{"id":"https://openalex.org/W4306147381","doi":"https://doi.org/10.1093/jamia/ocac187","title":"Clinician adherence to pharmacogenomics prescribing recommendations in clinical decision support alerts","display_name":"Clinician adherence to pharmacogenomics prescribing recommendations in clinical decision support alerts","publication_year":2022,"publication_date":"2022-10-13","ids":{"openalex":"https://openalex.org/W4306147381","doi":"https://doi.org/10.1093/jamia/ocac187","pmid":"https://pubmed.ncbi.nlm.nih.gov/36228116"},"language":"en","primary_location":{"id":"doi:10.1093/jamia/ocac187","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jamia/ocac187","pdf_url":null,"source":{"id":"https://openalex.org/S129839026","display_name":"Journal of the American Medical Informatics Association","issn_l":"1067-5027","issn":["1067-5027","1527-974X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Informatics Association","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9748527","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015254194","display_name":"Jenny Q. Nguyen","orcid":"https://orcid.org/0009-0001-7190-1231"},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jenny Q Nguyen","raw_affiliation_strings":["Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children\u2019s Research Hospital , Memphis, Tennessee, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children\u2019s Research Hospital , Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085620590","display_name":"Kristine R. Crews","orcid":"https://orcid.org/0000-0002-7558-558X"},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristine R Crews","raw_affiliation_strings":["Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children\u2019s Research Hospital , Memphis, Tennessee, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children\u2019s Research Hospital , Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044383499","display_name":"Ben T Moore","orcid":null},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ben T Moore","raw_affiliation_strings":["Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children\u2019s Research Hospital , Memphis, Tennessee, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children\u2019s Research Hospital , Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110176853","display_name":"Nancy M. Kornegay","orcid":null},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy M Kornegay","raw_affiliation_strings":["Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children\u2019s Research Hospital , Memphis, Tennessee, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children\u2019s Research Hospital , Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009874216","display_name":"Donald K. Baker","orcid":null},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald K Baker","raw_affiliation_strings":["Department of Information Services, St. Jude Children\u2019s Research Hospital , Memphis, Tennessee, USA"],"affiliations":[{"raw_affiliation_string":"Department of Information Services, St. Jude Children\u2019s Research Hospital , Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111979810","display_name":"Murad Hasan","orcid":null},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Murad Hasan","raw_affiliation_strings":["Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children\u2019s Research Hospital , Memphis, Tennessee, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children\u2019s Research Hospital , Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075133389","display_name":"Patrick Campbell","orcid":"https://orcid.org/0000-0002-2198-5991"},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick K Campbell","raw_affiliation_strings":["Department of Information Services, St. Jude Children\u2019s Research Hospital , Memphis, Tennessee, USA","Department of Oncology, St. Jude Children\u2019s Research Hospital , Memphis, Tennessee, USA"],"affiliations":[{"raw_affiliation_string":"Department of Information Services, St. Jude Children\u2019s Research Hospital , Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Department of Oncology, St. Jude Children\u2019s Research Hospital , Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044638854","display_name":"Shannon M. Dean","orcid":null},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shannon M Dean","raw_affiliation_strings":["Department of Information Services, St. Jude Children\u2019s Research Hospital , Memphis, Tennessee, USA","Department of Pediatrics, St. Jude Children\u2019s Research Hospital , Memphis, Tennesse, USA"],"affiliations":[{"raw_affiliation_string":"Department of Information Services, St. Jude Children\u2019s Research Hospital , Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Department of Pediatrics, St. Jude Children\u2019s Research Hospital , Memphis, Tennesse, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009866488","display_name":"Mary V. Relling","orcid":"https://orcid.org/0000-0002-3720-9591"},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary V Relling","raw_affiliation_strings":["Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children\u2019s Research Hospital , Memphis, Tennessee, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children\u2019s Research Hospital , Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073741381","display_name":"James M. Hoffman","orcid":"https://orcid.org/0000-0002-2625-7766"},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James M Hoffman","raw_affiliation_strings":["Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children\u2019s Research Hospital , Memphis, Tennessee, USA","Department of the Office of Quality and Patient Safety, St. Jude Children\u2019s Research Hospital , Memphis, Tennesse, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children\u2019s Research Hospital , Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Department of the Office of Quality and Patient Safety, St. Jude Children\u2019s Research Hospital , Memphis, Tennesse, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027182699","display_name":"Cyrine E. Haidar","orcid":"https://orcid.org/0000-0002-8998-2551"},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Cyrine E Haidar","raw_affiliation_strings":["Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children\u2019s Research Hospital , Memphis, Tennessee, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children\u2019s Research Hospital , Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5027182699"],"corresponding_institution_ids":["https://openalex.org/I1313298211"],"apc_list":{"value":3967,"currency":"USD","value_usd":3967},"apc_paid":null,"fwci":2.3944,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.88049398,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"30","issue":"1","first_page":"132","last_page":"138"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9940000176429749,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9940000176429749,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.9940000176429749,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.9901000261306763,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.7984071373939514},{"id":"https://openalex.org/keywords/pharmacogenomics","display_name":"Pharmacogenomics","score":0.6922422647476196},{"id":"https://openalex.org/keywords/clinical-decision-support-system","display_name":"Clinical decision support system","score":0.6163402199745178},{"id":"https://openalex.org/keywords/omeprazole","display_name":"Omeprazole","score":0.47861164808273315},{"id":"https://openalex.org/keywords/oxycodone","display_name":"Oxycodone","score":0.4371790289878845},{"id":"https://openalex.org/keywords/ondansetron","display_name":"Ondansetron","score":0.43418294191360474},{"id":"https://openalex.org/keywords/intensive-care-medicine","display_name":"Intensive care medicine","score":0.42741119861602783},{"id":"https://openalex.org/keywords/medical-emergency","display_name":"Medical emergency","score":0.36695122718811035},{"id":"https://openalex.org/keywords/decision-support-system","display_name":"Decision support system","score":0.3363904654979706},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.27936094999313354},{"id":"https://openalex.org/keywords/nausea","display_name":"Nausea","score":0.20900577306747437},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.1423751711845398},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.0975414514541626}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7984071373939514},{"id":"https://openalex.org/C170734499","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenomics","level":2,"score":0.6922422647476196},{"id":"https://openalex.org/C63527458","wikidata":"https://www.wikidata.org/wiki/Q5133829","display_name":"Clinical decision support system","level":3,"score":0.6163402199745178},{"id":"https://openalex.org/C2777498785","wikidata":"https://www.wikidata.org/wiki/Q422210","display_name":"Omeprazole","level":2,"score":0.47861164808273315},{"id":"https://openalex.org/C2776029756","wikidata":"https://www.wikidata.org/wiki/Q407535","display_name":"Oxycodone","level":4,"score":0.4371790289878845},{"id":"https://openalex.org/C2777170512","wikidata":"https://www.wikidata.org/wiki/Q410011","display_name":"Ondansetron","level":3,"score":0.43418294191360474},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.42741119861602783},{"id":"https://openalex.org/C545542383","wikidata":"https://www.wikidata.org/wiki/Q2751242","display_name":"Medical emergency","level":1,"score":0.36695122718811035},{"id":"https://openalex.org/C107327155","wikidata":"https://www.wikidata.org/wiki/Q330268","display_name":"Decision support system","level":2,"score":0.3363904654979706},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.27936094999313354},{"id":"https://openalex.org/C2780580376","wikidata":"https://www.wikidata.org/wiki/Q186889","display_name":"Nausea","level":2,"score":0.20900577306747437},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1423751711845398},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.0975414514541626},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010597","descriptor_name":"Pharmacogenetics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010597","descriptor_name":"Pharmacogenetics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010597","descriptor_name":"Pharmacogenetics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010597","descriptor_name":"Pharmacogenetics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019389","descriptor_name":"Cytochrome P-450 CYP2D6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019389","descriptor_name":"Cytochrome P-450 CYP2D6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019389","descriptor_name":"Cytochrome P-450 CYP2D6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019389","descriptor_name":"Cytochrome P-450 CYP2D6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020000","descriptor_name":"Decision Support Systems, Clinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020000","descriptor_name":"Decision Support Systems, Clinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020000","descriptor_name":"Decision Support Systems, Clinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020000","descriptor_name":"Decision Support Systems, Clinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057286","descriptor_name":"Electronic Health Records","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057286","descriptor_name":"Electronic Health Records","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057286","descriptor_name":"Electronic Health Records","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057286","descriptor_name":"Electronic Health Records","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/jamia/ocac187","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jamia/ocac187","pdf_url":null,"source":{"id":"https://openalex.org/S129839026","display_name":"Journal of the American Medical Informatics Association","issn_l":"1067-5027","issn":["1067-5027","1527-974X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Informatics Association","raw_type":"journal-article"},{"id":"pmid:36228116","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36228116","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Informatics Association : JAMIA","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:9748527","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9748527","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Am Med Inform Assoc","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9748527","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9748527","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Am Med Inform Assoc","raw_type":"Text"},"sustainable_development_goals":[{"score":0.5799999833106995,"display_name":"Peace, Justice and strong institutions","id":"https://metadata.un.org/sdg/16"}],"awards":[{"id":"https://openalex.org/G5256544861","display_name":null,"funder_award_id":"U24HG010135","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320313598","display_name":"American Lebanese Syrian Associated Charities","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1513910469","https://openalex.org/W1833822692","https://openalex.org/W1896195310","https://openalex.org/W1906914553","https://openalex.org/W1994175864","https://openalex.org/W2047955590","https://openalex.org/W2090323345","https://openalex.org/W2110922423","https://openalex.org/W2114476310","https://openalex.org/W2143158333","https://openalex.org/W2192672420","https://openalex.org/W2346702072","https://openalex.org/W2460539883","https://openalex.org/W2502485509","https://openalex.org/W2553123701","https://openalex.org/W2604895876","https://openalex.org/W2794370386","https://openalex.org/W2799673616","https://openalex.org/W2900459753","https://openalex.org/W2906055340","https://openalex.org/W2911938770","https://openalex.org/W2972613254","https://openalex.org/W3004612364","https://openalex.org/W3014693099","https://openalex.org/W3092344117","https://openalex.org/W3187808634","https://openalex.org/W3213025551","https://openalex.org/W3213354473","https://openalex.org/W4280601710","https://openalex.org/W4281557486"],"related_works":["https://openalex.org/W2056234161","https://openalex.org/W3147905712","https://openalex.org/W2472148225","https://openalex.org/W600243788","https://openalex.org/W2417483213","https://openalex.org/W2397758540","https://openalex.org/W2357007384","https://openalex.org/W2183675838","https://openalex.org/W2593910894","https://openalex.org/W2791082178"],"abstract_inverted_index":{"Thoughtful":[0],"integration":[1],"of":[2,22,27,59,90],"interruptive":[3],"clinical":[4],"decision":[5],"support":[6],"(CDS)":[7],"alerts":[8,67,85,102],"within":[9],"the":[10,20,79,96],"electronic":[11],"health":[12],"record":[13],"is":[14],"essential":[15],"to":[16,49,62,78,152],"guide":[17],"clinicians":[18,50],"on":[19],"application":[21],"pharmacogenomic":[23,37,52],"results":[24],"at":[25],"point":[26],"care.":[28],"St.":[29],"Jude":[30],"Children's":[31],"Research":[32],"Hospital":[33],"implemented":[34],"a":[35,43,56],"preemptive":[36],"testing":[38],"program":[39],"in":[40,42,83],"2011":[41],"multidisciplinary":[44],"effort":[45],"involving":[46],"extensive":[47],"education":[48],"about":[51],"implications.":[53],"We":[54],"conducted":[55],"retrospective":[57],"analysis":[58],"clinicians'":[60],"adherence":[61,144],"4783":[63],"pharmacogenomically":[64],"guided":[65],"CDS":[66,101,157],"that":[68],"triggered":[69],"for":[70],"12":[71],"genes":[72],"and":[73,105,111,117,123,130,132,137,154,159],"60":[74],"drugs.":[75],"Clinicians":[76],"adhered":[77],"therapeutic":[80],"recommendations":[81],"provided":[82],"4392":[84],"(92%).":[86],"In":[87],"our":[88,149,155],"population":[89],"pediatric":[91],"patients":[92],"with":[93],"catastrophic":[94],"illnesses,":[95],"most":[97],"frequently":[98],"presented":[99],"gene/drug":[100],"were":[103],"TPMT/NUDT15":[104],"thiopurines":[106],"(n":[107,113,119,127],"=":[108,114,120,128,140],"3850),":[109],"CYP2D6":[110,116],"ondansetron":[112],"667),":[115],"oxycodone":[118],"99),":[121],"G6PD":[122,124],"high-risk":[125],"medications":[126],"51),":[129],"CYP2C19":[131],"proton":[133],"pump":[134],"inhibitors":[135],"(omeprazole":[136],"pantoprazole;":[138],"n":[139],"50).":[141],"The":[142],"high":[143],"rate":[145],"was":[146],"facilitated":[147],"by":[148],"team":[150],"approach":[151],"prescribing":[153],"collaborative":[156],"design":[158],"delivery.":[160]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}