{"id":"https://openalex.org/W3154495123","doi":"https://doi.org/10.1093/nar/gkab273","title":"mmCSM-PPI: predicting the effects of multiple point mutations on protein\u2013protein interactions","display_name":"mmCSM-PPI: predicting the effects of multiple point mutations on protein\u2013protein interactions","publication_year":2021,"publication_date":"2021-04-16","ids":{"openalex":"https://openalex.org/W3154495123","doi":"https://doi.org/10.1093/nar/gkab273","mag":"3154495123","pmid":"https://pubmed.ncbi.nlm.nih.gov/33893812"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkab273","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkab273","pdf_url":"https://academic.oup.com/nar/article-pdf/49/W1/W417/38842375/gkab273.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/49/W1/W417/38842375/gkab273.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001797627","display_name":"Carlos H. M. Rodrigues","orcid":null},"institutions":[{"id":"https://openalex.org/I142471025","display_name":"Baker Heart and Diabetes Institute","ror":"https://ror.org/03rke0285","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I142471025"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Carlos H M Rodrigues","raw_affiliation_strings":["Computational Biology and Clinical Informatics, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia","Structural Biology and Bioinformatics, Department of Biochemistry and Pharmacology, University of Melbourne, Melbourne, Victoria, Australia","Systems and Computational Biology, Bio21 Institute, University of Melbourne, Melbourne, Victoria, Australia"],"affiliations":[{"raw_affiliation_string":"Computational Biology and Clinical Informatics, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia","institution_ids":["https://openalex.org/I142471025"]},{"raw_affiliation_string":"Structural Biology and Bioinformatics, Department of Biochemistry and Pharmacology, University of Melbourne, Melbourne, Victoria, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Systems and Computational Biology, Bio21 Institute, University of Melbourne, Melbourne, Victoria, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071950872","display_name":"Douglas E. V. Pires","orcid":"https://orcid.org/0000-0002-3004-2119"},"institutions":[{"id":"https://openalex.org/I142471025","display_name":"Baker Heart and Diabetes Institute","ror":"https://ror.org/03rke0285","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I142471025"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Douglas E V Pires","raw_affiliation_strings":["Computational Biology and Clinical Informatics, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia","School of Computing and Information Systems, University of Melbourne, Melbourne, Victoria, Australia","Structural Biology and Bioinformatics, Department of Biochemistry and Pharmacology, University of Melbourne, Melbourne, Victoria, Australia","Systems and Computational Biology, Bio21 Institute, University of Melbourne, Melbourne, Victoria, Australia"],"affiliations":[{"raw_affiliation_string":"Computational Biology and Clinical Informatics, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia","institution_ids":["https://openalex.org/I142471025"]},{"raw_affiliation_string":"School of Computing and Information Systems, University of Melbourne, Melbourne, Victoria, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Structural Biology and Bioinformatics, Department of Biochemistry and Pharmacology, University of Melbourne, Melbourne, Victoria, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Systems and Computational Biology, Bio21 Institute, University of Melbourne, Melbourne, Victoria, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091903225","display_name":"David B. Ascher","orcid":"https://orcid.org/0000-0003-2948-2413"},"institutions":[{"id":"https://openalex.org/I142471025","display_name":"Baker Heart and Diabetes Institute","ror":"https://ror.org/03rke0285","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I142471025"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["AU","GB"],"is_corresponding":true,"raw_author_name":"David B Ascher","raw_affiliation_strings":["Computational Biology and Clinical Informatics, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia","Department of Biochemistry, University of Cambridge, Cambridge, UK","Structural Biology and Bioinformatics, Department of Biochemistry and Pharmacology, University of Melbourne, Melbourne, Victoria, Australia","Systems and Computational Biology, Bio21 Institute, University of Melbourne, Melbourne, Victoria, Australia"],"affiliations":[{"raw_affiliation_string":"Computational Biology and Clinical Informatics, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia","institution_ids":["https://openalex.org/I142471025"]},{"raw_affiliation_string":"Department of Biochemistry, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Structural Biology and Bioinformatics, Department of Biochemistry and Pharmacology, University of Melbourne, Melbourne, Victoria, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Systems and Computational Biology, Bio21 Institute, University of Melbourne, Melbourne, Victoria, Australia","institution_ids":["https://openalex.org/I165779595"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5071950872","https://openalex.org/A5091903225"],"corresponding_institution_ids":["https://openalex.org/I142471025","https://openalex.org/I165779595","https://openalex.org/I241749"],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":{"value":3630,"currency":"USD","value_usd":3630},"fwci":4.6351,"has_fulltext":true,"cited_by_count":86,"citation_normalized_percentile":{"value":0.96191424,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"49","issue":"W1","first_page":"W417","last_page":"W424"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.948774516582489},{"id":"https://openalex.org/keywords/point-mutation","display_name":"Point mutation","score":0.6689467430114746},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.5783281326293945},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4793058931827545},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.4466198682785034},{"id":"https://openalex.org/keywords/protein\u2013protein-interaction","display_name":"Protein\u2013protein interaction","score":0.4112281799316406},{"id":"https://openalex.org/keywords/bacterial-protein","display_name":"Bacterial protein","score":0.4102538824081421},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.28145307302474976}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.948774516582489},{"id":"https://openalex.org/C176944494","wikidata":"https://www.wikidata.org/wiki/Q1415380","display_name":"Point mutation","level":4,"score":0.6689467430114746},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5783281326293945},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4793058931827545},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4466198682785034},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.4112281799316406},{"id":"https://openalex.org/C2993175405","wikidata":"https://www.wikidata.org/wiki/Q8054","display_name":"Bacterial protein","level":3,"score":0.4102538824081421},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.28145307302474976}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020125","descriptor_name":"Mutation, Missense","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020125","descriptor_name":"Mutation, Missense","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020125","descriptor_name":"Mutation, Missense","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020125","descriptor_name":"Mutation, Missense","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020125","descriptor_name":"Mutation, Missense","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1093/nar/gkab273","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkab273","pdf_url":"https://academic.oup.com/nar/article-pdf/49/W1/W417/38842375/gkab273.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmid:33893812","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33893812","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":null},{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/280511","is_oa":true,"landing_page_url":"http://hdl.handle.net/11343/280511","pdf_url":"http://hdl.handle.net/11343/280511","source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/321419.2","is_oa":true,"landing_page_url":"https://www.repository.cam.ac.uk/handle/1810/321419.2","pdf_url":"https://www.repository.cam.ac.uk/bitstreams/9285eca0-8273-4075-87a2-d46c6af0217a/download","source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8262703","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8262703","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/nar/gkab273","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkab273","pdf_url":"https://academic.oup.com/nar/article-pdf/49/W1/W417/38842375/gkab273.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1187375252","display_name":null,"funder_award_id":"1174405","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G1641483229","display_name":"Newton001 Understanding Antimicrobial Resistance Mutations in Tuberculosis: Towards Personalised Treatment to Combat Multi-drug Resistance","funder_award_id":"MR/M026302/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G4753511726","display_name":null,"funder_award_id":"JBF 4186","funder_id":"https://openalex.org/F4320313734","funder_display_name":"Jack Brockhoff Foundation"},{"id":"https://openalex.org/G6454673195","display_name":null,"funder_award_id":"GNT1174405","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320313734","display_name":"Jack Brockhoff Foundation","ror":"https://ror.org/02ybsyy31"},{"id":"https://openalex.org/F4320320240","display_name":"Research Councils UK","ror":"https://ror.org/00dq2kk65"},{"id":"https://openalex.org/F4320322858","display_name":"State Government of Victoria","ror":"https://ror.org/02xvc5r05"},{"id":"https://openalex.org/F4320330584","display_name":"Conselho Nacional das Funda\u00e7\u00f5es Estaduais de Amparo \u00e0 Pesquisa","ror":null},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3154495123.pdf","grobid_xml":"https://content.openalex.org/works/W3154495123.grobid-xml"},"referenced_works_count":72,"referenced_works":["https://openalex.org/W10419168","https://openalex.org/W194434573","https://openalex.org/W236727897","https://openalex.org/W1512701088","https://openalex.org/W1993591356","https://openalex.org/W2009867031","https://openalex.org/W2014731953","https://openalex.org/W2055942791","https://openalex.org/W2056053449","https://openalex.org/W2064488723","https://openalex.org/W2069152576","https://openalex.org/W2074964005","https://openalex.org/W2092387745","https://openalex.org/W2099672241","https://openalex.org/W2101234009","https://openalex.org/W2103459989","https://openalex.org/W2109984174","https://openalex.org/W2114850508","https://openalex.org/W2123400824","https://openalex.org/W2125359610","https://openalex.org/W2130479394","https://openalex.org/W2146208101","https://openalex.org/W2154319440","https://openalex.org/W2157807259","https://openalex.org/W2163052596","https://openalex.org/W2331480251","https://openalex.org/W2346940354","https://openalex.org/W2400041270","https://openalex.org/W2418388116","https://openalex.org/W2475308546","https://openalex.org/W2484261303","https://openalex.org/W2558879065","https://openalex.org/W2560264526","https://openalex.org/W2594240795","https://openalex.org/W2600041718","https://openalex.org/W2605361745","https://openalex.org/W2612814374","https://openalex.org/W2615841538","https://openalex.org/W2740835867","https://openalex.org/W2793062447","https://openalex.org/W2801491392","https://openalex.org/W2802419236","https://openalex.org/W2802777967","https://openalex.org/W2803413725","https://openalex.org/W2803713584","https://openalex.org/W2896220734","https://openalex.org/W2912646198","https://openalex.org/W2938646552","https://openalex.org/W2945403072","https://openalex.org/W2947097964","https://openalex.org/W2952725088","https://openalex.org/W2953103783","https://openalex.org/W2971652787","https://openalex.org/W2980372463","https://openalex.org/W2982575658","https://openalex.org/W2999447007","https://openalex.org/W3004759689","https://openalex.org/W3026328277","https://openalex.org/W3028862763","https://openalex.org/W3035828086","https://openalex.org/W3038264863","https://openalex.org/W3083008290","https://openalex.org/W3084341590","https://openalex.org/W3093556707","https://openalex.org/W3093944744","https://openalex.org/W3096435623","https://openalex.org/W3097939938","https://openalex.org/W3109430993","https://openalex.org/W4210375308","https://openalex.org/W4213345021","https://openalex.org/W4237367144","https://openalex.org/W6675354045"],"related_works":["https://openalex.org/W2550943714","https://openalex.org/W3212350425","https://openalex.org/W2388007221","https://openalex.org/W2511508046","https://openalex.org/W1974452506","https://openalex.org/W2363458739","https://openalex.org/W2385244308","https://openalex.org/W2028961943","https://openalex.org/W2364777039","https://openalex.org/W2375287167"],"abstract_inverted_index":{"Protein-protein":[0],"interactions":[1],"play":[2],"a":[3,25,70,129,150,163],"crucial":[4],"role":[5],"in":[6,21,45,81,98],"all":[7],"cellular":[8],"functions":[9],"and":[10,13,55,72,88,103,111,117,143,165,169],"biological":[11],"processes":[12],"mutations":[14,54],"leading":[15],"to":[16,30,48,59,100,127,134],"their":[17],"disruption":[18],"are":[19,44],"enriched":[20],"many":[22],"diseases.":[23],"While":[24],"number":[26],"of":[27,34,51,106,132],"computational":[28],"methods":[29],"assess":[31],"the":[32,49],"effects":[33],"variants":[35],"on":[36,62,149],"protein-protein":[37,82],"binding":[38,83],"affinity":[39,84],"have":[40,56],"been":[41,57],"proposed,":[42],"they":[43],"general":[46],"limited":[47],"analysis":[50],"single":[52,87],"point":[53],"shown":[58],"perform":[60],"poorly":[61],"independent":[63],"test":[64],"sets.":[65],"Here,":[66],"we":[67],"present":[68],"mmCSM-PPI,":[69],"scalable":[71],"effective":[73],"machine":[74],"learning":[75],"model":[76],"for":[77],"accurately":[78],"assessing":[79],"changes":[80],"caused":[85],"by":[86],"multiple":[89,107],"missense":[90],"mutations.":[91],"We":[92],"expanded":[93],"our":[94],"well-established":[95],"graph-based":[96],"signatures":[97],"order":[99],"capture":[101],"physicochemical":[102],"geometrical":[104],"properties":[105],"wild-type":[108],"residue":[109],"environments":[110],"integrated":[112],"them":[113],"with":[114],"substitution":[115],"scores":[116],"dynamics":[118],"terms":[119],"from":[120],"normal":[121],"mode":[122],"analysis.":[123],"mmCSM-PPI":[124],"was":[125],"able":[126],"achieve":[128],"Pearson's":[130],"correlation":[131],"up":[133],"0.75":[135],"(RMSE":[136,145],"=":[137,146],"1.64":[138],"kcal/mol)":[139,148],"under":[140],"10-fold":[141],"cross-validation":[142],"0.70":[144],"2.06":[147],"non-redundant":[151],"blind":[152],"test,":[153],"outperforming":[154],"existing":[155],"methods.":[156],"Our":[157],"method":[158],"is":[159],"freely":[160],"available":[161],"as":[162],"user-friendly":[164],"easy-to-use":[166],"web":[167],"server":[168],"API":[170],"at":[171],"http://biosig.unimelb.edu.au/mmcsm_ppi.":[172]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":22},{"year":2024,"cited_by_count":22},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}