{"id":"https://openalex.org/W2896190255","doi":"https://doi.org/10.1093/jamia/ocy106","title":"Mechanistic machine learning: how data assimilation leverages physiologic knowledge using Bayesian inference to forecast the future, infer the present, and phenotype","display_name":"Mechanistic machine learning: how data assimilation leverages physiologic knowledge using Bayesian inference to forecast the future, infer the present, and phenotype","publication_year":2018,"publication_date":"2018-08-17","ids":{"openalex":"https://openalex.org/W2896190255","doi":"https://doi.org/10.1093/jamia/ocy106","mag":"2896190255","pmid":"https://pubmed.ncbi.nlm.nih.gov/30312445"},"language":"en","primary_location":{"id":"doi:10.1093/jamia/ocy106","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jamia/ocy106","pdf_url":"https://watermark.silverchair.com/ocy106.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAqUwggKhBgkqhkiG9w0BBwagggKSMIICjgIBADCCAocGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMNLPngPXVEn_agD88AgEQgIICWCvSQPmeD5XUPhuVwi7DzGfoKfrvM6RUi_mGSp4F_mI5XHxrVod4taoMJu4c4VkeXH8Dc-0PFWFLwVBMCgSIb1V0yoeGAKWej7JTuAlw8gWlN_HzTyvWi3vklGLa1cOvQB2OnAhr-xphhTpUpSBRr9zTAPrpGMreVCW0KPE1gOyV2GPU8u2CpEfrt__knSL1ZJ0ZW8xq6Ha8Nv41N4Av4DzSn_FhQEYO96uDi1S2CVnxkM6t4u-QmCj48nFouPA2WSPETrIajbziNvmiE5oxRqdwb-pAZNk-yD4tNBKGUwXP-cGDb_SanOy-F4eM-ypuV-gl-_kt_zR3CowyYE2RhGhjtPuigityTFGlcn10pqXOUK5XOGqAfR3aGJTUTw0b7vD9-fytoq-uOAMjgdsKJg_pWD9877unEUI4PedfAkunfE1bf_aTQWgx1TjKA9X6BSTr5PP8gfBvng33xsi7Vw2h8PlbBtpHvhtlZdBBJQ0H2RJB0EOrJ7Ub5gVGJkMZ6eq_V_Vsr6liMc3fiJB8zrcghPvf9MSXpAHNiPpPLxWFBK1hb7PZW7lMqi_KyzBZJnshuZljXPB4jKENYdIPrBIS3U90zESUwnibGaZBpyONsEwOxFGTBm-aVCKY_AtJzJL7oKMcZuD7-mJI7nM-SC2uLlOEM5gtChF3RmMmJtJQ7s8362vKWwEF6Rl4D53aR_4tsasFe2yYnovCcr-xSehqY537PshMPeNnjYuRUHt49y2_Nsv-4hs487_dFi3uG9C_NKxfbViJZqYAs9wPvU9BHvZ4GobseQ","source":{"id":"https://openalex.org/S129839026","display_name":"Journal of the American Medical Informatics Association","issn_l":"1067-5027","issn":["1067-5027","1527-974X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Informatics Association","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://watermark.silverchair.com/ocy106.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAqUwggKhBgkqhkiG9w0BBwagggKSMIICjgIBADCCAocGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMNLPngPXVEn_agD88AgEQgIICWCvSQPmeD5XUPhuVwi7DzGfoKfrvM6RUi_mGSp4F_mI5XHxrVod4taoMJu4c4VkeXH8Dc-0PFWFLwVBMCgSIb1V0yoeGAKWej7JTuAlw8gWlN_HzTyvWi3vklGLa1cOvQB2OnAhr-xphhTpUpSBRr9zTAPrpGMreVCW0KPE1gOyV2GPU8u2CpEfrt__knSL1ZJ0ZW8xq6Ha8Nv41N4Av4DzSn_FhQEYO96uDi1S2CVnxkM6t4u-QmCj48nFouPA2WSPETrIajbziNvmiE5oxRqdwb-pAZNk-yD4tNBKGUwXP-cGDb_SanOy-F4eM-ypuV-gl-_kt_zR3CowyYE2RhGhjtPuigityTFGlcn10pqXOUK5XOGqAfR3aGJTUTw0b7vD9-fytoq-uOAMjgdsKJg_pWD9877unEUI4PedfAkunfE1bf_aTQWgx1TjKA9X6BSTr5PP8gfBvng33xsi7Vw2h8PlbBtpHvhtlZdBBJQ0H2RJB0EOrJ7Ub5gVGJkMZ6eq_V_Vsr6liMc3fiJB8zrcghPvf9MSXpAHNiPpPLxWFBK1hb7PZW7lMqi_KyzBZJnshuZljXPB4jKENYdIPrBIS3U90zESUwnibGaZBpyONsEwOxFGTBm-aVCKY_AtJzJL7oKMcZuD7-mJI7nM-SC2uLlOEM5gtChF3RmMmJtJQ7s8362vKWwEF6Rl4D53aR_4tsasFe2yYnovCcr-xSehqY537PshMPeNnjYuRUHt49y2_Nsv-4hs487_dFi3uG9C_NKxfbViJZqYAs9wPvU9BHvZ4GobseQ","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070746797","display_name":"David J. Albers","orcid":"https://orcid.org/0000-0002-5369-526X"},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David J Albers","raw_affiliation_strings":["Department of Biomedical Informatics, Columbia University, New York, New York, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, Columbia University, New York, New York, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042719367","display_name":"Matthew E. Levine","orcid":"https://orcid.org/0000-0002-5627-3169"},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew E Levine","raw_affiliation_strings":["Department of Biomedical Informatics, Columbia University, New York, New York, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, Columbia University, New York, New York, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032114852","display_name":"Andrew M. Stuart","orcid":"https://orcid.org/0000-0001-9091-7266"},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Stuart","raw_affiliation_strings":["Department of Computing and Mathematical Sciences, University California Institute of Technology, Pasadena, California, USA"],"affiliations":[{"raw_affiliation_string":"Department of Computing and Mathematical Sciences, University California Institute of Technology, Pasadena, California, USA","institution_ids":["https://openalex.org/I122411786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015187091","display_name":"Lena Mamykina","orcid":"https://orcid.org/0000-0001-5203-274X"},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lena Mamykina","raw_affiliation_strings":["Department of Biomedical Informatics, Columbia University, New York, New York, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, Columbia University, New York, New York, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069751145","display_name":"Bruce J. Gluckman","orcid":"https://orcid.org/0000-0001-7695-2225"},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce Gluckman","raw_affiliation_strings":["Department of Engineering Science and Mechanics, Pennsylvania State University, University Park, Pennsylvania, USA"],"affiliations":[{"raw_affiliation_string":"Department of Engineering Science and Mechanics, Pennsylvania State University, University Park, Pennsylvania, USA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053670656","display_name":"George Hripcsak","orcid":"https://orcid.org/0000-0003-2664-7614"},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George Hripcsak","raw_affiliation_strings":["Department of Biomedical Informatics, Columbia University, New York, New York, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, Columbia University, New York, New York, USA","institution_ids":["https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5070746797"],"corresponding_institution_ids":["https://openalex.org/I78577930"],"apc_list":{"value":3967,"currency":"USD","value_usd":3967},"apc_paid":null,"fwci":4.3905,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.95579365,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"25","issue":"10","first_page":"1392","last_page":"1401"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.9768000245094299,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.9768000245094299,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9664999842643738,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12814","display_name":"Gaussian Processes and Bayesian Inference","score":0.9578999876976013,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.678109884262085},{"id":"https://openalex.org/keywords/missing-data","display_name":"Missing data","score":0.6680322885513306},{"id":"https://openalex.org/keywords/data-assimilation","display_name":"Data assimilation","score":0.6671345233917236},{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.6396362781524658},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.5884344577789307},{"id":"https://openalex.org/keywords/smoothing","display_name":"Smoothing","score":0.5804252028465271},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5309540629386902},{"id":"https://openalex.org/keywords/bayesian-probability","display_name":"Bayesian probability","score":0.47357258200645447},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.45370692014694214},{"id":"https://openalex.org/keywords/bayesian-inference","display_name":"Bayesian inference","score":0.44667503237724304},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.112842857837677}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.678109884262085},{"id":"https://openalex.org/C9357733","wikidata":"https://www.wikidata.org/wiki/Q6878417","display_name":"Missing data","level":2,"score":0.6680322885513306},{"id":"https://openalex.org/C24552861","wikidata":"https://www.wikidata.org/wiki/Q2670177","display_name":"Data assimilation","level":2,"score":0.6671345233917236},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.6396362781524658},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5884344577789307},{"id":"https://openalex.org/C3770464","wikidata":"https://www.wikidata.org/wiki/Q775963","display_name":"Smoothing","level":2,"score":0.5804252028465271},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5309540629386902},{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.47357258200645447},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.45370692014694214},{"id":"https://openalex.org/C160234255","wikidata":"https://www.wikidata.org/wiki/Q812535","display_name":"Bayesian inference","level":3,"score":0.44667503237724304},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.112842857837677},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C153294291","wikidata":"https://www.wikidata.org/wiki/Q25261","display_name":"Meteorology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015190","descriptor_name":"Blood Glucose Self-Monitoring","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015190","descriptor_name":"Blood Glucose Self-Monitoring","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015190","descriptor_name":"Blood Glucose Self-Monitoring","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015190","descriptor_name":"Blood Glucose Self-Monitoring","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016011","descriptor_name":"Normal Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016011","descriptor_name":"Normal Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016011","descriptor_name":"Normal Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016011","descriptor_name":"Normal Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/jamia/ocy106","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jamia/ocy106","pdf_url":"https://watermark.silverchair.com/ocy106.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAqUwggKhBgkqhkiG9w0BBwagggKSMIICjgIBADCCAocGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMNLPngPXVEn_agD88AgEQgIICWCvSQPmeD5XUPhuVwi7DzGfoKfrvM6RUi_mGSp4F_mI5XHxrVod4taoMJu4c4VkeXH8Dc-0PFWFLwVBMCgSIb1V0yoeGAKWej7JTuAlw8gWlN_HzTyvWi3vklGLa1cOvQB2OnAhr-xphhTpUpSBRr9zTAPrpGMreVCW0KPE1gOyV2GPU8u2CpEfrt__knSL1ZJ0ZW8xq6Ha8Nv41N4Av4DzSn_FhQEYO96uDi1S2CVnxkM6t4u-QmCj48nFouPA2WSPETrIajbziNvmiE5oxRqdwb-pAZNk-yD4tNBKGUwXP-cGDb_SanOy-F4eM-ypuV-gl-_kt_zR3CowyYE2RhGhjtPuigityTFGlcn10pqXOUK5XOGqAfR3aGJTUTw0b7vD9-fytoq-uOAMjgdsKJg_pWD9877unEUI4PedfAkunfE1bf_aTQWgx1TjKA9X6BSTr5PP8gfBvng33xsi7Vw2h8PlbBtpHvhtlZdBBJQ0H2RJB0EOrJ7Ub5gVGJkMZ6eq_V_Vsr6liMc3fiJB8zrcghPvf9MSXpAHNiPpPLxWFBK1hb7PZW7lMqi_KyzBZJnshuZljXPB4jKENYdIPrBIS3U90zESUwnibGaZBpyONsEwOxFGTBm-aVCKY_AtJzJL7oKMcZuD7-mJI7nM-SC2uLlOEM5gtChF3RmMmJtJQ7s8362vKWwEF6Rl4D53aR_4tsasFe2yYnovCcr-xSehqY537PshMPeNnjYuRUHt49y2_Nsv-4hs487_dFi3uG9C_NKxfbViJZqYAs9wPvU9BHvZ4GobseQ","source":{"id":"https://openalex.org/S129839026","display_name":"Journal of the American Medical Informatics Association","issn_l":"1067-5027","issn":["1067-5027","1527-974X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Informatics Association","raw_type":"journal-article"},{"id":"pmid:30312445","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30312445","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Informatics Association : JAMIA","raw_type":null},{"id":"pmh:oai:authors.library.caltech.edu:90365","is_oa":true,"landing_page_url":"https://resolver.caltech.edu/CaltechAUTHORS:20181023-111929468","pdf_url":null,"source":{"id":"https://openalex.org/S4306402161","display_name":"CaltechAUTHORS (California Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I122411786","host_organization_name":"California Institute of Technology","host_organization_lineage":["https://openalex.org/I122411786"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:europepmc.org:5139698","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6188514","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/jamia/ocy106","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jamia/ocy106","pdf_url":"https://watermark.silverchair.com/ocy106.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAqUwggKhBgkqhkiG9w0BBwagggKSMIICjgIBADCCAocGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMNLPngPXVEn_agD88AgEQgIICWCvSQPmeD5XUPhuVwi7DzGfoKfrvM6RUi_mGSp4F_mI5XHxrVod4taoMJu4c4VkeXH8Dc-0PFWFLwVBMCgSIb1V0yoeGAKWej7JTuAlw8gWlN_HzTyvWi3vklGLa1cOvQB2OnAhr-xphhTpUpSBRr9zTAPrpGMreVCW0KPE1gOyV2GPU8u2CpEfrt__knSL1ZJ0ZW8xq6Ha8Nv41N4Av4DzSn_FhQEYO96uDi1S2CVnxkM6t4u-QmCj48nFouPA2WSPETrIajbziNvmiE5oxRqdwb-pAZNk-yD4tNBKGUwXP-cGDb_SanOy-F4eM-ypuV-gl-_kt_zR3CowyYE2RhGhjtPuigityTFGlcn10pqXOUK5XOGqAfR3aGJTUTw0b7vD9-fytoq-uOAMjgdsKJg_pWD9877unEUI4PedfAkunfE1bf_aTQWgx1TjKA9X6BSTr5PP8gfBvng33xsi7Vw2h8PlbBtpHvhtlZdBBJQ0H2RJB0EOrJ7Ub5gVGJkMZ6eq_V_Vsr6liMc3fiJB8zrcghPvf9MSXpAHNiPpPLxWFBK1hb7PZW7lMqi_KyzBZJnshuZljXPB4jKENYdIPrBIS3U90zESUwnibGaZBpyONsEwOxFGTBm-aVCKY_AtJzJL7oKMcZuD7-mJI7nM-SC2uLlOEM5gtChF3RmMmJtJQ7s8362vKWwEF6Rl4D53aR_4tsasFe2yYnovCcr-xSehqY537PshMPeNnjYuRUHt49y2_Nsv-4hs487_dFi3uG9C_NKxfbViJZqYAs9wPvU9BHvZ4GobseQ","source":{"id":"https://openalex.org/S129839026","display_name":"Journal of the American Medical Informatics Association","issn_l":"1067-5027","issn":["1067-5027","1527-974X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Informatics Association","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2145969733","display_name":null,"funder_award_id":"R01 LM006910","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6939398460","display_name":null,"funder_award_id":"U01 HG008680","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2896190255.pdf","grobid_xml":"https://content.openalex.org/works/W2896190255.grobid-xml"},"referenced_works_count":93,"referenced_works":["https://openalex.org/W206326520","https://openalex.org/W239062403","https://openalex.org/W575374134","https://openalex.org/W1029488735","https://openalex.org/W1496857014","https://openalex.org/W1502922572","https://openalex.org/W1512921847","https://openalex.org/W1512968617","https://openalex.org/W1542912205","https://openalex.org/W1550101322","https://openalex.org/W1844237527","https://openalex.org/W1970473426","https://openalex.org/W1972586138","https://openalex.org/W1981964073","https://openalex.org/W1982009363","https://openalex.org/W1984812560","https://openalex.org/W1985361918","https://openalex.org/W1985940938","https://openalex.org/W1988115241","https://openalex.org/W1995875735","https://openalex.org/W2002355073","https://openalex.org/W2004052104","https://openalex.org/W2004575876","https://openalex.org/W2008082177","https://openalex.org/W2009104157","https://openalex.org/W2009435671","https://openalex.org/W2035636354","https://openalex.org/W2044474419","https://openalex.org/W2045656233","https://openalex.org/W2046199531","https://openalex.org/W2047102900","https://openalex.org/W2051784711","https://openalex.org/W2056542068","https://openalex.org/W2059611538","https://openalex.org/W2066030944","https://openalex.org/W2068270626","https://openalex.org/W2079569240","https://openalex.org/W2082409570","https://openalex.org/W2094631910","https://openalex.org/W2096726205","https://openalex.org/W2099544223","https://openalex.org/W2105934661","https://openalex.org/W2113105229","https://openalex.org/W2117079761","https://openalex.org/W2122512809","https://openalex.org/W2123487311","https://openalex.org/W2135479785","https://openalex.org/W2137983211","https://openalex.org/W2140170995","https://openalex.org/W2140172493","https://openalex.org/W2146907631","https://openalex.org/W2148654972","https://openalex.org/W2149498546","https://openalex.org/W2152657433","https://openalex.org/W2153529786","https://openalex.org/W2161885246","https://openalex.org/W2162073557","https://openalex.org/W2164452299","https://openalex.org/W2167160009","https://openalex.org/W2169572027","https://openalex.org/W2171613573","https://openalex.org/W2173251738","https://openalex.org/W2296616510","https://openalex.org/W2299025998","https://openalex.org/W2332531077","https://openalex.org/W2406470551","https://openalex.org/W2484866470","https://openalex.org/W2499603195","https://openalex.org/W2557283755","https://openalex.org/W2608902687","https://openalex.org/W2762181533","https://openalex.org/W2797148637","https://openalex.org/W2903720301","https://openalex.org/W2904900506","https://openalex.org/W2966346117","https://openalex.org/W2966884603","https://openalex.org/W2969251945","https://openalex.org/W2998520439","https://openalex.org/W3000332379","https://openalex.org/W3021601205","https://openalex.org/W3171485246","https://openalex.org/W4210644139","https://openalex.org/W4210825123","https://openalex.org/W4211049957","https://openalex.org/W4211256860","https://openalex.org/W4233734028","https://openalex.org/W4247915326","https://openalex.org/W4250431399","https://openalex.org/W4250955649","https://openalex.org/W4293282014","https://openalex.org/W4301347335","https://openalex.org/W6638874522","https://openalex.org/W6677044744"],"related_works":["https://openalex.org/W2407375987","https://openalex.org/W2505726097","https://openalex.org/W2950975704","https://openalex.org/W2010643158","https://openalex.org/W3049691116","https://openalex.org/W2106867672","https://openalex.org/W4310268968","https://openalex.org/W3081214562","https://openalex.org/W2753713401","https://openalex.org/W2053745677"],"abstract_inverted_index":{"We":[0,53],"introduce":[1],"data":[2,14,33,69,96],"assimilation":[3,70,97],"as":[4,128],"a":[5],"computational":[6],"method":[7],"that":[8,46,118],"uses":[9],"machine":[10],"learning":[11],"to":[12,26,30,40,74,79,86],"combine":[13],"with":[15],"human":[16],"knowledge":[17],"in":[18,24,59,110],"the":[19,35,55,60,93,99,120,131],"form":[20],"of":[21,62,95],"mechanistic":[22,100],"models":[23,107],"order":[25],"forecast":[27,75],"future":[28,76],"states,":[29],"impute":[31,80],"missing":[32,82],"from":[34],"past":[36],"by":[37,66],"smoothing,":[38],"and":[39,43,49,85],"infer":[41,87],"measurable":[42],"unmeasurable":[44],"quantities":[45],"represent":[47],"clinically":[48],"scientifically":[50],"important":[51,116],"phenotypes.":[52,91],"demonstrate":[54],"advantages":[56],"it":[57],"affords":[58],"context":[61],"type":[63,88],"2":[64,89],"diabetes":[65,90],"showing":[67],"how":[68],"can":[71,108],"be":[72],"used":[73],"glucose":[77,83],"values,":[78,84],"previously":[81],"At":[92],"heart":[94],"is":[98],"model,":[101],"here":[102],"an":[103],"endocrine":[104],"model.":[105],"Such":[106],"vary":[109],"complexity,":[111],"contain":[112],"testable":[113],"hypotheses":[114],"about":[115],"mechanics":[117],"govern":[119],"system":[121],"(eg,":[122],"nutrition's":[123],"effect":[124],"on":[125],"glucose),":[126],"and,":[127],"such,":[129],"constrain":[130],"model":[132],"space,":[133],"allowing":[134],"for":[135],"accurate":[136],"estimation":[137],"using":[138],"very":[139],"little":[140],"data.":[141]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":7}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}
