{"id":"https://openalex.org/W3160199866","doi":"https://doi.org/10.1093/nar/gkab359","title":"KEA3: improved kinase enrichment analysis via data integration","display_name":"KEA3: improved kinase enrichment analysis via data integration","publication_year":2021,"publication_date":"2021-04-23","ids":{"openalex":"https://openalex.org/W3160199866","doi":"https://doi.org/10.1093/nar/gkab359","mag":"3160199866","pmid":"https://pubmed.ncbi.nlm.nih.gov/34019655"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkab359","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkab359","pdf_url":"https://academic.oup.com/nar/article-pdf/49/W1/W304/38842187/gkab359.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/49/W1/W304/38842187/gkab359.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041050302","display_name":"Maxim V. Kuleshov","orcid":"https://orcid.org/0000-0002-7812-7752"},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maxim V Kuleshov","raw_affiliation_strings":["Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1603, New York, NY 10029, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1603, New York, NY 10029, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060461473","display_name":"Zhuorui Xie","orcid":"https://orcid.org/0000-0002-8256-5878"},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhuorui Xie","raw_affiliation_strings":["Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1603, New York, NY 10029, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1603, New York, NY 10029, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071397789","display_name":"Alexandra B. London","orcid":null},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandra B K London","raw_affiliation_strings":["Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1603, New York, NY 10029, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1603, New York, NY 10029, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028936447","display_name":"Janice Yang","orcid":"https://orcid.org/0000-0002-8413-967X"},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janice Yang","raw_affiliation_strings":["Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1603, New York, NY 10029, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1603, New York, NY 10029, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007301355","display_name":"John Erol Evangelista","orcid":"https://orcid.org/0000-0003-4836-0518"},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John\u00a0Erol Evangelista","raw_affiliation_strings":["Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1603, New York, NY 10029, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1603, New York, NY 10029, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016259488","display_name":"Alexander Lachmann","orcid":"https://orcid.org/0000-0002-1982-7652"},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Lachmann","raw_affiliation_strings":["Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1603, New York, NY 10029, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1603, New York, NY 10029, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091107079","display_name":"Ingrid Shu","orcid":null},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ingrid Shu","raw_affiliation_strings":["Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1603, New York, NY 10029, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1603, New York, NY 10029, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033642313","display_name":"Denis Torre","orcid":"https://orcid.org/0000-0003-4615-223X"},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Denis Torre","raw_affiliation_strings":["Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1603, New York, NY 10029, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1603, New York, NY 10029, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032951414","display_name":"Avi Ma\u2019ayan","orcid":"https://orcid.org/0000-0002-6904-1017"},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Avi Ma\u2019ayan","raw_affiliation_strings":["Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1603, New York, NY 10029, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1603, New York, NY 10029, USA","institution_ids":["https://openalex.org/I98704320"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5032951414"],"corresponding_institution_ids":["https://openalex.org/I98704320"],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":{"value":3630,"currency":"USD","value_usd":3630},"fwci":8.5406,"has_fulltext":false,"cited_by_count":149,"citation_normalized_percentile":{"value":0.98688072,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"49","issue":"W1","first_page":"W304","last_page":"W316"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phosphoproteomics","display_name":"Phosphoproteomics","score":0.7816771268844604},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7525159120559692},{"id":"https://openalex.org/keywords/proteomics","display_name":"Proteomics","score":0.6594895124435425},{"id":"https://openalex.org/keywords/kinase","display_name":"Kinase","score":0.5821489095687866},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5255671739578247},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.43222206830978394},{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"Protein kinase A","score":0.2989082932472229},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.2913007140159607},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1846017837524414},{"id":"https://openalex.org/keywords/protein-phosphorylation","display_name":"Protein phosphorylation","score":0.1602400839328766}],"concepts":[{"id":"https://openalex.org/C6675166","wikidata":"https://www.wikidata.org/wiki/Q7187538","display_name":"Phosphoproteomics","level":5,"score":0.7816771268844604},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7525159120559692},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.6594895124435425},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5821489095687866},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5255671739578247},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43222206830978394},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.2989082932472229},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2913007140159607},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1846017837524414},{"id":"https://openalex.org/C87325107","wikidata":"https://www.wikidata.org/wiki/Q7251493","display_name":"Protein phosphorylation","level":4,"score":0.1602400839328766}],"mesh":[{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/nar/gkab359","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkab359","pdf_url":"https://academic.oup.com/nar/article-pdf/49/W1/W304/38842187/gkab359.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmid:34019655","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34019655","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:8265130","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8265130","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/nar/gkab359","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkab359","pdf_url":"https://academic.oup.com/nar/article-pdf/49/W1/W304/38842187/gkab359.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1128421816","display_name":null,"funder_award_id":"U54-HL127624","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2641618911","display_name":null,"funder_award_id":"U24-CA224260","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4448270500","display_name":null,"funder_award_id":"OT3-OD025467","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5793542644","display_name":null,"funder_award_id":"T32-GM062754","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3160199866.pdf","grobid_xml":"https://content.openalex.org/works/W3160199866.grobid-xml"},"referenced_works_count":82,"referenced_works":["https://openalex.org/W103031768","https://openalex.org/W1501199419","https://openalex.org/W1576399086","https://openalex.org/W1586635012","https://openalex.org/W1966327575","https://openalex.org/W1972603998","https://openalex.org/W1989277387","https://openalex.org/W1996310767","https://openalex.org/W1998593414","https://openalex.org/W2008544906","https://openalex.org/W2012399090","https://openalex.org/W2014022465","https://openalex.org/W2018838463","https://openalex.org/W2018872127","https://openalex.org/W2030205108","https://openalex.org/W2039473152","https://openalex.org/W2043274355","https://openalex.org/W2043764521","https://openalex.org/W2043794217","https://openalex.org/W2054260164","https://openalex.org/W2056127109","https://openalex.org/W2059005938","https://openalex.org/W2092123736","https://openalex.org/W2095867585","https://openalex.org/W2098023402","https://openalex.org/W2100786079","https://openalex.org/W2105597591","https://openalex.org/W2105869859","https://openalex.org/W2110336366","https://openalex.org/W2121720309","https://openalex.org/W2122863289","https://openalex.org/W2123280311","https://openalex.org/W2130687290","https://openalex.org/W2131549592","https://openalex.org/W2135415614","https://openalex.org/W2139648620","https://openalex.org/W2143146488","https://openalex.org/W2149248356","https://openalex.org/W2150934340","https://openalex.org/W2152010440","https://openalex.org/W2154089679","https://openalex.org/W2155653061","https://openalex.org/W2158564991","https://openalex.org/W2159675211","https://openalex.org/W2162172965","https://openalex.org/W2165923048","https://openalex.org/W2166043581","https://openalex.org/W2266222342","https://openalex.org/W2296335794","https://openalex.org/W2346694641","https://openalex.org/W2436103310","https://openalex.org/W2473416770","https://openalex.org/W2524066112","https://openalex.org/W2534390616","https://openalex.org/W2563500611","https://openalex.org/W2624282460","https://openalex.org/W2683363718","https://openalex.org/W2762082538","https://openalex.org/W2782874671","https://openalex.org/W2787229156","https://openalex.org/W2791340464","https://openalex.org/W2792086443","https://openalex.org/W2794211762","https://openalex.org/W2804408552","https://openalex.org/W2883833333","https://openalex.org/W2899197140","https://openalex.org/W2900569176","https://openalex.org/W2904372598","https://openalex.org/W2915769855","https://openalex.org/W2917858269","https://openalex.org/W2945883683","https://openalex.org/W2953067954","https://openalex.org/W2964315448","https://openalex.org/W3012652877","https://openalex.org/W3022285953","https://openalex.org/W3037945517","https://openalex.org/W3080828599","https://openalex.org/W3085042675","https://openalex.org/W3135513616","https://openalex.org/W4233698560","https://openalex.org/W4255855797","https://openalex.org/W6697144307"],"related_works":["https://openalex.org/W2777858391","https://openalex.org/W2021238335","https://openalex.org/W3103916745","https://openalex.org/W1993754486","https://openalex.org/W1553672389","https://openalex.org/W2038488430","https://openalex.org/W4380871527","https://openalex.org/W2980121198","https://openalex.org/W2766858995","https://openalex.org/W2088324202"],"abstract_inverted_index":{"Phosphoproteomics":[0],"and":[1,56,75,83,88,114,127],"proteomics":[2,57],"experiments":[3],"capture":[4],"a":[5,28,42,134],"global":[6],"snapshot":[7],"of":[8,34,45,95,140],"the":[9,61,93,103,138,141],"cellular":[10],"signaling":[11],"network,":[12],"but":[13],"these":[14],"methods":[15],"do":[16],"not":[17],"directly":[18],"measure":[19],"kinase":[20,105],"state.":[21],"Kinase":[22],"Enrichment":[23],"Analysis":[24],"3":[25],"(KEA3)":[26],"is":[27,147],"webserver":[29,146],"application":[30],"that":[31,124],"infers":[32],"overrepresentation":[33],"upstream":[35,62],"kinases":[36,63],"whose":[37],"putative":[38],"substrates":[39],"are":[40],"in":[41],"user-inputted":[43],"list":[44],"proteins.":[46],"KEA3":[47,70,100,145],"can":[48,101],"be":[49],"applied":[50],"to":[51,59,132],"analyze":[52],"data":[53,116,130],"from":[54,106,118],"phosphoproteomics":[55,115],"studies":[58],"predict":[60,102],"responsible":[64],"for":[65],"observed":[66],"differential":[67],"phosphorylations.":[68],"The":[69,144],"background":[71],"database":[72],"contains":[73],"measured":[74],"predicted":[76],"kinase-substrate":[77],"interactions":[78,81,84],"(KSI),":[79],"kinase-protein":[80],"(KPI),":[82],"supported":[85],"by":[86,110],"co-expression":[87],"co-occurrence":[89],"data.":[90],"To":[91],"benchmark":[92],"performance":[94],"KEA3,":[96],"we":[97],"examined":[98],"whether":[99],"perturbed":[104],"single-kinase":[107],"perturbation":[108],"followed":[109],"gene":[111],"expression":[112],"experiments,":[113],"collected":[117],"kinase-targeting":[119],"small":[120],"molecules.":[121],"We":[122],"show":[123],"integrating":[125],"KSIs":[126],"KPIs":[128],"across":[129],"sources":[131],"produce":[133],"composite":[135],"ranking":[136],"improves":[137],"recovery":[139],"expected":[142],"kinase.":[143],"available":[148],"at":[149],"https://maayanlab.cloud/kea3.":[150]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":47},{"year":2024,"cited_by_count":46},{"year":2023,"cited_by_count":25},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":8}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}
