{"id":"https://openalex.org/W4412712845","doi":"https://doi.org/10.1093/gpbjnl/qzaf063","title":"Whole-genome Sequence Analysis Revealed Novel Subjective Cognitive Decline-associated Genes in 10,763 Chinese","display_name":"Whole-genome Sequence Analysis Revealed Novel Subjective Cognitive Decline-associated Genes in 10,763 Chinese","publication_year":2025,"publication_date":"2025-07-29","ids":{"openalex":"https://openalex.org/W4412712845","doi":"https://doi.org/10.1093/gpbjnl/qzaf063","pmid":"https://pubmed.ncbi.nlm.nih.gov/40728933"},"language":"en","primary_location":{"id":"doi:10.1093/gpbjnl/qzaf063","is_oa":true,"landing_page_url":"https://doi.org/10.1093/gpbjnl/qzaf063","pdf_url":"https://academic.oup.com/gpb/advance-article-pdf/doi/10.1093/gpbjnl/qzaf063/63880987/qzaf063.pdf","source":{"id":"https://openalex.org/S155547894","display_name":"Genomics Proteomics & Bioinformatics","issn_l":"1672-0229","issn":["1672-0229","2210-3244"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, Proteomics &amp; Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/gpb/advance-article-pdf/doi/10.1093/gpbjnl/qzaf063/63880987/qzaf063.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087621232","display_name":"Mengying Wang","orcid":"https://orcid.org/0000-0001-5127-5491"},"institutions":[{"id":"https://openalex.org/I4210165441","display_name":"Hangzhou Medical College","ror":"https://ror.org/05gpas306","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165441"]},{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Mengying Wang","raw_affiliation_strings":["Center of Clinical Big Data and Analytics of the Second Affiliated Hospital and School of Public Health, Zhejiang University School of Medicine , Hangzhou 310058,","Department of Nutrition, Child, and Adolescent Health, School of Public Health, Hangzhou Medical College , Hangzhou 310007,","Zhejiang University School of Medicine Center for Clinical Big Data and Analytics of the Second Affiliated Hospital and School of Public Health, , Hangzhou 310058,"],"affiliations":[{"raw_affiliation_string":"Center of Clinical Big Data and Analytics of the Second Affiliated Hospital and School of Public Health, Zhejiang University School of Medicine , Hangzhou 310058,","institution_ids":["https://openalex.org/I4210158318"]},{"raw_affiliation_string":"Department of Nutrition, Child, and Adolescent Health, School of Public Health, Hangzhou Medical College , Hangzhou 310007,","institution_ids":["https://openalex.org/I4210165441"]},{"raw_affiliation_string":"Zhejiang University School of Medicine Center for Clinical Big Data and Analytics of the Second Affiliated Hospital and School of Public Health, , Hangzhou 310058,","institution_ids":["https://openalex.org/I4210158318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101296684","display_name":"Liyang Sun","orcid":null},"institutions":[{"id":"https://openalex.org/I4210124531","display_name":"Lanzhou University Second Hospital","ror":"https://ror.org/02erhaz63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124531"]},{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liyang Sun","raw_affiliation_strings":["The Second Affiliated Hospital of Zhejiang University School of Medicine, Lanxi Branch (Lanxi People\u2019s Hospital) , Lanxi 321100,"],"affiliations":[{"raw_affiliation_string":"The Second Affiliated Hospital of Zhejiang University School of Medicine, Lanxi Branch (Lanxi People\u2019s Hospital) , Lanxi 321100,","institution_ids":["https://openalex.org/I76214153","https://openalex.org/I4210124531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062885337","display_name":"Xin Xu","orcid":"https://orcid.org/0000-0002-4639-6480"},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Xu","raw_affiliation_strings":["Center of Clinical Big Data and Analytics of the Second Affiliated Hospital and School of Public Health, Zhejiang University School of Medicine , Hangzhou 310058,","Zhejiang University School of Medicine Center for Clinical Big Data and Analytics of the Second Affiliated Hospital and School of Public Health, , Hangzhou 310058,"],"affiliations":[{"raw_affiliation_string":"Center of Clinical Big Data and Analytics of the Second Affiliated Hospital and School of Public Health, Zhejiang University School of Medicine , Hangzhou 310058,","institution_ids":["https://openalex.org/I4210158318"]},{"raw_affiliation_string":"Zhejiang University School of Medicine Center for Clinical Big Data and Analytics of the Second Affiliated Hospital and School of Public Health, , Hangzhou 310058,","institution_ids":["https://openalex.org/I4210158318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025384959","display_name":"Ruoqi Dai","orcid":"https://orcid.org/0009-0005-1637-0318"},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruoqi Dai","raw_affiliation_strings":["Center of Clinical Big Data and Analytics of the Second Affiliated Hospital and School of Public Health, Zhejiang University School of Medicine , Hangzhou 310058,","Zhejiang University School of Medicine Center for Clinical Big Data and Analytics of the Second Affiliated Hospital and School of Public Health, , Hangzhou 310058,"],"affiliations":[{"raw_affiliation_string":"Center of Clinical Big Data and Analytics of the Second Affiliated Hospital and School of Public Health, Zhejiang University School of Medicine , Hangzhou 310058,","institution_ids":["https://openalex.org/I4210158318"]},{"raw_affiliation_string":"Zhejiang University School of Medicine Center for Clinical Big Data and Analytics of the Second Affiliated Hospital and School of Public Health, , Hangzhou 310058,","institution_ids":["https://openalex.org/I4210158318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101378463","display_name":"Qilong Tan","orcid":null},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qilong Tan","raw_affiliation_strings":["Center of Clinical Big Data and Analytics of the Second Affiliated Hospital and School of Public Health, Zhejiang University School of Medicine , Hangzhou 310058,","Zhejiang University School of Medicine Center for Clinical Big Data and Analytics of the Second Affiliated Hospital and School of Public Health, , Hangzhou 310058,"],"affiliations":[{"raw_affiliation_string":"Center of Clinical Big Data and Analytics of the Second Affiliated Hospital and School of Public Health, Zhejiang University School of Medicine , Hangzhou 310058,","institution_ids":["https://openalex.org/I4210158318"]},{"raw_affiliation_string":"Zhejiang University School of Medicine Center for Clinical Big Data and Analytics of the Second Affiliated Hospital and School of Public Health, , Hangzhou 310058,","institution_ids":["https://openalex.org/I4210158318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112113716","display_name":"Yun Zhu","orcid":"https://orcid.org/0000-0001-6656-3891"},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yun Zhu","raw_affiliation_strings":["Center of Clinical Big Data and Analytics of the Second Affiliated Hospital and School of Public Health, Zhejiang University School of Medicine , Hangzhou 310058,","Zhejiang University School of Medicine Center for Clinical Big Data and Analytics of the Second Affiliated Hospital and School of Public Health, , Hangzhou 310058,"],"affiliations":[{"raw_affiliation_string":"Center of Clinical Big Data and Analytics of the Second Affiliated Hospital and School of Public Health, Zhejiang University School of Medicine , Hangzhou 310058,","institution_ids":["https://openalex.org/I4210158318"]},{"raw_affiliation_string":"Zhejiang University School of Medicine Center for Clinical Big Data and Analytics of the Second Affiliated Hospital and School of Public Health, , Hangzhou 310058,","institution_ids":["https://openalex.org/I4210158318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040148135","display_name":"Andi Xu","orcid":null},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Andi Xu","raw_affiliation_strings":["Center of Clinical Big Data and Analytics of the Second Affiliated Hospital and School of Public Health, Zhejiang University School of Medicine , Hangzhou 310058,","Zhejiang University School of Medicine Center for Clinical Big Data and Analytics of the Second Affiliated Hospital and School of Public Health, , Hangzhou 310058,"],"affiliations":[{"raw_affiliation_string":"Center of Clinical Big Data and Analytics of the Second Affiliated Hospital and School of Public Health, Zhejiang University School of Medicine , Hangzhou 310058,","institution_ids":["https://openalex.org/I4210158318"]},{"raw_affiliation_string":"Zhejiang University School of Medicine Center for Clinical Big Data and Analytics of the Second Affiliated Hospital and School of Public Health, , Hangzhou 310058,","institution_ids":["https://openalex.org/I4210158318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087602260","display_name":"Weifang Zheng","orcid":null},"institutions":[{"id":"https://openalex.org/I4210106396","display_name":"Shanxi Province Hospital of Traditional Chinese Medicine","ror":"https://ror.org/01m06ya33","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106396"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weifang Zheng","raw_affiliation_strings":["Lanxi Hospital of Traditional Chinese Medicine , Lanxi 321100,"],"affiliations":[{"raw_affiliation_string":"Lanxi Hospital of Traditional Chinese Medicine , Lanxi 321100,","institution_ids":["https://openalex.org/I4210106396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109744988","display_name":"Yuanxing Tu","orcid":"https://orcid.org/0009-0001-5259-4643"},"institutions":[{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]},{"id":"https://openalex.org/I4210124531","display_name":"Lanzhou University Second Hospital","ror":"https://ror.org/02erhaz63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124531"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanxing Tu","raw_affiliation_strings":["The Second Affiliated Hospital of Zhejiang University School of Medicine, Lanxi Branch (Lanxi People\u2019s Hospital) , Lanxi 321100,"],"affiliations":[{"raw_affiliation_string":"The Second Affiliated Hospital of Zhejiang University School of Medicine, Lanxi Branch (Lanxi People\u2019s Hospital) , Lanxi 321100,","institution_ids":["https://openalex.org/I76214153","https://openalex.org/I4210124531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100624948","display_name":"Dan Zhou","orcid":"https://orcid.org/0000-0002-5313-8164"},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dan Zhou","raw_affiliation_strings":["Center of Clinical Big Data and Analytics of the Second Affiliated Hospital and School of Public Health, Zhejiang University School of Medicine , Hangzhou 310058,","Zhejiang University School of Medicine Center for Clinical Big Data and Analytics of the Second Affiliated Hospital and School of Public Health, , Hangzhou 310058,"],"affiliations":[{"raw_affiliation_string":"Center of Clinical Big Data and Analytics of the Second Affiliated Hospital and School of Public Health, Zhejiang University School of Medicine , Hangzhou 310058,","institution_ids":["https://openalex.org/I4210158318"]},{"raw_affiliation_string":"Zhejiang University School of Medicine Center for Clinical Big Data and Analytics of the Second Affiliated Hospital and School of Public Health, , Hangzhou 310058,","institution_ids":["https://openalex.org/I4210158318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100360783","display_name":"Wenyuan Li","orcid":"https://orcid.org/0000-0001-6196-9964"},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenyuan Li","raw_affiliation_strings":["Center of Clinical Big Data and Analytics of the Second Affiliated Hospital and School of Public Health, Zhejiang University School of Medicine , Hangzhou 310058,","Zhejiang University School of Medicine Center for Clinical Big Data and Analytics of the Second Affiliated Hospital and School of Public Health, , Hangzhou 310058,"],"affiliations":[{"raw_affiliation_string":"Center of Clinical Big Data and Analytics of the Second Affiliated Hospital and School of Public Health, Zhejiang University School of Medicine , Hangzhou 310058,","institution_ids":["https://openalex.org/I4210158318"]},{"raw_affiliation_string":"Zhejiang University School of Medicine Center for Clinical Big Data and Analytics of the Second Affiliated Hospital and School of Public Health, , Hangzhou 310058,","institution_ids":["https://openalex.org/I4210158318"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032513924","display_name":"Xifeng Wu","orcid":"https://orcid.org/0000-0003-2980-8129"},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]},{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]},{"id":"https://openalex.org/I4210123185","display_name":"Zhejiang Lab","ror":"https://ror.org/02m2h7991","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210123185"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xifeng Wu","raw_affiliation_strings":["Center of Clinical Big Data and Analytics of the Second Affiliated Hospital and School of Public Health, Zhejiang University School of Medicine , Hangzhou 310058,","National Institute for Data Science in Health and Medicine, Zhejiang University , Hangzhou 310058,","Zhejiang Key Laboratory of Intelligent Preventive Medicine , Hangzhou 310058,","Zhejiang University School of Medicine Center for Clinical Big Data and Analytics of the Second Affiliated Hospital and School of Public Health, , Hangzhou 310058,"],"affiliations":[{"raw_affiliation_string":"Center of Clinical Big Data and Analytics of the Second Affiliated Hospital and School of Public Health, Zhejiang University School of Medicine , Hangzhou 310058,","institution_ids":["https://openalex.org/I4210158318"]},{"raw_affiliation_string":"National Institute for Data Science in Health and Medicine, Zhejiang University , Hangzhou 310058,","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Zhejiang Key Laboratory of Intelligent Preventive Medicine , Hangzhou 310058,","institution_ids":["https://openalex.org/I4210123185"]},{"raw_affiliation_string":"Zhejiang University School of Medicine Center for Clinical Big Data and Analytics of the Second Affiliated Hospital and School of Public Health, , Hangzhou 310058,","institution_ids":["https://openalex.org/I4210158318"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5087621232"],"corresponding_institution_ids":["https://openalex.org/I4210158318","https://openalex.org/I4210165441"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":{"value":3500,"currency":"USD","value_usd":3500},"fwci":2.3261,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.88197192,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"23","issue":"5","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11107","display_name":"Selenium in Biological Systems","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11107","display_name":"Selenium in Biological Systems","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11626","display_name":"Metalloenzymes and iron-sulfur proteins","score":0.9426000118255615,"subfield":{"id":"https://openalex.org/subfields/2105","display_name":"Renewable Energy, Sustainability and the Environment"},"field":{"id":"https://openalex.org/fields/21","display_name":"Energy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.9307000041007996,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mendelian-randomization","display_name":"Mendelian randomization","score":0.7422186732292175},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6065796613693237},{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"Cognitive decline","score":0.573810875415802},{"id":"https://openalex.org/keywords/whole-genome-sequencing","display_name":"Whole genome sequencing","score":0.5657908320426941},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"Genome-wide association study","score":0.5561246275901794},{"id":"https://openalex.org/keywords/genetic-association","display_name":"Genetic association","score":0.5529574751853943},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.5522366762161255},{"id":"https://openalex.org/keywords/missense-mutation","display_name":"Missense mutation","score":0.5062114596366882},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.4994349479675293},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.46786975860595703},{"id":"https://openalex.org/keywords/cohort","display_name":"Cohort","score":0.4321010708808899},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.37309569120407104},{"id":"https://openalex.org/keywords/dementia","display_name":"Dementia","score":0.3510446548461914},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.33230745792388916},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3272692561149597},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2927953004837036},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.23894348740577698},{"id":"https://openalex.org/keywords/genetic-variants","display_name":"Genetic variants","score":0.2216968834400177},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.19769969582557678},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.1937553882598877},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.12541288137435913}],"concepts":[{"id":"https://openalex.org/C2779901538","wikidata":"https://www.wikidata.org/wiki/Q6816584","display_name":"Mendelian randomization","level":5,"score":0.7422186732292175},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6065796613693237},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.573810875415802},{"id":"https://openalex.org/C24432333","wikidata":"https://www.wikidata.org/wiki/Q2068526","display_name":"Whole genome sequencing","level":4,"score":0.5657908320426941},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.5561246275901794},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.5529574751853943},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5522366762161255},{"id":"https://openalex.org/C75563809","wikidata":"https://www.wikidata.org/wiki/Q2656896","display_name":"Missense mutation","level":4,"score":0.5062114596366882},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4994349479675293},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.46786975860595703},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4321010708808899},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.37309569120407104},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.3510446548461914},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.33230745792388916},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3272692561149597},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2927953004837036},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.23894348740577698},{"id":"https://openalex.org/C2993967602","wikidata":"https://www.wikidata.org/wiki/Q5532932","display_name":"Genetic variants","level":4,"score":0.2216968834400177},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.19769969582557678},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.1937553882598877},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12541288137435913}],"mesh":[{"descriptor_ui":"D000073336","descriptor_name":"Whole Genome Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000073336","descriptor_name":"Whole Genome Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000073336","descriptor_name":"Whole Genome Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000073336","descriptor_name":"Whole Genome Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000073336","descriptor_name":"Whole Genome Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000095225","descriptor_name":"East Asian People","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000095225","descriptor_name":"East Asian People","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000095225","descriptor_name":"East Asian People","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000095225","descriptor_name":"East Asian People","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000095225","descriptor_name":"East Asian People","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044466","descriptor_name":"Asian People","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044466","descriptor_name":"Asian People","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/gpbjnl/qzaf063","is_oa":true,"landing_page_url":"https://doi.org/10.1093/gpbjnl/qzaf063","pdf_url":"https://academic.oup.com/gpb/advance-article-pdf/doi/10.1093/gpbjnl/qzaf063/63880987/qzaf063.pdf","source":{"id":"https://openalex.org/S155547894","display_name":"Genomics Proteomics & Bioinformatics","issn_l":"1672-0229","issn":["1672-0229","2210-3244"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, Proteomics &amp; Bioinformatics","raw_type":"journal-article"},{"id":"pmid:40728933","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40728933","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, proteomics & bioinformatics","raw_type":null},{"id":"pmh:oai:europepmc.org:11370191","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12561000","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/gpbjnl/qzaf063","is_oa":true,"landing_page_url":"https://doi.org/10.1093/gpbjnl/qzaf063","pdf_url":"https://academic.oup.com/gpb/advance-article-pdf/doi/10.1093/gpbjnl/qzaf063/63880987/qzaf063.pdf","source":{"id":"https://openalex.org/S155547894","display_name":"Genomics Proteomics & Bioinformatics","issn_l":"1672-0229","issn":["1672-0229","2210-3244"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, Proteomics &amp; Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4412712845.pdf","grobid_xml":"https://content.openalex.org/works/W4412712845.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W1524156658","https://openalex.org/W1962263973","https://openalex.org/W1976836793","https://openalex.org/W2023381648","https://openalex.org/W2027875873","https://openalex.org/W2033151532","https://openalex.org/W2048505725","https://openalex.org/W2056985030","https://openalex.org/W2076188217","https://openalex.org/W2088581544","https://openalex.org/W2090705041","https://openalex.org/W2104549677","https://openalex.org/W2115182824","https://openalex.org/W2117089459","https://openalex.org/W2119180969","https://openalex.org/W2122395704","https://openalex.org/W2138345444","https://openalex.org/W2153860431","https://openalex.org/W2160995259","https://openalex.org/W2195783463","https://openalex.org/W2322302990","https://openalex.org/W2325841306","https://openalex.org/W2338893726","https://openalex.org/W2595351638","https://openalex.org/W2612881983","https://openalex.org/W2735794637","https://openalex.org/W2751686252","https://openalex.org/W2767834727","https://openalex.org/W2804255833","https://openalex.org/W2806395345","https://openalex.org/W2889290358","https://openalex.org/W2899967672","https://openalex.org/W2908002252","https://openalex.org/W2952113787","https://openalex.org/W2991212521","https://openalex.org/W2998968185","https://openalex.org/W3027871553","https://openalex.org/W3038671590","https://openalex.org/W3080999617","https://openalex.org/W3086336778","https://openalex.org/W3097162850","https://openalex.org/W3097163877","https://openalex.org/W3112120242","https://openalex.org/W3123589318","https://openalex.org/W3128898883","https://openalex.org/W3135386161","https://openalex.org/W3158867024","https://openalex.org/W3177165321","https://openalex.org/W3179300690","https://openalex.org/W3190031729","https://openalex.org/W3191451220","https://openalex.org/W3210382439","https://openalex.org/W4200583373","https://openalex.org/W4220820191","https://openalex.org/W4281716488","https://openalex.org/W4283020314","https://openalex.org/W4296196825","https://openalex.org/W4300717350","https://openalex.org/W4304193755","https://openalex.org/W4307838508","https://openalex.org/W4308616119","https://openalex.org/W4312181330","https://openalex.org/W4313453265","https://openalex.org/W4366819447","https://openalex.org/W4378212201"],"related_works":["https://openalex.org/W2901309888","https://openalex.org/W2169283889","https://openalex.org/W4210703904","https://openalex.org/W2052821216","https://openalex.org/W4404875725","https://openalex.org/W2036527494","https://openalex.org/W2610080820","https://openalex.org/W4294125588","https://openalex.org/W2416849719","https://openalex.org/W2015148400"],"abstract_inverted_index":{"Subjective":[0],"cognitive":[1,171],"decline":[2],"(SCD)":[3],"is":[4,98],"widely":[5],"regarded":[6],"as":[7,136],"a":[8,65,104,129,137,186],"potential":[9,138],"preclinical":[10],"stage":[11,54],"of":[12,93,174,216],"Alzheimer's":[13],"disease":[14],"(AD),":[15],"yet":[16],"its":[17,110],"genetic":[18,29,182,202],"basis":[19],"remains":[20],"poorly":[21],"understood.":[22],"To":[23],"address":[24],"this":[25],"gap,":[26],"we":[27,68,83,124,164],"investigated":[28,70],"biomarkers":[30],"associated":[31,76,120],"with":[32,58,77,121],"SCD":[33,141,181,197],"using":[34],"whole-genome":[35],"sequencing":[36],"(WGS)":[37],"in":[38,100,113,133,158,196],"10,763":[39],"Chinese":[40],"participants":[41],"from":[42,177,204],"the":[43,90,178,194,213],"Healthy":[44],"Zhejiang":[45],"One":[46],"Million":[47],"People":[48],"Cohort":[49],"(HOPE":[50],"Cohort).":[51],"The":[52],"discovery":[53],"included":[55],"9284":[56],"samples,":[57],"1479":[59],"samples":[60],"used":[61],"for":[62,140],"validation.":[63],"Using":[64],"two-stage":[66],"design,":[67],"systematically":[69],"both":[71,114,151],"common":[72,162],"and":[73,85,95,103,116,153,209],"rare":[74,80,145],"variants":[75],"SCD.":[78,96,217],"In":[79],"variant":[81],"analyses,":[82],"identified":[84,125],"replicated":[86],"an":[87,205],"association":[88],"between":[89],"upstream":[91],"region":[92],"SEPHS2":[94,97,152],"involved":[99],"selenophosphate":[101],"synthesis,":[102],"Mendelian":[105],"randomization":[106],"analysis":[107],"reveals":[108],"that":[109,150],"expression":[111],"levels":[112],"blood":[115],"brain":[117],"cerebellum":[118],"are":[119],"AD.":[122],"Additionally,":[123],"CLVS2,":[126],"which":[127,175],"encodes":[128],"protein":[130],"primarily":[131],"expressed":[132],"neuronal":[134],"cells,":[135],"regulator":[139],"based":[142],"on":[143],"missense":[144],"variants.":[146],"Multi-omics":[147],"evidence":[148,203],"suggests":[149],"CLVS2":[154],"may":[155],"play":[156],"roles":[157],"neurodegenerative":[159],"diseases.":[160],"For":[161],"variants,":[163],"validated":[165],"8":[166],"known":[167],"loci":[168],"related":[169],"to":[170],"decline,":[172],"3":[173],"originated":[176],"only":[179],"existing":[180],"study":[183,192],"conducted":[184],"under":[185],"migraine":[187],"background.":[188],"Overall,":[189],"our":[190],"WGS-based":[191],"fills":[193],"gap":[195],"research":[198],"by":[199],"providing":[200],"vital":[201],"East":[206],"Asian":[207],"population":[208],"offers":[210],"insights":[211],"into":[212],"pathogenic":[214],"mechanisms":[215]},"counts_by_year":[{"year":2025,"cited_by_count":2}],"updated_date":"2026-03-23T07:41:27.035349","created_date":"2025-10-10T00:00:00"}
