{"id":"https://openalex.org/W3093556707","doi":"https://doi.org/10.1093/nar/gkaa925","title":"ThermoMutDB: a thermodynamic database for missense mutations","display_name":"ThermoMutDB: a thermodynamic database for missense mutations","publication_year":2020,"publication_date":"2020-10-12","ids":{"openalex":"https://openalex.org/W3093556707","doi":"https://doi.org/10.1093/nar/gkaa925","mag":"3093556707","pmid":"https://pubmed.ncbi.nlm.nih.gov/33095862"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkaa925","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkaa925","pdf_url":"https://academic.oup.com/nar/article-pdf/49/D1/D475/35364638/gkaa925.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/49/D1/D475/35364638/gkaa925.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039730752","display_name":"Joicymara S. Xavier","orcid":"https://orcid.org/0000-0002-4649-6270"},"institutions":[{"id":"https://openalex.org/I4210109820","display_name":"Instituto de Ciencias Agrarias","ror":"https://ror.org/01q9drc95","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210109820"]},{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]},{"id":"https://openalex.org/I4210118133","display_name":"Universidade Federal dos Vales do Jequitinhonha e Mucuri","ror":"https://ror.org/02gen2282","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210118133"]}],"countries":["BR","ES"],"is_corresponding":false,"raw_author_name":"Joicymara S Xavier","raw_affiliation_strings":["Institute of Agricultural Sciences, Universidade Federal dos Vales do Jequitinhonha e Mucuri","Instituto Ren\u00e9 Rachou, Funda\u00e7\u00e3o Oswaldo Cruz"],"affiliations":[{"raw_affiliation_string":"Institute of Agricultural Sciences, Universidade Federal dos Vales do Jequitinhonha e Mucuri","institution_ids":["https://openalex.org/I4210118133","https://openalex.org/I4210109820"]},{"raw_affiliation_string":"Instituto Ren\u00e9 Rachou, Funda\u00e7\u00e3o Oswaldo Cruz","institution_ids":["https://openalex.org/I52325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100387325","display_name":"Thanh Nguyen","orcid":"https://orcid.org/0000-0002-4150-5991"},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Thanh-Binh Nguyen","raw_affiliation_strings":["Bio 21 Institute, University of Melbourne"],"affiliations":[{"raw_affiliation_string":"Bio 21 Institute, University of Melbourne","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046639935","display_name":"Malancha Karmarkar","orcid":null},"institutions":[{"id":"https://openalex.org/I142471025","display_name":"Baker Heart and Diabetes Institute","ror":"https://ror.org/03rke0285","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I142471025"]},{"id":"https://openalex.org/I165779595","display_name":"University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Malancha Karmarkar","raw_affiliation_strings":["Bio 21 Institute, University of Melbourne","Computational Biology and Clinical Informatics, Baker Heart and Diabetes Institute"],"affiliations":[{"raw_affiliation_string":"Bio 21 Institute, University of Melbourne","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Computational Biology and Clinical Informatics, Baker Heart and Diabetes Institute","institution_ids":["https://openalex.org/I142471025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077485626","display_name":"Stephanie Portelli","orcid":"https://orcid.org/0000-0003-3515-4301"},"institutions":[{"id":"https://openalex.org/I142471025","display_name":"Baker Heart and Diabetes Institute","ror":"https://ror.org/03rke0285","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I142471025"]},{"id":"https://openalex.org/I165779595","display_name":"University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Stephanie Portelli","raw_affiliation_strings":["Bio 21 Institute, University of Melbourne","Computational Biology and Clinical Informatics, Baker Heart and Diabetes Institute"],"affiliations":[{"raw_affiliation_string":"Bio 21 Institute, University of Melbourne","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Computational Biology and Clinical Informatics, Baker Heart and Diabetes Institute","institution_ids":["https://openalex.org/I142471025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041425614","display_name":"P\u00e2mela Marinho Rezende","orcid":null},"institutions":[{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"P\u00e2mela M Rezende","raw_affiliation_strings":["Instituto Ren\u00e9 Rachou, Funda\u00e7\u00e3o Oswaldo Cruz"],"affiliations":[{"raw_affiliation_string":"Instituto Ren\u00e9 Rachou, Funda\u00e7\u00e3o Oswaldo Cruz","institution_ids":["https://openalex.org/I52325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044393668","display_name":"Jo\u00e3o Paulo Linhares Velloso","orcid":"https://orcid.org/0000-0002-6458-2885"},"institutions":[{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jo\u00e3o P L Velloso","raw_affiliation_strings":["Instituto Ren\u00e9 Rachou, Funda\u00e7\u00e3o Oswaldo Cruz"],"affiliations":[{"raw_affiliation_string":"Instituto Ren\u00e9 Rachou, Funda\u00e7\u00e3o Oswaldo Cruz","institution_ids":["https://openalex.org/I52325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091903225","display_name":"David B. Ascher","orcid":"https://orcid.org/0000-0003-2948-2413"},"institutions":[{"id":"https://openalex.org/I142471025","display_name":"Baker Heart and Diabetes Institute","ror":"https://ror.org/03rke0285","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I142471025"]},{"id":"https://openalex.org/I165779595","display_name":"University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["AU","GB"],"is_corresponding":true,"raw_author_name":"David B Ascher","raw_affiliation_strings":["Bio 21 Institute, University of Melbourne","Computational Biology and Clinical Informatics, Baker Heart and Diabetes Institute","Department of Biochemistry, University of Cambridge"],"affiliations":[{"raw_affiliation_string":"Bio 21 Institute, University of Melbourne","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Computational Biology and Clinical Informatics, Baker Heart and Diabetes Institute","institution_ids":["https://openalex.org/I142471025"]},{"raw_affiliation_string":"Department of Biochemistry, University of Cambridge","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071950872","display_name":"Douglas E. V. Pires","orcid":"https://orcid.org/0000-0002-3004-2119"},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I142471025","display_name":"Baker Heart and Diabetes Institute","ror":"https://ror.org/03rke0285","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I142471025"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Douglas E V Pires","raw_affiliation_strings":["Bio 21 Institute, University of Melbourne","Computational Biology and Clinical Informatics, Baker Heart and Diabetes Institute","School of Computing and Information Systems, University of Melbourne"],"affiliations":[{"raw_affiliation_string":"Bio 21 Institute, University of Melbourne","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Computational Biology and Clinical Informatics, Baker Heart and Diabetes Institute","institution_ids":["https://openalex.org/I142471025"]},{"raw_affiliation_string":"School of Computing and Information Systems, University of Melbourne","institution_ids":["https://openalex.org/I165779595"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5071950872","https://openalex.org/A5091903225"],"corresponding_institution_ids":["https://openalex.org/I142471025","https://openalex.org/I165779595","https://openalex.org/I241749"],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":{"value":3630,"currency":"USD","value_usd":3630},"fwci":8.8162,"has_fulltext":true,"cited_by_count":100,"citation_normalized_percentile":{"value":0.98258988,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"49","issue":"D1","first_page":"D475","last_page":"D479"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.996399998664856,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.996399998664856,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9703999757766724,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.9162676930427551},{"id":"https://openalex.org/keywords/missense-mutation","display_name":"Missense mutation","score":0.8419876098632812},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.603672444820404},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.4743710160255432},{"id":"https://openalex.org/keywords/database","display_name":"Database","score":0.3376903235912323},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.16970974206924438}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9162676930427551},{"id":"https://openalex.org/C75563809","wikidata":"https://www.wikidata.org/wiki/Q2656896","display_name":"Missense mutation","level":4,"score":0.8419876098632812},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.603672444820404},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4743710160255432},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.3376903235912323},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16970974206924438},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020125","descriptor_name":"Mutation, Missense","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020125","descriptor_name":"Mutation, Missense","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020125","descriptor_name":"Mutation, Missense","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1093/nar/gkaa925","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkaa925","pdf_url":"https://academic.oup.com/nar/article-pdf/49/D1/D475/35364638/gkaa925.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmid:33095862","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33095862","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":null},{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/252648","is_oa":true,"landing_page_url":"http://hdl.handle.net/11343/252648","pdf_url":"http://hdl.handle.net/11343/252648","source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7778973","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7778973","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/nar/gkaa925","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkaa925","pdf_url":"https://academic.oup.com/nar/article-pdf/49/D1/D475/35364638/gkaa925.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Affordable and clean energy","score":0.7200000286102295,"id":"https://metadata.un.org/sdg/7"}],"awards":[{"id":"https://openalex.org/G1187375252","display_name":null,"funder_award_id":"1174405","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G1429890386","display_name":null,"funder_award_id":"(CNPq","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G1641483229","display_name":"Newton001 Understanding Antimicrobial Resistance Mutations in Tuberculosis: Towards Personalised Treatment to Combat Multi-drug Resistance","funder_award_id":"MR/M026302/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G1880401245","display_name":null,"funder_award_id":"JBF 4186, 2016","funder_id":"https://openalex.org/F4320313734","funder_display_name":"Jack Brockhoff Foundation"},{"id":"https://openalex.org/G3305864144","display_name":null,"funder_award_id":"Grant","funder_id":"https://openalex.org/F4320322980","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais"},{"id":"https://openalex.org/G3331681876","display_name":null,"funder_award_id":"CAPES","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G3938906640","display_name":null,"funder_award_id":"(CAPES)","funder_id":"https://openalex.org/F4320321091","funder_display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior"},{"id":"https://openalex.org/G5478999995","display_name":null,"funder_award_id":"200814/Z/16/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G5952577628","display_name":null,"funder_award_id":"200814_Z_16_Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G6111631661","display_name":null,"funder_award_id":"Pesquisa","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G6160365333","display_name":null,"funder_award_id":"Grant","funder_id":"https://openalex.org/F4320321091","funder_display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior"},{"id":"https://openalex.org/G6432950657","display_name":null,"funder_award_id":"Newton Fund RCUK-CONFAP Grant","funder_id":"https://openalex.org/F4320322980","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais"},{"id":"https://openalex.org/G6454673195","display_name":null,"funder_award_id":"GNT1174405","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G7295187585","display_name":null,"funder_award_id":"Grant","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G7614337225","display_name":null,"funder_award_id":"CAPES","funder_id":"https://openalex.org/F4320322980","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais"},{"id":"https://openalex.org/G8357976619","display_name":null,"funder_award_id":"FAPEMIG","funder_id":"https://openalex.org/F4320321091","funder_display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior"},{"id":"https://openalex.org/G8744266013","display_name":null,"funder_award_id":"MR/M026302/1","funder_id":"https://openalex.org/F4320322980","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320313734","display_name":"Jack Brockhoff Foundation","ror":"https://ror.org/02ybsyy31"},{"id":"https://openalex.org/F4320320240","display_name":"Research Councils UK","ror":"https://ror.org/00dq2kk65"},{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320322980","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","ror":"https://ror.org/00nc55f03"},{"id":"https://openalex.org/F4320330584","display_name":"Conselho Nacional das Funda\u00e7\u00f5es Estaduais de Amparo \u00e0 Pesquisa","ror":null},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3093556707.pdf","grobid_xml":"https://content.openalex.org/works/W3093556707.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1983090887","https://openalex.org/W2011402521","https://openalex.org/W2019574765","https://openalex.org/W2055942791","https://openalex.org/W2064488723","https://openalex.org/W2103459989","https://openalex.org/W2109984174","https://openalex.org/W2114850508","https://openalex.org/W2151373045","https://openalex.org/W2162388472","https://openalex.org/W2306598644","https://openalex.org/W2335773464","https://openalex.org/W2418388116","https://openalex.org/W2428593791","https://openalex.org/W2600041718","https://openalex.org/W2607003759","https://openalex.org/W2611805058","https://openalex.org/W2615841538","https://openalex.org/W2740835867","https://openalex.org/W2787839563","https://openalex.org/W2794541436","https://openalex.org/W2801491392","https://openalex.org/W2802419236","https://openalex.org/W2802777967","https://openalex.org/W2803413725","https://openalex.org/W2896220734","https://openalex.org/W2912646198","https://openalex.org/W2947097964","https://openalex.org/W2952725088","https://openalex.org/W2955704392","https://openalex.org/W3004759689","https://openalex.org/W3028862763","https://openalex.org/W3035828086","https://openalex.org/W3084341590"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2082860237","https://openalex.org/W2119695867","https://openalex.org/W2130076355","https://openalex.org/W1990804418","https://openalex.org/W1993764875","https://openalex.org/W2069150591","https://openalex.org/W4232163425","https://openalex.org/W2146849562","https://openalex.org/W2028961943"],"abstract_inverted_index":{"Proteins":[0],"are":[1],"intricate,":[2],"dynamic":[3],"structures,":[4],"and":[5,22,29,55,70,105,109,127],"small":[6],"changes":[7],"in":[8,64,87],"their":[9,19],"amino":[10],"acid":[11],"sequences":[12],"can":[13],"lead":[14],"to":[15,33,121,123,130],"large":[16],"effects":[17],"on":[18,74,99],"folding,":[20],"stability":[21],"dynamics.":[23],"To":[24],"facilitate":[25],"the":[26,100,131],"further":[27],"development":[28],"evaluation":[30],"of":[31,49,62],"methods":[32],"predict":[34],"these":[35],"changes,":[36],"we":[37,81,95],"have":[38,82,96,110],"developed":[39],"ThermoMutDB,":[40],"a":[41,134],"manually":[42],"curated":[43,89],"database":[44,132],"containing":[45],">14,669":[46],"experimental":[47,115],"data":[48,125],"thermodynamic":[50,72],"parameters":[51],"for":[52],"wild":[53],"type":[54],"mutant":[56],"proteins.":[57,77],"This":[58],"represents":[59],"an":[60],"increase":[61],"83%":[63],"unique":[65],"mutations":[66],"over":[67],"previous":[68],"databases":[69],"includes":[71],"information":[73,98],"204":[75],"new":[76,124],"During":[78],"manual":[79],"curation":[80],"also":[83],"corrected":[84],"annotation":[85],"errors":[86],"previously":[88],"entries.":[90],"Associated":[91],"with":[92,113],"each":[93],"entry,":[94],"included":[97],"unfolding":[101],"Gibbs":[102],"free":[103],"energy":[104],"melting":[106],"temperature":[107],"change,":[108],"associated":[111],"entries":[112],"available":[114,140],"structural":[116],"information.":[117],"ThermoMutDB":[118,137],"supports":[119],"users":[120],"contribute":[122],"points":[126],"programmatic":[128],"access":[129],"via":[133],"RESTful":[135],"API.":[136],"is":[138],"freely":[139],"at:":[141],"http://biosig.unimelb.edu.au/thermomutdb.":[142]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":19},{"year":2024,"cited_by_count":29},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":21},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":1}],"updated_date":"2026-03-14T08:43:22.919905","created_date":"2025-10-10T00:00:00"}