{"id":"https://openalex.org/W3203077262","doi":"https://doi.org/10.1093/nar/gkab868","title":"CovPDB: a high-resolution coverage of the covalent protein\u2013ligand interactome","display_name":"CovPDB: a high-resolution coverage of the covalent protein\u2013ligand interactome","publication_year":2021,"publication_date":"2021-09-15","ids":{"openalex":"https://openalex.org/W3203077262","doi":"https://doi.org/10.1093/nar/gkab868","mag":"3203077262","pmid":"https://pubmed.ncbi.nlm.nih.gov/34581813"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkab868","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkab868","pdf_url":"https://academic.oup.com/nar/article-pdf/50/D1/D445/42057646/gkab868.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/50/D1/D445/42057646/gkab868.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069806228","display_name":"Mingjie Gao","orcid":"https://orcid.org/0000-0003-3151-3020"},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mingjie Gao","raw_affiliation_strings":["Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universit\u00e4t Freiburg, Hermann-Herder-Stra\u00dfe 9, D-79104 Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universit\u00e4t Freiburg, Hermann-Herder-Stra\u00dfe 9, D-79104 Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049231945","display_name":"Aur\u00e9lien F. A. Moumbock","orcid":"https://orcid.org/0000-0002-6034-2016"},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Aur\u00e9lien\u00a0F\u00a0A Moumbock","raw_affiliation_strings":["Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universit\u00e4t Freiburg, Hermann-Herder-Stra\u00dfe 9, D-79104 Freiburg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-6034-2016","affiliations":[{"raw_affiliation_string":"Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universit\u00e4t Freiburg, Hermann-Herder-Stra\u00dfe 9, D-79104 Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080923680","display_name":"Ammar Qaseem","orcid":"https://orcid.org/0000-0002-2956-5086"},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ammar Qaseem","raw_affiliation_strings":["Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universit\u00e4t Freiburg, Hermann-Herder-Stra\u00dfe 9, D-79104 Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universit\u00e4t Freiburg, Hermann-Herder-Stra\u00dfe 9, D-79104 Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055722045","display_name":"Qianqing Xu","orcid":null},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Qianqing Xu","raw_affiliation_strings":["Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universit\u00e4t Freiburg, Hermann-Herder-Stra\u00dfe 9, D-79104 Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universit\u00e4t Freiburg, Hermann-Herder-Stra\u00dfe 9, D-79104 Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010380284","display_name":"Stefan G\u00fcnther","orcid":"https://orcid.org/0000-0003-3744-189X"},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Stefan G\u00fcnther","raw_affiliation_strings":["Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universit\u00e4t Freiburg, Hermann-Herder-Stra\u00dfe 9, D-79104 Freiburg, Germany"],"raw_orcid":"https://orcid.org/0000-0003-3744-189X","affiliations":[{"raw_affiliation_string":"Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universit\u00e4t Freiburg, Hermann-Herder-Stra\u00dfe 9, D-79104 Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5010380284"],"corresponding_institution_ids":["https://openalex.org/I161046081"],"apc_list":{"value":3992,"currency":"USD","value_usd":3992},"apc_paid":{"value":3519,"currency":"EUR","value_usd":3795},"fwci":4.101,"has_fulltext":true,"cited_by_count":54,"citation_normalized_percentile":{"value":0.94560828,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"50","issue":"D1","first_page":"D445","last_page":"D450"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11440","display_name":"Click Chemistry and Applications","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9865999817848206,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interactome","display_name":"Interactome","score":0.8100104331970215},{"id":"https://openalex.org/keywords/covalent-bond","display_name":"Covalent bond","score":0.7866688966751099},{"id":"https://openalex.org/keywords/ligand","display_name":"Ligand (biochemistry)","score":0.5429761409759521},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5302215218544006},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.5279837250709534},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.48470401763916016},{"id":"https://openalex.org/keywords/chemical-biology","display_name":"Chemical biology","score":0.46412065625190735},{"id":"https://openalex.org/keywords/combinatorial-chemistry","display_name":"Combinatorial chemistry","score":0.37202519178390503},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3282499313354492},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.3037342429161072},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.13458770513534546}],"concepts":[{"id":"https://openalex.org/C9760119","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interactome","level":3,"score":0.8100104331970215},{"id":"https://openalex.org/C180577832","wikidata":"https://www.wikidata.org/wiki/Q127920","display_name":"Covalent bond","level":2,"score":0.7866688966751099},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.5429761409759521},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5302215218544006},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.5279837250709534},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48470401763916016},{"id":"https://openalex.org/C171852809","wikidata":"https://www.wikidata.org/wiki/Q731154","display_name":"Chemical biology","level":2,"score":0.46412065625190735},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.37202519178390503},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3282499313354492},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3037342429161072},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13458770513534546},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072756","descriptor_name":"Protein Conformation, alpha-Helical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072756","descriptor_name":"Protein Conformation, alpha-Helical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072756","descriptor_name":"Protein Conformation, alpha-Helical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072757","descriptor_name":"Protein Conformation, beta-Strand","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072757","descriptor_name":"Protein Conformation, beta-Strand","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072757","descriptor_name":"Protein Conformation, beta-Strand","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054730","descriptor_name":"Protein Interaction Domains and Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054730","descriptor_name":"Protein Interaction Domains and Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054730","descriptor_name":"Protein Interaction Domains and Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D058977","descriptor_name":"Molecular Sequence Annotation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058977","descriptor_name":"Molecular Sequence Annotation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058977","descriptor_name":"Molecular Sequence Annotation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/nar/gkab868","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkab868","pdf_url":"https://academic.oup.com/nar/article-pdf/50/D1/D445/42057646/gkab868.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmid:34581813","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34581813","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8728183","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8728183","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/nar/gkab868","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkab868","pdf_url":"https://academic.oup.com/nar/article-pdf/50/D1/D445/42057646/gkab868.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4399999976158142}],"awards":[{"id":"https://openalex.org/G1388105661","display_name":null,"funder_award_id":"201908080143","funder_id":"https://openalex.org/F4320322725","funder_display_name":"China Scholarship Council"},{"id":"https://openalex.org/G4578989300","display_name":null,"funder_award_id":"RTG 2202","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G5556406666","display_name":null,"funder_award_id":"91653768","funder_id":"https://openalex.org/F4320320875","funder_display_name":"Deutscher Akademischer Austauschdienst"}],"funders":[{"id":"https://openalex.org/F4320320875","display_name":"Deutscher Akademischer Austauschdienst","ror":"https://ror.org/039djdh30"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321421","display_name":"Albert-Ludwigs-Universit\u00e4t Freiburg","ror":"https://ror.org/0245cg223"},{"id":"https://openalex.org/F4320322725","display_name":"China Scholarship Council","ror":"https://ror.org/04atp4p48"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3203077262.pdf","grobid_xml":"https://content.openalex.org/works/W3203077262.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W248383993","https://openalex.org/W1931365650","https://openalex.org/W1964172938","https://openalex.org/W1995770177","https://openalex.org/W2002368219","https://openalex.org/W2010993054","https://openalex.org/W2018661561","https://openalex.org/W2042620520","https://openalex.org/W2052030759","https://openalex.org/W2052250375","https://openalex.org/W2075221169","https://openalex.org/W2130479394","https://openalex.org/W2142678478","https://openalex.org/W2226713891","https://openalex.org/W2253581743","https://openalex.org/W2330799739","https://openalex.org/W2516944943","https://openalex.org/W2561191747","https://openalex.org/W2622009965","https://openalex.org/W2767891136","https://openalex.org/W2783215515","https://openalex.org/W2796108867","https://openalex.org/W2900090807","https://openalex.org/W2916067731","https://openalex.org/W2949252818","https://openalex.org/W2980410567","https://openalex.org/W2982977147","https://openalex.org/W3023915741","https://openalex.org/W3038238188","https://openalex.org/W3092386449","https://openalex.org/W3093091145","https://openalex.org/W3094640617","https://openalex.org/W3097145107","https://openalex.org/W3112376646","https://openalex.org/W3122260379","https://openalex.org/W3128963846","https://openalex.org/W3158513244","https://openalex.org/W3159719254","https://openalex.org/W6769535376"],"related_works":["https://openalex.org/W2043147644","https://openalex.org/W2508430021","https://openalex.org/W4309353047","https://openalex.org/W939393028","https://openalex.org/W2075924231","https://openalex.org/W1076866363","https://openalex.org/W46207720","https://openalex.org/W4210501338","https://openalex.org/W4220909743","https://openalex.org/W2025312328"],"abstract_inverted_index":{"In":[0],"recent":[1],"years,":[2],"the":[3,54,71,87,95,107,161],"drug":[4],"discovery":[5],"paradigm":[6],"has":[7],"shifted":[8],"toward":[9],"compounds":[10],"that":[11,152],"covalently":[12],"modify":[13],"disease-associated":[14],"target":[15,45,113],"proteins,":[16],"because":[17],"they":[18],"tend":[19],"to":[20,76,111,128,159,170],"possess":[21],"high":[22],"potency,":[23],"selectivity,":[24],"and":[25,98,124,138,148,156,180],"duration":[26],"of":[27,32,44,62,80,100,190],"action.":[28],"The":[29],"rational":[30],"design":[31],"novel":[33,172],"targeted":[34],"covalent":[35,63,108,140,162],"inhibitors":[36],"(TCIs)":[37],"typically":[38],"starts":[39],"from":[40,86],"resolved":[41],"macromolecular":[42],"structures":[43,79,97],"proteins":[46,114,123],"in":[47,168],"their":[48,112],"apo":[49],"or":[50],"holo":[51],"forms.":[52],"However,":[53],"existing":[55],"TCI":[56],"databases":[57],"contain":[58],"only":[59],"a":[60,165],"paucity":[61],"protein-ligand":[64],"(cP-L)":[65],"complexes.":[66],"Herein,":[67],"we":[68],"report":[69],"CovPDB,":[70],"first":[72],"database":[73],"solely":[74],"dedicated":[75],"high-resolution":[77],"cocrystal":[78],"biologically":[81],"relevant":[82],"cP-L":[83,130],"complexes,":[84,94,131],"curated":[85,93],"Protein":[88],"Data":[89],"Bank.":[90],"For":[91],"these":[92],"chemical":[96],"warheads":[99],"pre-reactive":[101],"electrophilic":[102],"ligands":[103],"as":[104,106,187],"well":[105],"bonding":[109],"mechanisms":[110],"were":[115],"expertly":[116],"manually":[117],"annotated.":[118],"Totally,":[119],"CovPDB":[120,174],"contains":[121],"733":[122],"1,501":[125],"ligands,":[126],"relating":[127],"2,294":[129],"93":[132],"reactive":[133],"warheads,":[134],"14":[135],"targetable":[136],"residues,":[137],"21":[139],"mechanisms.":[141],"Users":[142],"are":[143,183],"provided":[144],"with":[145],"an":[146],"intuitive":[147],"interactive":[149],"web":[150],"interface":[151],"allows":[153],"multiple":[154],"search":[155],"browsing":[157],"options":[158],"explore":[160],"interactome":[163],"at":[164,178],"molecular":[166],"level":[167],"order":[169],"develop":[171],"TCIs.":[173],"is":[175],"freely":[176],"accessible":[177],"http://www.pharmbioinf.uni-freiburg.de/covpdb/":[179],"its":[181],"contents":[182],"available":[184],"for":[185],"download":[186],"flat":[188],"files":[189],"various":[191],"formats.":[192]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":17},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":1}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2025-10-10T00:00:00"}