{"id":"https://openalex.org/W2949934519","doi":"https://doi.org/10.1093/jamia/ocx062","title":"Tissue specificity of in vitro drug sensitivity","display_name":"Tissue specificity of in vitro drug sensitivity","publication_year":2017,"publication_date":"2017-07-06","ids":{"openalex":"https://openalex.org/W2949934519","doi":"https://doi.org/10.1093/jamia/ocx062","mag":"2949934519","pmid":"https://pubmed.ncbi.nlm.nih.gov/29016819"},"language":"en","primary_location":{"id":"doi:10.1093/jamia/ocx062","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jamia/ocx062","pdf_url":null,"source":{"id":"https://openalex.org/S129839026","display_name":"Journal of the American Medical Informatics Association","issn_l":"1067-5027","issn":["1067-5027","1527-974X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Informatics Association","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6381764","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032490964","display_name":"Fupan Yao","orcid":null},"institutions":[{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Fupan Yao","raw_affiliation_strings":["Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada","Princess Margaret Cancer Centre, Toronto, Ontario, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Princess Margaret Cancer Centre, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011534913","display_name":"Seyed Ali Madani Tonekaboni","orcid":null},"institutions":[{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Seyed Ali Madani Tonekaboni","raw_affiliation_strings":["Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada","Princess Margaret Cancer Centre, Toronto, Ontario, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Princess Margaret Cancer Centre, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088177470","display_name":"Zhaleh Safikhani","orcid":"https://orcid.org/0000-0002-1429-1692"},"institutions":[{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Zhaleh Safikhani","raw_affiliation_strings":["Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada","Princess Margaret Cancer Centre, Toronto, Ontario, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Princess Margaret Cancer Centre, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066881174","display_name":"Petr Smirnov","orcid":"https://orcid.org/0000-0001-9395-8450"},"institutions":[{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Petr Smirnov","raw_affiliation_strings":["Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada","Princess Margaret Cancer Centre, Toronto, Ontario, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Princess Margaret Cancer Centre, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090035556","display_name":"Nehm\u00e9 El-Hachem","orcid":"https://orcid.org/0000-0002-5778-5342"},"institutions":[{"id":"https://openalex.org/I4210158752","display_name":"Montreal Clinical Research Institute","ror":"https://ror.org/05m8pzq90","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210158752","https://openalex.org/I70931966"]},{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Nehme El-Hachem","raw_affiliation_strings":["Department of Medicine, University of Montreal, Montre\u0301al, Quebec, Canada","Integrative Systems Biology, Institut de Recherches Cliniques de Montr\u00e9al, Montreal, Quebec, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Montreal, Montre\u0301al, Quebec, Canada","institution_ids":["https://openalex.org/I70931966"]},{"raw_affiliation_string":"Integrative Systems Biology, Institut de Recherches Cliniques de Montr\u00e9al, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I4210158752"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053145844","display_name":"Mark Freeman","orcid":"https://orcid.org/0000-0003-4521-2720"},"institutions":[{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Mark Freeman","raw_affiliation_strings":["Princess Margaret Cancer Centre, Toronto, Ontario, Canada"],"affiliations":[{"raw_affiliation_string":"Princess Margaret Cancer Centre, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065095260","display_name":"Venkata Manem","orcid":"https://orcid.org/0000-0003-1427-2819"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Venkata Satya Kumar Manem","raw_affiliation_strings":["Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada","Princess Margaret Cancer Centre, Toronto, Ontario, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Princess Margaret Cancer Centre, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2802654988"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010487226","display_name":"Benjamin Haibe\u2010Kains","orcid":"https://orcid.org/0000-0002-7684-0079"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I4210090991","display_name":"Institute of Cancer Research","ror":"https://ror.org/00dpztj76","country_code":"CA","type":"facility","lineage":["https://openalex.org/I176337269","https://openalex.org/I4210090991"]},{"id":"https://openalex.org/I112260969","display_name":"Ontario Institute for Cancer Research","ror":"https://ror.org/043q8yx54","country_code":"CA","type":"funder","lineage":["https://openalex.org/I112260969"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Benjamin Haibe-Kains","raw_affiliation_strings":["Department of Computer Science, University of Toronto, Toronto, Ontario, Canada","Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada","Ontario Institute of Cancer Research, Toronto, Ontario, Canada","Princess Margaret Cancer Centre, Toronto, Ontario, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Ontario Institute of Cancer Research, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I112260969","https://openalex.org/I4210090991"]},{"raw_affiliation_string":"Princess Margaret Cancer Centre, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2802654988"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5010487226"],"corresponding_institution_ids":["https://openalex.org/I112260969","https://openalex.org/I185261750","https://openalex.org/I2802654988","https://openalex.org/I4210090991"],"apc_list":{"value":3967,"currency":"USD","value_usd":3967},"apc_paid":null,"fwci":3.1796,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.93158888,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"25","issue":"2","first_page":"158","last_page":"166"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9948999881744385,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.994700014591217,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.7879984378814697},{"id":"https://openalex.org/keywords/concordance","display_name":"Concordance","score":0.7618421316146851},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.7231991291046143},{"id":"https://openalex.org/keywords/clinical-trial","display_name":"Clinical trial","score":0.5742121934890747},{"id":"https://openalex.org/keywords/gold-standard","display_name":"Gold standard (test)","score":0.5200216770172119},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.4774482846260071},{"id":"https://openalex.org/keywords/drug-response","display_name":"Drug response","score":0.47324782609939575},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.42924290895462036},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.3739544153213501},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3401550352573395},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3391488790512085},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.3378404974937439},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.2978437840938568},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.19527825713157654}],"concepts":[{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.7879984378814697},{"id":"https://openalex.org/C160798450","wikidata":"https://www.wikidata.org/wiki/Q4230870","display_name":"Concordance","level":2,"score":0.7618421316146851},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7231991291046143},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5742121934890747},{"id":"https://openalex.org/C40993552","wikidata":"https://www.wikidata.org/wiki/Q514654","display_name":"Gold standard (test)","level":2,"score":0.5200216770172119},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.4774482846260071},{"id":"https://openalex.org/C2994119904","wikidata":"https://www.wikidata.org/wiki/Q1251001","display_name":"Drug response","level":3,"score":0.47324782609939575},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.42924290895462036},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3739544153213501},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3401550352573395},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3391488790512085},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3378404974937439},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2978437840938568},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19527825713157654}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D066264","descriptor_name":"Datasets as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066264","descriptor_name":"Datasets as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066264","descriptor_name":"Datasets as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/jamia/ocx062","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jamia/ocx062","pdf_url":null,"source":{"id":"https://openalex.org/S129839026","display_name":"Journal of the American Medical Informatics Association","issn_l":"1067-5027","issn":["1067-5027","1527-974X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Informatics Association","raw_type":"journal-article"},{"id":"pmid:29016819","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29016819","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Informatics Association : JAMIA","raw_type":null},{"id":"pmh:oai:europepmc.org:5382421","is_oa":false,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6381764","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6381764","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6381764","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Am Med Inform Assoc","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6381764","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6381764","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Am Med Inform Assoc","raw_type":"Text"},"sustainable_development_goals":[{"score":0.6200000047683716,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320311169","display_name":"Cancer Research Society","ror":"https://ror.org/00t38a349"},{"id":"https://openalex.org/F4320313290","display_name":"Ontario Institute for Cancer Research","ror":"https://ror.org/043q8yx54"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":81,"referenced_works":["https://openalex.org/W1494237667","https://openalex.org/W1513255820","https://openalex.org/W1544902213","https://openalex.org/W1579189600","https://openalex.org/W1587447328","https://openalex.org/W1741548448","https://openalex.org/W1749623888","https://openalex.org/W1763457264","https://openalex.org/W1966684685","https://openalex.org/W1967220865","https://openalex.org/W1967717472","https://openalex.org/W1987219048","https://openalex.org/W1997338647","https://openalex.org/W2004908052","https://openalex.org/W2008621428","https://openalex.org/W2009313526","https://openalex.org/W2011474181","https://openalex.org/W2018044006","https://openalex.org/W2025183726","https://openalex.org/W2031441006","https://openalex.org/W2036318837","https://openalex.org/W2043398720","https://openalex.org/W2045970082","https://openalex.org/W2078448804","https://openalex.org/W2087312216","https://openalex.org/W2087563523","https://openalex.org/W2088484810","https://openalex.org/W2089705824","https://openalex.org/W2095798767","https://openalex.org/W2098791934","https://openalex.org/W2105836514","https://openalex.org/W2108068107","https://openalex.org/W2109553965","https://openalex.org/W2110065044","https://openalex.org/W2115007832","https://openalex.org/W2118151336","https://openalex.org/W2119899698","https://openalex.org/W2121906867","https://openalex.org/W2125789330","https://openalex.org/W2127553917","https://openalex.org/W2128167103","https://openalex.org/W2128360321","https://openalex.org/W2129925362","https://openalex.org/W2130072062","https://openalex.org/W2130410032","https://openalex.org/W2139132031","https://openalex.org/W2146902212","https://openalex.org/W2152883907","https://openalex.org/W2158804744","https://openalex.org/W2159457208","https://openalex.org/W2161821474","https://openalex.org/W2164417230","https://openalex.org/W2165836181","https://openalex.org/W2167778120","https://openalex.org/W2168102484","https://openalex.org/W2175970000","https://openalex.org/W2261944919","https://openalex.org/W2318806991","https://openalex.org/W2324892749","https://openalex.org/W2333198304","https://openalex.org/W2336811655","https://openalex.org/W2340150917","https://openalex.org/W2407075689","https://openalex.org/W2426801408","https://openalex.org/W2461427403","https://openalex.org/W2493204726","https://openalex.org/W2508320259","https://openalex.org/W2518696212","https://openalex.org/W2520107693","https://openalex.org/W2730223999","https://openalex.org/W2953253500","https://openalex.org/W2953289747","https://openalex.org/W4234509242","https://openalex.org/W4248123918","https://openalex.org/W4285719527","https://openalex.org/W6675933251","https://openalex.org/W6683896367","https://openalex.org/W6703373712","https://openalex.org/W6704084218","https://openalex.org/W6740757510","https://openalex.org/W7074219200"],"related_works":["https://openalex.org/W1601684588","https://openalex.org/W2108427450","https://openalex.org/W2104328188","https://openalex.org/W648938440","https://openalex.org/W2915108716","https://openalex.org/W4220795960","https://openalex.org/W2789177613","https://openalex.org/W2396330467","https://openalex.org/W1517024399","https://openalex.org/W2506500726"],"abstract_inverted_index":{"Our":[0,35],"meta-analysis":[1],"of":[2,19,56],"pan-cancer":[3],"drug":[4,59],"screening":[5],"datasets":[6],"indicates":[7],"that":[8,38],"most":[9],"tested":[10],"drugs":[11],"exhibit":[12],"tissue-specific":[13],"sensitivities":[14],"in":[15,57],"a":[16],"large":[17],"panel":[18],"cancer":[20],"cell":[21],"lines.":[22],"However,":[23],"the":[24,32,53],"observed":[25],"preclinical":[26,45],"results":[27,36],"do":[28],"not":[29],"translate":[30],"to":[31,51],"clinical":[33,47],"setting.":[34],"suggest":[37],"additional":[39],"research":[40],"into":[41],"showing":[42],"parallels":[43],"between":[44],"and":[46],"data":[48],"is":[49],"required":[50],"increase":[52],"translational":[54],"potential":[55],"vitro":[58],"screening.":[60]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2}],"updated_date":"2025-11-23T05:10:03.516525","created_date":"2025-10-10T00:00:00"}