{"id":"https://openalex.org/W4297461078","doi":"https://doi.org/10.1093/nar/gkac831","title":"GotEnzymes: an extensive database of enzyme parameter predictions","display_name":"GotEnzymes: an extensive database of enzyme parameter predictions","publication_year":2022,"publication_date":"2022-09-28","ids":{"openalex":"https://openalex.org/W4297461078","doi":"https://doi.org/10.1093/nar/gkac831","pmid":"https://pubmed.ncbi.nlm.nih.gov/36169223"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkac831","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkac831","pdf_url":"https://academic.oup.com/nar/article-pdf/51/D1/D583/48441078/gkac831.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/51/D1/D583/48441078/gkac831.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100731088","display_name":"Feiran Li","orcid":"https://orcid.org/0000-0001-9155-5260"},"institutions":[{"id":"https://openalex.org/I66862912","display_name":"Chalmers University of Technology","ror":"https://ror.org/040wg7k59","country_code":"SE","type":"education","lineage":["https://openalex.org/I66862912"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Feiran Li","raw_affiliation_strings":["Department of Biology and Biological Engineering, Chalmers University of Technology , Gothenburg \u00a0SE-412 96, Sweden","Novo Nordisk Foundation Center for Biosustainability, Chalmers University of Technology , Gothenburg \u00a0SE-412 96, Sweden"],"raw_orcid":"https://orcid.org/0000-0001-9155-5260","affiliations":[{"raw_affiliation_string":"Department of Biology and Biological Engineering, Chalmers University of Technology , Gothenburg \u00a0SE-412 96, Sweden","institution_ids":["https://openalex.org/I66862912"]},{"raw_affiliation_string":"Novo Nordisk Foundation Center for Biosustainability, Chalmers University of Technology , Gothenburg \u00a0SE-412 96, Sweden","institution_ids":["https://openalex.org/I66862912"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047568087","display_name":"Yu Chen","orcid":"https://orcid.org/0000-0003-3326-9068"},"institutions":[{"id":"https://openalex.org/I66862912","display_name":"Chalmers University of Technology","ror":"https://ror.org/040wg7k59","country_code":"SE","type":"education","lineage":["https://openalex.org/I66862912"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Yu Chen","raw_affiliation_strings":["Department of Biology and Biological Engineering, Chalmers University of Technology , Gothenburg \u00a0SE-412 96, Sweden","Novo Nordisk Foundation Center for Biosustainability, Chalmers University of Technology , Gothenburg \u00a0SE-412 96, Sweden"],"raw_orcid":"https://orcid.org/0000-0003-3326-9068","affiliations":[{"raw_affiliation_string":"Department of Biology and Biological Engineering, Chalmers University of Technology , Gothenburg \u00a0SE-412 96, Sweden","institution_ids":["https://openalex.org/I66862912"]},{"raw_affiliation_string":"Novo Nordisk Foundation Center for Biosustainability, Chalmers University of Technology , Gothenburg \u00a0SE-412 96, Sweden","institution_ids":["https://openalex.org/I66862912"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038426035","display_name":"Mihail Anton","orcid":null},"institutions":[{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]},{"id":"https://openalex.org/I66862912","display_name":"Chalmers University of Technology","ror":"https://ror.org/040wg7k59","country_code":"SE","type":"education","lineage":["https://openalex.org/I66862912"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Mihail Anton","raw_affiliation_strings":["Department of Biology and Biological Engineering, Chalmers University of Technology , Gothenburg \u00a0SE-412 96, Sweden","Department of Biology and Biological Engineering, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Chalmers University of Technology , Gothenburg \u00a0SE-412 96, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology and Biological Engineering, Chalmers University of Technology , Gothenburg \u00a0SE-412 96, Sweden","institution_ids":["https://openalex.org/I66862912"]},{"raw_affiliation_string":"Department of Biology and Biological Engineering, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Chalmers University of Technology , Gothenburg \u00a0SE-412 96, Sweden","institution_ids":["https://openalex.org/I2800139495","https://openalex.org/I66862912"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083238115","display_name":"Jens Nielsen","orcid":"https://orcid.org/0000-0002-9955-6003"},"institutions":[{"id":"https://openalex.org/I4210146628","display_name":"BioInnovation Institute","ror":"https://ror.org/048b3qc73","country_code":"DK","type":"nonprofit","lineage":["https://openalex.org/I4210146628"]},{"id":"https://openalex.org/I66862912","display_name":"Chalmers University of Technology","ror":"https://ror.org/040wg7k59","country_code":"SE","type":"education","lineage":["https://openalex.org/I66862912"]}],"countries":["DK","SE"],"is_corresponding":true,"raw_author_name":"Jens Nielsen","raw_affiliation_strings":["BioInnovation Institute , Ole Maal\u00f8es Vej 3 , Copenhagen \u00a0DK-2200, Denmark","Department of Biology and Biological Engineering, Chalmers University of Technology , Gothenburg \u00a0SE-412 96, Sweden","Novo Nordisk Foundation Center for Biosustainability, Chalmers University of Technology , Gothenburg \u00a0SE-412 96, Sweden"],"raw_orcid":"https://orcid.org/0000-0002-9955-6003","affiliations":[{"raw_affiliation_string":"BioInnovation Institute , Ole Maal\u00f8es Vej 3 , Copenhagen \u00a0DK-2200, Denmark","institution_ids":["https://openalex.org/I4210146628"]},{"raw_affiliation_string":"Department of Biology and Biological Engineering, Chalmers University of Technology , Gothenburg \u00a0SE-412 96, Sweden","institution_ids":["https://openalex.org/I66862912"]},{"raw_affiliation_string":"Novo Nordisk Foundation Center for Biosustainability, Chalmers University of Technology , Gothenburg \u00a0SE-412 96, Sweden","institution_ids":["https://openalex.org/I66862912"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5083238115","https://openalex.org/A5100731088"],"corresponding_institution_ids":["https://openalex.org/I4210146628","https://openalex.org/I66862912"],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":{"value":3630,"currency":"USD","value_usd":3630},"fwci":5.33,"has_fulltext":true,"cited_by_count":80,"citation_normalized_percentile":{"value":0.97220887,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"51","issue":"D1","first_page":"D583","last_page":"D586"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.9958999752998352,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10171","display_name":"Biofuel production and bioconversion","score":0.995199978351593,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.904915452003479},{"id":"https://openalex.org/keywords/database","display_name":"Database","score":0.4993419647216797},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.4263358414173126},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.37180131673812866},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.15654295682907104},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.07056847214698792}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.904915452003479},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.4993419647216797},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4263358414173126},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.37180131673812866},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15654295682907104},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.07056847214698792}],"mesh":[{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1093/nar/gkac831","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkac831","pdf_url":"https://academic.oup.com/nar/article-pdf/51/D1/D583/48441078/gkac831.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmid:36169223","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36169223","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":null},{"id":"pmh:oai:research.chalmers.se:532495","is_oa":true,"landing_page_url":"https://research.chalmers.se/en/publication/532495","pdf_url":"https://research.chalmers.se/publication/532495/file/532495_Fulltext.pdf","source":{"id":"https://openalex.org/S4306402469","display_name":"Chalmers Research (Chalmers University of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I66862912","host_organization_name":"Chalmers University of Technology","host_organization_lineage":["https://openalex.org/I66862912"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:9825421","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9825421","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/nar/gkac831","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkac831","pdf_url":"https://academic.oup.com/nar/article-pdf/51/D1/D583/48441078/gkac831.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Industry, innovation and infrastructure","id":"https://metadata.un.org/sdg/9","score":0.4399999976158142}],"awards":[{"id":"https://openalex.org/G1441096865","display_name":null,"funder_award_id":"2018-05973","funder_id":"https://openalex.org/F4320322327","funder_display_name":"Knut och Alice Wallenbergs Stiftelse"},{"id":"https://openalex.org/G3321450376","display_name":null,"funder_award_id":"05973","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G434337789","display_name":null,"funder_award_id":"HORIZON2020","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G500024693","display_name":null,"funder_award_id":"NNF10CC1016517","funder_id":"https://openalex.org/F4320322327","funder_display_name":"Knut och Alice Wallenbergs Stiftelse"},{"id":"https://openalex.org/G5417901379","display_name":null,"funder_award_id":"NNF10CC1016517","funder_id":"https://openalex.org/F4320322436","funder_display_name":"Novo Nordisk"},{"id":"https://openalex.org/G712881263","display_name":null,"funder_award_id":"2018-","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G7701966108","display_name":null,"funder_award_id":"NNF10CC1016517","funder_id":"https://openalex.org/F4320325957","funder_display_name":"Novo Nordisk Fonden"},{"id":"https://openalex.org/G796431723","display_name":null,"funder_award_id":"201805973","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G8690525661","display_name":"Bioinformatics Services for Data-Driven Design of Cell Factories and Communities","funder_award_id":"686070","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321523","display_name":"Chalmers Tekniska H\u00f6gskola","ror":"https://ror.org/040wg7k59"},{"id":"https://openalex.org/F4320322327","display_name":"Knut och Alice Wallenbergs Stiftelse","ror":"https://ror.org/004hzzk67"},{"id":"https://openalex.org/F4320322436","display_name":"Novo Nordisk","ror":"https://ror.org/0435rc536"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320325957","display_name":"Novo Nordisk Fonden","ror":"https://ror.org/04txyc737"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4297461078.pdf"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W2124019798","https://openalex.org/W2293809279","https://openalex.org/W2293953879","https://openalex.org/W2561960911","https://openalex.org/W2592233514","https://openalex.org/W2775548182","https://openalex.org/W2903357856","https://openalex.org/W2934480299","https://openalex.org/W2949670700","https://openalex.org/W2952015518","https://openalex.org/W2952944698","https://openalex.org/W2953321375","https://openalex.org/W2977870980","https://openalex.org/W3042615082","https://openalex.org/W3096828292","https://openalex.org/W3105895642","https://openalex.org/W3119482753","https://openalex.org/W3138864424","https://openalex.org/W3193199256","https://openalex.org/W3207760869","https://openalex.org/W4213112325","https://openalex.org/W4232516514","https://openalex.org/W4283032119"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2082860237","https://openalex.org/W2119695867","https://openalex.org/W2130076355","https://openalex.org/W1990804418","https://openalex.org/W1993764875","https://openalex.org/W2046158694","https://openalex.org/W2788277189","https://openalex.org/W2013243191","https://openalex.org/W1971568933"],"abstract_inverted_index":{"Enzyme":[0],"parameters":[1],"are":[2],"essential":[3],"for":[4,70],"quantitatively":[5],"understanding,":[6],"modelling,":[7],"and":[8,74,117],"engineering":[9],"cells.":[10],"However,":[11],"experimental":[12,116],"measurements":[13],"cover":[14],"only":[15],"a":[16,47,108],"small":[17],"fraction":[18],"of":[19,39,80,88],"known":[20],"enzyme-compound":[21,92],"pairs":[22,93],"in":[23,28,46],"model":[24],"organisms,":[25],"much":[26],"less":[27],"other":[29],"organisms.":[30,96],"Artificial":[31],"intelligence":[32],"(AI)":[33],"techniques":[34],"have":[35],"accelerated":[36],"the":[37,102],"pace":[38],"exploring":[40],"enzyme":[41,58,104],"properties":[42],"by":[43,61],"predicting":[44],"these":[45],"high-throughput":[48],"manner.":[49],"Here,":[50],"we":[51],"present":[52],"GotEnzymes,":[53,100],"an":[54],"extensive":[55],"database":[56],"with":[57,101,123],"parameter":[59],"predictions":[60],"AI":[62],"approaches,":[63],"which":[64],"is":[65],"publicly":[66],"available":[67],"at":[68],"https://metabolicatlas.org/gotenzymes":[69],"interactive":[71],"web":[72],"exploration":[73],"programmatic":[75],"access.":[76],"The":[77],"first":[78],"release":[79],"this":[81],"data":[82],"resource":[83],"contains":[84],"predicted":[85],"turnover":[86],"numbers":[87],"over":[89],"25.7":[90],"million":[91],"across":[94],"8099":[95],"We":[97],"believe":[98],"that":[99,120],"readily-predicted":[103],"parameters,":[105],"would":[106],"bring":[107],"speed":[109],"boost":[110],"to":[111],"biological":[112],"research":[113],"covering":[114],"both":[115],"computational":[118],"fields":[119],"involve":[121],"working":[122],"candidate":[124],"enzymes.":[125]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":30},{"year":2024,"cited_by_count":21},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-08-01T09:00:35.917206","created_date":"2025-10-10T00:00:00"}