{"id":"https://openalex.org/W2322120487","doi":"https://doi.org/10.1093/jamia/ocw022","title":"IMPACT: a whole-exome sequencing analysis pipeline for integrating molecular profiles with actionable therapeutics in clinical samples","display_name":"IMPACT: a whole-exome sequencing analysis pipeline for integrating molecular profiles with actionable therapeutics in clinical samples","publication_year":2016,"publication_date":"2016-03-28","ids":{"openalex":"https://openalex.org/W2322120487","doi":"https://doi.org/10.1093/jamia/ocw022","mag":"2322120487","pmid":"https://pubmed.ncbi.nlm.nih.gov/27026619"},"language":"en","primary_location":{"id":"doi:10.1093/jamia/ocw022","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jamia/ocw022","pdf_url":null,"source":{"id":"https://openalex.org/S129839026","display_name":"Journal of the American Medical Informatics Association","issn_l":"1067-5027","issn":["1067-5027","1527-974X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Informatics Association","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4926746","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042695602","display_name":"Jennifer D. Hintzsche","orcid":"https://orcid.org/0000-0002-3779-3070"},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz Medical Campus","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Hintzsche","raw_affiliation_strings":["Division of Medical Oncology, Department of Medicine, School of Medicine","Professor of Medicine, Rella and Monroe Rifkin Endowed Chair in Cancer Research, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;","Associate Professor of Bioinformatics, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Department of Medicine, School of Medicine","institution_ids":[]},{"raw_affiliation_string":"Professor of Medicine, Rella and Monroe Rifkin Endowed Chair in Cancer Research, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;","institution_ids":["https://openalex.org/I51713134"]},{"raw_affiliation_string":"Associate Professor of Bioinformatics, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100384983","display_name":"Jihye Kim","orcid":"https://orcid.org/0000-0002-0338-2329"},"institutions":[{"id":"https://openalex.org/I4210134151","display_name":"University of Colorado Cancer Center","ror":"https://ror.org/04cqn7d42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210134151"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz Medical Campus","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jihye Kim","raw_affiliation_strings":["Division of Medical Oncology, Department of Medicine, School of Medicine","University of Colorado Cancer Center All: University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA","Professor of Medicine, Rella and Monroe Rifkin Endowed Chair in Cancer Research, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;","Associate Professor of Bioinformatics, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Department of Medicine, School of Medicine","institution_ids":[]},{"raw_affiliation_string":"University of Colorado Cancer Center All: University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA","institution_ids":["https://openalex.org/I921990950","https://openalex.org/I51713134","https://openalex.org/I4210134151"]},{"raw_affiliation_string":"Professor of Medicine, Rella and Monroe Rifkin Endowed Chair in Cancer Research, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;","institution_ids":["https://openalex.org/I51713134"]},{"raw_affiliation_string":"Associate Professor of Bioinformatics, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064937521","display_name":"Vinod Kumar Yadav","orcid":"https://orcid.org/0000-0001-6450-7036"},"institutions":[{"id":"https://openalex.org/I4210097902","display_name":"Center for Personalized Cancer Treatment","ror":"https://ror.org/00xjcve44","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210097902"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz Medical Campus","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Vinod Yadav","raw_affiliation_strings":["Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, School of Medicine","Associate Professor of Bioinformatics, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;","Professor of Medicine, Rella and Monroe Rifkin Endowed Chair in Cancer Research, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, School of Medicine","institution_ids":["https://openalex.org/I4210097902"]},{"raw_affiliation_string":"Associate Professor of Bioinformatics, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;","institution_ids":["https://openalex.org/I51713134"]},{"raw_affiliation_string":"Professor of Medicine, Rella and Monroe Rifkin Endowed Chair in Cancer Research, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022583816","display_name":"Carol M. Amato","orcid":"https://orcid.org/0000-0002-4945-8819"},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz Medical Campus","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carol Amato","raw_affiliation_strings":["Division of Medical Oncology, Department of Medicine, School of Medicine","Associate Professor of Bioinformatics, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;","Professor of Medicine, Rella and Monroe Rifkin Endowed Chair in Cancer Research, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Department of Medicine, School of Medicine","institution_ids":[]},{"raw_affiliation_string":"Associate Professor of Bioinformatics, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;","institution_ids":["https://openalex.org/I51713134"]},{"raw_affiliation_string":"Professor of Medicine, Rella and Monroe Rifkin Endowed Chair in Cancer Research, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089081930","display_name":"Steven E. Robinson","orcid":null},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz Medical Campus","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven E Robinson","raw_affiliation_strings":["Division of Medical Oncology, Department of Medicine, School of Medicine","Associate Professor of Bioinformatics, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;","Professor of Medicine, Rella and Monroe Rifkin Endowed Chair in Cancer Research, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Department of Medicine, School of Medicine","institution_ids":[]},{"raw_affiliation_string":"Associate Professor of Bioinformatics, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;","institution_ids":["https://openalex.org/I51713134"]},{"raw_affiliation_string":"Professor of Medicine, Rella and Monroe Rifkin Endowed Chair in Cancer Research, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074714252","display_name":"Eric Seelenfreund","orcid":null},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz Medical Campus","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric Seelenfreund","raw_affiliation_strings":["Division of Medical Oncology, Department of Medicine, School of Medicine","Professor of Medicine, Rella and Monroe Rifkin Endowed Chair in Cancer Research, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;","Associate Professor of Bioinformatics, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Department of Medicine, School of Medicine","institution_ids":[]},{"raw_affiliation_string":"Professor of Medicine, Rella and Monroe Rifkin Endowed Chair in Cancer Research, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;","institution_ids":["https://openalex.org/I51713134"]},{"raw_affiliation_string":"Associate Professor of Bioinformatics, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000972573","display_name":"Yiqun G. Shellman","orcid":"https://orcid.org/0000-0003-0598-5753"},"institutions":[{"id":"https://openalex.org/I4210134151","display_name":"University of Colorado Cancer Center","ror":"https://ror.org/04cqn7d42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210134151"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz Medical Campus","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yiqun Shellman","raw_affiliation_strings":["Department of Dermatology, School of Medicine","University of Colorado Cancer Center All: University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA","Associate Professor of Bioinformatics, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;","Professor of Medicine, Rella and Monroe Rifkin Endowed Chair in Cancer Research, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, School of Medicine","institution_ids":[]},{"raw_affiliation_string":"University of Colorado Cancer Center All: University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA","institution_ids":["https://openalex.org/I921990950","https://openalex.org/I51713134","https://openalex.org/I4210134151"]},{"raw_affiliation_string":"Associate Professor of Bioinformatics, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;","institution_ids":["https://openalex.org/I51713134"]},{"raw_affiliation_string":"Professor of Medicine, Rella and Monroe Rifkin Endowed Chair in Cancer Research, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091190395","display_name":"J. Wisell","orcid":null},"institutions":[{"id":"https://openalex.org/I4210134151","display_name":"University of Colorado Cancer Center","ror":"https://ror.org/04cqn7d42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210134151"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz Medical Campus","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua Wisell","raw_affiliation_strings":["Department of Pathology, School of Medicine","University of Colorado Cancer Center All: University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA","Associate Professor of Bioinformatics, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;","Professor of Medicine, Rella and Monroe Rifkin Endowed Chair in Cancer Research, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, School of Medicine","institution_ids":[]},{"raw_affiliation_string":"University of Colorado Cancer Center All: University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA","institution_ids":["https://openalex.org/I921990950","https://openalex.org/I51713134","https://openalex.org/I4210134151"]},{"raw_affiliation_string":"Associate Professor of Bioinformatics, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;","institution_ids":["https://openalex.org/I51713134"]},{"raw_affiliation_string":"Professor of Medicine, Rella and Monroe Rifkin Endowed Chair in Cancer Research, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110037907","display_name":"Allison Applegate","orcid":null},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz Medical Campus","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allison Applegate","raw_affiliation_strings":["Division of Medical Oncology, Department of Medicine, School of Medicine","Associate Professor of Bioinformatics, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;","Professor of Medicine, Rella and Monroe Rifkin Endowed Chair in Cancer Research, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Department of Medicine, School of Medicine","institution_ids":[]},{"raw_affiliation_string":"Associate Professor of Bioinformatics, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;","institution_ids":["https://openalex.org/I51713134"]},{"raw_affiliation_string":"Professor of Medicine, Rella and Monroe Rifkin Endowed Chair in Cancer Research, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036784999","display_name":"Martin D. McCarter","orcid":"https://orcid.org/0000-0001-8174-1713"},"institutions":[{"id":"https://openalex.org/I4210134151","display_name":"University of Colorado Cancer Center","ror":"https://ror.org/04cqn7d42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210134151"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz Medical Campus","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin McCarter","raw_affiliation_strings":["Department of Surgery, School of Medicine","University of Colorado Cancer Center All: University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA","Associate Professor of Bioinformatics, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;","Professor of Medicine, Rella and Monroe Rifkin Endowed Chair in Cancer Research, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, School of Medicine","institution_ids":[]},{"raw_affiliation_string":"University of Colorado Cancer Center All: University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA","institution_ids":["https://openalex.org/I921990950","https://openalex.org/I51713134","https://openalex.org/I4210134151"]},{"raw_affiliation_string":"Associate Professor of Bioinformatics, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;","institution_ids":["https://openalex.org/I51713134"]},{"raw_affiliation_string":"Professor of Medicine, Rella and Monroe Rifkin Endowed Chair in Cancer Research, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072457552","display_name":"Neil F. Box","orcid":"https://orcid.org/0000-0002-3486-0346"},"institutions":[{"id":"https://openalex.org/I4210134151","display_name":"University of Colorado Cancer Center","ror":"https://ror.org/04cqn7d42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210134151"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz Medical Campus","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neil Box","raw_affiliation_strings":["Department of Dermatology, School of Medicine","University of Colorado Cancer Center All: University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA","Professor of Medicine, Rella and Monroe Rifkin Endowed Chair in Cancer Research, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;","Associate Professor of Bioinformatics, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, School of Medicine","institution_ids":[]},{"raw_affiliation_string":"University of Colorado Cancer Center All: University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA","institution_ids":["https://openalex.org/I921990950","https://openalex.org/I51713134","https://openalex.org/I4210134151"]},{"raw_affiliation_string":"Professor of Medicine, Rella and Monroe Rifkin Endowed Chair in Cancer Research, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;","institution_ids":["https://openalex.org/I51713134"]},{"raw_affiliation_string":"Associate Professor of Bioinformatics, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054490246","display_name":"John J. Tentler","orcid":null},"institutions":[{"id":"https://openalex.org/I4210134151","display_name":"University of Colorado Cancer Center","ror":"https://ror.org/04cqn7d42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210134151"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz Medical Campus","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Tentler","raw_affiliation_strings":["Division of Medical Oncology, Department of Medicine, School of Medicine","University of Colorado Cancer Center All: University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA","Professor of Medicine, Rella and Monroe Rifkin Endowed Chair in Cancer Research, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;","Associate Professor of Bioinformatics, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Department of Medicine, School of Medicine","institution_ids":[]},{"raw_affiliation_string":"University of Colorado Cancer Center All: University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA","institution_ids":["https://openalex.org/I921990950","https://openalex.org/I51713134","https://openalex.org/I4210134151"]},{"raw_affiliation_string":"Professor of Medicine, Rella and Monroe Rifkin Endowed Chair in Cancer Research, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;","institution_ids":["https://openalex.org/I51713134"]},{"raw_affiliation_string":"Associate Professor of Bioinformatics, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036093562","display_name":"Subhajyoti De","orcid":"https://orcid.org/0000-0002-2313-8593"},"institutions":[{"id":"https://openalex.org/I151808059","display_name":"Colorado School of Public Health","ror":"https://ror.org/005x9g035","country_code":"US","type":"education","lineage":["https://openalex.org/I151808059"]},{"id":"https://openalex.org/I4210097902","display_name":"Center for Personalized Cancer Treatment","ror":"https://ror.org/00xjcve44","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210097902"]},{"id":"https://openalex.org/I4210134151","display_name":"University of Colorado Cancer Center","ror":"https://ror.org/04cqn7d42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210134151"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz Medical Campus","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Subhajyoti De","raw_affiliation_strings":["Department of Biostatistics and Informatics, Colorado School of Public Health","Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, School of Medicine","University of Colorado Cancer Center All: University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA","Associate Professor of Bioinformatics, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;","Professor of Medicine, Rella and Monroe Rifkin Endowed Chair in Cancer Research, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Informatics, Colorado School of Public Health","institution_ids":["https://openalex.org/I151808059"]},{"raw_affiliation_string":"Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, School of Medicine","institution_ids":["https://openalex.org/I4210097902"]},{"raw_affiliation_string":"University of Colorado Cancer Center All: University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA","institution_ids":["https://openalex.org/I921990950","https://openalex.org/I51713134","https://openalex.org/I4210134151"]},{"raw_affiliation_string":"Associate Professor of Bioinformatics, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;","institution_ids":["https://openalex.org/I51713134"]},{"raw_affiliation_string":"Professor of Medicine, Rella and Monroe Rifkin Endowed Chair in Cancer Research, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034106929","display_name":"William A. Robinson","orcid":"https://orcid.org/0000-0003-1875-9691"},"institutions":[{"id":"https://openalex.org/I4210134151","display_name":"University of Colorado Cancer Center","ror":"https://ror.org/04cqn7d42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210134151"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz Medical Campus","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William A Robinson","raw_affiliation_strings":["Division of Medical Oncology, Department of Medicine, School of Medicine","University of Colorado Cancer Center All: University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA","Associate Professor of Bioinformatics, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;","Professor of Medicine, Rella and Monroe Rifkin Endowed Chair in Cancer Research, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Department of Medicine, School of Medicine","institution_ids":[]},{"raw_affiliation_string":"University of Colorado Cancer Center All: University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA","institution_ids":["https://openalex.org/I921990950","https://openalex.org/I51713134","https://openalex.org/I4210134151"]},{"raw_affiliation_string":"Associate Professor of Bioinformatics, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;","institution_ids":["https://openalex.org/I51713134"]},{"raw_affiliation_string":"Professor of Medicine, Rella and Monroe Rifkin Endowed Chair in Cancer Research, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019556057","display_name":"Aik Choon Tan","orcid":"https://orcid.org/0000-0003-2955-8369"},"institutions":[{"id":"https://openalex.org/I151808059","display_name":"Colorado School of Public Health","ror":"https://ror.org/005x9g035","country_code":"US","type":"education","lineage":["https://openalex.org/I151808059"]},{"id":"https://openalex.org/I4210134151","display_name":"University of Colorado Cancer Center","ror":"https://ror.org/04cqn7d42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210134151"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz Medical Campus","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aik Choon Tan","raw_affiliation_strings":["Department of Biostatistics and Informatics, Colorado School of Public Health","Division of Medical Oncology, Department of Medicine, School of Medicine","University of Colorado Cancer Center All: University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA","Associate Professor of Bioinformatics, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;","Professor of Medicine, Rella and Monroe Rifkin Endowed Chair in Cancer Research, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Informatics, Colorado School of Public Health","institution_ids":["https://openalex.org/I151808059"]},{"raw_affiliation_string":"Division of Medical Oncology, Department of Medicine, School of Medicine","institution_ids":[]},{"raw_affiliation_string":"University of Colorado Cancer Center All: University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA","institution_ids":["https://openalex.org/I921990950","https://openalex.org/I51713134","https://openalex.org/I4210134151"]},{"raw_affiliation_string":"Associate Professor of Bioinformatics, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;","institution_ids":["https://openalex.org/I51713134"]},{"raw_affiliation_string":"Professor of Medicine, Rella and Monroe Rifkin Endowed Chair in Cancer Research, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus;","institution_ids":["https://openalex.org/I51713134"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":15,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3967,"currency":"USD","value_usd":3967},"apc_paid":null,"fwci":3.6564,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.93100442,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"23","issue":"4","first_page":"721","last_page":"730"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.5033000111579895,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.5033000111579895,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.24740000069141388,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.09099999815225601,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroblastoma-ras-viral-oncogene-homolog","display_name":"Neuroblastoma RAS viral oncogene homolog","score":0.7041386365890503},{"id":"https://openalex.org/keywords/exome-sequencing","display_name":"Exome sequencing","score":0.6553202867507935},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.6152415871620178},{"id":"https://openalex.org/keywords/cdkn2a","display_name":"CDKN2A","score":0.5558604598045349},{"id":"https://openalex.org/keywords/exome","display_name":"Exome","score":0.4996476173400879},{"id":"https://openalex.org/keywords/kras","display_name":"KRAS","score":0.48718518018722534},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"Precision medicine","score":0.4756436347961426},{"id":"https://openalex.org/keywords/egfr-inhibitors","display_name":"EGFR inhibitors","score":0.4617284834384918},{"id":"https://openalex.org/keywords/melanoma","display_name":"Melanoma","score":0.43806177377700806},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4280582666397095},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3928569555282593},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.3768257796764374},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.34589844942092896},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.3105594217777252},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.23319965600967407},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.22333931922912598},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.20834514498710632},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.20454135537147522},{"id":"https://openalex.org/keywords/epidermal-growth-factor-receptor","display_name":"Epidermal growth factor receptor","score":0.12039515376091003},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.10941377282142639}],"concepts":[{"id":"https://openalex.org/C21790070","wikidata":"https://www.wikidata.org/wiki/Q18030215","display_name":"Neuroblastoma RAS viral oncogene homolog","level":5,"score":0.7041386365890503},{"id":"https://openalex.org/C16671776","wikidata":"https://www.wikidata.org/wiki/Q5420592","display_name":"Exome sequencing","level":4,"score":0.6553202867507935},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6152415871620178},{"id":"https://openalex.org/C2780265364","wikidata":"https://www.wikidata.org/wiki/Q5009957","display_name":"CDKN2A","level":3,"score":0.5558604598045349},{"id":"https://openalex.org/C10590036","wikidata":"https://www.wikidata.org/wiki/Q417664","display_name":"Exome","level":5,"score":0.4996476173400879},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.48718518018722534},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.4756436347961426},{"id":"https://openalex.org/C2777506169","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"EGFR inhibitors","level":4,"score":0.4617284834384918},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.43806177377700806},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4280582666397095},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3928569555282593},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.3768257796764374},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34589844942092896},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3105594217777252},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23319965600967407},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22333931922912598},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20834514498710632},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20454135537147522},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.12039515376091003},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.10941377282142639},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018773","descriptor_name":"Genes, erbB-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018773","descriptor_name":"Genes, erbB-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018773","descriptor_name":"Genes, erbB-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059472","descriptor_name":"Exome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059472","descriptor_name":"Exome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059472","descriptor_name":"Exome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1093/jamia/ocw022","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jamia/ocw022","pdf_url":null,"source":{"id":"https://openalex.org/S129839026","display_name":"Journal of the American Medical Informatics Association","issn_l":"1067-5027","issn":["1067-5027","1527-974X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Informatics Association","raw_type":"journal-article"},{"id":"pmid:27026619","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27026619","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Informatics Association : JAMIA","raw_type":null},{"id":"pmh:oai:open-archive.highwire.org:jaminfo:23/4/721","is_oa":false,"landing_page_url":"http://jamia.oxfordjournals.org/cgi/content/short/23/4/721","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"},{"id":"pmh:oai:pubmedcentral.nih.gov:4926746","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4926746","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Am Med Inform Assoc","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4926746","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4926746","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Am Med Inform Assoc","raw_type":"Text"},"sustainable_development_goals":[{"score":0.7099999785423279,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G1657669889","display_name":null,"funder_award_id":"P30CA046934","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2401886094","display_name":null,"funder_award_id":"P50CA058187","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6500554123","display_name":null,"funder_award_id":"P30CA046934","funder_id":"https://openalex.org/F4320311054","funder_display_name":"Cancer League of Colorado"}],"funders":[{"id":"https://openalex.org/F4320311054","display_name":"Cancer League of Colorado","ror":"https://ror.org/03cy6xx05"},{"id":"https://openalex.org/F4320311520","display_name":"David F. and Margaret T. Grohne Family Foundation","ror":null},{"id":"https://openalex.org/F4320315960","display_name":"Moore Family Foundation","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1548406394","https://openalex.org/W1967424408","https://openalex.org/W1974971448","https://openalex.org/W1980740976","https://openalex.org/W1984068087","https://openalex.org/W2022258787","https://openalex.org/W2032211985","https://openalex.org/W2038397847","https://openalex.org/W2048500586","https://openalex.org/W2059145105","https://openalex.org/W2061043894","https://openalex.org/W2072931688","https://openalex.org/W2076357933","https://openalex.org/W2088540000","https://openalex.org/W2098828466","https://openalex.org/W2103441770","https://openalex.org/W2108234281","https://openalex.org/W2112604819","https://openalex.org/W2114029728","https://openalex.org/W2122959041","https://openalex.org/W2140494950","https://openalex.org/W2142879323","https://openalex.org/W2152238559","https://openalex.org/W2155943701","https://openalex.org/W2160995259","https://openalex.org/W2161978970","https://openalex.org/W2162871445","https://openalex.org/W2166262263","https://openalex.org/W2168440186","https://openalex.org/W2171777347","https://openalex.org/W2180481128","https://openalex.org/W2261580330","https://openalex.org/W2885727518","https://openalex.org/W4247053599","https://openalex.org/W6678363132","https://openalex.org/W6692772360"],"related_works":["https://openalex.org/W2407916043","https://openalex.org/W1663620072","https://openalex.org/W2096540669","https://openalex.org/W4376881092","https://openalex.org/W2203677081","https://openalex.org/W2766812143","https://openalex.org/W2168280552","https://openalex.org/W4226377937","https://openalex.org/W2589730460","https://openalex.org/W2322120487"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Currently,":[1],"there":[2],"is":[3,250],"a":[4,8,163,220],"disconnect":[5],"between":[6],"finding":[7],"patient's":[9],"relevant":[10,206],"molecular":[11],"profile":[12],"and":[13,20,64,105,108,114,229],"predicting":[14,59],"actionable":[15,40,180,230],"therapeutics.":[16,41,181],"Here":[17],"we":[18,145],"develop":[19],"implement":[21],"the":[22,70,124,135,141,184,188],"Integrating":[23],"Molecular":[24],"Profiles":[25],"with":[26,86],"Actionable":[27],"Therapeutics":[28],"(IMPACT)":[29],"analysis":[30,173],"pipeline,":[31],"linking":[32],"variants":[33,178,207,228],"detected":[34],"from":[35],"whole-exome":[36,74],"sequencing":[37,75],"(WES)":[38],"to":[39,94,134,154,168,179,213,224,237,242],"METHODS":[42],"AND":[43],"MATERIALS:":[44],"The":[45,78,171],"IMPACT":[46,71,93,112,129,172,197,218],"pipeline":[47,72,174],"contains":[48],"4":[49],"analytical":[50],"modules:":[51],"detecting":[52],"somatic":[53,177,227],"variants,":[54,63],"calling":[55],"copy":[56],"number":[57],"alterations,":[58],"drugs":[60],"against":[61],"deleterious":[62],"analyzing":[65],"tumor":[66,98,189,240],"heterogeneity.":[67],"We":[68,90,157,182,194],"tested":[69],"on":[73],"data":[76],"in":[77,123,187,201],"Cancer":[79],"Genome":[80],"Atlas":[81],"(TCGA)":[82],"lung":[83,126],"adenocarcinoma":[84,127],"samples":[85,99,190,241],"known":[87,120],"EGFR":[88,121,132,138],"mutations.":[89],"also":[91,158,209],"used":[92],"analyze":[95],"melanoma":[96,142],"patient":[97,143,239],"before":[100],"treatment,":[101,104],"after":[102,106,191],"BRAF-inhibitor":[103,155],"BRAF-":[107],"MEK-inhibitor":[109],"treatment.":[110,156],"RESULTS:":[111],"Food":[113],"Drug":[115],"Administration":[116],"(FDA)":[117],"correctly":[118],"identified":[119,146,159],"mutations":[122,133],"TCGA":[125],"samples.":[128],"linked":[130,210],"these":[131,176,211],"appropriate":[136],"FDA-approved":[137],"inhibitors.":[139],"For":[140],"samples,":[144],"NRAS":[147],"p.Q61K":[148],"as":[149,162],"an":[150],"acquired":[151,165],"resistance":[152,166],"mutation":[153,167],"CDKN2A":[160],"deletion":[161],"novel":[164],"BRAFi/MEKi":[169],"inhibition.":[170],"predicts":[175],"observed":[183],"clonal":[185],"dynamic":[186],"various":[192],"treatments.":[193],"showed":[195],"that":[196],"not":[198],"only":[199],"helped":[200],"successful":[202],"prioritization":[203],"of":[204],"clinically":[205],"but":[208],"variations":[212],"possible":[214],"targeted":[215],"therapies.":[216,231],"CONCLUSION:":[217],"provides":[219],"new":[221],"bioinformatics":[222],"strategy":[223],"delineate":[225],"candidate":[226],"This":[232],"approach":[233],"can":[234],"be":[235],"applied":[236],"other":[238],"discover":[243],"effective":[244],"drug":[245],"targets":[246],"for":[247],"personalized":[248],"medicine.IMPACT":[249],"publicly":[251],"available":[252],"at":[253],"http://tanlab.ucdenver.edu/IMPACT.":[254]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":3}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
