{"id":"https://openalex.org/W4416721059","doi":"https://doi.org/10.1093/gpbjnl/qzaf118","title":"A Telomere-to-telomere Diploid Reference Genome and Centromere Structure of the Chinese Quartet","display_name":"A Telomere-to-telomere Diploid Reference Genome and Centromere Structure of the Chinese Quartet","publication_year":2025,"publication_date":"2025-11-26","ids":{"openalex":"https://openalex.org/W4416721059","doi":"https://doi.org/10.1093/gpbjnl/qzaf118","pmid":"https://pubmed.ncbi.nlm.nih.gov/41298323"},"language":"en","primary_location":{"id":"doi:10.1093/gpbjnl/qzaf118","is_oa":true,"landing_page_url":"https://doi.org/10.1093/gpbjnl/qzaf118","pdf_url":"https://academic.oup.com/gpb/advance-article-pdf/doi/10.1093/gpbjnl/qzaf118/65552679/qzaf118.pdf","source":{"id":"https://openalex.org/S155547894","display_name":"Genomics Proteomics & Bioinformatics","issn_l":"1672-0229","issn":["1672-0229","2210-3244"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, Proteomics &amp; Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/gpb/advance-article-pdf/doi/10.1093/gpbjnl/qzaf118/65552679/qzaf118.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100408153","display_name":"Bo Wang","orcid":"https://orcid.org/0000-0002-9041-878X"},"institutions":[{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Bo Wang (\u738b\u535a)","raw_affiliation_strings":["MOE Key Lab for Intelligent Networks & Networks Security, Faculty of Electronic and Information Engineering, Xi\u2019an Jiaotong University , Xi\u2019an 710049,","School of Automation Science and Engineering, Faculty of Electronic and Information Engineering, Xi\u2019an Jiaotong University , Xi\u2019an 710049,","MOE Key Lab for Intelligent Networks & Networks Security, Faculty of Electronic and Information Engineering, Xi'an Jiaotong University, Xi'an 710049, China"],"raw_orcid":"https://orcid.org/0000-0002-9041-878X","affiliations":[{"raw_affiliation_string":"MOE Key Lab for Intelligent Networks & Networks Security, Faculty of Electronic and Information Engineering, Xi\u2019an Jiaotong University , Xi\u2019an 710049,","institution_ids":["https://openalex.org/I87445476"]},{"raw_affiliation_string":"School of Automation Science and Engineering, Faculty of Electronic and Information Engineering, Xi\u2019an Jiaotong University , Xi\u2019an 710049,","institution_ids":["https://openalex.org/I87445476"]},{"raw_affiliation_string":"MOE Key Lab for Intelligent Networks & Networks Security, Faculty of Electronic and Information Engineering, Xi'an Jiaotong University, Xi'an 710049, China","institution_ids":["https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087950121","display_name":"Peng Jia","orcid":"https://orcid.org/0000-0002-3429-919X"},"institutions":[{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peng Jia (\u8d3e\u9e4f)","raw_affiliation_strings":["Department of Gynecology and Obstetrics, Center for Mathematical Medical, The First Affiliated Hospital of Xi\u2019an Jiaotong University , Xi\u2019an 710061,","Department of Gynecology and Obstetrics, Center for Mathematical Medical, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China"],"raw_orcid":"https://orcid.org/0000-0002-3429-919X","affiliations":[{"raw_affiliation_string":"Department of Gynecology and Obstetrics, Center for Mathematical Medical, The First Affiliated Hospital of Xi\u2019an Jiaotong University , Xi\u2019an 710061,","institution_ids":["https://openalex.org/I4210121771"]},{"raw_affiliation_string":"Department of Gynecology and Obstetrics, Center for Mathematical Medical, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China","institution_ids":["https://openalex.org/I4210121771"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031551214","display_name":"Stephen J. Bush","orcid":"https://orcid.org/0000-0001-9341-2562"},"institutions":[{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Stephen J Bush","raw_affiliation_strings":["School of Automation Science and Engineering, Faculty of Electronic and Information Engineering, Xi\u2019an Jiaotong University , Xi\u2019an 710049,","School of Automation Science and Engineering, Faculty of Electronic and Information Engineering, Xi'an Jiaotong University, Xi'an 710049, China"],"raw_orcid":"https://orcid.org/0000-0001-9341-2562","affiliations":[{"raw_affiliation_string":"School of Automation Science and Engineering, Faculty of Electronic and Information Engineering, Xi\u2019an Jiaotong University , Xi\u2019an 710049,","institution_ids":["https://openalex.org/I87445476"]},{"raw_affiliation_string":"School of Automation Science and Engineering, Faculty of Electronic and Information Engineering, Xi'an Jiaotong University, Xi'an 710049, China","institution_ids":["https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xia Wang (\u738b\u971e)","orcid":"https://orcid.org/0009-0003-1935-1249"},"institutions":[{"id":"https://openalex.org/I4210162136","display_name":"National Institute of Metrology","ror":"https://ror.org/05dw0p167","country_code":"CN","type":"other","lineage":["https://openalex.org/I4210162136"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xia Wang (\u738b\u971e)","raw_affiliation_strings":["Center for Advanced Measurement of Science, National Institute of Metrology , Beijing 100029,","Center for Advanced Measurement of Science, National Institute of Metrology, Beijing 100029, China"],"raw_orcid":"https://orcid.org/0009-0003-1935-1249","affiliations":[{"raw_affiliation_string":"Center for Advanced Measurement of Science, National Institute of Metrology , Beijing 100029,","institution_ids":["https://openalex.org/I4210162136"]},{"raw_affiliation_string":"Center for Advanced Measurement of Science, National Institute of Metrology, Beijing 100029, China","institution_ids":["https://openalex.org/I4210162136"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yi Yang (\u6768\u6021)","orcid":"https://orcid.org/0000-0003-0863-0878"},"institutions":[{"id":"https://openalex.org/I158809036","display_name":"Shenzhen Institute of Information Technology","ror":"https://ror.org/03wrf9427","country_code":"CN","type":"education","lineage":["https://openalex.org/I158809036"]},{"id":"https://openalex.org/I4210162136","display_name":"National Institute of Metrology","ror":"https://ror.org/05dw0p167","country_code":"CN","type":"other","lineage":["https://openalex.org/I4210162136"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Yang (\u6768\u6021)","raw_affiliation_strings":["Center for Advanced Measurement of Science, National Institute of Metrology , Beijing 100029,","Shenzhen Institute for Technology Innovation, National Institute of Metrology , Shenzhen 518107,","Shenzhen Institute for Technology Innovation, National Institute of Metrology, Shenzhen 518107, China"],"raw_orcid":"https://orcid.org/0000-0003-0863-0878","affiliations":[{"raw_affiliation_string":"Center for Advanced Measurement of Science, National Institute of Metrology , Beijing 100029,","institution_ids":["https://openalex.org/I4210162136"]},{"raw_affiliation_string":"Shenzhen Institute for Technology Innovation, National Institute of Metrology , Shenzhen 518107,","institution_ids":["https://openalex.org/I158809036"]},{"raw_affiliation_string":"Shenzhen Institute for Technology Innovation, National Institute of Metrology, Shenzhen 518107, China","institution_ids":["https://openalex.org/I158809036"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yu Zhang (\u5f20\u745c)","orcid":"https://orcid.org/0000-0002-8807-6389"},"institutions":[{"id":"https://openalex.org/I4210162136","display_name":"National Institute of Metrology","ror":"https://ror.org/05dw0p167","country_code":"CN","type":"other","lineage":["https://openalex.org/I4210162136"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Zhang (\u5f20\u745c)","raw_affiliation_strings":["Center for Advanced Measurement of Science, National Institute of Metrology , Beijing 100029,","Center for Advanced Measurement of Science, National Institute of Metrology, Beijing 100029, China"],"raw_orcid":"https://orcid.org/0000-0002-8807-6389","affiliations":[{"raw_affiliation_string":"Center for Advanced Measurement of Science, National Institute of Metrology , Beijing 100029,","institution_ids":["https://openalex.org/I4210162136"]},{"raw_affiliation_string":"Center for Advanced Measurement of Science, National Institute of Metrology, Beijing 100029, China","institution_ids":["https://openalex.org/I4210162136"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109755416","display_name":"Shijie Wan","orcid":"https://orcid.org/0009-0005-0834-892X"},"institutions":[{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shijie Wan (\u4e07\u4e16\u6770)","raw_affiliation_strings":["School of Computer Science and Technology, Faculty of Electronic and Information Engineering, Xi\u2019an Jiaotong University , Xi\u2019an 710049,","School of Computer Science and Technology, Faculty of Electronic and Information Engineering, Xi'an Jiaotong University, Xi'an 710049, China"],"raw_orcid":"https://orcid.org/0009-0005-0834-892X","affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Faculty of Electronic and Information Engineering, Xi\u2019an Jiaotong University , Xi\u2019an 710049,","institution_ids":["https://openalex.org/I87445476"]},{"raw_affiliation_string":"School of Computer Science and Technology, Faculty of Electronic and Information Engineering, Xi'an Jiaotong University, Xi'an 710049, China","institution_ids":["https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xiaofei Yang (\u6768\u6653\u98de)","orcid":"https://orcid.org/0000-0002-5118-7755"},"institutions":[{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaofei Yang (\u6768\u6653\u98de)","raw_affiliation_strings":["School of Computer Science and Technology, Faculty of Electronic and Information Engineering, Xi\u2019an Jiaotong University , Xi\u2019an 710049,","School of Computer Science and Technology, Faculty of Electronic and Information Engineering, Xi'an Jiaotong University, Xi'an 710049, China"],"raw_orcid":"https://orcid.org/0000-0002-5118-7755","affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Faculty of Electronic and Information Engineering, Xi\u2019an Jiaotong University , Xi\u2019an 710049,","institution_ids":["https://openalex.org/I87445476"]},{"raw_affiliation_string":"School of Computer Science and Technology, Faculty of Electronic and Information Engineering, Xi'an Jiaotong University, Xi'an 710049, China","institution_ids":["https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100653968","display_name":"Pengyu Zhang","orcid":"https://orcid.org/0000-0001-8696-4983"},"institutions":[{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pengyu Zhang (\u5f20\u9e4f\u5b87)","raw_affiliation_strings":["School of Automation Science and Engineering, Faculty of Electronic and Information Engineering, Xi\u2019an Jiaotong University , Xi\u2019an 710049,","School of Automation Science and Engineering, Faculty of Electronic and Information Engineering, Xi'an Jiaotong University, Xi'an 710049, China"],"raw_orcid":"https://orcid.org/0000-0001-8696-4983","affiliations":[{"raw_affiliation_string":"School of Automation Science and Engineering, Faculty of Electronic and Information Engineering, Xi\u2019an Jiaotong University , Xi\u2019an 710049,","institution_ids":["https://openalex.org/I87445476"]},{"raw_affiliation_string":"School of Automation Science and Engineering, Faculty of Electronic and Information Engineering, Xi'an Jiaotong University, Xi'an 710049, China","institution_ids":["https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014881178","display_name":"Yuanting Zheng","orcid":"https://orcid.org/0000-0003-4480-8303"},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4391768242","display_name":"State Key Laboratory of Genetic Engineering","ror":"https://ror.org/01n3rg866","country_code":null,"type":"facility","lineage":["https://openalex.org/I24943067","https://openalex.org/I4391768242"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanting Zheng (\u90d1\u5a9b\u5a77)","raw_affiliation_strings":["State Key Laboratory of Genetic Engineering, Human Phenome Institute and School of Life Sciences, Fudan University , Shanghai 200438,","State Key Laboratory of Genetic Engineering, Human Phenome Institute and School of Life Sciences, Fudan University, Shanghai, China"],"raw_orcid":"https://orcid.org/0000-0003-4480-8303","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Genetic Engineering, Human Phenome Institute and School of Life Sciences, Fudan University , Shanghai 200438,","institution_ids":["https://openalex.org/I24943067"]},{"raw_affiliation_string":"State Key Laboratory of Genetic Engineering, Human Phenome Institute and School of Life Sciences, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4391768242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041312244","display_name":"Leming Shi","orcid":"https://orcid.org/0000-0002-2981-4150"},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4391768242","display_name":"State Key Laboratory of Genetic Engineering","ror":"https://ror.org/01n3rg866","country_code":null,"type":"facility","lineage":["https://openalex.org/I24943067","https://openalex.org/I4391768242"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Leming Shi (\u77f3\u4e50\u660e)","raw_affiliation_strings":["State Key Laboratory of Genetic Engineering, Human Phenome Institute and School of Life Sciences, Fudan University , Shanghai 200438,","State Key Laboratory of Genetic Engineering, Human Phenome Institute and School of Life Sciences, Fudan University, Shanghai, China"],"raw_orcid":"https://orcid.org/0000-0002-2981-4150","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Genetic Engineering, Human Phenome Institute and School of Life Sciences, Fudan University , Shanghai 200438,","institution_ids":["https://openalex.org/I24943067"]},{"raw_affiliation_string":"State Key Laboratory of Genetic Engineering, Human Phenome Institute and School of Life Sciences, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4391768242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100717802","display_name":"Lianhua Dong","orcid":"https://orcid.org/0000-0002-8609-9552"},"institutions":[{"id":"https://openalex.org/I158809036","display_name":"Shenzhen Institute of Information Technology","ror":"https://ror.org/03wrf9427","country_code":"CN","type":"education","lineage":["https://openalex.org/I158809036"]},{"id":"https://openalex.org/I4210162136","display_name":"National Institute of Metrology","ror":"https://ror.org/05dw0p167","country_code":"CN","type":"other","lineage":["https://openalex.org/I4210162136"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lianhua Dong (\u8463\u83b2\u534e)","raw_affiliation_strings":["Center for Advanced Measurement of Science, National Institute of Metrology , Beijing 100029,","Shenzhen Institute for Technology Innovation, National Institute of Metrology , Shenzhen 518107,","Center for Advanced Measurement of Science, National Institute of Metrology, Beijing 100029, China","Shenzhen Institute for Technology Innovation, National Institute of Metrology, Shenzhen 518107, China"],"raw_orcid":"https://orcid.org/0000-0002-8609-9552","affiliations":[{"raw_affiliation_string":"Center for Advanced Measurement of Science, National Institute of Metrology , Beijing 100029,","institution_ids":["https://openalex.org/I4210162136"]},{"raw_affiliation_string":"Shenzhen Institute for Technology Innovation, National Institute of Metrology , Shenzhen 518107,","institution_ids":["https://openalex.org/I158809036"]},{"raw_affiliation_string":"Center for Advanced Measurement of Science, National Institute of Metrology, Beijing 100029, China","institution_ids":["https://openalex.org/I4210162136"]},{"raw_affiliation_string":"Shenzhen Institute for Technology Innovation, National Institute of Metrology, Shenzhen 518107, China","institution_ids":["https://openalex.org/I158809036"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032548139","display_name":"Kai Ye","orcid":"https://orcid.org/0000-0002-2851-6741"},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]},{"id":"https://openalex.org/I210716285","display_name":"University of Applied Sciences Leiden","ror":"https://ror.org/0093src13","country_code":"NL","type":"education","lineage":["https://openalex.org/I210716285"]},{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN","NL"],"is_corresponding":false,"raw_author_name":"Kai Ye (\u53f6\u51ef)","raw_affiliation_strings":["Department of Gynecology and Obstetrics, Center for Mathematical Medical, The First Affiliated Hospital of Xi\u2019an Jiaotong University , Xi\u2019an 710061,","Faculty of Science, Leiden University , 2311 EZ, Leiden,","MOE Key Lab for Intelligent Networks & Networks Security, Faculty of Electronic and Information Engineering, Xi\u2019an Jiaotong University , Xi\u2019an 710049,","School of Automation Science and Engineering, Faculty of Electronic and Information Engineering, Xi\u2019an Jiaotong University , Xi\u2019an 710049,","Faculty of Science, Leiden University, Leiden 2311 EZ, The Netherlands","Department of Gynecology and Obstetrics, Center for Mathematical Medical, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China","School of Automation Science and Engineering, Faculty of Electronic and Information Engineering, Xi'an Jiaotong University, Xi'an 710049, China"],"raw_orcid":"https://orcid.org/0000-0002-2851-6741","affiliations":[{"raw_affiliation_string":"Department of Gynecology and Obstetrics, Center for Mathematical Medical, The First Affiliated Hospital of Xi\u2019an Jiaotong University , Xi\u2019an 710061,","institution_ids":["https://openalex.org/I4210121771"]},{"raw_affiliation_string":"Faculty of Science, Leiden University , 2311 EZ, Leiden,","institution_ids":["https://openalex.org/I210716285","https://openalex.org/I121797337"]},{"raw_affiliation_string":"MOE Key Lab for Intelligent Networks & Networks Security, Faculty of Electronic and Information Engineering, Xi\u2019an Jiaotong University , Xi\u2019an 710049,","institution_ids":["https://openalex.org/I87445476"]},{"raw_affiliation_string":"School of Automation Science and Engineering, Faculty of Electronic and Information Engineering, Xi\u2019an Jiaotong University , Xi\u2019an 710049,","institution_ids":["https://openalex.org/I87445476"]},{"raw_affiliation_string":"Faculty of Science, Leiden University, Leiden 2311 EZ, The Netherlands","institution_ids":["https://openalex.org/I121797337"]},{"raw_affiliation_string":"Department of Gynecology and Obstetrics, Center for Mathematical Medical, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China","institution_ids":["https://openalex.org/I4210121771"]},{"raw_affiliation_string":"School of Automation Science and Engineering, Faculty of Electronic and Information Engineering, Xi'an Jiaotong University, Xi'an 710049, China","institution_ids":["https://openalex.org/I87445476"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5100408153"],"corresponding_institution_ids":["https://openalex.org/I87445476"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":{"value":3500,"currency":"USD","value_usd":3500},"fwci":1.5323,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.87669685,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":98},"biblio":{"volume":"23","issue":"6","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.6187000274658203,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.6187000274658203,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.2393999993801117,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.04610000178217888,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/centromere","display_name":"Centromere","score":0.7975000143051147},{"id":"https://openalex.org/keywords/reference-genome","display_name":"Reference genome","score":0.7361999750137329},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.7196000218391418},{"id":"https://openalex.org/keywords/human-genome","display_name":"Human genome","score":0.4797999858856201},{"id":"https://openalex.org/keywords/genomics","display_name":"Genomics","score":0.4767000079154968},{"id":"https://openalex.org/keywords/sequence-assembly","display_name":"Sequence assembly","score":0.47510001063346863},{"id":"https://openalex.org/keywords/chromosome","display_name":"Chromosome","score":0.4537000060081482},{"id":"https://openalex.org/keywords/genome-project","display_name":"Genome project","score":0.44909998774528503}],"concepts":[{"id":"https://openalex.org/C63491729","wikidata":"https://www.wikidata.org/wiki/Q14762596","display_name":"Centromere","level":4,"score":0.7975000143051147},{"id":"https://openalex.org/C192953774","wikidata":"https://www.wikidata.org/wiki/Q7307127","display_name":"Reference genome","level":4,"score":0.7361999750137329},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.7196000218391418},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6277999877929688},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5166000127792358},{"id":"https://openalex.org/C197077220","wikidata":"https://www.wikidata.org/wiki/Q720988","display_name":"Human genome","level":4,"score":0.4797999858856201},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4794999957084656},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.4767000079154968},{"id":"https://openalex.org/C18949551","wikidata":"https://www.wikidata.org/wiki/Q740578","display_name":"Sequence assembly","level":5,"score":0.47510001063346863},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.4537000060081482},{"id":"https://openalex.org/C89566754","wikidata":"https://www.wikidata.org/wiki/Q2273828","display_name":"Genome project","level":4,"score":0.44909998774528503},{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.4440000057220459},{"id":"https://openalex.org/C97425143","wikidata":"https://www.wikidata.org/wiki/Q164786","display_name":"1000 Genomes Project","level":5,"score":0.4433000087738037},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4350999891757965},{"id":"https://openalex.org/C2776321320","wikidata":"https://www.wikidata.org/wiki/Q857525","display_name":"Annotation","level":2,"score":0.3515999913215637},{"id":"https://openalex.org/C151020129","wikidata":"https://www.wikidata.org/wiki/Q7625067","display_name":"Structural variation","level":4,"score":0.33469998836517334},{"id":"https://openalex.org/C143191323","wikidata":"https://www.wikidata.org/wiki/Q118406","display_name":"Ploidy","level":3,"score":0.3301999866962433},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3262999951839447},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.31360000371932983},{"id":"https://openalex.org/C57808653","wikidata":"https://www.wikidata.org/wiki/Q7446270","display_name":"Segmental duplication","level":5,"score":0.2800000011920929},{"id":"https://openalex.org/C24432333","wikidata":"https://www.wikidata.org/wiki/Q2068526","display_name":"Whole genome sequencing","level":4,"score":0.27219998836517334},{"id":"https://openalex.org/C3020640247","wikidata":"https://www.wikidata.org/wiki/Q1981379","display_name":"Chinese population","level":4,"score":0.25850000977516174},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2581000030040741},{"id":"https://openalex.org/C105176652","wikidata":"https://www.wikidata.org/wiki/Q1147112","display_name":"Comparative genomics","level":5,"score":0.2574999928474426}],"mesh":[{"descriptor_ui":"D000095225","descriptor_name":"East Asian People","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000095225","descriptor_name":"East Asian People","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002503","descriptor_name":"Centromere","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002503","descriptor_name":"Centromere","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004171","descriptor_name":"Diploidy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004171","descriptor_name":"Diploidy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006239","descriptor_name":"Haplotypes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006239","descriptor_name":"Haplotypes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016615","descriptor_name":"Telomere","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016615","descriptor_name":"Telomere","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D044466","descriptor_name":"Asian People","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044466","descriptor_name":"Asian People","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/gpbjnl/qzaf118","is_oa":true,"landing_page_url":"https://doi.org/10.1093/gpbjnl/qzaf118","pdf_url":"https://academic.oup.com/gpb/advance-article-pdf/doi/10.1093/gpbjnl/qzaf118/65552679/qzaf118.pdf","source":{"id":"https://openalex.org/S155547894","display_name":"Genomics Proteomics & Bioinformatics","issn_l":"1672-0229","issn":["1672-0229","2210-3244"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, Proteomics &amp; Bioinformatics","raw_type":"journal-article"},{"id":"pmid:41298323","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41298323","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, proteomics & bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:13075991","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13075991/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Genomics Proteomics Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/gpbjnl/qzaf118","is_oa":true,"landing_page_url":"https://doi.org/10.1093/gpbjnl/qzaf118","pdf_url":"https://academic.oup.com/gpb/advance-article-pdf/doi/10.1093/gpbjnl/qzaf118/65552679/qzaf118.pdf","source":{"id":"https://openalex.org/S155547894","display_name":"Genomics Proteomics & Bioinformatics","issn_l":"1672-0229","issn":["1672-0229","2210-3244"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, Proteomics &amp; Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1098819714","display_name":null,"funder_award_id":"2023YFF0613300","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G1561453903","display_name":null,"funder_award_id":"32125009","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4262832189","display_name":null,"funder_award_id":"32422019","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G593745682","display_name":null,"funder_award_id":"2024JC-JCQN-28","funder_id":"https://openalex.org/F4320324173","funder_display_name":"Natural Science Foundation of Shaanxi Province"},{"id":"https://openalex.org/G6045992418","display_name":null,"funder_award_id":"32400509","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6134535952","display_name":null,"funder_award_id":"62172325","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6577795171","display_name":null,"funder_award_id":"32200510","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6899908350","display_name":null,"funder_award_id":"xzy012024088","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G8160189100","display_name":null,"funder_award_id":"2022YFC3400300","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320324173","display_name":"Natural Science Foundation of Shaanxi Province","ror":null},{"id":"https://openalex.org/F4320325627","display_name":"Education Department of Shaanxi Province","ror":null},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4416721059.pdf","grobid_xml":"https://content.openalex.org/works/W4416721059.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Recent":[0],"advances":[1,80,175],"in":[2],"sequencing":[3],"technologies":[4],"have":[5],"enabled":[6],"the":[7,38,81,84,170,176,196],"complete":[8,131],"assembly":[9,36,66,90],"of":[10,37,83,96,106,133,178,199],"human":[11],"genomes":[12],"from":[13],"telomere":[14,16],"to":[15],"(T2T),":[17],"resolving":[18],"previously":[19],"inaccessible":[20],"regions":[21],"such":[22],"as":[23,68],"centromeres":[24],"and":[25,48,59,79,98,109,118,154,174,195],"segmental":[26],"duplications.":[27],"Here,":[28],"we":[29,139],"present":[30],"an":[31,165],"updated,":[32],"higher-quality,":[33],"haplotype-phased":[34],"T2T":[35,180],"Chinese":[39,172],"Quartet":[40,85],"(T2T-CQ),":[41],"a":[42,69,151,179],"family":[43],"cohort":[44],"comprising":[45],"monozygotic":[46],"twins":[47],"their":[49],"parents,":[50],"generated":[51],"using":[52],"high-coverage":[53],"Oxford":[54],"Nanopore":[55],"Technologies":[56],"(ONT)":[57],"ultralong":[58],"PacBio":[60],"high-fidelity":[61],"(HiFi)":[62],"sequencing.":[63],"The":[64,88],"T2T-CQ":[65,89],"serves":[67],"crucial":[70],"reference":[71,86,182],"genome":[72],"for":[73,127,169],"integrating":[74],"publicly":[75],"available":[76],"multi-omics":[77],"data":[78],"utility":[82],"materials.":[87],"scores":[91,105,124],"highly":[92],"on":[93,146],"multiple":[94],"metrics":[95],"continuity":[97],"completeness,":[99],"with":[100],"Genome":[101],"Continuity":[102],"Inspector":[103],"(GCI)":[104],"77.76":[107],"(maternal)":[108],"76.41":[110],"(paternal),":[111],"21-mer":[112],"quality":[113],"values":[114],"(QVs)":[115],">":[116,125],"66,":[117],"Clipping":[119],"Reveals":[120],"Assembly":[121],"Quality":[122],"(CRAQ)":[123],"99.6":[126],"both":[128,190],"haplotypes,":[129],"enabling":[130],"annotation":[132],"centromeric":[134],"regions.":[135],"Within":[136],"these":[137],"regions,":[138],"identified":[140],"novel":[141],"13-mer":[142],"higher-order":[143],"repeat":[144],"patterns":[145],"chromosome":[147],"17":[148],"which":[149,184],"exhibited":[150],"monophyletic":[152],"origin":[153],"emerged":[155],"approximately":[156],"230":[157],"thousand":[158],"years":[159],"ago.":[160],"Overall,":[161],"this":[162],"work":[163],"establishes":[164],"essential":[166],"genomic":[167],"resource":[168],"Han":[171],"population":[173],"development":[177],"pan-Chinese":[181],"genome,":[183],"will":[185],"significantly":[186],"enable":[187],"future":[188],"investigations":[189],"into":[191],"population-specific":[192],"structural":[193],"variants":[194],"evolutionary":[197],"dynamics":[198],"centromeres.":[200]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-04-25T08:17:42.794288","created_date":"2025-11-28T00:00:00"}
