{"id":"https://openalex.org/W4402942636","doi":"https://doi.org/10.1093/gpbjnl/qzae063","title":"RNA 5-Methylcytosine Modification: Regulatory Molecules, Biological Functions, and Human Diseases","display_name":"RNA 5-Methylcytosine Modification: Regulatory Molecules, Biological Functions, and Human Diseases","publication_year":2024,"publication_date":"2024-09-28","ids":{"openalex":"https://openalex.org/W4402942636","doi":"https://doi.org/10.1093/gpbjnl/qzae063","pmid":"https://pubmed.ncbi.nlm.nih.gov/39340806"},"language":"en","primary_location":{"id":"doi:10.1093/gpbjnl/qzae063","is_oa":true,"landing_page_url":"https://doi.org/10.1093/gpbjnl/qzae063","pdf_url":null,"source":{"id":"https://openalex.org/S155547894","display_name":"Genomics Proteomics & Bioinformatics","issn_l":"1672-0229","issn":["1672-0229","2210-3244"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, Proteomics & Bioinformatics","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/gpbjnl/qzae063","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Yanfang Lu","orcid":"https://orcid.org/0000-0002-3545-8842"},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]},{"id":"https://openalex.org/I4210163756","display_name":"Henan Provincial Center for Disease Control and Prevention","ror":"https://ror.org/01479r334","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210163756"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yanfang Lu","raw_affiliation_strings":["Department of Integrated Traditional and Western Nephrology, The First Affiliated Hospital of Zhengzhou University , Zhengzhou 450052,","Henan Province Research Center for Kidney Disease , Zhengzhou 450052,","Key Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province , Zhengzhou 450052,","Research Institute of Nephrology, Zhengzhou University , Zhengzhou 450052,","The First Affiliated Hospital of Zhengzhou University Department of Integrated Traditional and Western Nephrology, , Zhengzhou 450052,"],"raw_orcid":"https://orcid.org/0000-0002-3545-8842","affiliations":[{"raw_affiliation_string":"Department of Integrated Traditional and Western Nephrology, The First Affiliated Hospital of Zhengzhou University , Zhengzhou 450052,","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"Henan Province Research Center for Kidney Disease , Zhengzhou 450052,","institution_ids":["https://openalex.org/I4210163756"]},{"raw_affiliation_string":"Key Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province , Zhengzhou 450052,","institution_ids":[]},{"raw_affiliation_string":"Research Institute of Nephrology, Zhengzhou University , Zhengzhou 450052,","institution_ids":["https://openalex.org/I38877650"]},{"raw_affiliation_string":"The First Affiliated Hospital of Zhengzhou University Department of Integrated Traditional and Western Nephrology, , Zhengzhou 450052,","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Liu Yang","orcid":"https://orcid.org/0000-0003-0944-6554"},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]},{"id":"https://openalex.org/I4210163756","display_name":"Henan Provincial Center for Disease Control and Prevention","ror":"https://ror.org/01479r334","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210163756"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liu Yang","raw_affiliation_strings":["Department of Integrated Traditional and Western Nephrology, The First Affiliated Hospital of Zhengzhou University , Zhengzhou 450052,","Henan Province Research Center for Kidney Disease , Zhengzhou 450052,","Key Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province , Zhengzhou 450052,","Research Institute of Nephrology, Zhengzhou University , Zhengzhou 450052,","The First Affiliated Hospital of Zhengzhou University Department of Integrated Traditional and Western Nephrology, , Zhengzhou 450052,"],"raw_orcid":"https://orcid.org/0000-0003-0944-6554","affiliations":[{"raw_affiliation_string":"Department of Integrated Traditional and Western Nephrology, The First Affiliated Hospital of Zhengzhou University , Zhengzhou 450052,","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"Henan Province Research Center for Kidney Disease , Zhengzhou 450052,","institution_ids":["https://openalex.org/I4210163756"]},{"raw_affiliation_string":"Key Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province , Zhengzhou 450052,","institution_ids":[]},{"raw_affiliation_string":"Research Institute of Nephrology, Zhengzhou University , Zhengzhou 450052,","institution_ids":["https://openalex.org/I38877650"]},{"raw_affiliation_string":"The First Affiliated Hospital of Zhengzhou University Department of Integrated Traditional and Western Nephrology, , Zhengzhou 450052,","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101619755","display_name":"Qi Feng","orcid":"https://orcid.org/0000-0001-8724-5710"},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]},{"id":"https://openalex.org/I4210163756","display_name":"Henan Provincial Center for Disease Control and Prevention","ror":"https://ror.org/01479r334","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210163756"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qi Feng","raw_affiliation_strings":["Department of Integrated Traditional and Western Nephrology, The First Affiliated Hospital of Zhengzhou University , Zhengzhou 450052,","Henan Province Research Center for Kidney Disease , Zhengzhou 450052,","Key Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province , Zhengzhou 450052,","Research Institute of Nephrology, Zhengzhou University , Zhengzhou 450052,","The First Affiliated Hospital of Zhengzhou University Department of Integrated Traditional and Western Nephrology, , Zhengzhou 450052,"],"raw_orcid":"https://orcid.org/0000-0001-8724-5710","affiliations":[{"raw_affiliation_string":"Department of Integrated Traditional and Western Nephrology, The First Affiliated Hospital of Zhengzhou University , Zhengzhou 450052,","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"Henan Province Research Center for Kidney Disease , Zhengzhou 450052,","institution_ids":["https://openalex.org/I4210163756"]},{"raw_affiliation_string":"Key Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province , Zhengzhou 450052,","institution_ids":[]},{"raw_affiliation_string":"Research Institute of Nephrology, Zhengzhou University , Zhengzhou 450052,","institution_ids":["https://openalex.org/I38877650"]},{"raw_affiliation_string":"The First Affiliated Hospital of Zhengzhou University Department of Integrated Traditional and Western Nephrology, , Zhengzhou 450052,","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yong Liu","orcid":"https://orcid.org/0009-0001-9803-9303"},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]},{"id":"https://openalex.org/I4210163756","display_name":"Henan Provincial Center for Disease Control and Prevention","ror":"https://ror.org/01479r334","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210163756"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yong Liu","raw_affiliation_strings":["Department of Integrated Traditional and Western Nephrology, The First Affiliated Hospital of Zhengzhou University , Zhengzhou 450052,","Henan Province Research Center for Kidney Disease , Zhengzhou 450052,","Key Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province , Zhengzhou 450052,","Research Institute of Nephrology, Zhengzhou University , Zhengzhou 450052,","The First Affiliated Hospital of Zhengzhou University Department of Integrated Traditional and Western Nephrology, , Zhengzhou 450052,"],"raw_orcid":"https://orcid.org/0009-0001-9803-9303","affiliations":[{"raw_affiliation_string":"Department of Integrated Traditional and Western Nephrology, The First Affiliated Hospital of Zhengzhou University , Zhengzhou 450052,","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"Henan Province Research Center for Kidney Disease , Zhengzhou 450052,","institution_ids":["https://openalex.org/I4210163756"]},{"raw_affiliation_string":"Key Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province , Zhengzhou 450052,","institution_ids":[]},{"raw_affiliation_string":"Research Institute of Nephrology, Zhengzhou University , Zhengzhou 450052,","institution_ids":["https://openalex.org/I38877650"]},{"raw_affiliation_string":"The First Affiliated Hospital of Zhengzhou University Department of Integrated Traditional and Western Nephrology, , Zhengzhou 450052,","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xiaohui Sun","orcid":"https://orcid.org/0009-0006-9381-7467"},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]},{"id":"https://openalex.org/I4210163756","display_name":"Henan Provincial Center for Disease Control and Prevention","ror":"https://ror.org/01479r334","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210163756"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaohui Sun","raw_affiliation_strings":["Department of Integrated Traditional and Western Nephrology, The First Affiliated Hospital of Zhengzhou University , Zhengzhou 450052,","Henan Province Research Center for Kidney Disease , Zhengzhou 450052,","Key Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province , Zhengzhou 450052,","Research Institute of Nephrology, Zhengzhou University , Zhengzhou 450052,","The First Affiliated Hospital of Zhengzhou University Department of Integrated Traditional and Western Nephrology, , Zhengzhou 450052,"],"raw_orcid":"https://orcid.org/0009-0006-9381-7467","affiliations":[{"raw_affiliation_string":"Department of Integrated Traditional and Western Nephrology, The First Affiliated Hospital of Zhengzhou University , Zhengzhou 450052,","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"Henan Province Research Center for Kidney Disease , Zhengzhou 450052,","institution_ids":["https://openalex.org/I4210163756"]},{"raw_affiliation_string":"Key Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province , Zhengzhou 450052,","institution_ids":[]},{"raw_affiliation_string":"Research Institute of Nephrology, Zhengzhou University , Zhengzhou 450052,","institution_ids":["https://openalex.org/I38877650"]},{"raw_affiliation_string":"The First Affiliated Hospital of Zhengzhou University Department of Integrated Traditional and Western Nephrology, , Zhengzhou 450052,","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Dongwei Liu","orcid":"https://orcid.org/0000-0001-8292-2428"},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]},{"id":"https://openalex.org/I4210163756","display_name":"Henan Provincial Center for Disease Control and Prevention","ror":"https://ror.org/01479r334","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210163756"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dongwei Liu","raw_affiliation_strings":["Department of Integrated Traditional and Western Nephrology, The First Affiliated Hospital of Zhengzhou University , Zhengzhou 450052,","Henan Province Research Center for Kidney Disease , Zhengzhou 450052,","Key Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province , Zhengzhou 450052,","Research Institute of Nephrology, Zhengzhou University , Zhengzhou 450052,","The First Affiliated Hospital of Zhengzhou University Department of Integrated Traditional and Western Nephrology, , Zhengzhou 450052,"],"raw_orcid":"https://orcid.org/0000-0001-8292-2428","affiliations":[{"raw_affiliation_string":"Department of Integrated Traditional and Western Nephrology, The First Affiliated Hospital of Zhengzhou University , Zhengzhou 450052,","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"Henan Province Research Center for Kidney Disease , Zhengzhou 450052,","institution_ids":["https://openalex.org/I4210163756"]},{"raw_affiliation_string":"Key Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province , Zhengzhou 450052,","institution_ids":[]},{"raw_affiliation_string":"Research Institute of Nephrology, Zhengzhou University , Zhengzhou 450052,","institution_ids":["https://openalex.org/I38877650"]},{"raw_affiliation_string":"The First Affiliated Hospital of Zhengzhou University Department of Integrated Traditional and Western Nephrology, , Zhengzhou 450052,","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111345132","display_name":"Long Qiao","orcid":null},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Long Qiao","raw_affiliation_strings":["Department of Obstetrics and Gynecology, The First Affiliated Hospital of Zhengzhou University , Zhengzhou 450052,","The First Affiliated Hospital of Zhengzhou University Department of Obstetrics and Gynecology, , Zhengzhou 450052,"],"raw_orcid":"https://orcid.org/0009-0006-9475-6977","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, The First Affiliated Hospital of Zhengzhou University , Zhengzhou 450052,","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"The First Affiliated Hospital of Zhengzhou University Department of Obstetrics and Gynecology, , Zhengzhou 450052,","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"last","author":{"id":null,"display_name":"Zhangsuo Liu","orcid":"https://orcid.org/0000-0002-2916-8371"},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]},{"id":"https://openalex.org/I4210163756","display_name":"Henan Provincial Center for Disease Control and Prevention","ror":"https://ror.org/01479r334","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210163756"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhangsuo Liu","raw_affiliation_strings":["Department of Integrated Traditional and Western Nephrology, The First Affiliated Hospital of Zhengzhou University , Zhengzhou 450052,","Henan Province Research Center for Kidney Disease , Zhengzhou 450052,","Key Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province , Zhengzhou 450052,","Research Institute of Nephrology, Zhengzhou University , Zhengzhou 450052,","The First Affiliated Hospital of Zhengzhou University Department of Integrated Traditional and Western Nephrology, , Zhengzhou 450052,"],"raw_orcid":"https://orcid.org/0000-0002-2916-8371","affiliations":[{"raw_affiliation_string":"Department of Integrated Traditional and Western Nephrology, The First Affiliated Hospital of Zhengzhou University , Zhengzhou 450052,","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"Henan Province Research Center for Kidney Disease , Zhengzhou 450052,","institution_ids":["https://openalex.org/I4210163756"]},{"raw_affiliation_string":"Key Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province , Zhengzhou 450052,","institution_ids":[]},{"raw_affiliation_string":"Research Institute of Nephrology, Zhengzhou University , Zhengzhou 450052,","institution_ids":["https://openalex.org/I38877650"]},{"raw_affiliation_string":"The First Affiliated Hospital of Zhengzhou University Department of Integrated Traditional and Western Nephrology, , Zhengzhou 450052,","institution_ids":["https://openalex.org/I4210156804"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I38877650","https://openalex.org/I4210156804","https://openalex.org/I4210163756"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":{"value":3500,"currency":"USD","value_usd":3500},"fwci":9.0741,"has_fulltext":true,"cited_by_count":43,"citation_normalized_percentile":{"value":0.98701477,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"22","issue":"5","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9836000204086304,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.7362091541290283},{"id":"https://openalex.org/keywords/rna-methylation","display_name":"RNA methylation","score":0.7314651012420654},{"id":"https://openalex.org/keywords/5-methylcytosine","display_name":"5-Methylcytosine","score":0.6975254416465759},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6241863965988159},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6164373755455017},{"id":"https://openalex.org/keywords/epigenetics","display_name":"Epigenetics","score":0.5661916136741638},{"id":"https://openalex.org/keywords/non-coding-rna","display_name":"Non-coding RNA","score":0.5613702535629272},{"id":"https://openalex.org/keywords/methylation","display_name":"Methylation","score":0.4594572186470032},{"id":"https://openalex.org/keywords/small-nucleolar-rna","display_name":"Small nucleolar RNA","score":0.451272189617157},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.42995965480804443},{"id":"https://openalex.org/keywords/translation","display_name":"Translation (biology)","score":0.42265868186950684},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.36178216338157654},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.343711256980896},{"id":"https://openalex.org/keywords/messenger-rna","display_name":"Messenger RNA","score":0.33203646540641785},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.31510233879089355},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.3080763816833496},{"id":"https://openalex.org/keywords/methyltransferase","display_name":"Methyltransferase","score":0.23510169982910156}],"concepts":[{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.7362091541290283},{"id":"https://openalex.org/C2909856833","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"RNA methylation","level":5,"score":0.7314651012420654},{"id":"https://openalex.org/C2775926025","wikidata":"https://www.wikidata.org/wiki/Q238563","display_name":"5-Methylcytosine","level":5,"score":0.6975254416465759},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6241863965988159},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6164373755455017},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5661916136741638},{"id":"https://openalex.org/C194993378","wikidata":"https://www.wikidata.org/wiki/Q427087","display_name":"Non-coding RNA","level":4,"score":0.5613702535629272},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.4594572186470032},{"id":"https://openalex.org/C179255354","wikidata":"https://www.wikidata.org/wiki/Q284416","display_name":"Small nucleolar RNA","level":5,"score":0.451272189617157},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.42995965480804443},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.42265868186950684},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.36178216338157654},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.343711256980896},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.33203646540641785},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.31510233879089355},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3080763816833496},{"id":"https://openalex.org/C91965660","wikidata":"https://www.wikidata.org/wiki/Q415875","display_name":"Methyltransferase","level":4,"score":0.23510169982910156}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009422","descriptor_name":"Nervous System Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009422","descriptor_name":"Nervous System Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009422","descriptor_name":"Nervous System Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009422","descriptor_name":"Nervous System Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009422","descriptor_name":"Nervous System Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009422","descriptor_name":"Nervous System Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009422","descriptor_name":"Nervous System Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009422","descriptor_name":"Nervous System Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012323","descriptor_name":"RNA Processing, Post-Transcriptional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012323","descriptor_name":"RNA Processing, Post-Transcriptional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012323","descriptor_name":"RNA Processing, Post-Transcriptional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012323","descriptor_name":"RNA Processing, Post-Transcriptional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044503","descriptor_name":"5-Methylcytosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D044503","descriptor_name":"5-Methylcytosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D044503","descriptor_name":"5-Methylcytosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D044503","descriptor_name":"5-Methylcytosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/gpbjnl/qzae063","is_oa":true,"landing_page_url":"https://doi.org/10.1093/gpbjnl/qzae063","pdf_url":null,"source":{"id":"https://openalex.org/S155547894","display_name":"Genomics Proteomics & Bioinformatics","issn_l":"1672-0229","issn":["1672-0229","2210-3244"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, Proteomics & Bioinformatics","raw_type":"journal-article"},{"id":"pmid:39340806","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39340806","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, proteomics & bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11634542","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11634542","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11634542/pdf/qzae063.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Genomics Proteomics Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/gpbjnl/qzae063","is_oa":true,"landing_page_url":"https://doi.org/10.1093/gpbjnl/qzae063","pdf_url":null,"source":{"id":"https://openalex.org/S155547894","display_name":"Genomics Proteomics & Bioinformatics","issn_l":"1672-0229","issn":["1672-0229","2210-3244"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, Proteomics & Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.699999988079071}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321543","display_name":"China Postdoctoral Science Foundation","ror":"https://ror.org/0426zh255"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":135,"referenced_works":["https://openalex.org/W1982704134","https://openalex.org/W1993399405","https://openalex.org/W2000553262","https://openalex.org/W2002679485","https://openalex.org/W2005311687","https://openalex.org/W2006710298","https://openalex.org/W2009368068","https://openalex.org/W2014520526","https://openalex.org/W2015969705","https://openalex.org/W2016601469","https://openalex.org/W2022268135","https://openalex.org/W2025429390","https://openalex.org/W2027593734","https://openalex.org/W2031388575","https://openalex.org/W2034209061","https://openalex.org/W2042418666","https://openalex.org/W2047475913","https://openalex.org/W2055735408","https://openalex.org/W2058767191","https://openalex.org/W2060902122","https://openalex.org/W2067022150","https://openalex.org/W2068012865","https://openalex.org/W2074408785","https://openalex.org/W2075839436","https://openalex.org/W2076772609","https://openalex.org/W2082519344","https://openalex.org/W2085398950","https://openalex.org/W2089556958","https://openalex.org/W2104162210","https://openalex.org/W2105938928","https://openalex.org/W2107059185","https://openalex.org/W2114172458","https://openalex.org/W2124457156","https://openalex.org/W2124800414","https://openalex.org/W2142215195","https://openalex.org/W2143801120","https://openalex.org/W2150673739","https://openalex.org/W2172336833","https://openalex.org/W2231633301","https://openalex.org/W2254494421","https://openalex.org/W2271549028","https://openalex.org/W2406330893","https://openalex.org/W2430983120","https://openalex.org/W2431177894","https://openalex.org/W2468387813","https://openalex.org/W2491926383","https://openalex.org/W2543761474","https://openalex.org/W2566913469","https://openalex.org/W2579273737","https://openalex.org/W2606518593","https://openalex.org/W2610162195","https://openalex.org/W2610182762","https://openalex.org/W2618440801","https://openalex.org/W2736275121","https://openalex.org/W2758059175","https://openalex.org/W2766067960","https://openalex.org/W2800069764","https://openalex.org/W2806083865","https://openalex.org/W2902132997","https://openalex.org/W2909313210","https://openalex.org/W2942870687","https://openalex.org/W2943731512","https://openalex.org/W2950063384","https://openalex.org/W2952332808","https://openalex.org/W2953714283","https://openalex.org/W2955421618","https://openalex.org/W2962401373","https://openalex.org/W2964438344","https://openalex.org/W2964888213","https://openalex.org/W2969856544","https://openalex.org/W2971081901","https://openalex.org/W2990525514","https://openalex.org/W3009234466","https://openalex.org/W3011350719","https://openalex.org/W3017677886","https://openalex.org/W3033496910","https://openalex.org/W3036007662","https://openalex.org/W3039873626","https://openalex.org/W3088289001","https://openalex.org/W3089695391","https://openalex.org/W3091875011","https://openalex.org/W3107082551","https://openalex.org/W3107817913","https://openalex.org/W3111284728","https://openalex.org/W3111994907","https://openalex.org/W3113111785","https://openalex.org/W3119670691","https://openalex.org/W3132408699","https://openalex.org/W3156862212","https://openalex.org/W3166058209","https://openalex.org/W3166076308","https://openalex.org/W3189500593","https://openalex.org/W3190474970","https://openalex.org/W3195751733","https://openalex.org/W3197911804","https://openalex.org/W3204984018","https://openalex.org/W3211057632","https://openalex.org/W4200182409","https://openalex.org/W4200598219","https://openalex.org/W4220651986","https://openalex.org/W4221102781","https://openalex.org/W4225262085","https://openalex.org/W4229030257","https://openalex.org/W4283591898","https://openalex.org/W4283744632","https://openalex.org/W4285799774","https://openalex.org/W4288809011","https://openalex.org/W4290471425","https://openalex.org/W4290566873","https://openalex.org/W4290878242","https://openalex.org/W4293809656","https://openalex.org/W4297264236","https://openalex.org/W4300660849","https://openalex.org/W4306194490","https://openalex.org/W4307113712","https://openalex.org/W4307634271","https://openalex.org/W4310980196","https://openalex.org/W4313514510","https://openalex.org/W4319232511","https://openalex.org/W4320881106","https://openalex.org/W4321004288","https://openalex.org/W4321243233","https://openalex.org/W4353055397","https://openalex.org/W4365479145","https://openalex.org/W4367681360","https://openalex.org/W4376115823","https://openalex.org/W4378194936","https://openalex.org/W4382810518","https://openalex.org/W4385325577","https://openalex.org/W4385516410","https://openalex.org/W4385555185","https://openalex.org/W4389076163","https://openalex.org/W4389455318","https://openalex.org/W6783688834","https://openalex.org/W6845020252"],"related_works":["https://openalex.org/W4296034215","https://openalex.org/W4281776466","https://openalex.org/W4242611624","https://openalex.org/W2547129954","https://openalex.org/W2890134923","https://openalex.org/W2095206021","https://openalex.org/W3144341322","https://openalex.org/W2158875805","https://openalex.org/W2145052031","https://openalex.org/W2075676541"],"abstract_inverted_index":{"RNA":[0,20,54,65,80,105],"methylation":[1,21],"modifications":[2],"influence":[3],"gene":[4],"expression,":[5],"and":[6,32,49,62,82,90,108,117,159],"disruptions":[7],"of":[8,64,70,77,92,124,140,161,170],"these":[9],"processes":[10,133],"are":[11],"often":[12],"associated":[13],"with":[14,127],"various":[15,93,141],"human":[16,94,142,162],"diseases.":[17,95],"The":[18],"common":[19],"modification":[22,56,81,107],"5-methylcytosine":[23],"(m5C),":[24],"which":[25],"is":[26],"dynamically":[27],"regulated":[28],"by":[29,164],"writers,":[30],"erasers,":[31],"readers,":[33],"widely":[34],"occurs":[35],"in":[36,85,112,130,137],"transfer":[37],"RNAs":[38,41,44,47,52,125],"(tRNAs),":[39],"messenger":[40],"(mRNAs),":[42],"ribosomal":[43],"(rRNAs),":[45],"enhancer":[46],"(eRNAs),":[48],"other":[50],"non-coding":[51],"(ncRNAs).":[53],"m5C":[55,79,106,128,173],"regulates":[57],"metabolism,":[58],"stability,":[59],"nuclear":[60],"export,":[61],"translation":[63],"molecules.":[66],"An":[67],"increasing":[68],"number":[69],"studies":[71,103],"have":[72],"revealed":[73],"the":[74,78,86,101,110,122,138,156,166,171],"critical":[75],"roles":[76],"its":[83,113],"regulators":[84],"development,":[87],"diagnosis,":[88,157],"prognosis,":[89],"treatment":[91],"In":[96],"this":[97],"review,":[98],"we":[99,120],"summarized":[100],"recent":[102],"on":[104,155],"discussed":[109],"advances":[111],"detection":[114],"methodologies,":[115],"distribution,":[116],"regulators.":[118],"Furthermore,":[119],"addressed":[121],"significance":[123],"modified":[126],"marks":[129],"essential":[131],"biological":[132],"as":[134,136],"well":[135],"development":[139],"disorders,":[143],"from":[144],"neurological":[145],"diseases":[146,163],"to":[147],"cancers.":[148],"This":[149],"review":[150],"provides":[151],"a":[152],"new":[153],"perspective":[154],"treatment,":[158],"monitoring":[160],"elucidating":[165],"complex":[167],"regulatory":[168],"network":[169],"epigenetic":[172],"modification.":[174]},"counts_by_year":[{"year":2026,"cited_by_count":20},{"year":2025,"cited_by_count":23}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}