{"id":"https://openalex.org/W3206478579","doi":"https://doi.org/10.1093/nar/gkab913","title":"NPCDR: natural product-based drug combination and its disease-specific molecular regulation","display_name":"NPCDR: natural product-based drug combination and its disease-specific molecular regulation","publication_year":2021,"publication_date":"2021-09-30","ids":{"openalex":"https://openalex.org/W3206478579","doi":"https://doi.org/10.1093/nar/gkab913","mag":"3206478579","pmid":"https://pubmed.ncbi.nlm.nih.gov/34664659"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkab913","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkab913","pdf_url":null,"source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/nar/gkab913","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013798948","display_name":"Xueni Sun","orcid":"https://orcid.org/0000-0001-9621-1088"},"institutions":[{"id":"https://openalex.org/I4210103863","display_name":"Affiliated Hospital of Hangzhou Normal University","ror":"https://ror.org/01bkvqx83","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103863"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xueni Sun","raw_affiliation_strings":["School of Pharmacy and Department of Medical Oncology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou 311121, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy and Department of Medical Oncology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou 311121, China","institution_ids":["https://openalex.org/I4210103863"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061828914","display_name":"Yintao Zhang","orcid":"https://orcid.org/0000-0002-5263-3438"},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yintao Zhang","raw_affiliation_strings":["College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063377124","display_name":"Ying Zhou","orcid":"https://orcid.org/0000-0003-2778-555X"},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Zhou","raw_affiliation_strings":["State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang Provincial Key Laboratory for Drug Clinical Research and Evaluation, The First Affiliated Hospital, Zhejiang University,\u00a079 QingChun Road, Hangzhou, Zhejiang 310000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang Provincial Key Laboratory for Drug Clinical Research and Evaluation, The First Affiliated Hospital, Zhejiang University,\u00a079 QingChun Road, Hangzhou, Zhejiang 310000, China","institution_ids":["https://openalex.org/I76130692","https://openalex.org/I4210166576"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079145492","display_name":"Xichen Lian","orcid":null},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xichen Lian","raw_affiliation_strings":["College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067610921","display_name":"Lili Yan","orcid":"https://orcid.org/0000-0002-6261-2542"},"institutions":[{"id":"https://openalex.org/I4210103863","display_name":"Affiliated Hospital of Hangzhou Normal University","ror":"https://ror.org/01bkvqx83","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103863"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lili Yan","raw_affiliation_strings":["School of Pharmacy and Department of Medical Oncology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou 311121, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy and Department of Medical Oncology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou 311121, China","institution_ids":["https://openalex.org/I4210103863"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091685833","display_name":"Ting Pan","orcid":"https://orcid.org/0000-0002-7106-7312"},"institutions":[{"id":"https://openalex.org/I4210103863","display_name":"Affiliated Hospital of Hangzhou Normal University","ror":"https://ror.org/01bkvqx83","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103863"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ting Pan","raw_affiliation_strings":["School of Pharmacy and Department of Medical Oncology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou 311121, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy and Department of Medical Oncology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou 311121, China","institution_ids":["https://openalex.org/I4210103863"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078492740","display_name":"Ting Jin","orcid":"https://orcid.org/0000-0001-5073-0667"},"institutions":[{"id":"https://openalex.org/I4210103863","display_name":"Affiliated Hospital of Hangzhou Normal University","ror":"https://ror.org/01bkvqx83","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103863"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ting Jin","raw_affiliation_strings":["School of Pharmacy and Department of Medical Oncology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou 311121, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy and Department of Medical Oncology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou 311121, China","institution_ids":["https://openalex.org/I4210103863"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086473975","display_name":"Han Xie","orcid":"https://orcid.org/0000-0003-4914-5131"},"institutions":[{"id":"https://openalex.org/I4210103863","display_name":"Affiliated Hospital of Hangzhou Normal University","ror":"https://ror.org/01bkvqx83","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103863"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Han Xie","raw_affiliation_strings":["School of Pharmacy and Department of Medical Oncology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou 311121, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy and Department of Medical Oncology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou 311121, China","institution_ids":["https://openalex.org/I4210103863"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041810844","display_name":"Zimao Liang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210103863","display_name":"Affiliated Hospital of Hangzhou Normal University","ror":"https://ror.org/01bkvqx83","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103863"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zimao Liang","raw_affiliation_strings":["School of Pharmacy and Department of Medical Oncology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou 311121, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy and Department of Medical Oncology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou 311121, China","institution_ids":["https://openalex.org/I4210103863"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001167855","display_name":"Wenqi Qiu","orcid":"https://orcid.org/0000-0003-3106-0930"},"institutions":[{"id":"https://openalex.org/I4210141719","display_name":"University of Hong Kong - Shenzhen Hospital","ror":"https://ror.org/047w7d678","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141719"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"Wenqi Qiu","raw_affiliation_strings":["Department of Surgery, HKU-SZH & Faculty of Medicine, The University of Hong Kong, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, HKU-SZH & Faculty of Medicine, The University of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I4210141719","https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100438343","display_name":"Jianxin Wang","orcid":"https://orcid.org/0000-0001-5988-1883"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianxin Wang","raw_affiliation_strings":["School of Computer Science and Engineering, Central South University, Changsha 410083, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Central South University, Changsha 410083, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101441372","display_name":"Zhaorong Li","orcid":"https://orcid.org/0000-0002-2047-6191"},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhaorong Li","raw_affiliation_strings":["Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Alibaba-Zhejiang University Joint Research Center of Future Digital Healthcare, Hangzhou 330110, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Alibaba-Zhejiang University Joint Research Center of Future Digital Healthcare, Hangzhou 330110, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100755257","display_name":"Feng Zhu","orcid":"https://orcid.org/0000-0001-8069-0053"},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Feng Zhu","raw_affiliation_strings":["College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China","Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Alibaba-Zhejiang University Joint Research Center of Future Digital Healthcare, Hangzhou 330110, China"],"raw_orcid":"https://orcid.org/0000-0001-8069-0053","affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Alibaba-Zhejiang University Joint Research Center of Future Digital Healthcare, Hangzhou 330110, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015970814","display_name":"Xinbing Sui","orcid":"https://orcid.org/0000-0001-7330-0467"},"institutions":[{"id":"https://openalex.org/I4210103863","display_name":"Affiliated Hospital of Hangzhou Normal University","ror":"https://ror.org/01bkvqx83","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103863"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xinbing Sui","raw_affiliation_strings":["School of Pharmacy and Department of Medical Oncology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou 311121, China"],"raw_orcid":"https://orcid.org/0000-0001-7330-0467","affiliations":[{"raw_affiliation_string":"School of Pharmacy and Department of Medical Oncology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou 311121, China","institution_ids":["https://openalex.org/I4210103863"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5015970814","https://openalex.org/A5100755257"],"corresponding_institution_ids":["https://openalex.org/I4210103863","https://openalex.org/I76130692"],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":{"value":3630,"currency":"USD","value_usd":3630},"fwci":5.6458,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.96511197,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"50","issue":"D1","first_page":"D1324","last_page":"D1333"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.9933000206947327,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/natural-product","display_name":"Natural product","score":0.6855719089508057},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.6704346537590027},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.6353746652603149},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.5785795450210571},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5507866740226746},{"id":"https://openalex.org/keywords/systems-pharmacology","display_name":"Systems pharmacology","score":0.5409094095230103},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5334349870681763},{"id":"https://openalex.org/keywords/database","display_name":"Database","score":0.5037025809288025},{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.4315930902957916},{"id":"https://openalex.org/keywords/molecular-pharmacology","display_name":"Molecular Pharmacology","score":0.415601909160614},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.40951478481292725},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.30506640672683716},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.2956236004829407},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.1617007553577423},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.10558351874351501}],"concepts":[{"id":"https://openalex.org/C2779396153","wikidata":"https://www.wikidata.org/wiki/Q901227","display_name":"Natural product","level":2,"score":0.6855719089508057},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6704346537590027},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.6353746652603149},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5785795450210571},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5507866740226746},{"id":"https://openalex.org/C2779446555","wikidata":"https://www.wikidata.org/wiki/Q7663877","display_name":"Systems pharmacology","level":3,"score":0.5409094095230103},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5334349870681763},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.5037025809288025},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.4315930902957916},{"id":"https://openalex.org/C14314382","wikidata":"https://www.wikidata.org/wiki/Q1943386","display_name":"Molecular Pharmacology","level":3,"score":0.415601909160614},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.40951478481292725},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.30506640672683716},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2956236004829407},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1617007553577423},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10558351874351501},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/nar/gkab913","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkab913","pdf_url":null,"source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmid:34664659","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34664659","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:8728151","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8728151","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/nar/gkab913","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkab913","pdf_url":null,"source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1171080475","display_name":null,"funder_award_id":"2020C03010","funder_id":"https://openalex.org/F8142712028","funder_display_name":"Key Research and Development Program of Zhejiang Province"},{"id":"https://openalex.org/G1660348008","display_name":null,"funder_award_id":"2018QNA7023","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G2446395889","display_name":null,"funder_award_id":"81872798","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2541664538","display_name":null,"funder_award_id":"82104207","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G322445034","display_name":null,"funder_award_id":"LR18H160001","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"},{"id":"https://openalex.org/G6337340033","display_name":null,"funder_award_id":"81874380","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6811296059","display_name":null,"funder_award_id":"82022075","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8196091623","display_name":null,"funder_award_id":"U1909208","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8951279597","display_name":null,"funder_award_id":"LR21H300001","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null},{"id":"https://openalex.org/F4320338464","display_name":"Natural Science Foundation of Zhejiang Province","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F8142712028","display_name":"Key Research and Development Program of Zhejiang Province","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":85,"referenced_works":["https://openalex.org/W1519298624","https://openalex.org/W1935434993","https://openalex.org/W1984694945","https://openalex.org/W1989277387","https://openalex.org/W2061136308","https://openalex.org/W2088226047","https://openalex.org/W2096525273","https://openalex.org/W2107427748","https://openalex.org/W2124679671","https://openalex.org/W2148671784","https://openalex.org/W2417819518","https://openalex.org/W2461427403","https://openalex.org/W2559588208","https://openalex.org/W2581145348","https://openalex.org/W2615102447","https://openalex.org/W2651157417","https://openalex.org/W2739691438","https://openalex.org/W2749464300","https://openalex.org/W2754437817","https://openalex.org/W2766193612","https://openalex.org/W2766490148","https://openalex.org/W2767891136","https://openalex.org/W2774184692","https://openalex.org/W2776685243","https://openalex.org/W2787229753","https://openalex.org/W2801053627","https://openalex.org/W2805978167","https://openalex.org/W2898264436","https://openalex.org/W2898440040","https://openalex.org/W2898468989","https://openalex.org/W2899291554","https://openalex.org/W2899608837","https://openalex.org/W2899903294","https://openalex.org/W2901643461","https://openalex.org/W2902341473","https://openalex.org/W2912716774","https://openalex.org/W2920058896","https://openalex.org/W2925026458","https://openalex.org/W2930701361","https://openalex.org/W2945590213","https://openalex.org/W2947963518","https://openalex.org/W2951025322","https://openalex.org/W2953666370","https://openalex.org/W2966200187","https://openalex.org/W2966483284","https://openalex.org/W2972740870","https://openalex.org/W2972788213","https://openalex.org/W2973530780","https://openalex.org/W2974996663","https://openalex.org/W2981350712","https://openalex.org/W2982291409","https://openalex.org/W2982368177","https://openalex.org/W2987928072","https://openalex.org/W2990089967","https://openalex.org/W2998808595","https://openalex.org/W3001887773","https://openalex.org/W3006180334","https://openalex.org/W3010925280","https://openalex.org/W3011235785","https://openalex.org/W3011366455","https://openalex.org/W3011649281","https://openalex.org/W3018788222","https://openalex.org/W3047161397","https://openalex.org/W3049036781","https://openalex.org/W3077250793","https://openalex.org/W3089574919","https://openalex.org/W3092072640","https://openalex.org/W3092386449","https://openalex.org/W3095583226","https://openalex.org/W3097046795","https://openalex.org/W3099496190","https://openalex.org/W3108860514","https://openalex.org/W3110555302","https://openalex.org/W3112376646","https://openalex.org/W3118695441","https://openalex.org/W3211402536","https://openalex.org/W4205544245","https://openalex.org/W4231254854","https://openalex.org/W4247001379","https://openalex.org/W4254589074","https://openalex.org/W6768806997","https://openalex.org/W6769655052","https://openalex.org/W6770414484","https://openalex.org/W6770440696","https://openalex.org/W6813094581"],"related_works":["https://openalex.org/W4327862425","https://openalex.org/W2584285938","https://openalex.org/W3201311513","https://openalex.org/W4367601179","https://openalex.org/W2127597456","https://openalex.org/W2904244272","https://openalex.org/W4388019188","https://openalex.org/W2325550854","https://openalex.org/W2765570325","https://openalex.org/W2086566345"],"abstract_inverted_index":{"Natural":[0],"product":[1],"(NP)":[2],"has":[3,13,83],"a":[4,17,95,144],"long":[5],"history":[6],"in":[7,117],"promoting":[8],"modern":[9],"drug":[10,78,125,148,188],"discovery,":[11],"which":[12],"derived":[14],"or":[15,131,168],"inspired":[16],"large":[18],"number":[19,145],"of":[20,45,123,146,183],"currently":[21],"prescribed":[22],"drugs.":[23],"Recently,":[24],"the":[25,30,42,49,59,70,120,138,162,180],"NPs":[26],"have":[27,176],"emerged":[28],"as":[29],"ideal":[31],"candidates":[32],"to":[33,39,67,87,161,175],"combine":[34],"with":[35,41],"other":[36],"therapeutic":[37,134],"strategies":[38],"deal":[40],"persistent":[43],"challenge":[44],"conventional":[46],"therapy,":[47],"and":[48,104,190,207],"molecular":[50,72,140],"regulation":[51,73,141],"mechanism":[52],"underlying":[53],"these":[54],"combinations":[55,126],"is":[56,64,173,195],"crucial":[57],"for":[58,75,143,179],"related":[60],"communities.":[61],"Thus,":[62],"it":[63],"urgently":[65],"demanded":[66],"comprehensively":[68],"provide":[69],"disease-specific":[71,139],"data":[74,142],"various":[76],"NP-based":[77,124,147],"combinations.":[79],"However,":[80],"no":[81],"database":[82,98,114,194],"been":[84],"developed":[85,97],"yet":[86],"describe":[88],"such":[89],"valuable":[90],"information.":[91],"In":[92],"this":[93],"study,":[94],"newly":[96],"entitled":[99],"'Natural":[100],"Product-based":[101],"Drug":[102],"Combination":[103],"Its":[105],"Disease-specific":[106],"Molecular":[107],"Regulation":[108],"(NPCDR)'":[109],"was":[110,115],"thus":[111],"introduced.":[112],"This":[113,193],"unique":[116],"(a)":[118],"providing":[119],"comprehensive":[121],"information":[122],"&":[127],"describing":[128,165],"their":[129,166],"clinically":[130],"experimentally":[132],"validated":[133],"effect,":[135],"(b)":[136],"giving":[137],"combinations,":[149],"(c)":[150],"fully":[151],"referencing":[152],"all":[153],"NPs,":[154],"drugs,":[155],"regulated":[156],"molecules/pathways":[157],"by":[158],"cross-linking":[159],"them":[160],"available":[163],"databases":[164],"biological":[167],"pharmaceutical":[169],"characteristics.":[170],"Therefore,":[171],"NPCDR":[172],"expected":[174],"great":[177],"implications":[178],"future":[181],"practice":[182],"network":[184],"pharmacology,":[185],"medical":[186],"biochemistry,":[187],"design,":[189],"medicinal":[191],"chemistry.":[192],"now":[196],"freely":[197],"accessible":[198],"without":[199],"any":[200],"login":[201],"requirement":[202],"at":[203],"both":[204],"official":[205],"(https://idrblab.org/npcdr/)":[206],"mirror":[208],"(http://npcdr.idrblab.net/)":[209],"sites.":[210]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":1}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}