{"id":"https://openalex.org/W4403423012","doi":"https://doi.org/10.1093/gpbjnl/qzae073","title":"MitoSort: Robust Demultiplexing of Pooled Single-cell Genomic Data Using Endogenous Mitochondrial Variants","display_name":"MitoSort: Robust Demultiplexing of Pooled Single-cell Genomic Data Using Endogenous Mitochondrial Variants","publication_year":2024,"publication_date":"2024-10-01","ids":{"openalex":"https://openalex.org/W4403423012","doi":"https://doi.org/10.1093/gpbjnl/qzae073","pmid":"https://pubmed.ncbi.nlm.nih.gov/39404807"},"language":"en","primary_location":{"id":"doi:10.1093/gpbjnl/qzae073","is_oa":true,"landing_page_url":"https://doi.org/10.1093/gpbjnl/qzae073","pdf_url":null,"source":{"id":"https://openalex.org/S155547894","display_name":"Genomics Proteomics & Bioinformatics","issn_l":"1672-0229","issn":["1672-0229","2210-3244"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, Proteomics & Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/gpbjnl/qzae073","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102101497","display_name":"Zhongjie Tang","orcid":"https://orcid.org/0009-0003-0534-5411"},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhongjie Tang","raw_affiliation_strings":["State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University , Guangzhou 510275,","State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China"],"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University , Guangzhou 510275,","institution_ids":["https://openalex.org/I157773358"]},{"raw_affiliation_string":"State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114222079","display_name":"Weixing Zhang","orcid":null},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weixing Zhang","raw_affiliation_strings":["State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University , Guangzhou 510275,","State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China"],"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University , Guangzhou 510275,","institution_ids":["https://openalex.org/I157773358"]},{"raw_affiliation_string":"State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101185840","display_name":"Peiyu Shi","orcid":"https://orcid.org/0000-0002-4640-0830"},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peiyu Shi","raw_affiliation_strings":["State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University , Guangzhou 510275,","State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China"],"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University , Guangzhou 510275,","institution_ids":["https://openalex.org/I157773358"]},{"raw_affiliation_string":"State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112738657","display_name":"Sijun Li","orcid":"https://orcid.org/0009-0006-1426-4375"},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sijun Li","raw_affiliation_strings":["State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University , Guangzhou 510275,","State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China"],"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University , Guangzhou 510275,","institution_ids":["https://openalex.org/I157773358"]},{"raw_affiliation_string":"State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072035701","display_name":"Xinhui Li","orcid":"https://orcid.org/0000-0003-1837-4249"},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinhui Li","raw_affiliation_strings":["State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University , Guangzhou 510275,","State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China"],"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University , Guangzhou 510275,","institution_ids":["https://openalex.org/I157773358"]},{"raw_affiliation_string":"State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104246852","display_name":"Yueming Li","orcid":"https://orcid.org/0009-0001-4958-3337"},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yueming Li","raw_affiliation_strings":["State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University , Guangzhou 510275,","State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China"],"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University , Guangzhou 510275,","institution_ids":["https://openalex.org/I157773358"]},{"raw_affiliation_string":"State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111844656","display_name":"Yicong Xu","orcid":null},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yicong Xu","raw_affiliation_strings":["State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University , Guangzhou 510275,","State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China"],"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University , Guangzhou 510275,","institution_ids":["https://openalex.org/I157773358"]},{"raw_affiliation_string":"State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018058687","display_name":"Yaqing Shu","orcid":"https://orcid.org/0000-0003-2768-1654"},"institutions":[{"id":"https://openalex.org/I4210146956","display_name":"Third Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/04tm3k558","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146956"]},{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yaqing Shu","raw_affiliation_strings":["Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University , Guangzhou 510630,","Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China"],"affiliations":[{"raw_affiliation_string":"Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University , Guangzhou 510630,","institution_ids":["https://openalex.org/I4210146956","https://openalex.org/I157773358"]},{"raw_affiliation_string":"Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China","institution_ids":["https://openalex.org/I4210146956","https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065347293","display_name":"Zheng Hu","orcid":"https://orcid.org/0000-0003-1552-0060"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210145761","display_name":"Shenzhen Institutes of Advanced Technology","ror":"https://ror.org/04gh4er46","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zheng Hu","raw_affiliation_strings":["CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences , Shenzhen 518055,","CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China"],"affiliations":[{"raw_affiliation_string":"CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences , Shenzhen 518055,","institution_ids":["https://openalex.org/I4210145761"]},{"raw_affiliation_string":"CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China","institution_ids":["https://openalex.org/I4210145761","https://openalex.org/I19820366"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086474710","display_name":"Jin Xu","orcid":"https://orcid.org/0000-0003-0944-9835"},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jin Xu","raw_affiliation_strings":["State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University , Guangzhou 510275,","State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China"],"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University , Guangzhou 510275,","institution_ids":["https://openalex.org/I157773358"]},{"raw_affiliation_string":"State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China","institution_ids":["https://openalex.org/I157773358"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5102101497"],"corresponding_institution_ids":["https://openalex.org/I157773358"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":{"value":3500,"currency":"USD","value_usd":3500},"fwci":1.0976,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.77433765,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"22","issue":"5","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9894000291824341,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.677415668964386},{"id":"https://openalex.org/keywords/barcode","display_name":"Barcode","score":0.6405280828475952},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6379473805427551},{"id":"https://openalex.org/keywords/single-cell-sequencing","display_name":"Single cell sequencing","score":0.5636925101280212},{"id":"https://openalex.org/keywords/genomics","display_name":"Genomics","score":0.5581579208374023},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.5286672115325928},{"id":"https://openalex.org/keywords/dna-sequencing","display_name":"DNA sequencing","score":0.4448933005332947},{"id":"https://openalex.org/keywords/single-cell-analysis","display_name":"Single-cell analysis","score":0.42562156915664673},{"id":"https://openalex.org/keywords/multiplex","display_name":"Multiplex","score":0.41665828227996826},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.41019344329833984},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.39781275391578674},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.39551740884780884},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.22379839420318604},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.21903717517852783},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.1981094777584076},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.15196266770362854},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.14800605177879333},{"id":"https://openalex.org/keywords/exome-sequencing","display_name":"Exome sequencing","score":0.14137259125709534}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.677415668964386},{"id":"https://openalex.org/C2776841711","wikidata":"https://www.wikidata.org/wiki/Q856","display_name":"Barcode","level":2,"score":0.6405280828475952},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6379473805427551},{"id":"https://openalex.org/C174749747","wikidata":"https://www.wikidata.org/wiki/Q15917269","display_name":"Single cell sequencing","level":5,"score":0.5636925101280212},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.5581579208374023},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5286672115325928},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.4448933005332947},{"id":"https://openalex.org/C2776950831","wikidata":"https://www.wikidata.org/wiki/Q15635432","display_name":"Single-cell analysis","level":3,"score":0.42562156915664673},{"id":"https://openalex.org/C2781188995","wikidata":"https://www.wikidata.org/wiki/Q6934982","display_name":"Multiplex","level":2,"score":0.41665828227996826},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.41019344329833984},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.39781275391578674},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.39551740884780884},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.22379839420318604},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.21903717517852783},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.1981094777584076},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.15196266770362854},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14800605177879333},{"id":"https://openalex.org/C16671776","wikidata":"https://www.wikidata.org/wiki/Q5420592","display_name":"Exome sequencing","level":4,"score":0.14137259125709534},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/gpbjnl/qzae073","is_oa":true,"landing_page_url":"https://doi.org/10.1093/gpbjnl/qzae073","pdf_url":null,"source":{"id":"https://openalex.org/S155547894","display_name":"Genomics Proteomics & Bioinformatics","issn_l":"1672-0229","issn":["1672-0229","2210-3244"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, Proteomics & Bioinformatics","raw_type":"journal-article"},{"id":"pmid:39404807","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39404807","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, proteomics & bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11671100","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11671100","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Genomics Proteomics Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/gpbjnl/qzae073","is_oa":true,"landing_page_url":"https://doi.org/10.1093/gpbjnl/qzae073","pdf_url":null,"source":{"id":"https://openalex.org/S155547894","display_name":"Genomics Proteomics & Bioinformatics","issn_l":"1672-0229","issn":["1672-0229","2210-3244"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, Proteomics & Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1602702667","https://openalex.org/W2071499539","https://openalex.org/W2119180969","https://openalex.org/W2121690903","https://openalex.org/W2155943701","https://openalex.org/W2169456326","https://openalex.org/W2774307122","https://openalex.org/W2785085486","https://openalex.org/W2946902586","https://openalex.org/W2951068818","https://openalex.org/W2965985232","https://openalex.org/W2995043840","https://openalex.org/W2997393200","https://openalex.org/W3023290106","https://openalex.org/W3048598023","https://openalex.org/W3113268000","https://openalex.org/W3164692211","https://openalex.org/W3164839005","https://openalex.org/W3180701164","https://openalex.org/W3194665116","https://openalex.org/W3206783061","https://openalex.org/W3207939237","https://openalex.org/W3210860076","https://openalex.org/W4206106410","https://openalex.org/W4213457742","https://openalex.org/W4220665746","https://openalex.org/W4221018545","https://openalex.org/W4223992851","https://openalex.org/W4281965038","https://openalex.org/W4283324185","https://openalex.org/W4289988756","https://openalex.org/W4307425817","https://openalex.org/W4313318449","https://openalex.org/W4321370806","https://openalex.org/W4322768301","https://openalex.org/W4376867947","https://openalex.org/W4379521442","https://openalex.org/W4382537165","https://openalex.org/W4386858974","https://openalex.org/W4394808545"],"related_works":["https://openalex.org/W4311391842","https://openalex.org/W3205054884","https://openalex.org/W2754340319","https://openalex.org/W2922477528","https://openalex.org/W2946428860","https://openalex.org/W4205731710","https://openalex.org/W2945005309","https://openalex.org/W2584157879","https://openalex.org/W4236025140","https://openalex.org/W2734237109"],"abstract_inverted_index":{"Multiplexing":[0],"across":[1],"donors":[2,207],"has":[3],"emerged":[4],"as":[5,69],"a":[6,100,199],"popular":[7],"strategy":[8],"to":[9,56,107,110,176],"increase":[10],"throughput,":[11],"reduce":[12],"costs,":[13],"overcome":[14],"technical":[15],"batch":[16],"effects,":[17],"and":[18,89,114,135,146,151,172,210,222],"improve":[19],"doublet":[20,152],"detection":[21,153],"in":[22,118,128,148,198,231],"single-cell":[23,40,57,70,119,178,213,233],"genomic":[24,65,120,234],"studies.":[25],"To":[26],"eliminate":[27],"additional":[28],"experimental":[29],"steps,":[30],"endogenous":[31,92],"nuclear":[32,64],"genome":[33],"variants":[34,84,106,187],"are":[35,85,188],"used":[36],"for":[37,72,94,154,165],"demultiplexing":[38,230],"pooled":[39,130,209],"RNA":[41],"sequencing":[42,58,76,179],"(scRNA-seq)":[43],"data":[44,138],"by":[45,126,212],"several":[46],"computational":[47,162],"tools.":[48],"However,":[49],"these":[50],"tools":[51],"have":[52],"limitations":[53,159],"when":[54],"applied":[55,175],"methods":[59],"that":[60,81,102,184],"do":[61],"not":[62],"cover":[63],"regions":[66],"well,":[67],"such":[68],"assay":[71],"transposase-accessible":[73],"chromatin":[74],"with":[75,139],"(scATAC-seq).":[77],"Here,":[78],"we":[79,192],"demonstrate":[80,193,219],"mitochondrial":[82,104,131,186],"germline":[83,105],"an":[86],"alternative,":[87],"robust,":[88],"computationally":[90],"efficient":[91],"barcode":[93],"sample":[95,229],"demultiplexing.":[96],"We":[97,122],"propose":[98],"MitoSort,":[99,225],"tool":[101],"uses":[103],"assign":[108],"cells":[109,204],"their":[111],"donor":[112],"origins":[113],"identify":[115],"cross-genotype":[116],"doublets":[117],"datasets.":[121],"evaluate":[123],"its":[124],"performance":[125],"using":[127],"silico":[129],"scATAC-seq":[132],"(mtscATAC-seq)":[133],"libraries":[134],"experimentally":[136],"multiplexed":[137],"cell":[140],"hashtags.":[141],"MitoSort":[142,169,197,236],"achieves":[143],"high":[144],"accuracy":[145,221],"efficiency":[147,223],"genotype":[149],"clustering":[150],"mtscATAC-seq":[155,182],"data,":[156],"addressing":[157],"the":[158,185,194,220],"of":[160,196,224],"current":[161],"techniques":[163],"tailored":[164],"scRNA-seq":[166],"data.":[167],"Moreover,":[168],"exhibits":[170],"versatility,":[171],"can":[173],"be":[174],"various":[177,232],"approaches":[180],"beyond":[181],"provided":[183],"reliably":[189],"detected.":[190],"Furthermore,":[191],"application":[195],"case":[200],"study":[201],"where":[202],"B":[203],"from":[205],"eight":[206],"were":[208],"assayed":[211],"multi-omics":[214],"sequencing.":[215],"Altogether,":[216],"our":[217],"results":[218],"which":[226],"enables":[227],"reliable":[228],"applications.":[235],"is":[237],"available":[238],"at":[239],"https://github.com/tangzhj/MitoSort.":[240]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1}],"updated_date":"2025-11-23T05:10:03.516525","created_date":"2024-10-16T00:00:00"}