{"id":"https://openalex.org/W4396804652","doi":"https://doi.org/10.1093/gpbjnl/qzae035","title":"Comprehensive Characterization of the Integrin Family Across 32 Cancer Types","display_name":"Comprehensive Characterization of the Integrin Family Across 32 Cancer Types","publication_year":2024,"publication_date":"2024-05-09","ids":{"openalex":"https://openalex.org/W4396804652","doi":"https://doi.org/10.1093/gpbjnl/qzae035","pmid":"https://pubmed.ncbi.nlm.nih.gov/39436262"},"language":"en","primary_location":{"id":"doi:10.1093/gpbjnl/qzae035","is_oa":true,"landing_page_url":"https://doi.org/10.1093/gpbjnl/qzae035","pdf_url":"https://academic.oup.com/gpb/advance-article-pdf/doi/10.1093/gpbjnl/qzae035/57492979/qzae035.pdf","source":{"id":"https://openalex.org/S155547894","display_name":"Genomics Proteomics & Bioinformatics","issn_l":"1672-0229","issn":["1672-0229","2210-3244"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, Proteomics & Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/gpb/advance-article-pdf/doi/10.1093/gpbjnl/qzae035/57492979/qzae035.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061515529","display_name":"Cheng Zou","orcid":"https://orcid.org/0000-0003-3632-5221"},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cheng Zou","raw_affiliation_strings":["Hunan Key Laboratory of Animal Models and Molecular Medicine, School of Biomedical Sciences, Hunan University , Changsha 410082,","Hunan Key Laboratory of Animal Models and Molecular Medicine, School of Biomedical Sciences, Hunan University, Changsha 410082, China"],"raw_orcid":"https://orcid.org/0000-0003-3632-5221","affiliations":[{"raw_affiliation_string":"Hunan Key Laboratory of Animal Models and Molecular Medicine, School of Biomedical Sciences, Hunan University , Changsha 410082,","institution_ids":["https://openalex.org/I16609230"]},{"raw_affiliation_string":"Hunan Key Laboratory of Animal Models and Molecular Medicine, School of Biomedical Sciences, Hunan University, Changsha 410082, China","institution_ids":["https://openalex.org/I16609230"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103108011","display_name":"Jinwei Zhu","orcid":"https://orcid.org/0009-0008-4424-9744"},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinwei Zhu","raw_affiliation_strings":["Hunan Key Laboratory of Animal Models and Molecular Medicine, School of Biomedical Sciences, Hunan University , Changsha 410082,","Hunan Key Laboratory of Animal Models and Molecular Medicine, School of Biomedical Sciences, Hunan University, Changsha 410082, China"],"raw_orcid":"https://orcid.org/0009-0008-4424-9744","affiliations":[{"raw_affiliation_string":"Hunan Key Laboratory of Animal Models and Molecular Medicine, School of Biomedical Sciences, Hunan University , Changsha 410082,","institution_ids":["https://openalex.org/I16609230"]},{"raw_affiliation_string":"Hunan Key Laboratory of Animal Models and Molecular Medicine, School of Biomedical Sciences, Hunan University, Changsha 410082, China","institution_ids":["https://openalex.org/I16609230"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055799795","display_name":"Jiangling Xiong","orcid":"https://orcid.org/0009-0008-3803-646X"},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiangling Xiong","raw_affiliation_strings":["Hunan Key Laboratory of Animal Models and Molecular Medicine, School of Biomedical Sciences, Hunan University , Changsha 410082,","Hunan Key Laboratory of Animal Models and Molecular Medicine, School of Biomedical Sciences, Hunan University, Changsha 410082, China"],"raw_orcid":"https://orcid.org/0009-0008-3803-646X","affiliations":[{"raw_affiliation_string":"Hunan Key Laboratory of Animal Models and Molecular Medicine, School of Biomedical Sciences, Hunan University , Changsha 410082,","institution_ids":["https://openalex.org/I16609230"]},{"raw_affiliation_string":"Hunan Key Laboratory of Animal Models and Molecular Medicine, School of Biomedical Sciences, Hunan University, Changsha 410082, China","institution_ids":["https://openalex.org/I16609230"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037591167","display_name":"\u88d5 \u6b66\u7530","orcid":"https://orcid.org/0009-0004-5408-995X"},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Tian","raw_affiliation_strings":["Hunan Key Laboratory of Animal Models and Molecular Medicine, School of Biomedical Sciences, Hunan University , Changsha 410082,","Hunan Key Laboratory of Animal Models and Molecular Medicine, School of Biomedical Sciences, Hunan University, Changsha 410082, China"],"raw_orcid":"https://orcid.org/0009-0004-5408-995X","affiliations":[{"raw_affiliation_string":"Hunan Key Laboratory of Animal Models and Molecular Medicine, School of Biomedical Sciences, Hunan University , Changsha 410082,","institution_ids":["https://openalex.org/I16609230"]},{"raw_affiliation_string":"Hunan Key Laboratory of Animal Models and Molecular Medicine, School of Biomedical Sciences, Hunan University, Changsha 410082, China","institution_ids":["https://openalex.org/I16609230"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037335167","display_name":"Yousong Peng","orcid":"https://orcid.org/0000-0002-5482-9506"},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]},{"id":"https://openalex.org/I198357462","display_name":"Changsha University","ror":"https://ror.org/011d8sm39","country_code":"CN","type":"education","lineage":["https://openalex.org/I198357462"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yousong Peng","raw_affiliation_strings":["College of Biology, Hunan University , Changsha 410082,","College of Biology, Hunan University, Changsha 410082, China"],"raw_orcid":"https://orcid.org/0000-0002-5482-9506","affiliations":[{"raw_affiliation_string":"College of Biology, Hunan University , Changsha 410082,","institution_ids":["https://openalex.org/I16609230","https://openalex.org/I198357462"]},{"raw_affiliation_string":"College of Biology, Hunan University, Changsha 410082, China","institution_ids":["https://openalex.org/I16609230"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021671441","display_name":"Edwin Cheung","orcid":"https://orcid.org/0000-0001-8034-2833"},"institutions":[{"id":"https://openalex.org/I204512498","display_name":"University of Macau","ror":"https://ror.org/01r4q9n85","country_code":"MO","type":"education","lineage":["https://openalex.org/I204512498"]}],"countries":["MO"],"is_corresponding":false,"raw_author_name":"Edwin Cheung","raw_affiliation_strings":["Faculty of Health Sciences, University of Macau, Macau Special Administrative Region 999078 ,","Faculty of Health Sciences, University of Macau, Macau Special Administrative Region 999078, China"],"raw_orcid":"https://orcid.org/0000-0001-8034-2833","affiliations":[{"raw_affiliation_string":"Faculty of Health Sciences, University of Macau, Macau Special Administrative Region 999078 ,","institution_ids":["https://openalex.org/I204512498"]},{"raw_affiliation_string":"Faculty of Health Sciences, University of Macau, Macau Special Administrative Region 999078, China","institution_ids":["https://openalex.org/I204512498"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037292353","display_name":"Dingxiao Zhang","orcid":"https://orcid.org/0000-0001-8505-8831"},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dingxiao Zhang","raw_affiliation_strings":["Hunan Key Laboratory of Animal Models and Molecular Medicine, School of Biomedical Sciences, Hunan University , Changsha 410082,","Hunan Key Laboratory of Animal Models and Molecular Medicine, School of Biomedical Sciences, Hunan University, Changsha 410082, China"],"raw_orcid":"https://orcid.org/0000-0001-8505-8831","affiliations":[{"raw_affiliation_string":"Hunan Key Laboratory of Animal Models and Molecular Medicine, School of Biomedical Sciences, Hunan University , Changsha 410082,","institution_ids":["https://openalex.org/I16609230"]},{"raw_affiliation_string":"Hunan Key Laboratory of Animal Models and Molecular Medicine, School of Biomedical Sciences, Hunan University, Changsha 410082, China","institution_ids":["https://openalex.org/I16609230"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":{"value":3500,"currency":"USD","value_usd":3500},"fwci":1.9834,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.85847817,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"22","issue":"4","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9973000288009644,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9973000288009644,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9957000017166138,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/integrin","display_name":"Integrin","score":0.7584527730941772},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.5563696622848511},{"id":"https://openalex.org/keywords/metastasis","display_name":"Metastasis","score":0.5491422414779663},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5331472754478455},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"Carcinogenesis","score":0.5194103717803955},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.5087092518806458},{"id":"https://openalex.org/keywords/interactome","display_name":"Interactome","score":0.46877187490463257},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.4455472230911255},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3567044138908386},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3203684687614441},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2413707971572876},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.19356966018676758},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.1497420370578766}],"concepts":[{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.7584527730941772},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5563696622848511},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5491422414779663},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5331472754478455},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5194103717803955},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5087092518806458},{"id":"https://openalex.org/C9760119","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interactome","level":3,"score":0.46877187490463257},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.4455472230911255},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3567044138908386},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3203684687614441},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2413707971572876},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19356966018676758},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.1497420370578766},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016023","descriptor_name":"Integrins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016023","descriptor_name":"Integrins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016023","descriptor_name":"Integrins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016023","descriptor_name":"Integrins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016023","descriptor_name":"Integrins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016023","descriptor_name":"Integrins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016023","descriptor_name":"Integrins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016023","descriptor_name":"Integrins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016023","descriptor_name":"Integrins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016023","descriptor_name":"Integrins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016023","descriptor_name":"Integrins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016023","descriptor_name":"Integrins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/gpbjnl/qzae035","is_oa":true,"landing_page_url":"https://doi.org/10.1093/gpbjnl/qzae035","pdf_url":"https://academic.oup.com/gpb/advance-article-pdf/doi/10.1093/gpbjnl/qzae035/57492979/qzae035.pdf","source":{"id":"https://openalex.org/S155547894","display_name":"Genomics Proteomics & Bioinformatics","issn_l":"1672-0229","issn":["1672-0229","2210-3244"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, Proteomics & Bioinformatics","raw_type":"journal-article"},{"id":"pmid:39436262","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39436262","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, proteomics & bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11849494","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11849494","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11849494/pdf/qzae035.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Genomics Proteomics Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/gpbjnl/qzae035","is_oa":true,"landing_page_url":"https://doi.org/10.1093/gpbjnl/qzae035","pdf_url":"https://academic.oup.com/gpb/advance-article-pdf/doi/10.1093/gpbjnl/qzae035/57492979/qzae035.pdf","source":{"id":"https://openalex.org/S155547894","display_name":"Genomics Proteomics & Bioinformatics","issn_l":"1672-0229","issn":["1672-0229","2210-3244"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, Proteomics & Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2289398921","display_name":null,"funder_award_id":"81972418","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320316880","display_name":"Natural Science Foundation of Shenzhen City","ror":null},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321543","display_name":"China Postdoctoral Science Foundation","ror":"https://ror.org/0426zh255"},{"id":"https://openalex.org/F4320322191","display_name":"Hunan University","ror":"https://ror.org/05htk5m33"},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4396804652.pdf"},"referenced_works_count":75,"referenced_works":["https://openalex.org/W1497915798","https://openalex.org/W1648301895","https://openalex.org/W1870664662","https://openalex.org/W1985987855","https://openalex.org/W2009720434","https://openalex.org/W2014550839","https://openalex.org/W2021536610","https://openalex.org/W2032570745","https://openalex.org/W2051486518","https://openalex.org/W2058477547","https://openalex.org/W2060672294","https://openalex.org/W2061546218","https://openalex.org/W2065264929","https://openalex.org/W2073347802","https://openalex.org/W2100948523","https://openalex.org/W2101244168","https://openalex.org/W2108068107","https://openalex.org/W2114843025","https://openalex.org/W2117592563","https://openalex.org/W2117692326","https://openalex.org/W2117977572","https://openalex.org/W2118428599","https://openalex.org/W2121604817","https://openalex.org/W2126579192","https://openalex.org/W2130410032","https://openalex.org/W2130430382","https://openalex.org/W2141720111","https://openalex.org/W2147000598","https://openalex.org/W2152656267","https://openalex.org/W2153056550","https://openalex.org/W2159707944","https://openalex.org/W2172697812","https://openalex.org/W2179438025","https://openalex.org/W2263206910","https://openalex.org/W2285093314","https://openalex.org/W2288944226","https://openalex.org/W2346239022","https://openalex.org/W2469048362","https://openalex.org/W2604805073","https://openalex.org/W2741363425","https://openalex.org/W2768599330","https://openalex.org/W2795867722","https://openalex.org/W2795903481","https://openalex.org/W2795989238","https://openalex.org/W2796207838","https://openalex.org/W2801923213","https://openalex.org/W2867022353","https://openalex.org/W2889052854","https://openalex.org/W2911871569","https://openalex.org/W2912137016","https://openalex.org/W2920879064","https://openalex.org/W2922256857","https://openalex.org/W2973216672","https://openalex.org/W2973690026","https://openalex.org/W2991341799","https://openalex.org/W3004498009","https://openalex.org/W3029490475","https://openalex.org/W3036319615","https://openalex.org/W3080500495","https://openalex.org/W3111329050","https://openalex.org/W3117275669","https://openalex.org/W3121525105","https://openalex.org/W3135035839","https://openalex.org/W3146360245","https://openalex.org/W3162215872","https://openalex.org/W3175752499","https://openalex.org/W3199815956","https://openalex.org/W3211062415","https://openalex.org/W4200043367","https://openalex.org/W4206662285","https://openalex.org/W4210835170","https://openalex.org/W4220653476","https://openalex.org/W4223912833","https://openalex.org/W4283451354","https://openalex.org/W6797786779"],"related_works":["https://openalex.org/W4292634579","https://openalex.org/W2022326234","https://openalex.org/W1531941329","https://openalex.org/W4388694323","https://openalex.org/W3215098729","https://openalex.org/W4243081378","https://openalex.org/W1979330259","https://openalex.org/W2622356054","https://openalex.org/W2804670115","https://openalex.org/W2178844921"],"abstract_inverted_index":{"Integrin":[0,175],"genes":[1],"are":[2],"widely":[3],"involved":[4],"in":[5,30,89,109,121],"tumorigenesis.":[6],"Yet,":[7],"a":[8,41,65,71,90,99,171,189],"comprehensive":[9,190],"characterization":[10,191],"of":[11,60,67,74,161,192],"integrin":[12,28,61,87,106,166],"family":[13,29,62],"members":[14],"and":[15,44,49,76,134,143,196,199],"their":[16],"interactome":[17],"at":[18],"the":[19],"pan-cancer":[20],"level":[21,73],"is":[22],"lacking.":[23],"Here,":[24],"we":[25,97,157,169,187],"systematically":[26],"analyzed":[27],"approximately":[31],"10,000":[32],"tumors":[33,69,126],"across":[34,194],"32":[35],"cancer":[36],"types.":[37],"Globally,":[38],"integrins":[39,193],"represent":[40],"frequently":[42],"altered":[43],"misexpressed":[45],"pathway,":[46],"with":[47,70,117,124,137],"alteration":[48],"dysregulation":[50],"overall":[51],"being":[52,127],"protumorigenic.":[53],"Expression":[54],"dysregulation,":[55],"better":[56],"than":[57],"mutational":[58],"landscape,":[59],"successfully":[63],"identifies":[64],"subgroup":[66],"aggressive":[68],"high":[72],"proliferation":[75],"stemness.":[77],"The":[78],"results":[79],"reveal":[80],"that":[81,163],"several":[82],"molecular":[83,119],"mechanisms":[84],"collectively":[85],"regulate":[86],"expression":[88],"context-dependent":[91],"manner.":[92],"For":[93],"potential":[94],"clinical":[95],"usage,":[96],"constructed":[98],"weighted":[100],"scoring":[101],"system,":[102],"integrinScore,":[103],"to":[104,151,179,182],"measure":[105],"signaling":[107],"patterns":[108],"individual":[110],"tumors.":[111],"Remarkably,":[112],"integrinScore":[113,131],"was":[114,132],"consistently":[115],"correlated":[116],"predefined":[118],"subtypes":[120],"multiple":[122],"cancers,":[123],"integrinScore-high":[125],"more":[128],"aggressive.":[129],"Importantly,":[130],"cancer-dependent":[133],"closely":[135],"associated":[136],"proliferation,":[138],"stemness,":[139],"tumor":[140],"microenvironment,":[141],"metastasis,":[142],"immune":[144],"signatures.":[145],"IntegrinScore":[146],"also":[147],"predicted":[148],"patients'":[149],"response":[150],"immunotherapy.":[152],"By":[153],"mining":[154],"drug":[155],"databases,":[156],"unraveled":[158],"an":[159],"array":[160],"compounds":[162],"may":[164],"modulate":[165],"signaling.":[167],"Finally,":[168],"built":[170],"user-friendly":[172],"database,":[173],"Pan-cancer":[174],"Explorer":[176],"(PIExplorer;":[177],"http://computationalbiology.cn/PIExplorer),":[178],"facilitate":[180],"researchers":[181],"explore":[183],"integrin-related":[184],"knowledge.":[185],"Collectively,":[186],"provide":[188],"cancers":[195],"offer":[197],"gene-specific":[198],"cancer-specific":[200],"rationales":[201],"for":[202],"developing":[203],"integrin-targeted":[204],"therapy.":[205]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}