{"id":"https://openalex.org/W4416055380","doi":"https://doi.org/10.1093/gpbjnl/qzaf102","title":"Association of Multiple-trait Polygenic Risk Score with Obesity and Cardiometabolic Diseases in Korean Population","display_name":"Association of Multiple-trait Polygenic Risk Score with Obesity and Cardiometabolic Diseases in Korean Population","publication_year":2025,"publication_date":"2025-10-01","ids":{"openalex":"https://openalex.org/W4416055380","doi":"https://doi.org/10.1093/gpbjnl/qzaf102","pmid":"https://pubmed.ncbi.nlm.nih.gov/41206923"},"language":"en","primary_location":{"id":"doi:10.1093/gpbjnl/qzaf102","is_oa":true,"landing_page_url":"https://doi.org/10.1093/gpbjnl/qzaf102","pdf_url":"https://academic.oup.com/gpb/advance-article-pdf/doi/10.1093/gpbjnl/qzaf102/65248562/qzaf102.pdf","source":{"id":"https://openalex.org/S155547894","display_name":"Genomics Proteomics & Bioinformatics","issn_l":"1672-0229","issn":["1672-0229","2210-3244"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, Proteomics & Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/gpb/advance-article-pdf/doi/10.1093/gpbjnl/qzaf102/65248562/qzaf102.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019792525","display_name":"Jinyeon Jo","orcid":"https://orcid.org/0000-0002-4192-1725"},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I4210139346","display_name":"Department of Public","ror":"https://ror.org/04qbta562","country_code":"IN","type":"government","lineage":["https://openalex.org/I148776243","https://openalex.org/I4210139346"]}],"countries":["IN","KR"],"is_corresponding":false,"raw_author_name":"Jinyeon Jo","raw_affiliation_strings":["Department of Public Health Sciences, Graduate School of Public Health, Seoul National University , Seoul 08826,","Department of Public Health Sciences, Graduate school of Public Health, Seoul National University, Seoul 08826, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-4192-1725","affiliations":[{"raw_affiliation_string":"Department of Public Health Sciences, Graduate School of Public Health, Seoul National University , Seoul 08826,","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Department of Public Health Sciences, Graduate school of Public Health, Seoul National University, Seoul 08826, Republic of Korea","institution_ids":["https://openalex.org/I4210139346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110581359","display_name":"Na-Young Ha","orcid":"https://orcid.org/0009-0002-5150-8181"},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I4210139346","display_name":"Department of Public","ror":"https://ror.org/04qbta562","country_code":"IN","type":"government","lineage":["https://openalex.org/I148776243","https://openalex.org/I4210139346"]}],"countries":["IN","KR"],"is_corresponding":false,"raw_author_name":"Nayoung Ha","raw_affiliation_strings":["Department of Public Health Sciences, Graduate School of Public Health, Seoul National University , Seoul 08826,","Department of Public Health Sciences, Graduate school of Public Health, Seoul National University, Seoul 08826, Republic of Korea"],"raw_orcid":"https://orcid.org/0009-0002-5150-8181","affiliations":[{"raw_affiliation_string":"Department of Public Health Sciences, Graduate School of Public Health, Seoul National University , Seoul 08826,","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Department of Public Health Sciences, Graduate school of Public Health, Seoul National University, Seoul 08826, Republic of Korea","institution_ids":["https://openalex.org/I4210139346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113328323","display_name":"Yunmi Ji","orcid":"https://orcid.org/0009-0002-7914-1625"},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2802457231","display_name":"New Generation University College","ror":"https://ror.org/015aem925","country_code":"ET","type":"education","lineage":["https://openalex.org/I2802457231"]}],"countries":["ET","KR"],"is_corresponding":false,"raw_author_name":"Yunmi Ji","raw_affiliation_strings":["Interdisciplinary Program in Bioinformatics, College of Natural Sciences, Seoul National University , Seoul 08826,","Interdisciplinary Program in Bioinformatics, College of Natural Sciences, Seoul National University, Seoul 08826, Republic of Korea"],"raw_orcid":"https://orcid.org/0009-0002-7914-1625","affiliations":[{"raw_affiliation_string":"Interdisciplinary Program in Bioinformatics, College of Natural Sciences, Seoul National University , Seoul 08826,","institution_ids":["https://openalex.org/I2802457231","https://openalex.org/I139264467"]},{"raw_affiliation_string":"Interdisciplinary Program in Bioinformatics, College of Natural Sciences, Seoul National University, Seoul 08826, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057423104","display_name":"Ah Ra","orcid":"https://orcid.org/0000-0002-4259-8309"},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I4210135449","display_name":"NCSOFT (South Korea)","ror":"https://ror.org/03q4mza74","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210135449"]},{"id":"https://openalex.org/I4210139346","display_name":"Department of Public","ror":"https://ror.org/04qbta562","country_code":"IN","type":"government","lineage":["https://openalex.org/I148776243","https://openalex.org/I4210139346"]},{"id":"https://openalex.org/I4210143161","display_name":"IDEX Corporation (United States)","ror":"https://ror.org/03jqyh750","country_code":"US","type":"company","lineage":["https://openalex.org/I4210143161"]}],"countries":["IN","KR","US"],"is_corresponding":false,"raw_author_name":"Ahra Do","raw_affiliation_strings":["Department of Public Health Sciences, Graduate School of Public Health, Seoul National University , Seoul 08826,","RexSoft Corp ., Seoul 08826,","Department of Public Health Sciences, Graduate school of Public Health, Seoul National University, Seoul 08826, Republic of Korea","RexSoft Corp., Seoul 08826, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-4259-8309","affiliations":[{"raw_affiliation_string":"Department of Public Health Sciences, Graduate School of Public Health, Seoul National University , Seoul 08826,","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"RexSoft Corp ., Seoul 08826,","institution_ids":["https://openalex.org/I4210143161"]},{"raw_affiliation_string":"Department of Public Health Sciences, Graduate school of Public Health, Seoul National University, Seoul 08826, Republic of Korea","institution_ids":["https://openalex.org/I4210139346"]},{"raw_affiliation_string":"RexSoft Corp., Seoul 08826, Republic of Korea","institution_ids":["https://openalex.org/I4210135449"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063910036","display_name":"Je Hyun Seo","orcid":"https://orcid.org/0000-0003-3127-7160"},"institutions":[{"id":"https://openalex.org/I4210101595","display_name":"Veterans Health Service Medical Center","ror":"https://ror.org/00xhz2q61","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210101595","https://openalex.org/I4210129722"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Je Hyun Seo","raw_affiliation_strings":["Veterans Medical Research Institute, Veterans Health Service Medical Center , Seoul 05368,","Veterans Medical Research Institute, Veterans Health Service Medical Center, Seoul 05368, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0003-3127-7160","affiliations":[{"raw_affiliation_string":"Veterans Medical Research Institute, Veterans Health Service Medical Center , Seoul 05368,","institution_ids":["https://openalex.org/I4210101595"]},{"raw_affiliation_string":"Veterans Medical Research Institute, Veterans Health Service Medical Center, Seoul 05368, Republic of Korea","institution_ids":["https://openalex.org/I4210101595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042178065","display_name":"Bumjo Oh","orcid":"https://orcid.org/0000-0002-2468-0755"},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2801402630","display_name":"Seoul Metropolitan Government","ror":"https://ror.org/002wfgr58","country_code":"KR","type":"government","lineage":["https://openalex.org/I2801402630"]},{"id":"https://openalex.org/I2802457231","display_name":"New Generation University College","ror":"https://ror.org/015aem925","country_code":"ET","type":"education","lineage":["https://openalex.org/I2802457231"]},{"id":"https://openalex.org/I4210100437","display_name":"SNUH SMG-SNU Boramae Medical Center","ror":"https://ror.org/014xqzt56","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I4210100437"]}],"countries":["ET","KR"],"is_corresponding":false,"raw_author_name":"Bumjo Oh","raw_affiliation_strings":["Department of Family Medicine, Seoul Metropolitan Government, Seoul National University Boramae Medical Center , Seoul 07061,","Department of Family Medicine, Seoul National University College of Medicine , Seoul 03080,","Department of Family Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul 07061, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-2468-0755","affiliations":[{"raw_affiliation_string":"Department of Family Medicine, Seoul Metropolitan Government, Seoul National University Boramae Medical Center , Seoul 07061,","institution_ids":["https://openalex.org/I2801402630"]},{"raw_affiliation_string":"Department of Family Medicine, Seoul National University College of Medicine , Seoul 03080,","institution_ids":["https://openalex.org/I2802457231"]},{"raw_affiliation_string":"Department of Family Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul 07061, Republic of Korea","institution_ids":["https://openalex.org/I2801402630","https://openalex.org/I139264467","https://openalex.org/I4210100437"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090214669","display_name":"Sungkyoung Choi","orcid":"https://orcid.org/0000-0002-4266-5911"},"institutions":[{"id":"https://openalex.org/I4575257","display_name":"Hanyang University","ror":"https://ror.org/046865y68","country_code":"KR","type":"education","lineage":["https://openalex.org/I4575257"]},{"id":"https://openalex.org/I93906172","display_name":"Anyang University","ror":"https://ror.org/018pdh902","country_code":"KR","type":"education","lineage":["https://openalex.org/I93906172"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sungkyoung Choi","raw_affiliation_strings":["Department of Mathematical Data Science, Hanyang University (ERICA) , Ansan 15588,","Department of Mathematical Data Science, Hanyang University (ERICA), Ansan 15588, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-4266-5911","affiliations":[{"raw_affiliation_string":"Department of Mathematical Data Science, Hanyang University (ERICA) , Ansan 15588,","institution_ids":["https://openalex.org/I93906172"]},{"raw_affiliation_string":"Department of Mathematical Data Science, Hanyang University (ERICA), Ansan 15588, Republic of Korea","institution_ids":["https://openalex.org/I93906172","https://openalex.org/I4575257"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059617653","display_name":"Eun Kyung Choe","orcid":"https://orcid.org/0000-0002-7222-1772"},"institutions":[{"id":"https://openalex.org/I2802457231","display_name":"New Generation University College","ror":"https://ror.org/015aem925","country_code":"ET","type":"education","lineage":["https://openalex.org/I2802457231"]},{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}],"countries":["ET","KR"],"is_corresponding":false,"raw_author_name":"Eun Kyung Choe","raw_affiliation_strings":["Division of Colorectal Surgery, Department of Surgery, Seoul National University College of Medicine , Seoul 03080,","Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center , Seoul 06236,","Division of Colorectal Surgery, Department of Surgery, Seoul National University College of Medicine, Seoul 03080, Republic of Korea","Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center, Seoul 06236, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-7222-1772","affiliations":[{"raw_affiliation_string":"Division of Colorectal Surgery, Department of Surgery, Seoul National University College of Medicine , Seoul 03080,","institution_ids":["https://openalex.org/I2802457231"]},{"raw_affiliation_string":"Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center , Seoul 06236,","institution_ids":["https://openalex.org/I2802835388"]},{"raw_affiliation_string":"Division of Colorectal Surgery, Department of Surgery, Seoul National University College of Medicine, Seoul 03080, Republic of Korea","institution_ids":["https://openalex.org/I2802457231"]},{"raw_affiliation_string":"Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center, Seoul 06236, Republic of Korea","institution_ids":["https://openalex.org/I2802835388"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030458503","display_name":"Woojoo Lee","orcid":"https://orcid.org/0000-0001-7447-7045"},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I4210139346","display_name":"Department of Public","ror":"https://ror.org/04qbta562","country_code":"IN","type":"government","lineage":["https://openalex.org/I148776243","https://openalex.org/I4210139346"]}],"countries":["IN","KR"],"is_corresponding":false,"raw_author_name":"Woojoo Lee","raw_affiliation_strings":["Department of Public Health Sciences, Graduate School of Public Health, Seoul National University , Seoul 08826,","Institute of Health and Environment, Seoul National University , Seoul 08826,","Department of Public Health Sciences, Graduate school of Public Health, Seoul National University, Seoul 08826, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0001-7447-7045","affiliations":[{"raw_affiliation_string":"Department of Public Health Sciences, Graduate School of Public Health, Seoul National University , Seoul 08826,","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Institute of Health and Environment, Seoul National University , Seoul 08826,","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Department of Public Health Sciences, Graduate school of Public Health, Seoul National University, Seoul 08826, Republic of Korea","institution_ids":["https://openalex.org/I4210139346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101471940","display_name":"Jang Won Son","orcid":"https://orcid.org/0000-0003-0339-0131"},"institutions":[{"id":"https://openalex.org/I4210133166","display_name":"The Catholic University of Korea Bucheon St. Mary's Hospital","ror":"https://ror.org/0443jbw36","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210133166","https://openalex.org/I4405260414","https://openalex.org/I87111246"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jang Won Son","raw_affiliation_strings":["Division of Endocrinology and Metabolism, Department of Internal Medicine, Bucheon St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea , Seoul 06591,","Division of Endocrinology and Metabolism, Department of Internal Medicine, Bucheon St Mary's hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0003-0339-0131","affiliations":[{"raw_affiliation_string":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Bucheon St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea , Seoul 06591,","institution_ids":["https://openalex.org/I4210133166"]},{"raw_affiliation_string":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Bucheon St Mary's hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea","institution_ids":["https://openalex.org/I4210133166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087186763","display_name":"Sungho Won","orcid":"https://orcid.org/0000-0001-5751-5089"},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I4210135449","display_name":"NCSOFT (South Korea)","ror":"https://ror.org/03q4mza74","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210135449"]},{"id":"https://openalex.org/I4210139346","display_name":"Department of Public","ror":"https://ror.org/04qbta562","country_code":"IN","type":"government","lineage":["https://openalex.org/I148776243","https://openalex.org/I4210139346"]},{"id":"https://openalex.org/I4210143161","display_name":"IDEX Corporation (United States)","ror":"https://ror.org/03jqyh750","country_code":"US","type":"company","lineage":["https://openalex.org/I4210143161"]}],"countries":["IN","KR","US"],"is_corresponding":false,"raw_author_name":"Sungho Won","raw_affiliation_strings":["Department of Public Health Sciences, Graduate School of Public Health, Seoul National University , Seoul 08826,","Institute of Health and Environment, Seoul National University , Seoul 08826,","RexSoft Corp ., Seoul 08826,","RexSoft Corp., Seoul 08826, Republic of Korea","Department of Public Health Sciences, Graduate school of Public Health, Seoul National University, Seoul 08826, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0001-5751-5089","affiliations":[{"raw_affiliation_string":"Department of Public Health Sciences, Graduate School of Public Health, Seoul National University , Seoul 08826,","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Institute of Health and Environment, Seoul National University , Seoul 08826,","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"RexSoft Corp ., Seoul 08826,","institution_ids":["https://openalex.org/I4210143161"]},{"raw_affiliation_string":"RexSoft Corp., Seoul 08826, Republic of Korea","institution_ids":["https://openalex.org/I4210135449"]},{"raw_affiliation_string":"Department of Public Health Sciences, Graduate school of Public Health, Seoul National University, Seoul 08826, Republic of Korea","institution_ids":["https://openalex.org/I4210139346"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":11,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":{"value":3500,"currency":"USD","value_usd":3500},"fwci":1.2846,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.84729053,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"23","issue":"5","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9889000058174133,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9889000058174133,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/obesity","display_name":"Obesity","score":0.8094000220298767},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"Body mass index","score":0.6452000141143799},{"id":"https://openalex.org/keywords/waist","display_name":"Waist","score":0.6022999882698059},{"id":"https://openalex.org/keywords/heritability","display_name":"Heritability","score":0.6001999974250793},{"id":"https://openalex.org/keywords/abdominal-obesity","display_name":"Abdominal obesity","score":0.5655999779701233},{"id":"https://openalex.org/keywords/korean-population","display_name":"Korean population","score":0.557200014591217},{"id":"https://openalex.org/keywords/genetic-association","display_name":"Genetic association","score":0.5479000210762024},{"id":"https://openalex.org/keywords/polygenic-risk-score","display_name":"Polygenic risk score","score":0.5004000067710876},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"Genome-wide association study","score":0.49619999527931213}],"concepts":[{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.8094000220298767},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.6452000141143799},{"id":"https://openalex.org/C2776193436","wikidata":"https://www.wikidata.org/wiki/Q236232","display_name":"Waist","level":3,"score":0.6022999882698059},{"id":"https://openalex.org/C161890455","wikidata":"https://www.wikidata.org/wiki/Q1503548","display_name":"Heritability","level":2,"score":0.6001999974250793},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5787000060081482},{"id":"https://openalex.org/C2777693730","wikidata":"https://www.wikidata.org/wiki/Q1140549","display_name":"Abdominal obesity","level":4,"score":0.5655999779701233},{"id":"https://openalex.org/C3019947015","wikidata":"https://www.wikidata.org/wiki/Q5256025","display_name":"Korean population","level":2,"score":0.557200014591217},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.5479000210762024},{"id":"https://openalex.org/C2993137441","wikidata":"https://www.wikidata.org/wiki/Q28135712","display_name":"Polygenic risk score","level":5,"score":0.5004000067710876},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.49619999527931213},{"id":"https://openalex.org/C9287583","wikidata":"https://www.wikidata.org/wiki/Q5532883","display_name":"Genetic architecture","level":4,"score":0.4878000020980835},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.4708999991416931},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4666000008583069},{"id":"https://openalex.org/C144621757","wikidata":"https://www.wikidata.org/wiki/Q3083720","display_name":"Missing heritability problem","level":5,"score":0.45660001039505005},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4510999917984009},{"id":"https://openalex.org/C2992519594","wikidata":"https://www.wikidata.org/wiki/Q870433","display_name":"Genetic model","level":3,"score":0.4410000145435333},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.41940000653266907},{"id":"https://openalex.org/C179420905","wikidata":"https://www.wikidata.org/wiki/Q223871","display_name":"Mediation","level":2,"score":0.39410001039505005},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.3580999970436096},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.34389999508857727},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33329999446868896},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.3248000144958496},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.3138999938964844},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3089999854564667},{"id":"https://openalex.org/C67636389","wikidata":"https://www.wikidata.org/wiki/Q784237","display_name":"Genetic predisposition","level":3,"score":0.3066999912261963},{"id":"https://openalex.org/C2993967602","wikidata":"https://www.wikidata.org/wiki/Q5532932","display_name":"Genetic variants","level":4,"score":0.2948000133037567},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27900001406669617},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.2782000005245209},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.27000001072883606},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.25189998745918274}],"mesh":[{"descriptor_ui":"D000096442","descriptor_name":"Genetic Risk Score","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000096442","descriptor_name":"Genetic Risk Score","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020412","descriptor_name":"Multifactorial Inheritance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020412","descriptor_name":"Multifactorial Inheritance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044466","descriptor_name":"Asian People","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044466","descriptor_name":"Asian People","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056910","descriptor_name":"Republic of Korea","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D056910","descriptor_name":"Republic of Korea","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/gpbjnl/qzaf102","is_oa":true,"landing_page_url":"https://doi.org/10.1093/gpbjnl/qzaf102","pdf_url":"https://academic.oup.com/gpb/advance-article-pdf/doi/10.1093/gpbjnl/qzaf102/65248562/qzaf102.pdf","source":{"id":"https://openalex.org/S155547894","display_name":"Genomics Proteomics & Bioinformatics","issn_l":"1672-0229","issn":["1672-0229","2210-3244"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, Proteomics & Bioinformatics","raw_type":"journal-article"},{"id":"pmid:41206923","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41206923","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, proteomics & bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:12975335","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12975335/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Genomics Proteomics Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/gpbjnl/qzaf102","is_oa":true,"landing_page_url":"https://doi.org/10.1093/gpbjnl/qzaf102","pdf_url":"https://academic.oup.com/gpb/advance-article-pdf/doi/10.1093/gpbjnl/qzaf102/65248562/qzaf102.pdf","source":{"id":"https://openalex.org/S155547894","display_name":"Genomics Proteomics & Bioinformatics","issn_l":"1672-0229","issn":["1672-0229","2210-3244"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, Proteomics & Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G5390342583","display_name":null,"funder_award_id":"RS-2024-00346850","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G5799203089","display_name":null,"funder_award_id":"KSC-2022-CRE-0319","funder_id":"https://openalex.org/F4320337144","funder_display_name":"National Supercomputing Center, Korea Institute of Science and Technology Information"},{"id":"https://openalex.org/G7206953387","display_name":null,"funder_award_id":"KSC-2023-CRE-0117","funder_id":"https://openalex.org/F4320337144","funder_display_name":"National Supercomputing Center, Korea Institute of Science and Technology Information"}],"funders":[{"id":"https://openalex.org/F4320318372","display_name":"Korea Disease Control and Prevention Agency","ror":"https://ror.org/04jgeq066"},{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322105","display_name":"Korea Institute of Science and Technology Information","ror":"https://ror.org/01k4yrm29"},{"id":"https://openalex.org/F4320322107","display_name":"Korea Health Industry Development Institute","ror":"https://ror.org/00fdzyk40"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320328359","display_name":"Ministry of Science and ICT, South Korea","ror":"https://ror.org/01wpjm123"},{"id":"https://openalex.org/F4320337144","display_name":"National Supercomputing Center, Korea Institute of Science and Technology Information","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4416055380.pdf","grobid_xml":"https://content.openalex.org/works/W4416055380.grobid-xml"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W1542476404","https://openalex.org/W1546792714","https://openalex.org/W1908991493","https://openalex.org/W1970560511","https://openalex.org/W1978823050","https://openalex.org/W1984068087","https://openalex.org/W1993828353","https://openalex.org/W2001956441","https://openalex.org/W2015918699","https://openalex.org/W2033151532","https://openalex.org/W2039153962","https://openalex.org/W2040259846","https://openalex.org/W2047783882","https://openalex.org/W2064529437","https://openalex.org/W2076450470","https://openalex.org/W2091946425","https://openalex.org/W2099085143","https://openalex.org/W2099786709","https://openalex.org/W2105079646","https://openalex.org/W2110048796","https://openalex.org/W2122520859","https://openalex.org/W2131803107","https://openalex.org/W2153860431","https://openalex.org/W2161633633","https://openalex.org/W2169795969","https://openalex.org/W2179438025","https://openalex.org/W2328176404","https://openalex.org/W2341084900","https://openalex.org/W2438256301","https://openalex.org/W2510411424","https://openalex.org/W2529241974","https://openalex.org/W2587257410","https://openalex.org/W2609876203","https://openalex.org/W2609955914","https://openalex.org/W2613151407","https://openalex.org/W2735376054","https://openalex.org/W2770092353","https://openalex.org/W2780667489","https://openalex.org/W2794694102","https://openalex.org/W2800592973","https://openalex.org/W2887378263","https://openalex.org/W2895486342","https://openalex.org/W2901303766","https://openalex.org/W2920792207","https://openalex.org/W2946345857","https://openalex.org/W2951553270","https://openalex.org/W2981587292","https://openalex.org/W2982152435","https://openalex.org/W3094168254","https://openalex.org/W3111018742","https://openalex.org/W3162800482","https://openalex.org/W3202209876","https://openalex.org/W4206782992","https://openalex.org/W4220764353","https://openalex.org/W4283206544","https://openalex.org/W4283766168","https://openalex.org/W4292811746","https://openalex.org/W4382631096","https://openalex.org/W4385607015","https://openalex.org/W4387229859","https://openalex.org/W4388735806","https://openalex.org/W4401997218","https://openalex.org/W4405544323"],"related_works":[],"abstract_inverted_index":{"We":[0],"conducted":[1],"a":[2,9],"comprehensive":[3],"genetic":[4,31,93,140,157,183],"investigation":[5],"of":[6,11,33,173,181],"obesity":[7,34,75,83,97,144,160,188],"in":[8,164],"cohort":[10],"93,673":[12],"Korean":[13,166],"individuals,":[14],"categorized":[15],"by":[16,108],"body":[17],"mass":[18],"index":[19],"and":[20,25,35,44,54,68,80,98,103,119,135,155,161,177],"waist":[21],"circumference":[22],"using":[23,50],"Korean-specific":[24],"international":[26],"criteria.":[27],"To":[28],"explore":[29],"the":[30,59,131,165,171,179,187],"architecture":[32],"its":[36,162],"related":[37],"comorbidities,":[38],"we":[39],"performed":[40],"genome-wide":[41,65],"association":[42],"studies":[43],"constructed":[45],"polygenic":[46],"risk":[47,115],"scores":[48],"(PRSs)":[49],"both":[51],"conventional":[52],"single-trait":[53,102],"advanced":[55],"multiple-trait":[56,104,132,174],"models,":[57],"including":[58],"PRSsum":[60],"approach.":[61],"Our":[62],"analyses":[63,137],"identified":[64],"significant":[66],"loci":[67,154],"demonstrated":[69],"their":[70],"higher":[71],"heritability":[72],"for":[73,77,81,85,116,185],"general":[74],"than":[76,84],"abdominal":[78,96],"obesity,":[79,117],"moderate":[82],"severe":[86],"obesity.":[87],"East":[88],"Asian":[89],"populations":[90],"showed":[91],"stronger":[92],"correlations":[94],"between":[95],"obesity-related":[99],"diseases.":[100],"Both":[101],"PRSs":[105],"stratified":[106],"individuals":[107,112,125],"risk,":[109,128],"with":[110],"low-PRS":[111],"exhibiting":[113],"reduced":[114],"hypertension,":[118],"type":[120],"2":[121],"diabetes,":[122],"while":[123],"high-PRS":[124],"displayed":[126],"elevated":[127],"particularly":[129],"under":[130],"model.":[133],"Interaction":[134],"mediation":[136],"revealed":[138,152],"distinct":[139],"pathways":[141],"through":[142],"which":[143],"contributes":[145],"to":[146],"disease":[147],"development.":[148],"Collectively,":[149],"our":[150],"findings":[151],"key":[153],"shared":[156],"mechanisms":[158],"linking":[159],"comorbidities":[163],"population.":[167],"These":[168],"insights":[169],"highlight":[170],"value":[172],"PRS":[175],"models":[176],"underscore":[178],"importance":[180],"ancestry-specific":[182],"research":[184],"addressing":[186],"epidemic.":[189]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-11-09T00:00:00"}