{"id":"https://openalex.org/W3014482292","doi":"https://doi.org/10.1093/nar/gkaa216","title":"SynergyFinder 2.0: visual analytics of multi-drug combination synergies","display_name":"SynergyFinder 2.0: visual analytics of multi-drug combination synergies","publication_year":2020,"publication_date":"2020-03-25","ids":{"openalex":"https://openalex.org/W3014482292","doi":"https://doi.org/10.1093/nar/gkaa216","mag":"3014482292","pmid":"https://pubmed.ncbi.nlm.nih.gov/32246720"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkaa216","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkaa216","pdf_url":"https://watermark.silverchair.com/gkaa216.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAq8wggKrBgkqhkiG9w0BBwagggKcMIICmAIBADCCApEGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMWFtc5XVwYqW_YheeAgEQgIICYohylUMeyI7Cf_13laUCg8yOfOMQGj8Tq7GeZoDRjghszPeLeJkSwDhkDgfcUl0S3ZL0h_0FH2uV8hTkIFl35bjrhg39rmd_AMcPZITUku03c7MFQny20jbVGnUm9ai6hPlE-HUg9WJP3melYYnf23ncBaEmHYKYoxin9oW1PJWgZovvdOnSOiUYGLjSJ1DoOOMK4EcGnWMFBjFb5lzb3kXEoWnY_kaDcdSi3GansDOQuiKPo62XS27K4iw4HO95oYaCxIqWYUB0lBzLh39K2_yMKdot6XfaJb7fTvbDslgxjPUqBJPAv_n1ghJidKHcwdVGSoVWE749K6mDXesiU0IFLGwNpCkVNK27zUJ3e7sRbMZrIwbOs2EaGkmJEnmdNE9sAjBL0uu0W9dDs5dwn3ZBOkHGDaLdyNPP0OS8xB30_W8DY5WZy5dPrJcnJBBpfze64K-KGosRBW-t-ufLEIUQWFVtIE74XxwzOj-DGHXyUwEXVWgxG1kqyRsV3DLFwhtTEgTRMrnogzi1ftVz_3XoCrR9d4yG_z3j_Ax5gwHjMtyrdTjHkFbL7ptPPc-3_EqWd-LMmfZcOlSF1fZXyJ8Pn7nkLLh50y7uC5nOo91bG76nUK1LIDr8YV0648OK99bhb010d1kI0W0b_688Rof7NsX97BBakjOGuFFzEcDgoZivfjTQ2z2SquzUZ-JwC_B4qviUsChvwF_Jx4chUlzLJQ8JWbkpLES-W9liUTHUgbV4r_8Wun_VAWeRhnweHpa9EwloK7PLPk25rI6f_YAeSdzVAsotUaEOhcaoquXr3oY","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://watermark.silverchair.com/gkaa216.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAq8wggKrBgkqhkiG9w0BBwagggKcMIICmAIBADCCApEGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMWFtc5XVwYqW_YheeAgEQgIICYohylUMeyI7Cf_13laUCg8yOfOMQGj8Tq7GeZoDRjghszPeLeJkSwDhkDgfcUl0S3ZL0h_0FH2uV8hTkIFl35bjrhg39rmd_AMcPZITUku03c7MFQny20jbVGnUm9ai6hPlE-HUg9WJP3melYYnf23ncBaEmHYKYoxin9oW1PJWgZovvdOnSOiUYGLjSJ1DoOOMK4EcGnWMFBjFb5lzb3kXEoWnY_kaDcdSi3GansDOQuiKPo62XS27K4iw4HO95oYaCxIqWYUB0lBzLh39K2_yMKdot6XfaJb7fTvbDslgxjPUqBJPAv_n1ghJidKHcwdVGSoVWE749K6mDXesiU0IFLGwNpCkVNK27zUJ3e7sRbMZrIwbOs2EaGkmJEnmdNE9sAjBL0uu0W9dDs5dwn3ZBOkHGDaLdyNPP0OS8xB30_W8DY5WZy5dPrJcnJBBpfze64K-KGosRBW-t-ufLEIUQWFVtIE74XxwzOj-DGHXyUwEXVWgxG1kqyRsV3DLFwhtTEgTRMrnogzi1ftVz_3XoCrR9d4yG_z3j_Ax5gwHjMtyrdTjHkFbL7ptPPc-3_EqWd-LMmfZcOlSF1fZXyJ8Pn7nkLLh50y7uC5nOo91bG76nUK1LIDr8YV0648OK99bhb010d1kI0W0b_688Rof7NsX97BBakjOGuFFzEcDgoZivfjTQ2z2SquzUZ-JwC_B4qviUsChvwF_Jx4chUlzLJQ8JWbkpLES-W9liUTHUgbV4r_8Wun_VAWeRhnweHpa9EwloK7PLPk25rI6f_YAeSdzVAsotUaEOhcaoquXr3oY","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070170202","display_name":"Aleksandr Ianevski","orcid":"https://orcid.org/0000-0002-7780-482X"},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I32943570","display_name":"Helsinki Institute for Information Technology","ror":"https://ror.org/05kph4940","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I32943570","https://openalex.org/I9927081"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I9927081","display_name":"Aalto University","ror":"https://ror.org/020hwjq30","country_code":"FI","type":"education","lineage":["https://openalex.org/I9927081"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Aleksandr Ianevski","raw_affiliation_strings":["Helsinki Institute for Information Technology (HIIT), Department of Computer Science, Aalto University, FI-02150 Espoo, Finland","Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, FI-00290 Helsinki, Finland"],"affiliations":[{"raw_affiliation_string":"Helsinki Institute for Information Technology (HIIT), Department of Computer Science, Aalto University, FI-02150 Espoo, Finland","institution_ids":["https://openalex.org/I32943570","https://openalex.org/I9927081"]},{"raw_affiliation_string":"Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, FI-00290 Helsinki, Finland","institution_ids":["https://openalex.org/I4210133586","https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010340744","display_name":"Anil K. Giri","orcid":null},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Anil K Giri","raw_affiliation_strings":["Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, FI-00290 Helsinki, Finland"],"affiliations":[{"raw_affiliation_string":"Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, FI-00290 Helsinki, Finland","institution_ids":["https://openalex.org/I4210133586","https://openalex.org/I133731052"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016681267","display_name":"Tero Aittokallio","orcid":"https://orcid.org/0000-0002-0886-9769"},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]},{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]},{"id":"https://openalex.org/I32943570","display_name":"Helsinki Institute for Information Technology","ror":"https://ror.org/05kph4940","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I32943570","https://openalex.org/I9927081"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I9927081","display_name":"Aalto University","ror":"https://ror.org/020hwjq30","country_code":"FI","type":"education","lineage":["https://openalex.org/I9927081"]}],"countries":["FI","NO"],"is_corresponding":true,"raw_author_name":"Tero Aittokallio","raw_affiliation_strings":["Helsinki Institute for Information Technology (HIIT), Department of Computer Science, Aalto University, FI-02150 Espoo, Finland","Institute for Cancer Research, Department of Cancer Genetics, Oslo University Hospital, N-0310 Oslo, Norway","Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, FI-00290 Helsinki, Finland","Oslo Centre for Biostatistics and Epidemiology (OCBE), Faculty of Medicine, University of Oslo, N-0317 Oslo, Norway"],"affiliations":[{"raw_affiliation_string":"Helsinki Institute for Information Technology (HIIT), Department of Computer Science, Aalto University, FI-02150 Espoo, Finland","institution_ids":["https://openalex.org/I32943570","https://openalex.org/I9927081"]},{"raw_affiliation_string":"Institute for Cancer Research, Department of Cancer Genetics, Oslo University Hospital, N-0310 Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]},{"raw_affiliation_string":"Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, FI-00290 Helsinki, Finland","institution_ids":["https://openalex.org/I4210133586","https://openalex.org/I133731052"]},{"raw_affiliation_string":"Oslo Centre for Biostatistics and Epidemiology (OCBE), Faculty of Medicine, University of Oslo, N-0317 Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5010340744","https://openalex.org/A5016681267","https://openalex.org/A5070170202"],"corresponding_institution_ids":["https://openalex.org/I1281400175","https://openalex.org/I133731052","https://openalex.org/I184942183","https://openalex.org/I32943570","https://openalex.org/I4210133586","https://openalex.org/I9927081"],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":{"value":3630,"currency":"USD","value_usd":3630},"fwci":86.5738,"has_fulltext":true,"cited_by_count":931,"citation_normalized_percentile":{"value":0.99963374,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"48","issue":"W1","first_page":"W488","last_page":"W493"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9919000267982483,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11407","display_name":"Innovative Microfluidic and Catalytic Techniques Innovation","score":0.9387999773025513,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.900962769985199},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.539067804813385},{"id":"https://openalex.org/keywords/visual-analytics","display_name":"Visual analytics","score":0.5347231030464172},{"id":"https://openalex.org/keywords/analytics","display_name":"Analytics","score":0.48546770215034485},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.46771472692489624},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.3769008219242096},{"id":"https://openalex.org/keywords/visualization","display_name":"Visualization","score":0.3267670273780823},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.1852167248725891},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.1306983232498169},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.12981662154197693}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.900962769985199},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.539067804813385},{"id":"https://openalex.org/C59732488","wikidata":"https://www.wikidata.org/wiki/Q2528440","display_name":"Visual analytics","level":3,"score":0.5347231030464172},{"id":"https://openalex.org/C79158427","wikidata":"https://www.wikidata.org/wiki/Q485396","display_name":"Analytics","level":2,"score":0.48546770215034485},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.46771472692489624},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.3769008219242096},{"id":"https://openalex.org/C36464697","wikidata":"https://www.wikidata.org/wiki/Q451553","display_name":"Visualization","level":2,"score":0.3267670273780823},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.1852167248725891},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.1306983232498169},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.12981662154197693}],"mesh":[{"descriptor_ui":"D003196","descriptor_name":"Computer Graphics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003196","descriptor_name":"Computer Graphics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003196","descriptor_name":"Computer Graphics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003196","descriptor_name":"Computer Graphics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003196","descriptor_name":"Computer Graphics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1093/nar/gkaa216","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkaa216","pdf_url":"https://watermark.silverchair.com/gkaa216.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAq8wggKrBgkqhkiG9w0BBwagggKcMIICmAIBADCCApEGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMWFtc5XVwYqW_YheeAgEQgIICYohylUMeyI7Cf_13laUCg8yOfOMQGj8Tq7GeZoDRjghszPeLeJkSwDhkDgfcUl0S3ZL0h_0FH2uV8hTkIFl35bjrhg39rmd_AMcPZITUku03c7MFQny20jbVGnUm9ai6hPlE-HUg9WJP3melYYnf23ncBaEmHYKYoxin9oW1PJWgZovvdOnSOiUYGLjSJ1DoOOMK4EcGnWMFBjFb5lzb3kXEoWnY_kaDcdSi3GansDOQuiKPo62XS27K4iw4HO95oYaCxIqWYUB0lBzLh39K2_yMKdot6XfaJb7fTvbDslgxjPUqBJPAv_n1ghJidKHcwdVGSoVWE749K6mDXesiU0IFLGwNpCkVNK27zUJ3e7sRbMZrIwbOs2EaGkmJEnmdNE9sAjBL0uu0W9dDs5dwn3ZBOkHGDaLdyNPP0OS8xB30_W8DY5WZy5dPrJcnJBBpfze64K-KGosRBW-t-ufLEIUQWFVtIE74XxwzOj-DGHXyUwEXVWgxG1kqyRsV3DLFwhtTEgTRMrnogzi1ftVz_3XoCrR9d4yG_z3j_Ax5gwHjMtyrdTjHkFbL7ptPPc-3_EqWd-LMmfZcOlSF1fZXyJ8Pn7nkLLh50y7uC5nOo91bG76nUK1LIDr8YV0648OK99bhb010d1kI0W0b_688Rof7NsX97BBakjOGuFFzEcDgoZivfjTQ2z2SquzUZ-JwC_B4qviUsChvwF_Jx4chUlzLJQ8JWbkpLES-W9liUTHUgbV4r_8Wun_VAWeRhnweHpa9EwloK7PLPk25rI6f_YAeSdzVAsotUaEOhcaoquXr3oY","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmid:32246720","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32246720","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:7319457","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7319457","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"},{"id":"pmh:oai:helda.helsinki.fi:10138/320430","is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/320430","pdf_url":"http://hdl.handle.net/10138/320430","source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:aaltodoc.aalto.fi:123456789/113808","is_oa":true,"landing_page_url":"https://research.aalto.fi/en/publications/e5f93e7b-2f66-4d2f-9c46-e2341430fdf2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401662","display_name":"Aaltodoc (Aalto University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I9927081","host_organization_name":"Aalto University","host_organization_lineage":["https://openalex.org/I9927081"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"publishedVersion"},{"id":"pmh:oai:www.duo.uio.no:10852/83897","is_oa":true,"landing_page_url":"http://urn.nb.no/URN:NBN:no-86626","pdf_url":null,"source":{"id":"https://openalex.org/S4306401717","display_name":"Duo Research Archive (University of Oslo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I184942183","host_organization_name":"University of Oslo","host_organization_lineage":["https://openalex.org/I184942183"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"0305-1048","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1093/nar/gkaa216","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkaa216","pdf_url":"https://watermark.silverchair.com/gkaa216.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAq8wggKrBgkqhkiG9w0BBwagggKcMIICmAIBADCCApEGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMWFtc5XVwYqW_YheeAgEQgIICYohylUMeyI7Cf_13laUCg8yOfOMQGj8Tq7GeZoDRjghszPeLeJkSwDhkDgfcUl0S3ZL0h_0FH2uV8hTkIFl35bjrhg39rmd_AMcPZITUku03c7MFQny20jbVGnUm9ai6hPlE-HUg9WJP3melYYnf23ncBaEmHYKYoxin9oW1PJWgZovvdOnSOiUYGLjSJ1DoOOMK4EcGnWMFBjFb5lzb3kXEoWnY_kaDcdSi3GansDOQuiKPo62XS27K4iw4HO95oYaCxIqWYUB0lBzLh39K2_yMKdot6XfaJb7fTvbDslgxjPUqBJPAv_n1ghJidKHcwdVGSoVWE749K6mDXesiU0IFLGwNpCkVNK27zUJ3e7sRbMZrIwbOs2EaGkmJEnmdNE9sAjBL0uu0W9dDs5dwn3ZBOkHGDaLdyNPP0OS8xB30_W8DY5WZy5dPrJcnJBBpfze64K-KGosRBW-t-ufLEIUQWFVtIE74XxwzOj-DGHXyUwEXVWgxG1kqyRsV3DLFwhtTEgTRMrnogzi1ftVz_3XoCrR9d4yG_z3j_Ax5gwHjMtyrdTjHkFbL7ptPPc-3_EqWd-LMmfZcOlSF1fZXyJ8Pn7nkLLh50y7uC5nOo91bG76nUK1LIDr8YV0648OK99bhb010d1kI0W0b_688Rof7NsX97BBakjOGuFFzEcDgoZivfjTQ2z2SquzUZ-JwC_B4qviUsChvwF_Jx4chUlzLJQ8JWbkpLES-W9liUTHUgbV4r_8Wun_VAWeRhnweHpa9EwloK7PLPk25rI6f_YAeSdzVAsotUaEOhcaoquXr3oY","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6499999761581421}],"awards":[{"id":"https://openalex.org/G3634603146","display_name":null,"funder_award_id":"313267","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G3732400637","display_name":null,"funder_award_id":"326238","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G3756483984","display_name":null,"funder_award_id":"310507","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G65047521","display_name":null,"funder_award_id":"292611","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G8318064016","display_name":null,"funder_award_id":"Horizon","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320310086","display_name":"Helsingin Yliopisto","ror":"https://ror.org/040af2s02"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321108","display_name":"Academy of Finland","ror":"https://ror.org/05k73zm37"},{"id":"https://openalex.org/F4320323760","display_name":"Sigrid Jus\u00e9liuksen S\u00e4\u00e4ti\u00f6","ror":"https://ror.org/00ckakm23"},{"id":"https://openalex.org/F4320323824","display_name":"Sy\u00f6p\u00e4j\u00e4rjest\u00f6t","ror":"https://ror.org/05pgg4z49"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3014482292.pdf","grobid_xml":"https://content.openalex.org/works/W3014482292.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W573209969","https://openalex.org/W1578932543","https://openalex.org/W1696775091","https://openalex.org/W1915767302","https://openalex.org/W2002069093","https://openalex.org/W2060737851","https://openalex.org/W2111366496","https://openalex.org/W2143400953","https://openalex.org/W2160547085","https://openalex.org/W2335854816","https://openalex.org/W2439807060","https://openalex.org/W2518086895","https://openalex.org/W2556090342","https://openalex.org/W2597613988","https://openalex.org/W2605336808","https://openalex.org/W2608863179","https://openalex.org/W2764287995","https://openalex.org/W2786726389","https://openalex.org/W2790982990","https://openalex.org/W2799310948","https://openalex.org/W2824475905","https://openalex.org/W2887752833","https://openalex.org/W2899687620","https://openalex.org/W2904151535","https://openalex.org/W2905302554","https://openalex.org/W2907559772","https://openalex.org/W2911532461","https://openalex.org/W2913242533","https://openalex.org/W2914639997","https://openalex.org/W2918402786","https://openalex.org/W2958443347","https://openalex.org/W2972783946","https://openalex.org/W2979198871","https://openalex.org/W2980286751","https://openalex.org/W2982115750","https://openalex.org/W2987538316","https://openalex.org/W2992010506","https://openalex.org/W3003840025","https://openalex.org/W6639832135","https://openalex.org/W6703221619"],"related_works":["https://openalex.org/W2362367986","https://openalex.org/W348707231","https://openalex.org/W2571228289","https://openalex.org/W4293108519","https://openalex.org/W3041760129","https://openalex.org/W2952667803","https://openalex.org/W202848325","https://openalex.org/W2171036274","https://openalex.org/W2186032312","https://openalex.org/W2350094487"],"abstract_inverted_index":{"SynergyFinder":[0,22,68,145],"(https://synergyfinder.fimm.fi)":[1],"is":[2,147],"a":[3,25],"stand-alone":[4],"web-application":[5],"for":[6,30,50],"interactive":[7],"analysis":[8,106],"and":[9,49,88,104,126,137,162],"visualization":[10,90,125],"of":[11,33,53,55,67,79,91,107,112,139,158],"drug":[12,36],"combination":[13,56,85],"screening":[14,161],"data.":[15],"Since":[16],"its":[17,152],"first":[18],"release":[19],"in":[20,38,155],"2017,":[21],"has":[23,72],"become":[24],"widely":[26],"used":[27],"web-tool":[28],"both":[29],"the":[31,64,77,120,140],"discovery":[32],"novel":[34,80],"synergistic":[35],"combinations":[37],"pre-clinical":[39],"model":[40],"systems":[41],"(e.g.":[42],"cell":[43],"lines":[44],"or":[45,59],"primary":[46],"patient-derived":[47],"cells),":[48],"better":[51],"understanding":[52],"mechanisms":[54],"treatment":[57],"efficacy":[58],"resistance.":[60],"Here,":[61],"we":[62],"describe":[63],"latest":[65],"version":[66],"(release":[69],"2.0),":[70],"which":[71],"extensively":[73],"been":[74],"upgraded":[75],"through":[76],"addition":[78],"features":[81],"supporting":[82],"especially":[83],"higher-order":[84],"data":[86],"analytics":[87],"exploratory":[89],"multi-drug":[92,159],"synergy":[93],"patterns,":[94],"along":[95],"with":[96],"automated":[97],"outlier":[98],"detection":[99],"procedure,":[100],"extended":[101],"curve-fitting":[102],"functionality":[103],"statistical":[105],"replicate":[108],"measurements.":[109],"A":[110],"number":[111],"additional":[113],"improvements":[114],"were":[115],"also":[116],"implemented":[117],"based":[118],"on":[119],"user":[121,130],"requests,":[122],"including":[123],"new":[124],"export":[127],"options,":[128],"updated":[129],"interface,":[131],"as":[132,134],"well":[133],"enhanced":[135],"stability":[136],"performance":[138],"web-tool.":[141],"With":[142],"these":[143],"improvements,":[144],"2.0":[146],"expected":[148],"to":[149],"greatly":[150],"extend":[151],"potential":[153],"applications":[154],"various":[156],"areas":[157],"combinatorial":[160],"precision":[163],"medicine.":[164]},"counts_by_year":[{"year":2026,"cited_by_count":38},{"year":2025,"cited_by_count":122},{"year":2024,"cited_by_count":175},{"year":2023,"cited_by_count":192},{"year":2022,"cited_by_count":211},{"year":2021,"cited_by_count":151},{"year":2020,"cited_by_count":41},{"year":2019,"cited_by_count":1}],"updated_date":"2026-04-02T15:55:50.835912","created_date":"2025-10-10T00:00:00"}