157762","https://openalex.org/W2883250809","https://openalex.org/W2897295193","https://openalex.org/W2910305771","https://openalex.org/W2916364858","https://openalex.org/W2951233129","https://openalex.org/W3000249748","https://openalex.org/W3004494456","https://openalex.org/W3035700080","https://openalex.org/W3039159245","https://openalex.org/W3044027016","https://openalex.org/W3093469725","https://openalex.org/W3095895133","https://openalex.org/W3098804002","https://openalex.org/W3135625811","https://openalex.org/W3194369599","https://openalex.org/W3200094259","https://openalex.org/W3213062168","https://openalex.org/W4205812412","https://openalex.org/W4214553676","https://openalex.org/W4220903176","https://openalex.org/W4280491484","https://openalex.org/W4288734496"],"related_works":["https://openalex.org/W3170941595","https://openalex.org/W2989961838","https://openalex.org/W3105994629","https://openalex.org/W2134298288","https://openalex.org/W3133159313","https://openalex.org/W2951741674","https://openalex.org/W2529755192","https://openalex.org/W3097519727","https://openalex.org/W2338850193","https://openalex.org/W3092284562"],"abstract_inverted_index":{"CRISPR-Cas":[0],"base":[1,46,112,186],"editing":[2,17,22,47,64,88,90,106],"(BE)":[3],"system":[4,79],"is":[5,174],"a":[6,77,163,175],"powerful":[7,176],"tool":[8,179],"to":[9,60,136,180],"expand":[10],"the":[11,62,87,105,115,182],"scope":[12],"and":[13,26,76,92,108,133,177,188],"efficiency":[14,91,107],"of":[15,45,66,95,111,127,146,166,184],"genome":[16],"with":[18],"single-nucleotide":[19],"resolution.":[20],"The":[21],"efficiency,":[23],"product":[24,93,109],"purity,":[25],"off-target":[27,129,167],"effect":[28,165],"differ":[29],"among":[30],"various":[31,96],"BE":[32,68,97,193],"systems.":[33,98],"Herein,":[34],"we":[35],"developed":[36],"CRISPRbase":[37,58,173],"(http://crisprbase.maolab.org),":[38],"by":[39,70],"integrating":[40,71],"1":[41],"252":[42],"935":[43],"records":[44],"outcomes":[48,183],"in":[49,120,139],"more":[50,124],"than":[51,125,156],"50":[52],"cell":[53],"types":[54],"from":[55],"17":[56],"species.":[57],"helps":[59],"evaluate":[61],"putative":[63],"precision":[65],"different":[67,185],"systems":[69],"multiple":[72],"annotations,":[73],"functional":[74,196],"predictions":[75],"blasting":[78],"for":[80,195],"single-guide":[81],"RNA":[82],"sequences.":[83],"We":[84],"systematically":[85],"assessed":[86],"window,":[89],"purity":[94,110],"Intensive":[99],"efforts":[100],"were":[101,131,150],"focused":[102],"on":[103,169],"increasing":[104],"editors":[113,187],"since":[114],"byproduct":[116],"could":[117],"be":[118],"detrimental":[119],"certain":[121],"applications.":[122],"Remarkably,":[123],"half":[126],"cancer-related":[128,148],"mutations":[130,149,152,159,168],"non-synonymous":[132],"extremely":[134],"damaging":[135],"protein":[137],"functions":[138],"most":[140,145],"common":[141],"tumor":[142],"types.":[143],"Luckily,":[144],"these":[147],"passenger":[151],"(4840/5703,":[153],"84.87%)":[154],"rather":[155],"cancer":[157],"driver":[158],"(863/5703,":[160],"15.13%),":[161],"indicating":[162],"weak":[164],"carcinogenesis.":[170],"In":[171],"summary,":[172],"convenient":[178],"study":[181],"help":[189],"researchers":[190],"choose":[191],"appropriate":[192],"designs":[194],"studies.":[197]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}