{"id":"https://openalex.org/W4392928502","doi":"https://doi.org/10.1093/jamia/ocae049","title":"An interpretable predictive deep learning platform for pediatric metabolic diseases","display_name":"An interpretable predictive deep learning platform for pediatric metabolic diseases","publication_year":2024,"publication_date":"2024-03-18","ids":{"openalex":"https://openalex.org/W4392928502","doi":"https://doi.org/10.1093/jamia/ocae049","pmid":"https://pubmed.ncbi.nlm.nih.gov/38497983"},"language":"en","primary_location":{"id":"doi:10.1093/jamia/ocae049","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jamia/ocae049","pdf_url":"https://academic.oup.com/jamia/advance-article-pdf/doi/10.1093/jamia/ocae049/57005260/ocae049.pdf","source":{"id":"https://openalex.org/S129839026","display_name":"Journal of the American Medical Informatics Association","issn_l":"1067-5027","issn":["1067-5027","1527-974X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Informatics Association","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/jamia/advance-article-pdf/doi/10.1093/jamia/ocae049/57005260/ocae049.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061145340","display_name":"Hamed Javidi","orcid":"https://orcid.org/0000-0002-6332-1229"},"institutions":[{"id":"https://openalex.org/I102607778","display_name":"Cleveland State University","ror":"https://ror.org/002tx1f22","country_code":"US","type":"education","lineage":["https://openalex.org/I102607778"]},{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I36373038","display_name":"Cleveland Clinic Lerner College of Medicine","ror":"https://ror.org/02x4b0932","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750","https://openalex.org/I36373038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hamed Javidi","raw_affiliation_strings":["Center for Quantitative Metabolic Research, Cleveland Clinic , Cleveland, OH 44195, United States","Department of Electrical Engineering and Computer Science, Cleveland State University , Cleveland, OH 44115, United States","Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic , Cleveland, OH 44195, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Quantitative Metabolic Research, Cleveland Clinic , Cleveland, OH 44195, United States","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"Department of Electrical Engineering and Computer Science, Cleveland State University , Cleveland, OH 44115, United States","institution_ids":["https://openalex.org/I102607778"]},{"raw_affiliation_string":"Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic , Cleveland, OH 44195, United States","institution_ids":["https://openalex.org/I36373038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080452144","display_name":"Arshiya Mariam","orcid":"https://orcid.org/0000-0003-4427-0275"},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I36373038","display_name":"Cleveland Clinic Lerner College of Medicine","ror":"https://ror.org/02x4b0932","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750","https://openalex.org/I36373038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arshiya Mariam","raw_affiliation_strings":["Center for Quantitative Metabolic Research, Cleveland Clinic , Cleveland, OH 44195, United States","Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic , Cleveland, OH 44195, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Quantitative Metabolic Research, Cleveland Clinic , Cleveland, OH 44195, United States","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic , Cleveland, OH 44195, United States","institution_ids":["https://openalex.org/I36373038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086062578","display_name":"Lina Alkhaled","orcid":"https://orcid.org/0000-0002-3071-0789"},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lina Alkhaled","raw_affiliation_strings":["Center for Quantitative Metabolic Research, Cleveland Clinic , Cleveland, OH 44195, United States","Endocrinology and Metabolism Institute, Cleveland Clinic , Cleveland, OH 44195, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Quantitative Metabolic Research, Cleveland Clinic , Cleveland, OH 44195, United States","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"Endocrinology and Metabolism Institute, Cleveland Clinic , Cleveland, OH 44195, United States","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089515974","display_name":"Kevin M. Pantalone","orcid":"https://orcid.org/0000-0002-3897-4551"},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin M Pantalone","raw_affiliation_strings":["Center for Quantitative Metabolic Research, Cleveland Clinic , Cleveland, OH 44195, United States","Endocrinology and Metabolism Institute, Cleveland Clinic , Cleveland, OH 44195, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Quantitative Metabolic Research, Cleveland Clinic , Cleveland, OH 44195, United States","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"Endocrinology and Metabolism Institute, Cleveland Clinic , Cleveland, OH 44195, United States","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064332538","display_name":"Daniel M. Rotroff","orcid":"https://orcid.org/0000-0003-0553-3220"},"institutions":[{"id":"https://openalex.org/I102607778","display_name":"Cleveland State University","ror":"https://ror.org/002tx1f22","country_code":"US","type":"education","lineage":["https://openalex.org/I102607778"]},{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I36373038","display_name":"Cleveland Clinic Lerner College of Medicine","ror":"https://ror.org/02x4b0932","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750","https://openalex.org/I36373038"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Daniel M Rotroff","raw_affiliation_strings":["Center for Quantitative Metabolic Research, Cleveland Clinic , Cleveland, OH 44195, United States","Department of Electrical Engineering and Computer Science, Cleveland State University , Cleveland, OH 44115, United States","Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic , Cleveland, OH 44195, United States","Endocrinology and Metabolism Institute, Cleveland Clinic , Cleveland, OH 44195, United States"],"raw_orcid":"https://orcid.org/0000-0003-0553-3220","affiliations":[{"raw_affiliation_string":"Center for Quantitative Metabolic Research, Cleveland Clinic , Cleveland, OH 44195, United States","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"Department of Electrical Engineering and Computer Science, Cleveland State University , Cleveland, OH 44115, United States","institution_ids":["https://openalex.org/I102607778"]},{"raw_affiliation_string":"Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic , Cleveland, OH 44195, United States","institution_ids":["https://openalex.org/I36373038"]},{"raw_affiliation_string":"Endocrinology and Metabolism Institute, Cleveland Clinic , Cleveland, OH 44195, United States","institution_ids":["https://openalex.org/I1316902750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5064332538"],"corresponding_institution_ids":["https://openalex.org/I102607778","https://openalex.org/I1316902750","https://openalex.org/I36373038"],"apc_list":{"value":3967,"currency":"USD","value_usd":3967},"apc_paid":{"value":3967,"currency":"USD","value_usd":3967},"fwci":3.2723,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.92512768,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"31","issue":"6","first_page":"1227","last_page":"1238"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11396","display_name":"Artificial Intelligence in Healthcare","score":0.19429999589920044,"subfield":{"id":"https://openalex.org/subfields/3605","display_name":"Health Information Management"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11396","display_name":"Artificial Intelligence in Healthcare","score":0.19429999589920044,"subfield":{"id":"https://openalex.org/subfields/3605","display_name":"Health Information Management"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.12999999523162842,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.10930000245571136,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prediabetes","display_name":"Prediabetes","score":0.873466968536377},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.7890969514846802},{"id":"https://openalex.org/keywords/percentile","display_name":"Percentile","score":0.711073637008667},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"Metabolic syndrome","score":0.6492407321929932},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"Body mass index","score":0.631554126739502},{"id":"https://openalex.org/keywords/cohort","display_name":"Cohort","score":0.6039151549339294},{"id":"https://openalex.org/keywords/receiver-operating-characteristic","display_name":"Receiver operating characteristic","score":0.5683779120445251},{"id":"https://openalex.org/keywords/overweight","display_name":"Overweight","score":0.5539695620536804},{"id":"https://openalex.org/keywords/longitudinal-study","display_name":"Longitudinal study","score":0.4357547163963318},{"id":"https://openalex.org/keywords/obesity","display_name":"Obesity","score":0.42008838057518005},{"id":"https://openalex.org/keywords/pediatrics","display_name":"Pediatrics","score":0.39477890729904175},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"Diabetes mellitus","score":0.35199230909347534},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"Type 2 diabetes","score":0.3348432183265686},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.25419408082962036},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.1322576403617859},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.10730811953544617},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.09765931963920593}],"concepts":[{"id":"https://openalex.org/C2779668308","wikidata":"https://www.wikidata.org/wiki/Q2087205","display_name":"Prediabetes","level":4,"score":0.873466968536377},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7890969514846802},{"id":"https://openalex.org/C122048520","wikidata":"https://www.wikidata.org/wiki/Q2913954","display_name":"Percentile","level":2,"score":0.711073637008667},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.6492407321929932},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.631554126739502},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.6039151549339294},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.5683779120445251},{"id":"https://openalex.org/C2780586474","wikidata":"https://www.wikidata.org/wiki/Q332428","display_name":"Overweight","level":3,"score":0.5539695620536804},{"id":"https://openalex.org/C2777895361","wikidata":"https://www.wikidata.org/wiki/Q1758614","display_name":"Longitudinal study","level":2,"score":0.4357547163963318},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.42008838057518005},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.39477890729904175},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.35199230909347534},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.3348432183265686},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25419408082962036},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.1322576403617859},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.10730811953544617},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.09765931963920593},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008659","descriptor_name":"Metabolic Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D008659","descriptor_name":"Metabolic Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D008659","descriptor_name":"Metabolic Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D008659","descriptor_name":"Metabolic Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D011236","descriptor_name":"Prediabetic State","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D011236","descriptor_name":"Prediabetic State","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D011236","descriptor_name":"Prediabetic State","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D011236","descriptor_name":"Prediabetic State","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D057286","descriptor_name":"Electronic Health Records","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057286","descriptor_name":"Electronic Health Records","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057286","descriptor_name":"Electronic Health Records","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057286","descriptor_name":"Electronic Health Records","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063766","descriptor_name":"Pediatric Obesity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063766","descriptor_name":"Pediatric Obesity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063766","descriptor_name":"Pediatric Obesity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063766","descriptor_name":"Pediatric Obesity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/jamia/ocae049","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jamia/ocae049","pdf_url":"https://academic.oup.com/jamia/advance-article-pdf/doi/10.1093/jamia/ocae049/57005260/ocae049.pdf","source":{"id":"https://openalex.org/S129839026","display_name":"Journal of the American Medical Informatics Association","issn_l":"1067-5027","issn":["1067-5027","1527-974X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Informatics Association","raw_type":"journal-article"},{"id":"pmid:38497983","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38497983","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Informatics Association : JAMIA","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11105121","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11105121","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11105121/pdf/ocae049.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Am Med Inform Assoc","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/jamia/ocae049","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jamia/ocae049","pdf_url":"https://academic.oup.com/jamia/advance-article-pdf/doi/10.1093/jamia/ocae049/57005260/ocae049.pdf","source":{"id":"https://openalex.org/S129839026","display_name":"Journal of the American Medical Informatics Association","issn_l":"1067-5027","issn":["1067-5027","1527-974X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Informatics Association","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.46000000834465027,"display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G1222248885","display_name":null,"funder_award_id":"4R33NS113258","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6032963692","display_name":null,"funder_award_id":"1R61NS113258","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320309680","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4392928502.pdf"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W44874218","https://openalex.org/W1966927387","https://openalex.org/W2001160247","https://openalex.org/W2008283534","https://openalex.org/W2018409805","https://openalex.org/W2027624649","https://openalex.org/W2032908038","https://openalex.org/W2076063813","https://openalex.org/W2078721019","https://openalex.org/W2105714645","https://openalex.org/W2110298216","https://openalex.org/W2160827694","https://openalex.org/W2312070181","https://openalex.org/W2319041462","https://openalex.org/W2395172628","https://openalex.org/W2518582440","https://openalex.org/W2605289354","https://openalex.org/W2762689525","https://openalex.org/W2805089815","https://openalex.org/W2810728605","https://openalex.org/W2898193553","https://openalex.org/W2902438447","https://openalex.org/W2919115771","https://openalex.org/W2936573766","https://openalex.org/W2940299115","https://openalex.org/W2952312197","https://openalex.org/W2966481576","https://openalex.org/W2968051427","https://openalex.org/W2987169144","https://openalex.org/W2987555034","https://openalex.org/W3040301052","https://openalex.org/W3048995338","https://openalex.org/W3091886278","https://openalex.org/W3119464161","https://openalex.org/W3131964654","https://openalex.org/W3173753568","https://openalex.org/W3195466285","https://openalex.org/W3197723339","https://openalex.org/W4224238239","https://openalex.org/W4225774598","https://openalex.org/W4288040759","https://openalex.org/W4288052479","https://openalex.org/W4300337452","https://openalex.org/W4313888128","https://openalex.org/W4322727651","https://openalex.org/W4322770563","https://openalex.org/W4323971778","https://openalex.org/W6601876111","https://openalex.org/W6752925309","https://openalex.org/W6766618355","https://openalex.org/W6811090802"],"related_works":["https://openalex.org/W2116128857","https://openalex.org/W2285022769","https://openalex.org/W2414156024","https://openalex.org/W4321115625","https://openalex.org/W3084006752","https://openalex.org/W2945745351","https://openalex.org/W4292226712","https://openalex.org/W4211112213","https://openalex.org/W4284883166","https://openalex.org/W2808579301"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Metabolic":[1],"disease":[2],"in":[3,52,63,105],"children":[4,114],"is":[5],"increasing":[6],"worldwide":[7],"and":[8,78,102,133,157,164,184,189],"predisposes":[9],"a":[10,87,126,226],"wide":[11],"array":[12],"of":[13,22,39,60,96,130,140,230,247,257],"chronic":[14],"comorbid":[15],"conditions":[16],"with":[17,115,125],"severe":[18],"impacts":[19],"on":[20],"quality":[21],"life.":[23],"Tools":[24],"for":[25,159,186,252],"early":[26],"detection":[27],"are":[28,50],"needed":[29],"to":[30,33,92,154],"promptly":[31],"intervene":[32],"prevent":[34],"or":[35,117],"slow":[36],"the":[37,58,94,195,211,219,231,248,255],"development":[38],"these":[40],"long-term":[41],"complications.":[42],"MATERIALS":[43],"AND":[44],"METHODS:":[45],"No":[46],"clinically":[47],"available":[48,174],"tools":[49],"currently":[51],"widespread":[53],"use":[54,68,171],"that":[55,239],"can":[56],"predict":[57,93],"onset":[59,95],"metabolic":[61,103,162],"diseases":[62],"pediatric":[64,106],"patients.":[65],"Here,":[66],"we":[67],"interpretable":[69,236],"deep":[70],"learning,":[71],"leveraging":[72],"longitudinal":[73,177,216,259],"clinical":[74],"measurements,":[75],"demographical":[76],"data,":[77,175,214],"diagnosis":[79],"codes":[80],"from":[81,86],"electronic":[82],"health":[83,90,233],"record":[84],"data":[85,178,217,260],"large":[88],"integrated":[89],"system":[91],"prediabetes,":[97,165,190],"type":[98],"2":[99],"diabetes":[100],"(T2D),":[101],"syndrome":[104],"cohorts.":[107],"RESULTS:":[108],"The":[109],"cohort":[110],"included":[111],"49":[112],"517":[113],"overweight":[116],"obesity":[118],"aged":[119],"2-18":[120],"(54.9%":[121],"male,":[122],"73%":[123],"Caucasian),":[124],"median":[127],"follow-up":[128],"time":[129],"7.5":[131],"years":[132],"mean":[134],"body":[135],"mass":[136],"index":[137],"(BMI)":[138],"percentile":[139],"88.6%.":[141],"Our":[142,235],"model":[143,220,237],"demonstrated":[144],"area":[145],"under":[146],"receiver":[147],"operating":[148],"characteristic":[149],"curve":[150],"(AUC)":[151],"accuracies":[152,221],"up":[153],"0.87,":[155],"0.79,":[156],"0.79":[158],"predicting":[160],"T2D,":[161,187],"syndrome,":[163,188],"respectively.":[166],"Whereas":[167],"most":[168,196,206,212,249],"risk":[169,207],"calculators":[170,208],"only":[172,210],"recently":[173],"incorporating":[176,215,258],"improved":[179,218],"AUCs":[180],"by":[181],"13.04%,":[182],"11.48%,":[183],"11.67%":[185],"respectively,":[191],"versus":[192],"models":[193],"using":[194,209],"recent":[197,213],"BMI":[198,240],"(P":[199],"<":[200],"2.2":[201],"\u00d7":[202],"10-16).":[203],"DISCUSSION:":[204],"Despite":[205],"because":[222],"utilizing":[223],"trajectories":[224,241],"provides":[225],"more":[227],"comprehensive":[228],"characterization":[229],"patient's":[232],"history.":[234],"indicated":[238],"were":[242],"consistently":[243],"identified":[244],"as":[245],"one":[246],"influential":[250],"features":[251],"prediction,":[253],"highlighting":[254],"advantages":[256],"when":[261],"available.":[262]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}