{"id":"https://openalex.org/W2736783104","doi":"https://doi.org/10.1093/jamia/ocx069","title":"A genome-by-environment interaction classifier for precision medicine: personal transcriptome response to rhinovirus identifies children prone to asthma exacerbations","display_name":"A genome-by-environment interaction classifier for precision medicine: personal transcriptome response to rhinovirus identifies children prone to asthma exacerbations","publication_year":2017,"publication_date":"2017-06-29","ids":{"openalex":"https://openalex.org/W2736783104","doi":"https://doi.org/10.1093/jamia/ocx069","mag":"2736783104","pmid":"https://pubmed.ncbi.nlm.nih.gov/29016970"},"language":"en","primary_location":{"id":"doi:10.1093/jamia/ocx069","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jamia/ocx069","pdf_url":"https://academic.oup.com/jamia/article-pdf/24/6/1116/25332143/ocx069.pdf","source":{"id":"https://openalex.org/S129839026","display_name":"Journal of the American Medical Informatics Association","issn_l":"1067-5027","issn":["1067-5027","1527-974X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Informatics Association","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/jamia/article-pdf/24/6/1116/25332143/ocx069.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071438373","display_name":"Vincent Gardeux","orcid":"https://orcid.org/0000-0001-8954-2161"},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vincent Gardeux","raw_affiliation_strings":["BIO5 Institute, University of Arizona, Tucson, AZ, USA","Center for Biomedical Informatics and Biostatistics, University of Arizona, Tucson, AZ, USA","Department of Medicine, University of Arizona, Tucson, AZ, USA"],"affiliations":[{"raw_affiliation_string":"BIO5 Institute, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Center for Biomedical Informatics and Biostatistics, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Department of Medicine, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031514900","display_name":"Joanne Berghout","orcid":"https://orcid.org/0000-0002-9250-9159"},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joanne Berghout","raw_affiliation_strings":["BIO5 Institute, University of Arizona, Tucson, AZ, USA","Center for Biomedical Informatics and Biostatistics, University of Arizona, Tucson, AZ, USA","Department of Medicine, University of Arizona, Tucson, AZ, USA"],"affiliations":[{"raw_affiliation_string":"BIO5 Institute, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Center for Biomedical Informatics and Biostatistics, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Department of Medicine, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070645277","display_name":"Ikbel Achour","orcid":"https://orcid.org/0000-0001-6103-4069"},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ikbel Achour","raw_affiliation_strings":["BIO5 Institute, University of Arizona, Tucson, AZ, USA","Center for Biomedical Informatics and Biostatistics, University of Arizona, Tucson, AZ, USA","Department of Medicine, University of Arizona, Tucson, AZ, USA"],"affiliations":[{"raw_affiliation_string":"BIO5 Institute, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Center for Biomedical Informatics and Biostatistics, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Department of Medicine, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071638480","display_name":"A. Grant Schissler","orcid":"https://orcid.org/0000-0002-5101-3958"},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Grant Schissler","raw_affiliation_strings":["BIO5 Institute, University of Arizona, Tucson, AZ, USA","Center for Biomedical Informatics and Biostatistics, University of Arizona, Tucson, AZ, USA","Department of Medicine, University of Arizona, Tucson, AZ, USA","Interdisciplinary Program in Statistics, University of Arizona, Tucson, AZ, USA"],"affiliations":[{"raw_affiliation_string":"BIO5 Institute, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Center for Biomedical Informatics and Biostatistics, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Department of Medicine, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Interdisciplinary Program in Statistics, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108099314","display_name":"Qike Li","orcid":null},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qike Li","raw_affiliation_strings":["BIO5 Institute, University of Arizona, Tucson, AZ, USA","Center for Biomedical Informatics and Biostatistics, University of Arizona, Tucson, AZ, USA","Department of Medicine, University of Arizona, Tucson, AZ, USA","Interdisciplinary Program in Statistics, University of Arizona, Tucson, AZ, USA"],"affiliations":[{"raw_affiliation_string":"BIO5 Institute, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Center for Biomedical Informatics and Biostatistics, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Department of Medicine, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Interdisciplinary Program in Statistics, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084359412","display_name":"Colleen Kenost","orcid":null},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Colleen Kenost","raw_affiliation_strings":["Center for Biomedical Informatics and Biostatistics, University of Arizona, Tucson, AZ, USA"],"affiliations":[{"raw_affiliation_string":"Center for Biomedical Informatics and Biostatistics, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100627205","display_name":"Jianrong Li","orcid":"https://orcid.org/0000-0002-8232-9322"},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianrong Li","raw_affiliation_strings":["Center for Biomedical Informatics and Biostatistics, University of Arizona, Tucson, AZ, USA"],"affiliations":[{"raw_affiliation_string":"Center for Biomedical Informatics and Biostatistics, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088495960","display_name":"Yuan Shang","orcid":"https://orcid.org/0000-0002-7093-4234"},"institutions":[{"id":"https://openalex.org/I2800531696","display_name":"Arizona Science Center","ror":"https://ror.org/05g3rxr48","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2800531696"]},{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I4210138309","display_name":"Center for Innovation","ror":"https://ror.org/04c1v2b17","country_code":"US","type":"facility","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210089489","https://openalex.org/I4210138309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuan Shang","raw_affiliation_strings":["BIO5 Institute, University of Arizona, Tucson, AZ, USA","Center for Biomedical Informatics and Biostatistics, University of Arizona, Tucson, AZ, USA","Center for Innovation in Brain Science, University of Arizona, Tucson, AZ, USA","Department of Medicine, University of Arizona, Tucson, AZ, USA"],"affiliations":[{"raw_affiliation_string":"BIO5 Institute, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Center for Biomedical Informatics and Biostatistics, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Center for Innovation in Brain Science, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I2800531696","https://openalex.org/I4210138309","https://openalex.org/I138006243"]},{"raw_affiliation_string":"Department of Medicine, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026627982","display_name":"Anthony Bosco","orcid":"https://orcid.org/0000-0002-4335-615X"},"institutions":[{"id":"https://openalex.org/I175234967","display_name":"The Kids Research Institute Australia","ror":"https://ror.org/01dbmzx78","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I175234967"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Anthony Bosco","raw_affiliation_strings":["Telethon Institute for Child Health Research, Perth, Australia"],"affiliations":[{"raw_affiliation_string":"Telethon Institute for Child Health Research, Perth, Australia","institution_ids":["https://openalex.org/I175234967"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001037934","display_name":"Donald Saner","orcid":null},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I2802412784","display_name":"Banner Health","ror":"https://ror.org/039wwwz66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802412784"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald Saner","raw_affiliation_strings":["Banner Health, Phoenix, AZ, USA","Center for Biomedical Informatics and Biostatistics, University of Arizona, Tucson, AZ, USA","Department of Medicine, University of Arizona, Tucson, AZ, USA"],"affiliations":[{"raw_affiliation_string":"Banner Health, Phoenix, AZ, USA","institution_ids":["https://openalex.org/I2802412784"]},{"raw_affiliation_string":"Center for Biomedical Informatics and Biostatistics, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Department of Medicine, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008526963","display_name":"Marilyn Halonen","orcid":"https://orcid.org/0000-0001-9606-935X"},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marilyn J Halonen","raw_affiliation_strings":["Department of Pharmacology, University of Arizona, Tucson, AZ, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015707215","display_name":"Daniel J. Jackson","orcid":"https://orcid.org/0000-0001-6938-2690"},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel J Jackson","raw_affiliation_strings":["Department of Pediatrics, School of Medicine and Public Health, University of Wisconsin, WI, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, School of Medicine and Public Health, University of Wisconsin, WI, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066737474","display_name":"Haiquan Li","orcid":"https://orcid.org/0000-0002-8049-0278"},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Haiquan Li","raw_affiliation_strings":["Center for Biomedical Informatics and Biostatistics, University of Arizona, Tucson, AZ, USA","Department of Medicine, University of Arizona, Tucson, AZ, USA"],"affiliations":[{"raw_affiliation_string":"Center for Biomedical Informatics and Biostatistics, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Department of Medicine, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056700648","display_name":"Fernando D. Mart\u00ednez","orcid":"https://orcid.org/0000-0001-6094-2727"},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Fernando D Martinez","raw_affiliation_strings":["BIO5 Institute, University of Arizona, Tucson, AZ, USA","Department of Pediatrics, University of Arizona, Tucson, AZ, USA"],"affiliations":[{"raw_affiliation_string":"BIO5 Institute, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Department of Pediatrics, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074706648","display_name":"Yves A. Lussier","orcid":"https://orcid.org/0000-0001-9854-1005"},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yves A Lussier","raw_affiliation_strings":["BIO5 Institute, University of Arizona, Tucson, AZ, USA","Center for Biomedical Informatics and Biostatistics, University of Arizona, Tucson, AZ, USA","Department of Medicine, University of Arizona, Tucson, AZ, USA","UA Cancer Center, University of Arizona, Tucson, AZ, USA"],"affiliations":[{"raw_affiliation_string":"BIO5 Institute, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Center for Biomedical Informatics and Biostatistics, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Department of Medicine, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"UA Cancer Center, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":15,"corresponding_author_ids":["https://openalex.org/A5056700648","https://openalex.org/A5066737474","https://openalex.org/A5074706648"],"corresponding_institution_ids":["https://openalex.org/I138006243"],"apc_list":{"value":3967,"currency":"USD","value_usd":3967},"apc_paid":null,"fwci":2.4884,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.89183363,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"24","issue":"6","first_page":"1116","last_page":"1126"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11243","display_name":"Respiratory viral infections research","score":0.993399977684021,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12528","display_name":"IL-33, ST2, and ILC Pathways","score":0.9869999885559082,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.7960406541824341},{"id":"https://openalex.org/keywords/rhinovirus","display_name":"Rhinovirus","score":0.7057903409004211},{"id":"https://openalex.org/keywords/exacerbation","display_name":"Exacerbation","score":0.5212419629096985},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"Precision medicine","score":0.5092645883560181},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"Gene expression profiling","score":0.5062434077262878},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.49634653329849243},{"id":"https://openalex.org/keywords/asthma","display_name":"Asthma","score":0.4693003296852112},{"id":"https://openalex.org/keywords/asthma-exacerbations","display_name":"Asthma exacerbations","score":0.4643905758857727},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.4285500645637512},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.41409873962402344},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.402972936630249},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.4015129506587982},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3455405831336975},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.25673043727874756},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.240504652261734},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.16807138919830322},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.16367819905281067},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.0877712070941925},{"id":"https://openalex.org/keywords/virus","display_name":"Virus","score":0.07795712351799011}],"concepts":[{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.7960406541824341},{"id":"https://openalex.org/C2779278377","wikidata":"https://www.wikidata.org/wiki/Q1351647","display_name":"Rhinovirus","level":3,"score":0.7057903409004211},{"id":"https://openalex.org/C2777014857","wikidata":"https://www.wikidata.org/wiki/Q1383410","display_name":"Exacerbation","level":2,"score":0.5212419629096985},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.5092645883560181},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.5062434077262878},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49634653329849243},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.4693003296852112},{"id":"https://openalex.org/C2909082789","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma exacerbations","level":3,"score":0.4643905758857727},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4285500645637512},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.41409873962402344},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.402972936630249},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4015129506587982},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3455405831336975},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25673043727874756},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.240504652261734},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16807138919830322},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16367819905281067},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0877712070941925},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.07795712351799011}],"mesh":[{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003663","descriptor_name":"Decision Trees","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003663","descriptor_name":"Decision Trees","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003663","descriptor_name":"Decision Trees","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012229","descriptor_name":"Rhinovirus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012229","descriptor_name":"Rhinovirus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012229","descriptor_name":"Rhinovirus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D059647","descriptor_name":"Gene-Environment Interaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059647","descriptor_name":"Gene-Environment Interaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059647","descriptor_name":"Gene-Environment Interaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066230","descriptor_name":"Patient-Specific Modeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066230","descriptor_name":"Patient-Specific Modeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066230","descriptor_name":"Patient-Specific Modeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066264","descriptor_name":"Datasets as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066264","descriptor_name":"Datasets as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066264","descriptor_name":"Datasets as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/jamia/ocx069","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jamia/ocx069","pdf_url":"https://academic.oup.com/jamia/article-pdf/24/6/1116/25332143/ocx069.pdf","source":{"id":"https://openalex.org/S129839026","display_name":"Journal of the American Medical Informatics Association","issn_l":"1067-5027","issn":["1067-5027","1527-974X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Informatics Association","raw_type":"journal-article"},{"id":"pmid:29016970","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29016970","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Informatics Association : JAMIA","raw_type":null},{"id":"pmh:oai:repository.arizona.edu:10150/627819","is_oa":true,"landing_page_url":"http://hdl.handle.net/10150/627819","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Journal of the American Medical Informatics Association : JAMIA","raw_type":"Article"},{"id":"pmh:oai:europepmc.org:5034212","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6080688","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/jamia/ocx069","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jamia/ocx069","pdf_url":"https://academic.oup.com/jamia/article-pdf/24/6/1116/25332143/ocx069.pdf","source":{"id":"https://openalex.org/S129839026","display_name":"Journal of the American Medical Informatics Association","issn_l":"1067-5027","issn":["1067-5027","1527-974X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Informatics Association","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2736783104.pdf","grobid_xml":"https://content.openalex.org/works/W2736783104.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1236321187","https://openalex.org/W1884291487","https://openalex.org/W1966288602","https://openalex.org/W1972784839","https://openalex.org/W1974767214","https://openalex.org/W1983634772","https://openalex.org/W1984000581","https://openalex.org/W1984830992","https://openalex.org/W1989532420","https://openalex.org/W1999697113","https://openalex.org/W2016357017","https://openalex.org/W2023685287","https://openalex.org/W2035559941","https://openalex.org/W2043864886","https://openalex.org/W2050026907","https://openalex.org/W2057539362","https://openalex.org/W2060427373","https://openalex.org/W2063841568","https://openalex.org/W2100980426","https://openalex.org/W2103017472","https://openalex.org/W2107665951","https://openalex.org/W2109034705","https://openalex.org/W2109103446","https://openalex.org/W2117731105","https://openalex.org/W2119613819","https://openalex.org/W2132065245","https://openalex.org/W2133990480","https://openalex.org/W2139291708","https://openalex.org/W2141672817","https://openalex.org/W2143654815","https://openalex.org/W2145029433","https://openalex.org/W2145686583","https://openalex.org/W2148750103","https://openalex.org/W2153947402","https://openalex.org/W2160063406","https://openalex.org/W2160697532","https://openalex.org/W2167116947","https://openalex.org/W2170989872","https://openalex.org/W2173780949","https://openalex.org/W2424069973","https://openalex.org/W2491197135","https://openalex.org/W2515572166","https://openalex.org/W2549881333","https://openalex.org/W4298038408"],"related_works":["https://openalex.org/W2902262817","https://openalex.org/W4200354030","https://openalex.org/W1968184194","https://openalex.org/W2803609089","https://openalex.org/W2366151192","https://openalex.org/W2315327467","https://openalex.org/W4225925351","https://openalex.org/W2330224070","https://openalex.org/W2906504096","https://openalex.org/W1957770986"],"abstract_inverted_index":{"The":[0],"proposed":[1],"framework":[2],"provides":[3],"an":[4],"innovative":[5],"approach":[6],"to":[7,18,34,38,45,53],"precision":[8],"medicine.":[9],"We":[10],"show":[11],"that":[12],"quantifying":[13],"personal":[14],"pathway-level":[15],"transcriptomic":[16],"response":[17],"a":[19,31],"disease-relevant":[20],"environmental":[21],"challenge":[22],"predicts":[23],"disease":[24,47],"progression.":[25],"This":[26],"genome-by-environment":[27],"interaction":[28],"assay":[29],"offers":[30],"noninvasive":[32],"opportunity":[33],"translate":[35],"omics":[36],"data":[37],"clinical":[39],"practice":[40],"by":[41],"improving":[42],"the":[43,51],"ability":[44],"predict":[46],"exacerbation":[48],"and":[49],"increasing":[50],"potential":[52],"produce":[54],"more":[55],"effective":[56],"treatment":[57],"decisions.":[58]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":1}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}