{"id":"https://openalex.org/W4389142483","doi":"https://doi.org/10.1093/imamci/dnad030","title":"HPA axis differential flatness and Liouvillian study for higher resiliency investigations","display_name":"HPA axis differential flatness and Liouvillian study for higher resiliency investigations","publication_year":2023,"publication_date":"2023-11-24","ids":{"openalex":"https://openalex.org/W4389142483","doi":"https://doi.org/10.1093/imamci/dnad030"},"language":"en","primary_location":{"id":"doi:10.1093/imamci/dnad030","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1093/imamci/dnad030","pdf_url":null,"source":{"id":"https://openalex.org/S162756791","display_name":"IMA Journal of Mathematical Control and Information","issn_l":"0265-0754","issn":["0265-0754","1471-6887"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IMA Journal of Mathematical Control and Information","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042111278","display_name":"Florentina Nicolau","orcid":"https://orcid.org/0000-0001-5580-8849"},"institutions":[{"id":"https://openalex.org/I86175216","display_name":"\u00c9cole Nationale Sup\u00e9rieure de l'\u00c9lectronique et de ses Applications","ror":"https://ror.org/03qeacd72","country_code":"FR","type":"education","lineage":["https://openalex.org/I86175216"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Florentina Nicolau","raw_affiliation_strings":["Quartz EA7393 Laboratory, ENSEA , 95014 Cergy-Pontoise , France"],"affiliations":[{"raw_affiliation_string":"Quartz EA7393 Laboratory, ENSEA , 95014 Cergy-Pontoise , France","institution_ids":["https://openalex.org/I86175216"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113809999","display_name":"Hugues Mounier","orcid":"https://orcid.org/0000-0002-7069-3119"},"institutions":[{"id":"https://openalex.org/I4210107720","display_name":"CentraleSup\u00e9lec","ror":"https://ror.org/019tcpt25","country_code":"FR","type":"facility","lineage":["https://openalex.org/I277688954","https://openalex.org/I4210107720"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"funder","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Hugues Mounier","raw_affiliation_strings":["Laboratoire des Signaux et Syst\u00e8mes, Universit\u00e9 Paris-Saclay, CentraleSup\u00e9lec, CNRS (UMR 8605) , 91192 Gif-sur-Yvette , France"],"affiliations":[{"raw_affiliation_string":"Laboratoire des Signaux et Syst\u00e8mes, Universit\u00e9 Paris-Saclay, CentraleSup\u00e9lec, CNRS (UMR 8605) , 91192 Gif-sur-Yvette , France","institution_ids":["https://openalex.org/I4210107720","https://openalex.org/I277688954","https://openalex.org/I1294671590"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049184270","display_name":"Ioannis P. Androulakis","orcid":"https://orcid.org/0000-0002-3795-3628"},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ioannis P Androulakis","raw_affiliation_strings":["Department of Chemical and Biochemical Engineering and Department of Biomedical Engineering, Rutgers, the State University of New Jersey , 599 Taylor Road, Piscataway, NJ 08854 , USA"],"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biochemical Engineering and Department of Biomedical Engineering, Rutgers, the State University of New Jersey , 599 Taylor Road, Piscataway, NJ 08854 , USA","institution_ids":["https://openalex.org/I102322142"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5042111278"],"corresponding_institution_ids":["https://openalex.org/I86175216"],"apc_list":{"value":2582,"currency":"GBP","value_usd":3167},"apc_paid":null,"fwci":0.1615,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.4877193,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"40","issue":"4","first_page":"746","last_page":"788"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.9613999724388123,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.9484999775886536,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/flatness","display_name":"Flatness (cosmology)","score":0.9357380867004395},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.48970916867256165},{"id":"https://openalex.org/keywords/control-theory","display_name":"Control theory (sociology)","score":0.41290903091430664},{"id":"https://openalex.org/keywords/pure-mathematics","display_name":"Pure mathematics","score":0.3227187991142273},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.2683214247226715},{"id":"https://openalex.org/keywords/control","display_name":"Control (management)","score":0.2517228126525879},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.20077478885650635},{"id":"https://openalex.org/keywords/quantum-mechanics","display_name":"Quantum mechanics","score":0.06334283947944641}],"concepts":[{"id":"https://openalex.org/C2778530986","wikidata":"https://www.wikidata.org/wiki/Q5457948","display_name":"Flatness (cosmology)","level":3,"score":0.9357380867004395},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.48970916867256165},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.41290903091430664},{"id":"https://openalex.org/C202444582","wikidata":"https://www.wikidata.org/wiki/Q837863","display_name":"Pure mathematics","level":1,"score":0.3227187991142273},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2683214247226715},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.2517228126525879},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.20077478885650635},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.06334283947944641},{"id":"https://openalex.org/C26405456","wikidata":"https://www.wikidata.org/wiki/Q338","display_name":"Cosmology","level":2,"score":0.0},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/imamci/dnad030","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1093/imamci/dnad030","pdf_url":null,"source":{"id":"https://openalex.org/S162756791","display_name":"IMA Journal of Mathematical Control and Information","issn_l":"0265-0754","issn":["0265-0754","1471-6887"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IMA Journal of Mathematical Control and Information","raw_type":"journal-article"},{"id":"pmh:oai:HAL:hal-04354707v1","is_oa":false,"landing_page_url":"https://hal.science/hal-04354707","pdf_url":null,"source":{"id":"https://openalex.org/S4406922466","display_name":"SPIRE - Sciences Po Institutional REpository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IMA Journal of Mathematical Control and Information, 2023, &#x27E8;10.1093/imamci/dnad030&#x27E9;","raw_type":"Journal articles"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":68,"referenced_works":["https://openalex.org/W94433250","https://openalex.org/W1498187975","https://openalex.org/W1511649216","https://openalex.org/W1512746852","https://openalex.org/W1570505366","https://openalex.org/W1826150769","https://openalex.org/W1964299572","https://openalex.org/W1965191890","https://openalex.org/W1966186934","https://openalex.org/W1967473768","https://openalex.org/W1970434009","https://openalex.org/W1971327350","https://openalex.org/W1971902590","https://openalex.org/W1987623216","https://openalex.org/W2005981023","https://openalex.org/W2007636259","https://openalex.org/W2019062333","https://openalex.org/W2022766125","https://openalex.org/W2026824332","https://openalex.org/W2028488940","https://openalex.org/W2054959757","https://openalex.org/W2063167964","https://openalex.org/W2064129791","https://openalex.org/W2065297540","https://openalex.org/W2068945449","https://openalex.org/W2070267857","https://openalex.org/W2080240501","https://openalex.org/W2083391079","https://openalex.org/W2088907143","https://openalex.org/W2094014274","https://openalex.org/W2108975219","https://openalex.org/W2112396687","https://openalex.org/W2121978115","https://openalex.org/W2129968987","https://openalex.org/W2133188546","https://openalex.org/W2140998418","https://openalex.org/W2146048330","https://openalex.org/W2172061419","https://openalex.org/W2339582451","https://openalex.org/W2503349831","https://openalex.org/W2546829433","https://openalex.org/W2802567738","https://openalex.org/W2914489354","https://openalex.org/W2965340283","https://openalex.org/W2973972677","https://openalex.org/W2987000003","https://openalex.org/W3001881119","https://openalex.org/W3002455706","https://openalex.org/W3013106498","https://openalex.org/W3119074918","https://openalex.org/W3155942024","https://openalex.org/W3207781852","https://openalex.org/W3208152729","https://openalex.org/W3208166247","https://openalex.org/W4205324173","https://openalex.org/W4232303308","https://openalex.org/W4235143360","https://openalex.org/W4241171433","https://openalex.org/W4285585363","https://openalex.org/W4319436560","https://openalex.org/W4385452175","https://openalex.org/W6602627776","https://openalex.org/W6603810838","https://openalex.org/W6638826494","https://openalex.org/W6646345509","https://openalex.org/W6794674373","https://openalex.org/W6802135958","https://openalex.org/W6848812774"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2789295429","https://openalex.org/W2066314436","https://openalex.org/W2733767282","https://openalex.org/W2510927817","https://openalex.org/W2540573954","https://openalex.org/W2743501974","https://openalex.org/W2782313579","https://openalex.org/W1979597421","https://openalex.org/W2588834286"],"abstract_inverted_index":{"Abstract":[0],"In":[1,44],"this":[2],"paper,":[3],"we":[4,23,26,46,101,126],"study":[5,65],"several":[6],"existing":[7],"quantitative":[8],"models":[9],"of":[10,32,54,59,70,83,133],"the":[11,30,33,41,55,60,66,79,103,130,134,138],"hypothalamic\u2013pituitary\u2013adrenal":[12],"(HPA)":[13],"axis":[14,35],"from":[15],"a":[16,150,159],"control":[17,57],"systems":[18,58],"theory":[19],"viewpoint,":[20],"that":[21,25,128],"is,":[22],"suppose":[24],"can":[27],"act":[28],"on":[29,49],"dynamics":[31],"HPA":[34,61],"throughout":[36],"some":[37],"parameters,":[38],"which":[39,93,125],"are":[40,94],"system":[42],"inputs.":[43],"particular,":[45],"will":[47],"focus":[48],"flatness":[50,140],"and":[51,72,78,99,106],"Liouvillian":[52,160],"properties":[53],"considered":[56],"axis.":[62],"We":[63],"first":[64],"minimal":[67],"three-dimensional":[68],"model":[69,82,108,147],"Bangsgaard":[71],"Ottesen":[73],"(2017,":[74],"Math.":[75],"Biosci.,":[76],"287:24\u201335)":[77],"semi-mechanistic":[80],"four-dimensional":[81],"Gupta":[84],"et":[85],"al.":[86],"(2007,":[87],"Theor.":[88],"Biol.":[89],"Medical":[90],"Model.,":[91],"4(1):8)":[92],"shown":[95],"to":[96],"be":[97],"flat,":[98],"then,":[100],"consider":[102],"more":[104,145],"involved":[105,136,146],"important":[107],"proposed":[109],"in":[110,137],"Rao":[111],"&amp;":[112],"Androulakis":[113],"(2019,":[114],"Sci.":[115],"Rep.,":[116],"9(1):11212;":[117],"2020,":[118],"IFAC-PapersOnLine,":[119],"53(2):15858\u201315863),":[120],"with":[121],"seven":[122],"states,":[123],"for":[124,129],"prove":[127],"nominal":[131],"values":[132],"parameters":[135],"model,":[139],"no":[141],"longer":[142],"holds.":[143],"The":[144],"satisfies":[148],"however":[149],"similar":[151],"but":[152],"weaker":[153],"property":[154],"than":[155],"flatness:":[156],"it":[157],"is":[158],"system.":[161]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2025-12-21T01:58:51.020947","created_date":"2025-10-10T00:00:00"}
