{"id":"https://openalex.org/W4392288691","doi":"https://doi.org/10.1093/gpbjnl/qzae019","title":"Substrate and Functional Diversity of Protein Lysine Post-translational Modifications","display_name":"Substrate and Functional Diversity of Protein Lysine Post-translational Modifications","publication_year":2024,"publication_date":"2024-02-01","ids":{"openalex":"https://openalex.org/W4392288691","doi":"https://doi.org/10.1093/gpbjnl/qzae019","pmid":"https://pubmed.ncbi.nlm.nih.gov/38862432"},"language":"en","primary_location":{"id":"doi:10.1093/gpbjnl/qzae019","is_oa":true,"landing_page_url":"https://doi.org/10.1093/gpbjnl/qzae019","pdf_url":"https://academic.oup.com/gpb/advance-article-pdf/doi/10.1093/gpbjnl/qzae019/56794455/qzae019.pdf","source":{"id":"https://openalex.org/S155547894","display_name":"Genomics Proteomics & Bioinformatics","issn_l":"1672-0229","issn":["1672-0229","2210-3244"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, Proteomics & Bioinformatics","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/gpb/advance-article-pdf/doi/10.1093/gpbjnl/qzae019/56794455/qzae019.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033669250","display_name":"Bingbing Hao","orcid":"https://orcid.org/0009-0006-8860-5582"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210112820","display_name":"Shanghai Institute of Materia Medica","ror":"https://ror.org/022syn853","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Bingbing Hao","raw_affiliation_strings":["State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203,","Tianjian Laboratory of Advanced Biomedical Sciences, Institute of Advanced Biomedical Sciences, Zhengzhou University , Zhengzhou 450001,","University of Chinese Academy of Sciences , Beijing 100049,","State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China","Tianjian Laboratory of Advanced Biomedical Sciences, Institute of Advanced Biomedical Sciences, Zhengzhou University, Zhengzhou 450001, China","University of Chinese Academy of Sciences, Beijing 100049, China"],"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203,","institution_ids":["https://openalex.org/I4210112820","https://openalex.org/I19820366"]},{"raw_affiliation_string":"Tianjian Laboratory of Advanced Biomedical Sciences, Institute of Advanced Biomedical Sciences, Zhengzhou University , Zhengzhou 450001,","institution_ids":["https://openalex.org/I38877650"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences , Beijing 100049,","institution_ids":["https://openalex.org/I4210165038"]},{"raw_affiliation_string":"State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China","institution_ids":["https://openalex.org/I4210112820","https://openalex.org/I19820366"]},{"raw_affiliation_string":"Tianjian Laboratory of Advanced Biomedical Sciences, Institute of Advanced Biomedical Sciences, Zhengzhou University, Zhengzhou 450001, China","institution_ids":["https://openalex.org/I38877650"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences, Beijing 100049, China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114546921","display_name":"Kaifeng Chen","orcid":"https://orcid.org/0009-0008-0602-2987"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112820","display_name":"Shanghai Institute of Materia Medica","ror":"https://ror.org/022syn853","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kaifeng Chen","raw_affiliation_strings":["State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203,","University of Chinese Academy of Sciences , Beijing 100049,","University of Chinese Academy of Sciences, Beijing 100049, China","State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China"],"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203,","institution_ids":["https://openalex.org/I4210112820","https://openalex.org/I19820366"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences , Beijing 100049,","institution_ids":["https://openalex.org/I4210165038"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences, Beijing 100049, China","institution_ids":["https://openalex.org/I4210165038"]},{"raw_affiliation_string":"State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China","institution_ids":["https://openalex.org/I4210112820","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087136121","display_name":"Linhui Zhai","orcid":"https://orcid.org/0000-0003-1576-4137"},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112820","display_name":"Shanghai Institute of Materia Medica","ror":"https://ror.org/022syn853","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Linhui Zhai","raw_affiliation_strings":["State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203,","State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University , Nanjing 210023,","Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Zhongshan 528400,","Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528400, China","State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China","State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210023, China"],"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203,","institution_ids":["https://openalex.org/I4210112820","https://openalex.org/I19820366"]},{"raw_affiliation_string":"State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University , Nanjing 210023,","institution_ids":["https://openalex.org/I161716053","https://openalex.org/I881766915"]},{"raw_affiliation_string":"Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Zhongshan 528400,","institution_ids":["https://openalex.org/I4210112820","https://openalex.org/I19820366"]},{"raw_affiliation_string":"Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528400, China","institution_ids":["https://openalex.org/I4210112820","https://openalex.org/I19820366"]},{"raw_affiliation_string":"State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China","institution_ids":["https://openalex.org/I4210112820","https://openalex.org/I19820366"]},{"raw_affiliation_string":"State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210023, China","institution_ids":["https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020286509","display_name":"Muyin Liu","orcid":"https://orcid.org/0000-0002-9954-4467"},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]},{"id":"https://openalex.org/I4210128921","display_name":"The First Affiliated Hospital, Sun Yat-sen University","ror":"https://ror.org/037p24858","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128921"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Muyin Liu","raw_affiliation_strings":["Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University , Shanghai 200032,","Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China"],"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University , Shanghai 200032,","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]},{"raw_affiliation_string":"Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China","institution_ids":["https://openalex.org/I4210128921","https://openalex.org/I4210127074","https://openalex.org/I24943067","https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100395563","display_name":"Bin Liu","orcid":"https://orcid.org/0000-0003-1569-2604"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bin Liu","raw_affiliation_strings":["Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, College of Pharmacy, Jiangsu Ocean University , Lianyungang 222005,","Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, College of Pharmacy, Jiangsu Ocean University, Lianyungang 222005, China"],"affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, College of Pharmacy, Jiangsu Ocean University , Lianyungang 222005,","institution_ids":[]},{"raw_affiliation_string":"Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, College of Pharmacy, Jiangsu Ocean University, Lianyungang 222005, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086770255","display_name":"Minjia Tan","orcid":"https://orcid.org/0000-0002-6784-9653"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112820","display_name":"Shanghai Institute of Materia Medica","ror":"https://ror.org/022syn853","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Minjia Tan","raw_affiliation_strings":["State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203,","University of Chinese Academy of Sciences , Beijing 100049,","Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Zhongshan 528400,","University of Chinese Academy of Sciences, Beijing 100049, China","Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528400, China","State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China"],"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203,","institution_ids":["https://openalex.org/I4210112820","https://openalex.org/I19820366"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences , Beijing 100049,","institution_ids":["https://openalex.org/I4210165038"]},{"raw_affiliation_string":"Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Zhongshan 528400,","institution_ids":["https://openalex.org/I4210112820","https://openalex.org/I19820366"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences, Beijing 100049, China","institution_ids":["https://openalex.org/I4210165038"]},{"raw_affiliation_string":"Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528400, China","institution_ids":["https://openalex.org/I4210112820","https://openalex.org/I19820366"]},{"raw_affiliation_string":"State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China","institution_ids":["https://openalex.org/I4210112820","https://openalex.org/I19820366"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5033669250"],"corresponding_institution_ids":["https://openalex.org/I19820366","https://openalex.org/I38877650","https://openalex.org/I4210112820","https://openalex.org/I4210165038"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":{"value":3500,"currency":"USD","value_usd":3500},"fwci":5.9306,"has_fulltext":true,"cited_by_count":26,"citation_normalized_percentile":{"value":0.97053434,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"22","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lysine","display_name":"Lysine","score":0.8024699687957764},{"id":"https://openalex.org/keywords/posttranslational-modification","display_name":"Posttranslational modification","score":0.6755023002624512},{"id":"https://openalex.org/keywords/substrate","display_name":"Substrate (aquarium)","score":0.5923119783401489},{"id":"https://openalex.org/keywords/substrate-specificity","display_name":"Substrate specificity","score":0.5634159445762634},{"id":"https://openalex.org/keywords/diversity","display_name":"Diversity (politics)","score":0.5270241498947144},{"id":"https://openalex.org/keywords/functional-diversity","display_name":"Functional diversity","score":0.5242112874984741},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.43877509236335754},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4139104187488556},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.34846261143684387},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.31020522117614746},{"id":"https://openalex.org/keywords/amino-acid","display_name":"Amino acid","score":0.2781250476837158},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.1784258782863617},{"id":"https://openalex.org/keywords/ecology","display_name":"Ecology","score":0.11902928352355957}],"concepts":[{"id":"https://openalex.org/C2776016237","wikidata":"https://www.wikidata.org/wiki/Q178430","display_name":"Lysine","level":3,"score":0.8024699687957764},{"id":"https://openalex.org/C100631289","wikidata":"https://www.wikidata.org/wiki/Q898362","display_name":"Posttranslational modification","level":3,"score":0.6755023002624512},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.5923119783401489},{"id":"https://openalex.org/C2994592520","wikidata":"https://www.wikidata.org/wiki/Q5090496","display_name":"Substrate specificity","level":3,"score":0.5634159445762634},{"id":"https://openalex.org/C2781316041","wikidata":"https://www.wikidata.org/wiki/Q1230584","display_name":"Diversity (politics)","level":2,"score":0.5270241498947144},{"id":"https://openalex.org/C2988890453","wikidata":"https://www.wikidata.org/wiki/Q5508815","display_name":"Functional diversity","level":2,"score":0.5242112874984741},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43877509236335754},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4139104187488556},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34846261143684387},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31020522117614746},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.2781250476837158},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1784258782863617},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.11902928352355957},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C19165224","wikidata":"https://www.wikidata.org/wiki/Q23404","display_name":"Anthropology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008239","descriptor_name":"Lysine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008239","descriptor_name":"Lysine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008239","descriptor_name":"Lysine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008239","descriptor_name":"Lysine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008239","descriptor_name":"Lysine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008239","descriptor_name":"Lysine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/gpbjnl/qzae019","is_oa":true,"landing_page_url":"https://doi.org/10.1093/gpbjnl/qzae019","pdf_url":"https://academic.oup.com/gpb/advance-article-pdf/doi/10.1093/gpbjnl/qzae019/56794455/qzae019.pdf","source":{"id":"https://openalex.org/S155547894","display_name":"Genomics Proteomics & Bioinformatics","issn_l":"1672-0229","issn":["1672-0229","2210-3244"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, Proteomics & Bioinformatics","raw_type":"journal-article"},{"id":"pmid:38862432","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38862432","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, proteomics & bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:12016574","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12016574","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12016574/pdf/qzae019.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Genomics Proteomics Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/gpbjnl/qzae019","is_oa":true,"landing_page_url":"https://doi.org/10.1093/gpbjnl/qzae019","pdf_url":"https://academic.oup.com/gpb/advance-article-pdf/doi/10.1093/gpbjnl/qzae019/56794455/qzae019.pdf","source":{"id":"https://openalex.org/S155547894","display_name":"Genomics Proteomics & Bioinformatics","issn_l":"1672-0229","issn":["1672-0229","2210-3244"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, Proteomics & Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1121271761","display_name":null,"funder_award_id":"Program","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1477544716","display_name":null,"funder_award_id":"Guangdong","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2087396116","display_name":null,"funder_award_id":"China","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2642236564","display_name":null,"funder_award_id":"32171434","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3085993365","display_name":null,"funder_award_id":"(Grant No.","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3317480652","display_name":null,"funder_award_id":"Science","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G391238517","display_name":null,"funder_award_id":", and","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4778903190","display_name":null,"funder_award_id":"81821005","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5939423041","display_name":null,"funder_award_id":"Technology","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5994120800","display_name":null,"funder_award_id":"Natural","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7608752429","display_name":null,"funder_award_id":"Talent","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7726157001","display_name":null,"funder_award_id":"Grant No.","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7887889386","display_name":null,"funder_award_id":"32071432","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8012778378","display_name":null,"funder_award_id":"22225702","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8464521582","display_name":null,"funder_award_id":"22XD1420900","funder_id":"https://openalex.org/F4320335796","funder_display_name":"Program of Shanghai Academic Research Leader"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320324852","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760"},{"id":"https://openalex.org/F4320326896","display_name":"State Key Laboratory of Pharmaceutical Biotechnology","ror":null},{"id":"https://openalex.org/F4320335796","display_name":"Program of Shanghai Academic Research Leader","ror":null}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4392288691.pdf"},"referenced_works_count":288,"referenced_works":["https://openalex.org/W196082105","https://openalex.org/W855491747","https://openalex.org/W1188264494","https://openalex.org/W1527383154","https://openalex.org/W1530314158","https://openalex.org/W1617606969","https://openalex.org/W1955146052","https://openalex.org/W1955278061","https://openalex.org/W1967619674","https://openalex.org/W1968637358","https://openalex.org/W1969899640","https://openalex.org/W1974515407","https://openalex.org/W1976295398","https://openalex.org/W1976596063","https://openalex.org/W1977147304","https://openalex.org/W1978321553","https://openalex.org/W1978720506","https://openalex.org/W1984658022","https://openalex.org/W1985003152","https://openalex.org/W1987909353","https://openalex.org/W1988031203","https://openalex.org/W1997952190","https://openalex.org/W2004380688","https://openalex.org/W2009826707","https://openalex.org/W2010429928","https://openalex.org/W2012165444","https://openalex.org/W2013587251","https://openalex.org/W2015345028","https://openalex.org/W2021710587","https://openalex.org/W2022760167","https://openalex.org/W2022922908","https://openalex.org/W2024588431","https://openalex.org/W2029001448","https://openalex.org/W2029130907","https://openalex.org/W2029903254","https://openalex.org/W2032991279","https://openalex.org/W2034439646","https://openalex.org/W2034614265","https://openalex.org/W2034717128","https://openalex.org/W2036357556","https://openalex.org/W2037877475","https://openalex.org/W2040788846","https://openalex.org/W2046301798","https://openalex.org/W2046345187","https://openalex.org/W2047045824","https://openalex.org/W2048611034","https://openalex.org/W2053851813","https://openalex.org/W2058065156","https://openalex.org/W2058434102","https://openalex.org/W2058901070","https://openalex.org/W2060354742","https://openalex.org/W2060882402","https://openalex.org/W2061184183","https://openalex.org/W2064437293","https://openalex.org/W2064921878","https://openalex.org/W2066745745","https://openalex.org/W2068078666","https://openalex.org/W2068499430","https://openalex.org/W2071430789","https://openalex.org/W2072155586","https://openalex.org/W2073590048","https://openalex.org/W2074129822","https://openalex.org/W2074329146","https://openalex.org/W2076194625","https://openalex.org/W2078495108","https://openalex.org/W2080553628","https://openalex.org/W2082592723","https://openalex.org/W2087714970","https://openalex.org/W2088511656","https://openalex.org/W2093700088","https://openalex.org/W2097263358","https://openalex.org/W2104130372","https://openalex.org/W2108979389","https://openalex.org/W2109845335","https://openalex.org/W2112447932","https://openalex.org/W2115862579","https://openalex.org/W2116062594","https://openalex.org/W2117514345","https://openalex.org/W2123829154","https://openalex.org/W2125517883","https://openalex.org/W2132485651","https://openalex.org/W2134095164","https://openalex.org/W2140219059","https://openalex.org/W2143538182","https://openalex.org/W2144379757","https://openalex.org/W2144633939","https://openalex.org/W2145745183","https://openalex.org/W2148741118","https://openalex.org/W2151026975","https://openalex.org/W2154986076","https://openalex.org/W2156475142","https://openalex.org/W2161413435","https://openalex.org/W2162002416","https://openalex.org/W2168921982","https://openalex.org/W2169880855","https://openalex.org/W2172012754","https://openalex.org/W2187478032","https://openalex.org/W2256642547","https://openalex.org/W2299508065","https://openalex.org/W2337350186","https://openalex.org/W2339716966","https://openalex.org/W2339772771","https://openalex.org/W2398560682","https://openalex.org/W2436312957","https://openalex.org/W2466668521","https://openalex.org/W2469206364","https://openalex.org/W2485886299","https://openalex.org/W2522255615","https://openalex.org/W2524879615","https://openalex.org/W2535463226","https://openalex.org/W2547642576","https://openalex.org/W2548531681","https://openalex.org/W2560129407","https://openalex.org/W2574401607","https://openalex.org/W2582452337","https://openalex.org/W2587137472","https://openalex.org/W2587873618","https://openalex.org/W2588201113","https://openalex.org/W2588760275","https://openalex.org/W2591935811","https://openalex.org/W2593444972","https://openalex.org/W2596064219","https://openalex.org/W2606879989","https://openalex.org/W2607585298","https://openalex.org/W2610365886","https://openalex.org/W2611495100","https://openalex.org/W2613130271","https://openalex.org/W2615638297","https://openalex.org/W2615829409","https://openalex.org/W2619266720","https://openalex.org/W2620472692","https://openalex.org/W2740419787","https://openalex.org/W2744865654","https://openalex.org/W2757682641","https://openalex.org/W2765094222","https://openalex.org/W2765633514","https://openalex.org/W2766922695","https://openalex.org/W2768844677","https://openalex.org/W2769807955","https://openalex.org/W2773645338","https://openalex.org/W2774906913","https://openalex.org/W2778449372","https://openalex.org/W2779743226","https://openalex.org/W2781959102","https://openalex.org/W2782311151","https://openalex.org/W2783301628","https://openalex.org/W2788462335","https://openalex.org/W2789195722","https://openalex.org/W2794342080","https://openalex.org/W2800196575","https://openalex.org/W2802116908","https://openalex.org/W2803484505","https://openalex.org/W2803754954","https://openalex.org/W2804756982","https://openalex.org/W2805922232","https://openalex.org/W2807292246","https://openalex.org/W2807645032","https://openalex.org/W2808998679","https://openalex.org/W2809303501","https://openalex.org/W2809438292","https://openalex.org/W2811227283","https://openalex.org/W2883006823","https://openalex.org/W2886279431","https://openalex.org/W2888201883","https://openalex.org/W2892042921","https://openalex.org/W2892763111","https://openalex.org/W2893791677","https://openalex.org/W2896845606","https://openalex.org/W2898489609","https://openalex.org/W2899910765","https://openalex.org/W2901744469","https://openalex.org/W2913126315","https://openalex.org/W2913761875","https://openalex.org/W2920947723","https://openalex.org/W2922787847","https://openalex.org/W2924776977","https://openalex.org/W2934913364","https://openalex.org/W2943411914","https://openalex.org/W2949886238","https://openalex.org/W2956607802","https://openalex.org/W2957519155","https://openalex.org/W2959957995","https://openalex.org/W2960484170","https://openalex.org/W2962480977","https://openalex.org/W2969180815","https://openalex.org/W2971693570","https://openalex.org/W2972180383","https://openalex.org/W2974503966","https://openalex.org/W2976557881","https://openalex.org/W2982216374","https://openalex.org/W2982630887","https://openalex.org/W2988547350","https://openalex.org/W2991176781","https://openalex.org/W2993780966","https://openalex.org/W2996264357","https://openalex.org/W2997007028","https://openalex.org/W2997396822","https://openalex.org/W2999253180","https://openalex.org/W3001423028","https://openalex.org/W3003441605","https://openalex.org/W3006291327","https://openalex.org/W3010697764","https://openalex.org/W3012638023","https://openalex.org/W3016613092","https://openalex.org/W3021201604","https://openalex.org/W3031875037","https://openalex.org/W3033104501","https://openalex.org/W3043267233","https://openalex.org/W3043639762","https://openalex.org/W3051945163","https://openalex.org/W3080164425","https://openalex.org/W3082862577","https://openalex.org/W3089917708","https://openalex.org/W3096781140","https://openalex.org/W3110510664","https://openalex.org/W3112029186","https://openalex.org/W3112644955","https://openalex.org/W3115758135","https://openalex.org/W3119572339","https://openalex.org/W3120171708","https://openalex.org/W3123057917","https://openalex.org/W3123248772","https://openalex.org/W3125269882","https://openalex.org/W3125546385","https://openalex.org/W3125967610","https://openalex.org/W3125983721","https://openalex.org/W3126771999","https://openalex.org/W3131093652","https://openalex.org/W3133262269","https://openalex.org/W3133450021","https://openalex.org/W3134161298","https://openalex.org/W3135140442","https://openalex.org/W3136101519","https://openalex.org/W3136448722","https://openalex.org/W3139050257","https://openalex.org/W3141770882","https://openalex.org/W3144967468","https://openalex.org/W3166678477","https://openalex.org/W3183573772","https://openalex.org/W3184657756","https://openalex.org/W3186939347","https://openalex.org/W3188077199","https://openalex.org/W3188662067","https://openalex.org/W3189265697","https://openalex.org/W3191137525","https://openalex.org/W3191620207","https://openalex.org/W3192752762","https://openalex.org/W3194892592","https://openalex.org/W3200668880","https://openalex.org/W3200745244","https://openalex.org/W3201746772","https://openalex.org/W3201754678","https://openalex.org/W3203773879","https://openalex.org/W3205559869","https://openalex.org/W3206354625","https://openalex.org/W3207087052","https://openalex.org/W3214133275","https://openalex.org/W3217810285","https://openalex.org/W4200147207","https://openalex.org/W4200432404","https://openalex.org/W4205702645","https://openalex.org/W4206661770","https://openalex.org/W4210860294","https://openalex.org/W4212895872","https://openalex.org/W4220670155","https://openalex.org/W4220884294","https://openalex.org/W4223995297","https://openalex.org/W4226088363","https://openalex.org/W4226268704","https://openalex.org/W4229376013","https://openalex.org/W4229450931","https://openalex.org/W4229457798","https://openalex.org/W4249409198","https://openalex.org/W4281783183","https://openalex.org/W4283331244","https://openalex.org/W4283377063","https://openalex.org/W4283697719","https://openalex.org/W4285384278","https://openalex.org/W4286776313","https://openalex.org/W4289711990","https://openalex.org/W4290085957","https://openalex.org/W4292673636","https://openalex.org/W4294024826","https://openalex.org/W4309046893","https://openalex.org/W4323349706","https://openalex.org/W6766685082","https://openalex.org/W6792145061","https://openalex.org/W6808599005"],"related_works":["https://openalex.org/W2412924645","https://openalex.org/W1968047324","https://openalex.org/W2069291669","https://openalex.org/W2321548162","https://openalex.org/W1518813207","https://openalex.org/W2427104702","https://openalex.org/W1997122699","https://openalex.org/W2059804810","https://openalex.org/W3169419422","https://openalex.org/W4394934847"],"abstract_inverted_index":{"Lysine":[0],"post-translational":[1],"modifications":[2],"(PTMs)":[3],"are":[4,11],"widespread":[5],"and":[6,24,36,45,73,92,107,119,134,143,146],"versatile":[7],"protein":[8],"PTMs":[9,30,82,118,125],"that":[10],"involved":[12],"in":[13,33,123],"diverse":[14,116],"biological":[15,135],"processes":[16],"by":[17,126],"regulating":[18],"the":[19,71,87,112,120,132],"fundamental":[20],"functions":[21,136],"of":[22,28,58,75,80,94,96,111,115,137,150],"histone":[23,142],"non-histone":[25,144],"proteins.":[26],"Dysregulation":[27],"lysine":[29,38,81,97,105,117,124,138,151],"is":[31,83],"implicated":[32],"many":[34],"diseases,":[35],"targeting":[37],"PTM":[39,139,152],"regulatory":[40,88,113,153],"factors,":[41],"including":[42],"writers,":[43],"erasers,":[44],"readers,":[46],"has":[47],"become":[48],"an":[49],"effective":[50],"strategy":[51],"for":[52,85,155],"disease":[53,156],"therapy.":[54,157],"The":[55,77],"continuing":[56],"development":[57],"mass":[59],"spectrometry":[60],"(MS)":[61],"technologies":[62,68],"coupled":[63],"with":[64],"antibody-based":[65],"affinity":[66],"enrichment":[67],"greatly":[69],"promotes":[70],"discovery":[72],"decoding":[74],"PTMs.":[76,98],"global":[78],"characterization":[79],"crucial":[84],"deciphering":[86],"networks,":[89],"molecular":[90],"functions,":[91],"mechanisms":[93],"action":[95],"In":[99],"this":[100],"review,":[101],"we":[102],"focus":[103],"on":[104,141],"PTMs,":[106],"provide":[108],"a":[109],"summary":[110],"enzymes":[114],"proteomics":[121],"advances":[122],"MS":[127],"technologies.":[128],"We":[129],"also":[130],"discuss":[131],"types":[133],"crosstalks":[140],"proteins":[145],"current":[147],"druggable":[148],"targets":[149],"factors":[154]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":17},{"year":2024,"cited_by_count":2}],"updated_date":"2026-04-13T07:58:08.660418","created_date":"2025-10-10T00:00:00"}