{"id":"https://openalex.org/W2560405247","doi":"https://doi.org/10.1093/jamia/ocw161","title":"Synergistic drug combinations from electronic health records and gene expression","display_name":"Synergistic drug combinations from electronic health records and gene expression","publication_year":2016,"publication_date":"2016-11-08","ids":{"openalex":"https://openalex.org/W2560405247","doi":"https://doi.org/10.1093/jamia/ocw161","mag":"2560405247","pmid":"https://pubmed.ncbi.nlm.nih.gov/27940607"},"language":"en","primary_location":{"id":"doi:10.1093/jamia/ocw161","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jamia/ocw161","pdf_url":"https://academic.oup.com/jamia/article-pdf/24/3/565/25332104/ocw161.pdf","source":{"id":"https://openalex.org/S129839026","display_name":"Journal of the American Medical Informatics Association","issn_l":"1067-5027","issn":["1067-5027","1527-974X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Informatics Association","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/jamia/article-pdf/24/3/565/25332104/ocw161.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080793911","display_name":"Yen Low","orcid":null},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yen S Low","raw_affiliation_strings":["Stanford Center for Biomedical Informatics Research, Stanford University, Stanford, CA, USA","Stanford Center for Biomedical Informatics Research, Stanford University,\n Stanford, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford Center for Biomedical Informatics Research, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Stanford Center for Biomedical Informatics Research, Stanford University,\n Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075994473","display_name":"Aaron C. Daugherty","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aaron C Daugherty","raw_affiliation_strings":["twoXAR, Inc., Palo Alto, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"twoXAR, Inc., Palo Alto, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027656934","display_name":"Elizabeth A. Schroeder","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elizabeth A Schroeder","raw_affiliation_strings":["twoXAR, Inc., Palo Alto, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"twoXAR, Inc., Palo Alto, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055644612","display_name":"William Chen","orcid":"https://orcid.org/0000-0001-8924-5853"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Chen","raw_affiliation_strings":["Stanford Center for Biomedical Informatics Research, Stanford University, Stanford, CA, USA","Stanford Center for Biomedical Informatics Research, Stanford University,\n Stanford, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford Center for Biomedical Informatics Research, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Stanford Center for Biomedical Informatics Research, Stanford University,\n Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075207512","display_name":"Tina Seto","orcid":"https://orcid.org/0000-0002-7937-9564"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tina Seto","raw_affiliation_strings":["Clinical Informatics, Stanford University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Informatics, Stanford University","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108628027","display_name":"Susan Weber","orcid":null},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan Weber","raw_affiliation_strings":["Clinical Informatics, Stanford University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Informatics, Stanford University","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011340023","display_name":"Michael Lim","orcid":"https://orcid.org/0000-0003-0523-3076"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Lim","raw_affiliation_strings":["Department of Statistics, Stanford University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, Stanford University","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045744709","display_name":"Trevor Hastie","orcid":"https://orcid.org/0000-0002-0164-3142"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Trevor Hastie","raw_affiliation_strings":["Department of Health Research and Policy, Stanford University","Department of Statistics, Stanford University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Research and Policy, Stanford University","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Statistics, Stanford University","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021906307","display_name":"Maya B. Mathur","orcid":"https://orcid.org/0000-0001-6698-2607"},"institutions":[{"id":"https://openalex.org/I4210098931","display_name":"Quantitative BioSciences","ror":"https://ror.org/010brsj79","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210098931"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maya Mathur","raw_affiliation_strings":["Quantitative Sciences Unit, Stanford University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Quantitative Sciences Unit, Stanford University","institution_ids":["https://openalex.org/I4210098931","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032969374","display_name":"Manisha Desai","orcid":"https://orcid.org/0000-0002-6949-2651"},"institutions":[{"id":"https://openalex.org/I4210098931","display_name":"Quantitative BioSciences","ror":"https://ror.org/010brsj79","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210098931"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Manisha Desai","raw_affiliation_strings":["Quantitative Sciences Unit, Stanford University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Quantitative Sciences Unit, Stanford University","institution_ids":["https://openalex.org/I4210098931","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084574895","display_name":"Carl Farrington","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carl Farrington","raw_affiliation_strings":["twoXAR, Inc., Palo Alto, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"twoXAR, Inc., Palo Alto, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058770643","display_name":"Andrew A. Radin","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew A Radin","raw_affiliation_strings":["twoXAR, Inc., Palo Alto, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"twoXAR, Inc., Palo Alto, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086033147","display_name":"Marina Sirota","orcid":"https://orcid.org/0000-0002-7246-6083"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marina Sirota","raw_affiliation_strings":["twoXAR, Inc., Palo Alto, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"twoXAR, Inc., Palo Alto, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010697966","display_name":"Pragati Kenkare","orcid":null},"institutions":[{"id":"https://openalex.org/I4210124598","display_name":"Palo Alto Institute","ror":"https://ror.org/02xf01n45","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210124598"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pragati Kenkare","raw_affiliation_strings":["Palo Alto Medical Foundation Research Institute, Palo Alto, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Palo Alto Medical Foundation Research Institute, Palo Alto, CA, USA","institution_ids":["https://openalex.org/I4210124598"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026636003","display_name":"Caroline A. Thompson","orcid":"https://orcid.org/0000-0001-9990-9756"},"institutions":[{"id":"https://openalex.org/I4210124598","display_name":"Palo Alto Institute","ror":"https://ror.org/02xf01n45","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210124598"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caroline A Thompson","raw_affiliation_strings":["Palo Alto Medical Foundation Research Institute, Palo Alto, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Palo Alto Medical Foundation Research Institute, Palo Alto, CA, USA","institution_ids":["https://openalex.org/I4210124598"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102899933","display_name":"Peter Paul Yu","orcid":"https://orcid.org/0000-0003-0982-923X"},"institutions":[{"id":"https://openalex.org/I4210124598","display_name":"Palo Alto Institute","ror":"https://ror.org/02xf01n45","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210124598"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter P Yu","raw_affiliation_strings":["Palo Alto Medical Foundation Research Institute, Palo Alto, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Palo Alto Medical Foundation Research Institute, Palo Alto, CA, USA","institution_ids":["https://openalex.org/I4210124598"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085743511","display_name":"Scarlett Lin Gomez","orcid":"https://orcid.org/0000-0002-5143-4867"},"institutions":[{"id":"https://openalex.org/I1321488844","display_name":"Cancer Prevention Institute of California","ror":"https://ror.org/03bx60s49","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1321488844"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scarlett L Gomez","raw_affiliation_strings":["Cancer Prevention Institute of California, Fremont, CA, USA","Department of Health Research and Policy, Stanford University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Prevention Institute of California, Fremont, CA, USA","institution_ids":["https://openalex.org/I1321488844"]},{"raw_affiliation_string":"Department of Health Research and Policy, Stanford University","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066769011","display_name":"George W. Sledge","orcid":"https://orcid.org/0000-0003-0297-0775"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George W Sledge","raw_affiliation_strings":["Division of Oncology, Department of Medicine, Stanford University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oncology, Department of Medicine, Stanford University","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067783851","display_name":"Allison W. Kurian","orcid":"https://orcid.org/0000-0002-6175-9470"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allison W Kurian","raw_affiliation_strings":["Department of Health Research and Policy, Stanford University","Division of Oncology, Department of Medicine, Stanford University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Research and Policy, Stanford University","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Division of Oncology, Department of Medicine, Stanford University","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041175834","display_name":"Nigam H. Shah","orcid":"https://orcid.org/0000-0001-9385-7158"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nigam H Shah","raw_affiliation_strings":["Stanford Center for Biomedical Informatics Research, Stanford University, Stanford, CA, USA","Stanford Center for Biomedical Informatics Research, Stanford University,\n Stanford, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford Center for Biomedical Informatics Research, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Stanford Center for Biomedical Informatics Research, Stanford University,\n Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":20,"corresponding_author_ids":["https://openalex.org/A5080793911"],"corresponding_institution_ids":["https://openalex.org/I97018004"],"apc_list":{"value":3967,"currency":"USD","value_usd":3967},"apc_paid":null,"fwci":0.5222,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.72764743,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"24","issue":"3","first_page":"565","last_page":"576"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.7710000276565552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.7710000276565552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.02500000037252903,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.019099999219179153,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/health-records","display_name":"Health records","score":0.7173244953155518},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.5561601519584656},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.44371742010116577},{"id":"https://openalex.org/keywords/medical-record","display_name":"Medical record","score":0.42950835824012756},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.424822062253952},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.361754834651947},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3402657210826874},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.30256474018096924},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.29572346806526184},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2533286511898041},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.201386958360672},{"id":"https://openalex.org/keywords/health-care","display_name":"Health care","score":0.16440781950950623},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.15855008363723755},{"id":"https://openalex.org/keywords/political-science","display_name":"Political science","score":0.08296892046928406}],"concepts":[{"id":"https://openalex.org/C3019952477","wikidata":"https://www.wikidata.org/wiki/Q1324077","display_name":"Health records","level":3,"score":0.7173244953155518},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5561601519584656},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.44371742010116577},{"id":"https://openalex.org/C195910791","wikidata":"https://www.wikidata.org/wiki/Q1324077","display_name":"Medical record","level":2,"score":0.42950835824012756},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.424822062253952},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.361754834651947},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3402657210826874},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30256474018096924},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.29572346806526184},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2533286511898041},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.201386958360672},{"id":"https://openalex.org/C160735492","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Health care","level":2,"score":0.16440781950950623},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15855008363723755},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.08296892046928406},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057286","descriptor_name":"Electronic Health Records","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057286","descriptor_name":"Electronic Health Records","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057286","descriptor_name":"Electronic Health Records","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1093/jamia/ocw161","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jamia/ocw161","pdf_url":"https://academic.oup.com/jamia/article-pdf/24/3/565/25332104/ocw161.pdf","source":{"id":"https://openalex.org/S129839026","display_name":"Journal of the American Medical Informatics Association","issn_l":"1067-5027","issn":["1067-5027","1527-974X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Informatics Association","raw_type":"journal-article"},{"id":"pmid:27940607","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27940607","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Informatics Association : JAMIA","raw_type":null},{"id":"pmh:ark:/13030/qt9t55d1kj","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:escholarship.org/ark:/13030/qt9t55d1kj","is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/9t55d1kj","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of the American Medical Informatics Association : JAMIA, vol 24, iss 3","raw_type":"article"},{"id":"pmh:oai:europepmc.org:5034196","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6080645","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/jamia/ocw161","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jamia/ocw161","pdf_url":"https://academic.oup.com/jamia/article-pdf/24/3/565/25332104/ocw161.pdf","source":{"id":"https://openalex.org/S129839026","display_name":"Journal of the American Medical Informatics Association","issn_l":"1067-5027","issn":["1067-5027","1527-974X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Informatics Association","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8500000238418579,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G1155718844","display_name":null,"funder_award_id":"RO1-EB001988-15","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1362058311","display_name":null,"funder_award_id":"R01 GM101430","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3189620423","display_name":null,"funder_award_id":"DMS-1407548","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306260","display_name":"Breast Cancer Research Foundation","ror":"https://ror.org/0348ff195"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2560405247.pdf"},"referenced_works_count":75,"referenced_works":["https://openalex.org/W120504716","https://openalex.org/W1203311283","https://openalex.org/W1591554783","https://openalex.org/W1896423335","https://openalex.org/W1915767302","https://openalex.org/W1965830162","https://openalex.org/W1966133006","https://openalex.org/W1968050000","https://openalex.org/W1969346822","https://openalex.org/W1971090058","https://openalex.org/W1975046168","https://openalex.org/W1975826537","https://openalex.org/W1980543403","https://openalex.org/W1989184257","https://openalex.org/W1997730815","https://openalex.org/W2004622459","https://openalex.org/W2005507304","https://openalex.org/W2006883643","https://openalex.org/W2013770071","https://openalex.org/W2018518196","https://openalex.org/W2019707847","https://openalex.org/W2020541351","https://openalex.org/W2021733365","https://openalex.org/W2034826026","https://openalex.org/W2035049695","https://openalex.org/W2038690665","https://openalex.org/W2039065701","https://openalex.org/W2040133337","https://openalex.org/W2040608814","https://openalex.org/W2041610798","https://openalex.org/W2042008937","https://openalex.org/W2042243090","https://openalex.org/W2042941042","https://openalex.org/W2058983099","https://openalex.org/W2059005938","https://openalex.org/W2062941476","https://openalex.org/W2068810652","https://openalex.org/W2069976248","https://openalex.org/W2076220518","https://openalex.org/W2088560256","https://openalex.org/W2089559915","https://openalex.org/W2098239448","https://openalex.org/W2100471807","https://openalex.org/W2101432452","https://openalex.org/W2105007748","https://openalex.org/W2105050951","https://openalex.org/W2108577553","https://openalex.org/W2112688502","https://openalex.org/W2113554382","https://openalex.org/W2119002393","https://openalex.org/W2120865735","https://openalex.org/W2127714324","https://openalex.org/W2130410032","https://openalex.org/W2135046866","https://openalex.org/W2137632714","https://openalex.org/W2141806195","https://openalex.org/W2144535676","https://openalex.org/W2150227991","https://openalex.org/W2150239221","https://openalex.org/W2153181024","https://openalex.org/W2154947819","https://openalex.org/W2155626151","https://openalex.org/W2158731007","https://openalex.org/W2159096710","https://openalex.org/W2165276227","https://openalex.org/W2168264491","https://openalex.org/W2232325453","https://openalex.org/W2282724676","https://openalex.org/W2294336242","https://openalex.org/W2304724046","https://openalex.org/W2323326409","https://openalex.org/W2510203672","https://openalex.org/W4253759977","https://openalex.org/W4407751074","https://openalex.org/W6639748099"],"related_works":["https://openalex.org/W4206379684","https://openalex.org/W2366105490","https://openalex.org/W2580680567","https://openalex.org/W4285170202","https://openalex.org/W2554558516","https://openalex.org/W2355354922","https://openalex.org/W2527724968","https://openalex.org/W2356296688","https://openalex.org/W2739554337","https://openalex.org/W2413325029"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Using":[1],"electronic":[2],"health":[3],"records":[4],"(EHRs)":[5],"and":[6,23,34,64,94,159,163,166,169,187,196,198,218,224],"biomolecular":[7,28],"data,":[8,29],"we":[9,118,149],"sought":[10],"to":[11,61,107,141],"discover":[12],"drug":[13,66,122,132,229],"pairs":[14,67,123,133,153,176,181],"with":[15,58,69,97,110,155],"synergistic":[16,121,131],"repurposing":[17],"potential.":[18],"EHRs":[19,74,127,217],"provide":[20,37,225],"real-world":[21],"treatment":[22],"outcome":[24],"patterns,":[25],"while":[26],"complementary":[27,212],"including":[30],"disease-specific":[31],"gene":[32,91,142,184,219],"expression":[33,92,185],"drug-protein":[35,98,194],"interactions,":[36],"mechanistic":[38,226],"understanding.":[39],"METHOD:":[40],"We":[41,80],"applied":[42],"Group":[43],"Lasso":[44],"INTERaction":[45],"NETwork":[46],"(glinternet),":[47],"an":[48],"overlap":[49],"group":[50],"lasso":[51],"penalty":[52],"on":[53],"a":[54,138,204,209],"logistic":[55],"regression":[56],"model,":[57],"pairwise":[59],"interactions":[60,192],"identify":[62],"variables":[63],"interacting":[65],"associated":[68,154],"reduced":[70],"5-year":[71],"mortality":[72],"using":[73,137,183],"of":[75,211],"9945":[76],"breast":[77,89,111],"cancer":[78,90,112],"patients.":[79],"identified":[81],"differentially":[82],"expressed":[83],"genes":[84],"from":[85,134],"14":[86],"case-control":[87],"human":[88],"datasets":[93],"integrated":[95],"them":[96],"networks.":[99],"Drugs":[100],"in":[101,115,125,193],"the":[102,126],"network":[103],"were":[104,128,177],"scored":[105],"according":[106],"their":[108],"association":[109],"individually":[113],"or":[114],"pairs.":[116],"Lastly,":[117],"determined":[119],"whether":[120],"found":[124],"enriched":[129,179],"among":[130,180],"gene-expression":[135],"data":[136,186,213],"method":[139],"similar":[140],"set":[143],"enrichment":[144],"analysis.":[145],"RESULTS:":[146],"From":[147],"EHRs,":[148],"discovered":[150,182],"3":[151],"drug-class":[152],"lower":[156],"mortality:":[157],"anti-inflammatories":[158,162],"hormone":[160],"antagonists,":[161],"lipid":[164,167],"modifiers,":[165],"modifiers":[168],"obstructive":[170],"airway":[171],"drugs.":[172],"The":[173],"first":[174],"2":[175],"also":[178],"are":[188],"supported":[189],"by":[190],"molecular":[191],"networks":[195],"preclinical":[197],"epidemiologic":[199],"evidence.":[200],"CONCLUSIONS:":[201],"This":[202],"is":[203],"proof-of-concept":[205],"study":[206],"demonstrating":[207],"that":[208],"combination":[210],"sources,":[214],"such":[215],"as":[216],"expression,":[220],"can":[221],"corroborate":[222],"discoveries":[223],"insight":[227],"into":[228],"synergism":[230],"for":[231],"repurposing.":[232]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2}],"updated_date":"2026-05-22T06:13:13.366637","created_date":"2025-10-10T00:00:00"}