{"id":"https://openalex.org/W2191378904","doi":"https://doi.org/10.1093/database/bav112","title":"ONRLDB\u2014manually curated database of experimentally validated ligands for orphan nuclear receptors: insights into new drug discovery","display_name":"ONRLDB\u2014manually curated database of experimentally validated ligands for orphan nuclear receptors: insights into new drug discovery","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2191378904","doi":"https://doi.org/10.1093/database/bav112","mag":"2191378904","pmid":"https://pubmed.ncbi.nlm.nih.gov/26637529"},"language":"en","primary_location":{"id":"doi:10.1093/database/bav112","is_oa":true,"landing_page_url":"https://doi.org/10.1093/database/bav112","pdf_url":"https://academic.oup.com/database/article-pdf/doi/10.1093/database/bav112/7299217/bav112.pdf","source":{"id":"https://openalex.org/S4210201630","display_name":"Database","issn_l":"1758-0463","issn":["1758-0463"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Database","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/database/article-pdf/doi/10.1093/database/bav112/7299217/bav112.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088596158","display_name":"Ravikanth Nanduri","orcid":"https://orcid.org/0000-0002-0031-2333"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ravikanth Nanduri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007137245","display_name":"Isha Bhutani","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Isha Bhutani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061909483","display_name":"Arun Kumar Somavarapu","orcid":"https://orcid.org/0000-0001-6123-6875"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arun Kumar Somavarapu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112440375","display_name":"Sahil Mahajan","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sahil Mahajan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050982370","display_name":"Raman Parkesh","orcid":"https://orcid.org/0000-0003-4096-654X"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raman Parkesh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5064792308","display_name":"Pawan Gupta","orcid":"https://orcid.org/0000-0001-6692-7237"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pawan Gupta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1415,"currency":"GBP","value_usd":1735},"apc_paid":{"value":1415,"currency":"GBP","value_usd":1735},"fwci":3.6342,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.9344427,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"2015","issue":null,"first_page":"bav112","last_page":"bav112"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.996399998664856,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12893","display_name":"Organic Chemistry Cycloaddition Reactions","score":0.9958999752998352,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.7504773736000061},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5364236831665039},{"id":"https://openalex.org/keywords/orphan-drug","display_name":"Orphan drug","score":0.5284388065338135},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.49999475479125977},{"id":"https://openalex.org/keywords/nuclear-receptor","display_name":"Nuclear receptor","score":0.4622608721256256},{"id":"https://openalex.org/keywords/database","display_name":"Database","score":0.4441807270050049},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.4167514443397522},{"id":"https://openalex.org/keywords/information-retrieval","display_name":"Information retrieval","score":0.3779612183570862},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.370949923992157},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2564757466316223},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.10085386037826538}],"concepts":[{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.7504773736000061},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5364236831665039},{"id":"https://openalex.org/C75480439","wikidata":"https://www.wikidata.org/wiki/Q1367466","display_name":"Orphan drug","level":2,"score":0.5284388065338135},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.49999475479125977},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.4622608721256256},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.4441807270050049},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.4167514443397522},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.3779612183570862},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.370949923992157},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2564757466316223},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10085386037826538},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000071518","descriptor_name":"Liver X Receptors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071518","descriptor_name":"Liver X Receptors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071518","descriptor_name":"Liver X Receptors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015262","descriptor_name":"Xenobiotics","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015262","descriptor_name":"Xenobiotics","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015262","descriptor_name":"Xenobiotics","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015262","descriptor_name":"Xenobiotics","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015262","descriptor_name":"Xenobiotics","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015262","descriptor_name":"Xenobiotics","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016247","descriptor_name":"Information Storage and Retrieval","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016247","descriptor_name":"Information Storage and Retrieval","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016247","descriptor_name":"Information Storage and Retrieval","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057093","descriptor_name":"Orphan Nuclear Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D057093","descriptor_name":"Orphan Nuclear Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D057093","descriptor_name":"Orphan Nuclear Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/database/bav112","is_oa":true,"landing_page_url":"https://doi.org/10.1093/database/bav112","pdf_url":"https://academic.oup.com/database/article-pdf/doi/10.1093/database/bav112/7299217/bav112.pdf","source":{"id":"https://openalex.org/S4210201630","display_name":"Database","issn_l":"1758-0463","issn":["1758-0463"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Database","raw_type":"journal-article"},{"id":"pmid:26637529","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26637529","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Database : the journal of biological databases and curation","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:4669993","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4669993","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Database (Oxford)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/database/bav112","is_oa":true,"landing_page_url":"https://doi.org/10.1093/database/bav112","pdf_url":"https://academic.oup.com/database/article-pdf/doi/10.1093/database/bav112/7299217/bav112.pdf","source":{"id":"https://openalex.org/S4210201630","display_name":"Database","issn_l":"1758-0463","issn":["1758-0463"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Database","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320338259","display_name":"CSIR - Institute of Microbial Technology","ror":"https://ror.org/055rjs771"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2191378904.pdf"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1505090413","https://openalex.org/W1553258895","https://openalex.org/W1907819046","https://openalex.org/W1968682237","https://openalex.org/W1977936595","https://openalex.org/W1995277882","https://openalex.org/W2001568863","https://openalex.org/W2004953603","https://openalex.org/W2015927691","https://openalex.org/W2017479161","https://openalex.org/W2024390103","https://openalex.org/W2026930722","https://openalex.org/W2031906658","https://openalex.org/W2052429604","https://openalex.org/W2057530150","https://openalex.org/W2060153789","https://openalex.org/W2061879307","https://openalex.org/W2066704041","https://openalex.org/W2073950955","https://openalex.org/W2076524169","https://openalex.org/W2076793953","https://openalex.org/W2076960251","https://openalex.org/W2079080809","https://openalex.org/W2080886752","https://openalex.org/W2096541451","https://openalex.org/W2096864392","https://openalex.org/W2128966273","https://openalex.org/W2129438079","https://openalex.org/W2131144673","https://openalex.org/W2141885448","https://openalex.org/W2146687192","https://openalex.org/W2155456304","https://openalex.org/W2157959969","https://openalex.org/W2160516810","https://openalex.org/W2162304802","https://openalex.org/W2165823429","https://openalex.org/W2166401510","https://openalex.org/W2169678694","https://openalex.org/W2170146596","https://openalex.org/W2171335055","https://openalex.org/W2316620683","https://openalex.org/W6633057035"],"related_works":["https://openalex.org/W4311342885","https://openalex.org/W4242937172","https://openalex.org/W4291910309","https://openalex.org/W2912312465","https://openalex.org/W4380148866","https://openalex.org/W2004538550","https://openalex.org/W4311334856","https://openalex.org/W4390660638","https://openalex.org/W2525669273","https://openalex.org/W2037979734"],"abstract_inverted_index":{"Orphan":[0,8],"nuclear":[1,29],"receptors":[2,90],"are":[3,40],"potential":[4],"therapeutic":[5],"targets.":[6],"The":[7,97],"Nuclear":[9],"Receptor":[10],"Ligand":[11],"Binding":[12],"Database":[13,189],"(ONRLDB)":[14],"is":[15,73,167],"an":[16,150],"interactive,":[17],"comprehensive":[18,155],"and":[19,52,58,64,70,116,138,153,161,178],"manually":[20],"curated":[21],"database":[22,98],"of":[23,34,37,55,84,126,159,172],"small":[24,81],"molecule":[25,82],"ligands":[26,173,182],"targeting":[27],"orphan":[28],"receptors.":[30],"Currently,":[31],"ONRLDB":[32,72,166],"consists":[33],"\u223c11,000":[35],"ligands,":[36],"which":[38],"\u223c6500":[39],"unique.":[41],"All":[42],"entries":[43],"include":[44],"information":[45],"for":[46,157,179],"the":[47,79,88,127,145,186],"ligand,":[48],"such":[49],"as":[50],"EC50":[51],"IC50,":[53],"number":[54],"aromatic":[56],"rings":[57],"rotatable":[59],"bonds,":[60],"XlogP,":[61],"hydrogen":[62],"donor":[63],"acceptor":[65],"count,":[66],"molecular":[67],"weight":[68],"(MW)":[69],"structure.":[71],"a":[74,85,92,154],"cross-platform":[75],"database,":[76],"where":[77],"either":[78],"cognate":[80,89],"modulators":[83],"receptor":[86],"or":[87,109,183],"to":[91,122,169,184],"ligand":[93,128],"can":[94,99,119],"be":[95,100,120],"searched.":[96],"searched":[101],"using":[102],"three":[103],"methods:":[104],"text":[105],"search,":[106,113],"advanced":[107,124],"search":[108],"similarity":[110,132],"search.":[111],"Substructure":[112],"cataloguing":[114],"tools,":[115,142],"clustering":[117],"tools":[118],"used":[121],"perform":[123],"analysis":[125],"based":[129,174],"on":[130,175],"chemical":[131],"fingerprints,":[133],"hierarchical":[134],"clustering,":[135],"binning":[136],"partition":[137],"multidimensional":[139],"scaling.":[140],"These":[141],"together":[143],"with":[144],"Tree":[146],"function":[147],"provided,":[148],"deliver":[149],"interactive":[151],"platform":[152],"resource":[156],"identification":[158],"common":[160],"unique":[162],"scaffolds.":[163],"As":[164],"demonstrated,":[165],"designed":[168],"allow":[170],"selection":[171],"various":[176],"properties":[177],"designing":[180],"novel":[181],"improve":[185],"existing":[187],"ones.":[188],"URL:":[190],"http://www.onrldb.org/.":[191]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":5}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
