{"id":"https://openalex.org/W4410301465","doi":"https://doi.org/10.1093/gpbjnl/qzaf044","title":"CircAge: A Comprehensive Resource for Aging-associated Circular RNAs Across Species and Tissues","display_name":"CircAge: A Comprehensive Resource for Aging-associated Circular RNAs Across Species and Tissues","publication_year":2025,"publication_date":"2025-05-12","ids":{"openalex":"https://openalex.org/W4410301465","doi":"https://doi.org/10.1093/gpbjnl/qzaf044","pmid":"https://pubmed.ncbi.nlm.nih.gov/40353835"},"language":"en","primary_location":{"id":"doi:10.1093/gpbjnl/qzaf044","is_oa":true,"landing_page_url":"https://doi.org/10.1093/gpbjnl/qzaf044","pdf_url":"https://academic.oup.com/gpb/advance-article-pdf/doi/10.1093/gpbjnl/qzaf044/63155410/qzaf044.pdf","source":{"id":"https://openalex.org/S155547894","display_name":"Genomics Proteomics & Bioinformatics","issn_l":"1672-0229","issn":["1672-0229","2210-3244"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, Proteomics & Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/gpb/advance-article-pdf/doi/10.1093/gpbjnl/qzaf044/63155410/qzaf044.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114948745","display_name":"Xin Dong","orcid":"https://orcid.org/0000-0002-8692-7469"},"institutions":[{"id":"https://openalex.org/I18489884","display_name":"Kunming Institute of Zoology","ror":"https://ror.org/03m0vk445","country_code":"CN","type":"facility","lineage":["https://openalex.org/I18489884","https://openalex.org/I19820366"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Dong","raw_affiliation_strings":["State Key Laboratory of Genetic Evolution & Animal Models, Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences , Kunming 650201,"],"raw_orcid":"https://orcid.org/0000-0002-8692-7469","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Genetic Evolution & Animal Models, Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences , Kunming 650201,","institution_ids":["https://openalex.org/I18489884","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zhen Zhou","orcid":"https://orcid.org/0009-0004-1701-473X"},"institutions":[{"id":"https://openalex.org/I18489884","display_name":"Kunming Institute of Zoology","ror":"https://ror.org/03m0vk445","country_code":"CN","type":"facility","lineage":["https://openalex.org/I18489884","https://openalex.org/I19820366"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhen Zhou","raw_affiliation_strings":["State Key Laboratory of Genetic Evolution & Animal Models, Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences , Kunming 650201,","University of Chinese Academy of Sciences , Beijing 100049,"],"raw_orcid":"https://orcid.org/0009-0004-1701-473X","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Genetic Evolution & Animal Models, Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences , Kunming 650201,","institution_ids":["https://openalex.org/I18489884","https://openalex.org/I19820366"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences , Beijing 100049,","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yanan Wang","orcid":"https://orcid.org/0000-0002-7144-603X"},"institutions":[{"id":"https://openalex.org/I18489884","display_name":"Kunming Institute of Zoology","ror":"https://ror.org/03m0vk445","country_code":"CN","type":"facility","lineage":["https://openalex.org/I18489884","https://openalex.org/I19820366"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanan Wang","raw_affiliation_strings":["Biodiversity Data Center of Kunming Institute of Zoology, Chinese Academy of Sciences , Kunming 650201,","State Key Laboratory of Genetic Evolution & Animal Models, Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences , Kunming 650201,","University of Chinese Academy of Sciences , Beijing 100049,","Yunnan Key Laboratory of Biodiversity Information, Kunming Institute of Zoology, Chinese Academy of Sciences , Kunming 650201,","Chinese Academy of Sciences Biodiversity Data Center of Kunming Institute of Zoology, , Kunming 650201,"],"raw_orcid":"https://orcid.org/0000-0002-7144-603X","affiliations":[{"raw_affiliation_string":"Biodiversity Data Center of Kunming Institute of Zoology, Chinese Academy of Sciences , Kunming 650201,","institution_ids":["https://openalex.org/I18489884"]},{"raw_affiliation_string":"State Key Laboratory of Genetic Evolution & Animal Models, Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences , Kunming 650201,","institution_ids":["https://openalex.org/I18489884","https://openalex.org/I19820366"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences , Beijing 100049,","institution_ids":["https://openalex.org/I4210165038"]},{"raw_affiliation_string":"Yunnan Key Laboratory of Biodiversity Information, Kunming Institute of Zoology, Chinese Academy of Sciences , Kunming 650201,","institution_ids":["https://openalex.org/I18489884","https://openalex.org/I19820366"]},{"raw_affiliation_string":"Chinese Academy of Sciences Biodiversity Data Center of Kunming Institute of Zoology, , Kunming 650201,","institution_ids":["https://openalex.org/I18489884"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ayesha Nisar","orcid":"https://orcid.org/0009-0009-3416-7494"},"institutions":[{"id":"https://openalex.org/I18489884","display_name":"Kunming Institute of Zoology","ror":"https://ror.org/03m0vk445","country_code":"CN","type":"facility","lineage":["https://openalex.org/I18489884","https://openalex.org/I19820366"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ayesha Nisar","raw_affiliation_strings":["State Key Laboratory of Genetic Evolution & Animal Models, Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences , Kunming 650201,","University of Chinese Academy of Sciences , Beijing 100049,"],"raw_orcid":"https://orcid.org/0009-0009-3416-7494","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Genetic Evolution & Animal Models, Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences , Kunming 650201,","institution_ids":["https://openalex.org/I18489884","https://openalex.org/I19820366"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences , Beijing 100049,","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012811861","display_name":"Shao-Yan Pu","orcid":null},"institutions":[{"id":"https://openalex.org/I18489884","display_name":"Kunming Institute of Zoology","ror":"https://ror.org/03m0vk445","country_code":"CN","type":"facility","lineage":["https://openalex.org/I18489884","https://openalex.org/I19820366"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shaoyan Pu","raw_affiliation_strings":["Biodiversity Data Center of Kunming Institute of Zoology, Chinese Academy of Sciences , Kunming 650201,","State Key Laboratory of Genetic Evolution & Animal Models, Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences , Kunming 650201,","Yunnan Key Laboratory of Biodiversity Information, Kunming Institute of Zoology, Chinese Academy of Sciences , Kunming 650201,","Chinese Academy of Sciences Biodiversity Data Center of Kunming Institute of Zoology, , Kunming 650201,"],"raw_orcid":"https://orcid.org/0009-0009-5441-4763","affiliations":[{"raw_affiliation_string":"Biodiversity Data Center of Kunming Institute of Zoology, Chinese Academy of Sciences , Kunming 650201,","institution_ids":["https://openalex.org/I18489884"]},{"raw_affiliation_string":"State Key Laboratory of Genetic Evolution & Animal Models, Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences , Kunming 650201,","institution_ids":["https://openalex.org/I18489884","https://openalex.org/I19820366"]},{"raw_affiliation_string":"Yunnan Key Laboratory of Biodiversity Information, Kunming Institute of Zoology, Chinese Academy of Sciences , Kunming 650201,","institution_ids":["https://openalex.org/I18489884","https://openalex.org/I19820366"]},{"raw_affiliation_string":"Chinese Academy of Sciences Biodiversity Data Center of Kunming Institute of Zoology, , Kunming 650201,","institution_ids":["https://openalex.org/I18489884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067408475","display_name":"Longbao Lv","orcid":"https://orcid.org/0000-0002-8437-6333"},"institutions":[{"id":"https://openalex.org/I18489884","display_name":"Kunming Institute of Zoology","ror":"https://ror.org/03m0vk445","country_code":"CN","type":"facility","lineage":["https://openalex.org/I18489884","https://openalex.org/I19820366"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Longbao Lv","raw_affiliation_strings":["Laboratory Animal Center, Kunming Institute of Zoology, Chinese Academy of Sciences , Kunming 650201,","National Resource Center for Non-Human Primates, Kunming Institute of Zoology, Chinese Academy of Sciences , Kunming 650201,"],"raw_orcid":"https://orcid.org/0000-0002-8437-6333","affiliations":[{"raw_affiliation_string":"Laboratory Animal Center, Kunming Institute of Zoology, Chinese Academy of Sciences , Kunming 650201,","institution_ids":["https://openalex.org/I18489884"]},{"raw_affiliation_string":"National Resource Center for Non-Human Primates, Kunming Institute of Zoology, Chinese Academy of Sciences , Kunming 650201,","institution_ids":["https://openalex.org/I18489884","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114950409","display_name":"Yijiang Li","orcid":"https://orcid.org/0009-0003-3287-5944"},"institutions":[{"id":"https://openalex.org/I18489884","display_name":"Kunming Institute of Zoology","ror":"https://ror.org/03m0vk445","country_code":"CN","type":"facility","lineage":["https://openalex.org/I18489884","https://openalex.org/I19820366"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yijiang Li","raw_affiliation_strings":["Laboratory Animal Center, Kunming Institute of Zoology, Chinese Academy of Sciences , Kunming 650201,","National Resource Center for Non-Human Primates, Kunming Institute of Zoology, Chinese Academy of Sciences , Kunming 650201,"],"raw_orcid":"https://orcid.org/0009-0003-3287-5944","affiliations":[{"raw_affiliation_string":"Laboratory Animal Center, Kunming Institute of Zoology, Chinese Academy of Sciences , Kunming 650201,","institution_ids":["https://openalex.org/I18489884"]},{"raw_affiliation_string":"National Resource Center for Non-Human Primates, Kunming Institute of Zoology, Chinese Academy of Sciences , Kunming 650201,","institution_ids":["https://openalex.org/I18489884","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087729652","display_name":"Xuemei Lu","orcid":"https://orcid.org/0000-0001-6044-6002"},"institutions":[{"id":"https://openalex.org/I18489884","display_name":"Kunming Institute of Zoology","ror":"https://ror.org/03m0vk445","country_code":"CN","type":"facility","lineage":["https://openalex.org/I18489884","https://openalex.org/I19820366"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuemei Lu","raw_affiliation_strings":["Biodiversity Data Center of Kunming Institute of Zoology, Chinese Academy of Sciences , Kunming 650201,","State Key Laboratory of Genetic Evolution & Animal Models, Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences , Kunming 650201,","University of Chinese Academy of Sciences , Beijing 100049,","Yunnan Key Laboratory of Biodiversity Information, Kunming Institute of Zoology, Chinese Academy of Sciences , Kunming 650201,","Chinese Academy of Sciences Biodiversity Data Center of Kunming Institute of Zoology, , Kunming 650201,"],"raw_orcid":"https://orcid.org/0000-0001-6044-6002","affiliations":[{"raw_affiliation_string":"Biodiversity Data Center of Kunming Institute of Zoology, Chinese Academy of Sciences , Kunming 650201,","institution_ids":["https://openalex.org/I18489884"]},{"raw_affiliation_string":"State Key Laboratory of Genetic Evolution & Animal Models, Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences , Kunming 650201,","institution_ids":["https://openalex.org/I18489884","https://openalex.org/I19820366"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences , Beijing 100049,","institution_ids":["https://openalex.org/I4210165038"]},{"raw_affiliation_string":"Yunnan Key Laboratory of Biodiversity Information, Kunming Institute of Zoology, Chinese Academy of Sciences , Kunming 650201,","institution_ids":["https://openalex.org/I18489884","https://openalex.org/I19820366"]},{"raw_affiliation_string":"Chinese Academy of Sciences Biodiversity Data Center of Kunming Institute of Zoology, , Kunming 650201,","institution_ids":["https://openalex.org/I18489884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064289105","display_name":"Yonghan He","orcid":"https://orcid.org/0000-0003-4409-4590"},"institutions":[{"id":"https://openalex.org/I18489884","display_name":"Kunming Institute of Zoology","ror":"https://ror.org/03m0vk445","country_code":"CN","type":"facility","lineage":["https://openalex.org/I18489884","https://openalex.org/I19820366"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yonghan He","raw_affiliation_strings":["State Key Laboratory of Genetic Evolution & Animal Models, Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences , Kunming 650201,","University of Chinese Academy of Sciences , Beijing 100049,"],"raw_orcid":"https://orcid.org/0000-0003-4409-4590","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Genetic Evolution & Animal Models, Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences , Kunming 650201,","institution_ids":["https://openalex.org/I18489884","https://openalex.org/I19820366"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences , Beijing 100049,","institution_ids":["https://openalex.org/I4210165038"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":{"value":3500,"currency":"USD","value_usd":3500},"fwci":1.7279,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.83648473,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"23","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9858999848365784,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circular-rna","display_name":"Circular RNA","score":0.7261765003204346},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6927369832992554},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6842935085296631},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.6683845520019531},{"id":"https://openalex.org/keywords/non-coding-rna","display_name":"Non-coding RNA","score":0.5385646820068359},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.5184961557388306},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.4163852334022522},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2848259508609772},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2584928274154663}],"concepts":[{"id":"https://openalex.org/C2775893923","wikidata":"https://www.wikidata.org/wiki/Q17113455","display_name":"Circular RNA","level":4,"score":0.7261765003204346},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6927369832992554},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6842935085296631},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.6683845520019531},{"id":"https://openalex.org/C194993378","wikidata":"https://www.wikidata.org/wiki/Q427087","display_name":"Non-coding RNA","level":4,"score":0.5385646820068359},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5184961557388306},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4163852334022522},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2848259508609772},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2584928274154663}],"mesh":[{"descriptor_ui":"D000079962","descriptor_name":"RNA, Circular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000079962","descriptor_name":"RNA, Circular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000079962","descriptor_name":"RNA, Circular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000079962","descriptor_name":"RNA, Circular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000079962","descriptor_name":"RNA, Circular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000079962","descriptor_name":"RNA, Circular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008253","descriptor_name":"Macaca mulatta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008253","descriptor_name":"Macaca mulatta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008253","descriptor_name":"Macaca mulatta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/gpbjnl/qzaf044","is_oa":true,"landing_page_url":"https://doi.org/10.1093/gpbjnl/qzaf044","pdf_url":"https://academic.oup.com/gpb/advance-article-pdf/doi/10.1093/gpbjnl/qzaf044/63155410/qzaf044.pdf","source":{"id":"https://openalex.org/S155547894","display_name":"Genomics Proteomics & Bioinformatics","issn_l":"1672-0229","issn":["1672-0229","2210-3244"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, Proteomics & Bioinformatics","raw_type":"journal-article"},{"id":"pmid:40353835","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40353835","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, proteomics & bioinformatics","raw_type":null},{"id":"pmh:oai:europepmc.org:11257707","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12448220","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:12448220","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12448220/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Genomics Proteomics Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/gpbjnl/qzaf044","is_oa":true,"landing_page_url":"https://doi.org/10.1093/gpbjnl/qzaf044","pdf_url":"https://academic.oup.com/gpb/advance-article-pdf/doi/10.1093/gpbjnl/qzaf044/63155410/qzaf044.pdf","source":{"id":"https://openalex.org/S155547894","display_name":"Genomics Proteomics & Bioinformatics","issn_l":"1672-0229","issn":["1672-0229","2210-3244"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, Proteomics & Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.47999998927116394,"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land"}],"awards":[{"id":"https://openalex.org/G4098923704","display_name":null,"funder_award_id":"82171558","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6682497220","display_name":null,"funder_award_id":"82471599","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321133","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35"},{"id":"https://openalex.org/F4320321543","display_name":"China Postdoctoral Science Foundation","ror":"https://ror.org/0426zh255"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4410301465.pdf","grobid_xml":"https://content.openalex.org/works/W4410301465.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1966411071","https://openalex.org/W1991082489","https://openalex.org/W2023139734","https://openalex.org/W2035618305","https://openalex.org/W2041509376","https://openalex.org/W2048194168","https://openalex.org/W2115662330","https://openalex.org/W2134629862","https://openalex.org/W2142678478","https://openalex.org/W2169456326","https://openalex.org/W2464424326","https://openalex.org/W2565297817","https://openalex.org/W2617715606","https://openalex.org/W2768632638","https://openalex.org/W2884961061","https://openalex.org/W2912017471","https://openalex.org/W2942409680","https://openalex.org/W2950826375","https://openalex.org/W2990125632","https://openalex.org/W3020855961","https://openalex.org/W3043586480","https://openalex.org/W3080715228","https://openalex.org/W3194665116","https://openalex.org/W3201334827","https://openalex.org/W4206027885","https://openalex.org/W4281911383","https://openalex.org/W4311928702","https://openalex.org/W4312158493","https://openalex.org/W4386947375"],"related_works":["https://openalex.org/W3028919671","https://openalex.org/W2024248021","https://openalex.org/W4323652392","https://openalex.org/W4401192968","https://openalex.org/W3168973927","https://openalex.org/W3030028889","https://openalex.org/W2058984380","https://openalex.org/W1988125422","https://openalex.org/W3038088324","https://openalex.org/W2900182103"],"abstract_inverted_index":{"Circular":[0],"RNAs":[1],"(circRNAs)":[2],"represent":[3],"a":[4,12,32,45,93,137,149],"novel":[5,167],"class":[6],"of":[7,105,132,144,152,166,179],"RNA":[8],"molecules":[9],"characterized":[10],"by":[11],"circular":[13],"structure":[14],"and":[15,57,73,123,127,169,175,181,186],"enhanced":[16],"stability.":[17],"Emerging":[18],"evidence":[19],"indicates":[20],"that":[21,35],"circRNAs":[22,106,145],"play":[23],"pivotal":[24],"regulatory":[25,142],"roles":[26],"in":[27,96,146,160],"the":[28,129,141,164,177],"aging":[29,173,185],"process.":[30],"However,":[31],"systematic":[33],"resource":[34,135],"integrates":[36],"aging-associated":[37,153],"circRNA":[38,97],"data":[39,90],"remains":[40],"lacking.":[41],"Therefore,":[42],"we":[43,64,83],"developed":[44],"comprehensive":[46,150],"database,":[47],"CircAge,":[48],"which":[49],"encompasses":[50],"756":[51],"aging-related":[52],"samples":[53,70],"from":[54,71,79],"7":[55],"species":[56],"24":[58],"tissue":[59,69],"types.":[60],"Through":[61],"high-throughput":[62],"sequencing,":[63],"also":[65],"generated":[66],"47":[67],"new":[68],"mice":[72],"rhesus":[74],"monkeys.":[75],"By":[76],"integrating":[77],"predictions":[78],"multiple":[80],"bioinformatics":[81],"tools,":[82],"identified":[84],"over":[85],"529,856":[86],"unique":[87],"circRNAs.":[88,133],"Our":[89],"analysis":[91],"revealed":[92],"general":[94],"increase":[95],"expression":[98],"levels":[99],"with":[100,102],"age,":[101],"approximately":[103],"23%":[104],"demonstrating":[107],"sequence":[108],"conservation":[109],"across":[110],"species.":[111],"The":[112],"CircAge":[113,155,189],"database":[114],"systematically":[115],"predicts":[116],"potential":[117,131],"interactions":[118],"between":[119],"circRNAs,":[120,154],"microRNAs":[121],"(miRNAs),":[122],"RNA-binding":[124],"proteins":[125],"(RBPs),":[126],"assesses":[128],"coding":[130],"This":[134],"lays":[136],"foundation":[138],"for":[139,172,184],"elucidating":[140],"mechanisms":[143],"aging.":[147],"As":[148],"repository":[151],"will":[156],"significantly":[157],"accelerate":[158],"research":[159],"this":[161],"field,":[162],"facilitating":[163],"discovery":[165],"biomarkers":[168],"therapeutic":[170,182],"targets":[171],"biology":[174],"supporting":[176],"development":[178],"diagnostic":[180],"strategies":[183],"age-related":[187],"diseases.":[188],"is":[190],"publicly":[191],"available":[192],"at":[193],"https://circage.kiz.ac.cn.":[194]},"counts_by_year":[{"year":2026,"cited_by_count":3}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}