{"id":"https://openalex.org/W3195744487","doi":"https://doi.org/10.1093/nar/gkab740","title":"3\u2032aQTL-atlas: an atlas of 3\u2032UTR alternative polyadenylation quantitative trait loci across human normal tissues","display_name":"3\u2032aQTL-atlas: an atlas of 3\u2032UTR alternative polyadenylation quantitative trait loci across human normal tissues","publication_year":2021,"publication_date":"2021-08-14","ids":{"openalex":"https://openalex.org/W3195744487","doi":"https://doi.org/10.1093/nar/gkab740","mag":"3195744487","pmid":"https://pubmed.ncbi.nlm.nih.gov/34432052"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkab740","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkab740","pdf_url":"https://academic.oup.com/nar/article-pdf/50/D1/D39/42058041/gkab740.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/50/D1/D39/42058041/gkab740.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053000157","display_name":"Ya Cui","orcid":"https://orcid.org/0000-0003-1574-0928"},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ya Cui","raw_affiliation_strings":["Division of Computational Biomedicine, Department of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA"],"raw_orcid":"https://orcid.org/0000-0003-1574-0928","affiliations":[{"raw_affiliation_string":"Division of Computational Biomedicine, Department of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071835937","display_name":"Fanglue Peng","orcid":"https://orcid.org/0000-0001-8818-3785"},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fanglue Peng","raw_affiliation_strings":["Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA"],"raw_orcid":"https://orcid.org/0000-0001-8818-3785","affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100411866","display_name":"Dan Wang","orcid":"https://orcid.org/0000-0003-0313-5528"},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dan Wang","raw_affiliation_strings":["Department of Medicine, Division of Cardiology, University of California, Los Angeles, Los Angeles, CA, 90095, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Cardiology, University of California, Los Angeles, Los Angeles, CA, 90095, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100614504","display_name":"Yumei Li","orcid":"https://orcid.org/0000-0003-3538-6268"},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yumei Li","raw_affiliation_strings":["Division of Computational Biomedicine, Department of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Computational Biomedicine, Department of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036607034","display_name":"Jason Sheng Li","orcid":"https://orcid.org/0000-0003-0485-7194"},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason Sheng Li","raw_affiliation_strings":["Division of Computational Biomedicine, Department of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Computational Biomedicine, Department of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100440418","display_name":"Lei Li","orcid":"https://orcid.org/0000-0003-3924-2544"},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lei Li","raw_affiliation_strings":["Division of Computational Biomedicine, Department of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Computational Biomedicine, Department of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100318082","display_name":"Wei Li","orcid":"https://orcid.org/0000-0001-9931-5990"},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Wei Li","raw_affiliation_strings":["Division of Computational Biomedicine, Department of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA"],"raw_orcid":"https://orcid.org/0000-0001-9931-5990","affiliations":[{"raw_affiliation_string":"Division of Computational Biomedicine, Department of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA","institution_ids":["https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100318082","https://openalex.org/A5100440418"],"corresponding_institution_ids":["https://openalex.org/I204250578"],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":{"value":3630,"currency":"USD","value_usd":3630},"fwci":1.822,"has_fulltext":true,"cited_by_count":34,"citation_normalized_percentile":{"value":0.85937927,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"50","issue":"D1","first_page":"D39","last_page":"D45"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9966999888420105,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7958666086196899},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"Genome-wide association study","score":0.7603016495704651},{"id":"https://openalex.org/keywords/quantitative-trait-locus","display_name":"Quantitative trait locus","score":0.6560488939285278},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.6372739672660828},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.6159488558769226},{"id":"https://openalex.org/keywords/expression-quantitative-trait-loci","display_name":"Expression quantitative trait loci","score":0.606103241443634},{"id":"https://openalex.org/keywords/polyadenylation","display_name":"Polyadenylation","score":0.588792622089386},{"id":"https://openalex.org/keywords/genetic-association","display_name":"Genetic association","score":0.5059279799461365},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4984395503997803},{"id":"https://openalex.org/keywords/human-genome","display_name":"Human genome","score":0.47425878047943115},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4032306373119354},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.36273881793022156},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.24325689673423767},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.19150450825691223}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7958666086196899},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.7603016495704651},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.6560488939285278},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.6372739672660828},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6159488558769226},{"id":"https://openalex.org/C168393362","wikidata":"https://www.wikidata.org/wiki/Q5421706","display_name":"Expression quantitative trait loci","level":5,"score":0.606103241443634},{"id":"https://openalex.org/C142575336","wikidata":"https://www.wikidata.org/wiki/Q412148","display_name":"Polyadenylation","level":4,"score":0.588792622089386},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.5059279799461365},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4984395503997803},{"id":"https://openalex.org/C197077220","wikidata":"https://www.wikidata.org/wiki/Q720988","display_name":"Human genome","level":4,"score":0.47425878047943115},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4032306373119354},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.36273881793022156},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.24325689673423767},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.19150450825691223}],"mesh":[{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020413","descriptor_name":"3' Untranslated Regions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020413","descriptor_name":"3' Untranslated Regions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020413","descriptor_name":"3' Untranslated Regions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020413","descriptor_name":"3' Untranslated Regions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D026723","descriptor_name":"Polyadenylation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D026723","descriptor_name":"Polyadenylation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D026723","descriptor_name":"Polyadenylation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D026723","descriptor_name":"Polyadenylation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D039104","descriptor_name":"RNA 3' Polyadenylation Signals","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D039104","descriptor_name":"RNA 3' Polyadenylation Signals","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D039104","descriptor_name":"RNA 3' Polyadenylation Signals","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D039104","descriptor_name":"RNA 3' Polyadenylation Signals","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/nar/gkab740","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkab740","pdf_url":"https://academic.oup.com/nar/article-pdf/50/D1/D39/42058041/gkab740.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmid:34432052","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34432052","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":null},{"id":"pmh:oai:digitalcommons.library.tmc.edu:baylor_docs-3675","is_oa":false,"landing_page_url":"https://digitalcommons.library.tmc.edu/baylor_docs/2704","pdf_url":null,"source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty and Staff Publications","raw_type":"text"},{"id":"pmh:oai:pubmedcentral.nih.gov:8728222","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8728222","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/nar/gkab740","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkab740","pdf_url":"https://academic.oup.com/nar/article-pdf/50/D1/D39/42058041/gkab740.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G154508745","display_name":null,"funder_award_id":"R01CA193466","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G249540480","display_name":null,"funder_award_id":"P30 CA062203","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4909090881","display_name":null,"funder_award_id":"R01 CA193466","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G595377479","display_name":null,"funder_award_id":"R01CA193466","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337349","display_name":"NIH Office of the Director","ror":"https://ror.org/00fj8a872"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320338403","display_name":"Common Fund","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3195744487.pdf","grobid_xml":"https://content.openalex.org/works/W3195744487.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1964895626","https://openalex.org/W1978116054","https://openalex.org/W1982663009","https://openalex.org/W1985267020","https://openalex.org/W1986911601","https://openalex.org/W1988264905","https://openalex.org/W2026255377","https://openalex.org/W2031276095","https://openalex.org/W2069506056","https://openalex.org/W2074114726","https://openalex.org/W2091808830","https://openalex.org/W2099610622","https://openalex.org/W2100697281","https://openalex.org/W2102619694","https://openalex.org/W2103441770","https://openalex.org/W2108264419","https://openalex.org/W2108871359","https://openalex.org/W2132640619","https://openalex.org/W2152406028","https://openalex.org/W2163975718","https://openalex.org/W2169456326","https://openalex.org/W2274689446","https://openalex.org/W2508591721","https://openalex.org/W2525507785","https://openalex.org/W2553059833","https://openalex.org/W2559028527","https://openalex.org/W2761275051","https://openalex.org/W2766614445","https://openalex.org/W2768718979","https://openalex.org/W2770095154","https://openalex.org/W2786594082","https://openalex.org/W2811205482","https://openalex.org/W2888423279","https://openalex.org/W2943309532","https://openalex.org/W2978910436","https://openalex.org/W2979798809","https://openalex.org/W2982225121","https://openalex.org/W3025047014","https://openalex.org/W3084033366","https://openalex.org/W3126160703","https://openalex.org/W3133859624","https://openalex.org/W3163200965","https://openalex.org/W6746163975"],"related_works":["https://openalex.org/W104925310","https://openalex.org/W2464196154","https://openalex.org/W2150283886","https://openalex.org/W1995613491","https://openalex.org/W2951751247","https://openalex.org/W2143143063","https://openalex.org/W2112543488","https://openalex.org/W4323567910","https://openalex.org/W4384126845","https://openalex.org/W2071852132"],"abstract_inverted_index":{"Genome-wide":[0],"association":[1],"studies":[2],"(GWAS)":[3],"have":[4],"identified":[5],"thousands":[6],"of":[7,21,34,53,97,106,176,189],"non-coding":[8],"single-nucleotide":[9],"polymorphisms":[10],"(SNPs)":[11],"associated":[12,103],"with":[13,104,136],"human":[14,85,116,196],"traits":[15,197],"and":[16,56,63,81,155,191,198],"diseases.":[17,199],"However,":[18],"functional":[19],"interpretation":[20],"these":[22],"SNPs":[23,55,102],"remains":[24],"a":[25,94,129,149,173],"significant":[26,182],"challenge.":[27],"Our":[28],"recent":[29],"study":[30],"established":[31],"the":[32,67,89,186],"concept":[33],"3'":[35],"untranslated":[36],"region":[37],"(3'UTR)":[38],"alternative":[39],"polyadenylation":[40],"(APA)":[41],"quantitative":[42],"trait":[43],"loci":[44],"(3'aQTLs),":[45],"which":[46],"can":[47],"be":[48],"used":[49],"to":[50,79,163,171,181],"interpret":[51],"\u223c16.1%":[52],"GWAS":[54,177],"are":[57],"distinct":[58],"from":[59,123],"gene":[60],"expression":[61],"QTLs":[62],"splicing":[64],"QTLs.":[65],"Despite":[66],"growing":[68],"interest":[69],"in":[70,132,195],"3'aQTLs,":[71],"there":[72],"is":[73],"no":[74],"comprehensive":[75,95],"database":[76],"for":[77],"users":[78],"search":[80],"visualize":[82],"them":[83],"across":[84,114,147],"normal":[86],"tissues.":[87],"In":[88],"3'aQTL-atlas":[90,127,161],"(https://wlcb.oit.uci.edu/3aQTLatlas),":[91],"we":[92],"provide":[93],"list":[96],"3'aQTLs":[98],"containing":[99],"\u223c1.49":[100],"million":[101],"APA":[105,165,190],"target":[107],"genes,":[108],"based":[109],"on":[110],"15,201":[111],"RNA-seq":[112],"samples":[113],"49":[115],"Genotype-Tissue":[117],"Expression":[118],"(GTEx":[119],"v8)":[120],"tissues":[121],"isolated":[122],"838":[124],"individuals.":[125],"The":[126,160],"provides":[128],"\u223c2-fold":[130],"increase":[131],"sample":[133],"size":[134],"compared":[135],"our":[137],"published":[138],"study.":[139],"It":[140],"also":[141],"includes":[142],"3'aQTL":[143,150,153],"searches":[144],"by":[145],"Gene/SNP":[146],"tissues,":[148],"genome":[151],"browser,":[152],"boxplots,":[154],"GWAS-3'aQTL":[156],"colocalization":[157],"event":[158],"visualization.":[159],"aims":[162],"establish":[164],"as":[166],"an":[167],"emerging":[168],"molecular":[169],"phenotype":[170],"explain":[172],"large":[174],"fraction":[175],"risk":[178],"SNPs,":[179],"leading":[180],"novel":[183],"insights":[184],"into":[185],"genetic":[187],"basis":[188],"APA-linked":[192],"susceptibility":[193],"genes":[194]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":5}],"updated_date":"2026-07-03T08:13:44.112507","created_date":"2025-10-10T00:00:00"}