{"id":"https://openalex.org/W2153138487","doi":"https://doi.org/10.1093/database/bat080","title":"A CTD-Pfizer collaboration: manual curation of 88 000 scientific articles text mined for drug-disease and drug-phenotype interactions","display_name":"A CTD-Pfizer collaboration: manual curation of 88 000 scientific articles text mined for drug-disease and drug-phenotype interactions","publication_year":2013,"publication_date":"2013-11-28","ids":{"openalex":"https://openalex.org/W2153138487","doi":"https://doi.org/10.1093/database/bat080","mag":"2153138487","pmid":"https://pubmed.ncbi.nlm.nih.gov/24288140"},"language":"en","primary_location":{"id":"doi:10.1093/database/bat080","doi":"https://doi.org/10.1093/database/bat080","is_oa":true,"landing_page_url":"https://doi.org/10.1093/database/bat080","pdf_url":"https://academic.oup.com/database/article-pdf/doi/10.1093/database/bat080/16734825/bat080.pdf","source":{"id":"https://openalex.org/S4210201630","display_name":"Database","issn_l":"1758-0463","issn":["1758-0463"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Database","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/database/article-pdf/doi/10.1093/database/bat080/16734825/bat080.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064334598","display_name":"Allan Peter Davis","orcid":"https://orcid.org/0000-0002-5741-7128","observed_orcids":["https://orcid.org/0000-0002-5741-7128"]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]},{"id":"https://openalex.org/I2800736356","display_name":"Mount Desert Island Biological Laboratory","ror":"https://ror.org/04dw1bf40","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2800736356"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"A. P. Davis","raw_affiliation_strings":["Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA","Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, 2Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, 3Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, 4Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, 5Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, 6Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and 7Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA","institution_ids":["https://openalex.org/I137902535","https://openalex.org/I2800736356"]},{"raw_affiliation_string":"Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, 2Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, 3Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, 4Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, 5Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, 6Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and 7Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA","institution_ids":["https://openalex.org/I137902535","https://openalex.org/I2800736356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076813284","display_name":"Thomas C. Wiegers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]},{"id":"https://openalex.org/I2800736356","display_name":"Mount Desert Island Biological Laboratory","ror":"https://ror.org/04dw1bf40","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2800736356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. C. Wiegers","raw_affiliation_strings":["Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, 2 Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, 3 Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, 4 Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, 5 Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, 6 Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and 7 Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA","Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, 2Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, 3Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, 4Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, 5Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, 6Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and 7Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, 2 Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, 3 Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, 4 Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, 5 Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, 6 Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and 7 Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA","institution_ids":["https://openalex.org/I137902535","https://openalex.org/I2800736356"]},{"raw_affiliation_string":"Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, 2Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, 3Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, 4Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, 5Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, 6Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and 7Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA","institution_ids":["https://openalex.org/I137902535","https://openalex.org/I2800736356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102723391","display_name":"Patricia Roberts\u2010Miller","orcid":"https://orcid.org/0009-0002-9995-6282","observed_orcids":["https://orcid.org/0009-0002-9995-6282"]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]},{"id":"https://openalex.org/I2800736356","display_name":"Mount Desert Island Biological Laboratory","ror":"https://ror.org/04dw1bf40","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2800736356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. M. Roberts","raw_affiliation_strings":["Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, 2 Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, 3 Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, 4 Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, 5 Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, 6 Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and 7 Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA","Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, 2Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, 3Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, 4Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, 5Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, 6Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and 7Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, 2 Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, 3 Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, 4 Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, 5 Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, 6 Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and 7 Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA","institution_ids":["https://openalex.org/I137902535","https://openalex.org/I2800736356"]},{"raw_affiliation_string":"Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, 2Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, 3Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, 4Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, 5Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, 6Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and 7Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA","institution_ids":["https://openalex.org/I137902535","https://openalex.org/I2800736356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060495675","display_name":"Benjamin L. King","orcid":"https://orcid.org/0000-0001-6463-1336","observed_orcids":["https://orcid.org/0000-0001-6463-1336"]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]},{"id":"https://openalex.org/I2800736356","display_name":"Mount Desert Island Biological Laboratory","ror":"https://ror.org/04dw1bf40","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2800736356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. L. King","raw_affiliation_strings":["Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, 2 Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, 3 Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, 4 Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, 5 Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, 6 Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and 7 Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA","Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, 2Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, 3Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, 4Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, 5Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, 6Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and 7Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, 2 Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, 3 Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, 4 Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, 5 Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, 6 Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and 7 Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA","institution_ids":["https://openalex.org/I137902535","https://openalex.org/I2800736356"]},{"raw_affiliation_string":"Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, 2Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, 3Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, 4Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, 5Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, 6Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and 7Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA","institution_ids":["https://openalex.org/I137902535","https://openalex.org/I2800736356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047308911","display_name":"Jean M. Lay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]},{"id":"https://openalex.org/I2800736356","display_name":"Mount Desert Island Biological Laboratory","ror":"https://ror.org/04dw1bf40","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2800736356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. M. Lay","raw_affiliation_strings":["Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, 2 Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, 3 Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, 4 Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, 5 Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, 6 Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and 7 Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA","Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, 2Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, 3Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, 4Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, 5Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, 6Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and 7Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, 2 Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, 3 Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, 4 Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, 5 Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, 6 Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and 7 Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA","institution_ids":["https://openalex.org/I137902535","https://openalex.org/I2800736356"]},{"raw_affiliation_string":"Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, 2Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, 3Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, 4Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, 5Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, 6Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and 7Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA","institution_ids":["https://openalex.org/I137902535","https://openalex.org/I2800736356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080422723","display_name":"Kelley Lennon-Hopkins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]},{"id":"https://openalex.org/I2800736356","display_name":"Mount Desert Island Biological Laboratory","ror":"https://ror.org/04dw1bf40","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2800736356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Lennon-Hopkins","raw_affiliation_strings":["Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, 2 Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, 3 Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, 4 Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, 5 Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, 6 Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and 7 Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA","Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, 2Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, 3Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, 4Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, 5Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, 6Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and 7Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, 2 Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, 3 Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, 4 Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, 5 Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, 6 Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and 7 Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA","institution_ids":["https://openalex.org/I137902535","https://openalex.org/I2800736356"]},{"raw_affiliation_string":"Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, 2Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, 3Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, 4Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, 5Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, 6Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and 7Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA","institution_ids":["https://openalex.org/I137902535","https://openalex.org/I2800736356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063325560","display_name":"Daniela Sciaky","orcid":"https://orcid.org/0009-0000-3182-9493","observed_orcids":["https://orcid.org/0009-0000-3182-9493"]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]},{"id":"https://openalex.org/I2800736356","display_name":"Mount Desert Island Biological Laboratory","ror":"https://ror.org/04dw1bf40","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2800736356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Sciaky","raw_affiliation_strings":["Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, 2 Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, 3 Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, 4 Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, 5 Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, 6 Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and 7 Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA","Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, 2Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, 3Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, 4Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, 5Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, 6Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and 7Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, 2 Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, 3 Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, 4 Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, 5 Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, 6 Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and 7 Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA","institution_ids":["https://openalex.org/I137902535","https://openalex.org/I2800736356"]},{"raw_affiliation_string":"Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, 2Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, 3Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, 4Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, 5Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, 6Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and 7Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA","institution_ids":["https://openalex.org/I137902535","https://openalex.org/I2800736356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109052924","display_name":"Randi Johnson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]},{"id":"https://openalex.org/I2800736356","display_name":"Mount Desert Island Biological Laboratory","ror":"https://ror.org/04dw1bf40","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2800736356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Johnson","raw_affiliation_strings":["Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, 2 Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, 3 Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, 4 Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, 5 Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, 6 Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and 7 Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA","Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, 2Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, 3Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, 4Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, 5Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, 6Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and 7Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, 2 Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, 3 Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, 4 Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, 5 Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, 6 Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and 7 Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA","institution_ids":["https://openalex.org/I137902535","https://openalex.org/I2800736356"]},{"raw_affiliation_string":"Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, 2Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, 3Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, 4Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, 5Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, 6Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and 7Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA","institution_ids":["https://openalex.org/I137902535","https://openalex.org/I2800736356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5096924246","display_name":"H. Keating","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]},{"id":"https://openalex.org/I2800736356","display_name":"Mount Desert Island Biological Laboratory","ror":"https://ror.org/04dw1bf40","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2800736356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Keating","raw_affiliation_strings":["Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, 2 Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, 3 Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, 4 Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, 5 Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, 6 Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and 7 Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA","Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, 2Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, 3Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, 4Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, 5Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, 6Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and 7Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, 2 Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, 3 Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, 4 Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, 5 Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, 6 Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and 7 Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA","institution_ids":["https://openalex.org/I137902535","https://openalex.org/I2800736356"]},{"raw_affiliation_string":"Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, 2Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, 3Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, 4Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, 5Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, 6Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and 7Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA","institution_ids":["https://openalex.org/I137902535","https://openalex.org/I2800736356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031183535","display_name":"Nigel Greene","orcid":"https://orcid.org/0000-0003-0433-4596","observed_orcids":["https://orcid.org/0000-0003-0433-4596"]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]},{"id":"https://openalex.org/I2800736356","display_name":"Mount Desert Island Biological Laboratory","ror":"https://ror.org/04dw1bf40","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2800736356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. Greene","raw_affiliation_strings":["Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, 2 Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, 3 Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, 4 Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, 5 Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, 6 Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and 7 Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA","Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, 2Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, 3Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, 4Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, 5Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, 6Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and 7Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, 2 Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, 3 Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, 4 Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, 5 Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, 6 Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and 7 Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA","institution_ids":["https://openalex.org/I137902535","https://openalex.org/I2800736356"]},{"raw_affiliation_string":"Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, 2Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, 3Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, 4Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, 5Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, 6Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and 7Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA","institution_ids":["https://openalex.org/I137902535","https://openalex.org/I2800736356"]}]},{"author_position":"middle","author":{"id":null,"display_name":"R. Hernandez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]},{"id":"https://openalex.org/I2800736356","display_name":"Mount Desert Island Biological Laboratory","ror":"https://ror.org/04dw1bf40","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2800736356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Hernandez","raw_affiliation_strings":["Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, 2 Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, 3 Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, 4 Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, 5 Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, 6 Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and 7 Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA","Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, 2Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, 3Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, 4Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, 5Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, 6Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and 7Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, 2 Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, 3 Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, 4 Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, 5 Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, 6 Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and 7 Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA","institution_ids":["https://openalex.org/I137902535","https://openalex.org/I2800736356"]},{"raw_affiliation_string":"Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, 2Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, 3Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, 4Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, 5Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, 6Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and 7Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA","institution_ids":["https://openalex.org/I137902535","https://openalex.org/I2800736356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046959420","display_name":"Kevin J. McConnell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]},{"id":"https://openalex.org/I2800736356","display_name":"Mount Desert Island Biological Laboratory","ror":"https://ror.org/04dw1bf40","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2800736356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. J. McConnell","raw_affiliation_strings":["Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, 2 Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, 3 Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, 4 Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, 5 Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, 6 Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and 7 Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA","Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, 2Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, 3Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, 4Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, 5Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, 6Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and 7Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, 2 Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, 3 Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, 4 Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, 5 Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, 6 Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and 7 Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA","institution_ids":["https://openalex.org/I137902535","https://openalex.org/I2800736356"]},{"raw_affiliation_string":"Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, 2Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, 3Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, 4Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, 5Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, 6Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and 7Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA","institution_ids":["https://openalex.org/I137902535","https://openalex.org/I2800736356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054882931","display_name":"Ahmed E. EnayetAllah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]},{"id":"https://openalex.org/I2800736356","display_name":"Mount Desert Island Biological Laboratory","ror":"https://ror.org/04dw1bf40","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2800736356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. E. Enayetallah","raw_affiliation_strings":["Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, 2 Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, 3 Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, 4 Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, 5 Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, 6 Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and 7 Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA","Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, 2Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, 3Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, 4Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, 5Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, 6Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and 7Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, 2 Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, 3 Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, 4 Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, 5 Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, 6 Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and 7 Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA","institution_ids":["https://openalex.org/I137902535","https://openalex.org/I2800736356"]},{"raw_affiliation_string":"Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, 2Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, 3Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, 4Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, 5Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, 6Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and 7Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA","institution_ids":["https://openalex.org/I137902535","https://openalex.org/I2800736356"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102941229","display_name":"Carolyn J. Mattingly","orcid":"https://orcid.org/0000-0002-2146-9436","observed_orcids":["https://orcid.org/0000-0002-2146-9436"]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]},{"id":"https://openalex.org/I2800736356","display_name":"Mount Desert Island Biological Laboratory","ror":"https://ror.org/04dw1bf40","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2800736356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. J. Mattingly","raw_affiliation_strings":["Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, 2 Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, 3 Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, 4 Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, 5 Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, 6 Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and 7 Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA","Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, 2Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, 3Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, 4Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, 5Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, 6Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and 7Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, 2 Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, 3 Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, 4 Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, 5 Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, 6 Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and 7 Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA","institution_ids":["https://openalex.org/I137902535","https://openalex.org/I2800736356"]},{"raw_affiliation_string":"Department of Biological Sciences, 3510 Thomas Hall, North Carolina State University, Raleigh, NC 27695-7617, USA, 2Computational Sciences Center of Emphasis, 200 Cambridgepark Drive, Pfizer Inc., Cambridge, MA 02139, USA, 3Department of Bioinformatics, P.O. Box 35, Old Bar Harbor Road, MDI Biological Laboratory, Salisbury Cove, ME 04672, USA, 4Compound Safety Prediction, MS 8118-B3, Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA, 5Computational Sciences Center of Emphasis, Pfizer Inc., Ramsgate Road, Sandwich, Kent CT13 9NJ, UK, 6Computational Sciences Center of Emphasis, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA and 7Drug Safety Research and Development, 558 Eastern Point Road, Pfizer Inc., Groton, CT 06340, USA","institution_ids":["https://openalex.org/I137902535","https://openalex.org/I2800736356"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5064334598"],"corresponding_institution_ids":["https://openalex.org/I137902535","https://openalex.org/I2800736356"],"apc_list":{"value":2729,"currency":"USD","value_usd":2729},"apc_paid":{"value":2729,"currency":"USD","value_usd":2729},"fwci":4.8406,"has_fulltext":true,"cited_by_count":107,"citation_normalized_percentile":{"value":0.96238367,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"2013","issue":"0","first_page":"bat080","last_page":"bat080"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/comparative-toxicogenomics-database","display_name":"Comparative Toxicogenomics Database","score":0.8840000033378601},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.5059999823570251},{"id":"https://openalex.org/keywords/drug-disease-interactions","display_name":"drug-disease interactions","score":0.7689999938011169},{"id":"https://openalex.org/keywords/chemical-gene-interactions","display_name":"chemical-gene interactions","score":0.7599999904632568},{"id":"https://openalex.org/keywords/gene-disease-interaction","display_name":"gene-disease interaction","score":0.7749999761581421},{"id":"https://openalex.org/keywords/text-mining","display_name":"text mining","score":0.5989999771118164},{"id":"https://openalex.org/keywords/manual-curation","display_name":"manual curation","score":0.8949999809265137},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.6060000061988831},{"id":"https://openalex.org/keywords/cardiotoxicity","display_name":"cardiotoxicity","score":0.8379999995231628},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.7490000128746033},{"id":"https://openalex.org/keywords/nephrotoxicity","display_name":"nephrotoxicity","score":0.9810000061988831},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.9810000061988831},{"id":"https://openalex.org/keywords/toxicogenomics","display_name":"toxicogenomics","score":0.7850000262260437},{"id":"https://openalex.org/keywords/chemical-toxicity-prediction","display_name":"chemical toxicity prediction","score":0.46299999952316284}],"concepts":[{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6152248978614807},{"id":"https://openalex.org/C125533998","wikidata":"https://www.wikidata.org/wiki/Q1024499","display_name":"CTD","level":2,"score":0.551480770111084},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5279492735862732},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.4031851887702942},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.39590030908584595},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.1565425992012024},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15353354811668396},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.0},{"id":"https://openalex.org/C111368507","wikidata":"https://www.wikidata.org/wiki/Q43518","display_name":"Oceanography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003299","descriptor_name":"Cooperative Behavior","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003299","descriptor_name":"Cooperative Behavior","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003299","descriptor_name":"Cooperative Behavior","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004345","descriptor_name":"Drug Industry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004345","descriptor_name":"Drug Industry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004345","descriptor_name":"Drug Industry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011642","descriptor_name":"Publications","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011642","descriptor_name":"Publications","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011642","descriptor_name":"Publications","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D043922","descriptor_name":"Toxicogenetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D043922","descriptor_name":"Toxicogenetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D043922","descriptor_name":"Toxicogenetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1093/database/bat080","doi":"https://doi.org/10.1093/database/bat080","is_oa":true,"landing_page_url":"https://doi.org/10.1093/database/bat080","pdf_url":"https://academic.oup.com/database/article-pdf/doi/10.1093/database/bat080/16734825/bat080.pdf","source":{"id":"https://openalex.org/S4210201630","display_name":"Database","issn_l":"1758-0463","issn":["1758-0463"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Database","raw_type":"journal-article"},{"id":"pmid:24288140","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24288140","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Database : the journal of biological databases and curation","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2833740","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3842776","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3842776","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3842776","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Database (Oxford)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/database/bat080","doi":"https://doi.org/10.1093/database/bat080","is_oa":true,"landing_page_url":"https://doi.org/10.1093/database/bat080","pdf_url":"https://academic.oup.com/database/article-pdf/doi/10.1093/database/bat080/16734825/bat080.pdf","source":{"id":"https://openalex.org/S4210201630","display_name":"Database","issn_l":"1758-0463","issn":["1758-0463"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Database","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/17","score":0.5299999713897705,"display_name":"Partnerships for the goals"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1096228966","display_name":null,"funder_award_id":"ES019604","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G2076065259","display_name":null,"funder_award_id":"R01-ES014065","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G642129057","display_name":null,"funder_award_id":"ES014065","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G688181372","display_name":null,"funder_award_id":"R01ES019604","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2153138487.pdf","grobid_xml":"https://content.openalex.org/works/W2153138487.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1419557475","https://openalex.org/W1552651695","https://openalex.org/W1972931870","https://openalex.org/W1985501129","https://openalex.org/W1987063389","https://openalex.org/W1991919884","https://openalex.org/W1993119069","https://openalex.org/W2003749631","https://openalex.org/W2009585391","https://openalex.org/W2014247325","https://openalex.org/W2016381774","https://openalex.org/W2020275295","https://openalex.org/W2025017430","https://openalex.org/W2031133736","https://openalex.org/W2032729847","https://openalex.org/W2040610660","https://openalex.org/W2046548753","https://openalex.org/W2053403152","https://openalex.org/W2058298068","https://openalex.org/W2071021089","https://openalex.org/W2089941494","https://openalex.org/W2091064692","https://openalex.org/W2103017472","https://openalex.org/W2105481534","https://openalex.org/W2113514677","https://openalex.org/W2124001239","https://openalex.org/W2127832128","https://openalex.org/W2136640051","https://openalex.org/W2137052779","https://openalex.org/W2137937634","https://openalex.org/W2142572836","https://openalex.org/W2148083369","https://openalex.org/W2158418435","https://openalex.org/W2158743996","https://openalex.org/W2175779775","https://openalex.org/W2918064359"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W2783711748","https://openalex.org/W2045822978","https://openalex.org/W2750507929","https://openalex.org/W2748723174","https://openalex.org/W2750309893","https://openalex.org/W2749338267","https://openalex.org/W2748209892","https://openalex.org/W2746181009","https://openalex.org/W2349858109"],"abstract_inverted_index":{"Improving":[0],"the":[1,54,58,131,197,215,229,233],"prediction":[2],"of":[3,32,71,185,196,217,232],"chemical":[4],"toxicity":[5,36],"is":[6,25],"a":[7,29,46,69],"goal":[8],"common":[9],"to":[10,27,63,79,129,145,159,172],"both":[11],"environmental":[12,234],"health":[13,235],"research":[14,55],"and":[15,40,53,66,87,105,118,133,142,175,220,224,227,237],"pharmaceutical":[16,77,208,238],"drug":[17,173],"development.":[18],"To":[19],"improve":[20],"safety":[21,49,174],"detection":[22],"assays,":[23],"it":[24],"critical":[26],"have":[28],"reference":[30],"set":[31],"molecules":[33],"with":[34,115],"well-defined":[35],"annotations":[37,190],"for":[38,166,180,207],"training":[39],"validation":[41],"purposes.":[42],"Here,":[43],"we":[44,151],"describe":[45,125],"collaboration":[47,221],"between":[48,222],"researchers":[50],"at":[51,57],"Pfizer":[52],"team":[56],"Comparative":[59],"Toxicogenomics":[60],"Database":[61,240],"(CTD)":[62],"text":[64],"mine":[65],"manually":[67],"review":[68],"collection":[70],"88,629":[72],"articles":[73],"relating":[74],"over":[75],"1,200":[76],"drugs":[78],"their":[80],"potential":[81],"involvement":[82],"in":[83],"cardiovascular,":[84],"neurological,":[85],"renal":[86],"hepatic":[88],"toxicity.":[89],"In":[90],"1":[91],"year,":[92],"CTD":[93],"biocurators":[94],"curated":[95,191],"254,173":[96],"toxicogenomic":[97],"interactions":[98,111,120],"(152,173":[99],"chemical-disease,":[100],"58,572":[101],"chemical-gene,":[102],"5,345":[103],"gene-disease":[104],"38,083":[106],"phenotype":[107,119,147],"interactions).":[108],"All":[109],"chemical-gene-disease":[110],"are":[112],"fully":[113],"integrated":[114],"public":[116,223],"CTD,":[117],"can":[121,156,163],"be":[122,164],"downloaded.":[123],"We":[124],"Pfizer's":[126],"text-mining":[127],"process":[128],"collate":[130],"articles,":[132],"CTD's":[134],"curation":[135,162],"strategy,":[136],"performance":[137],"metrics,":[138],"enhanced":[139],"data":[140,154],"content":[141],"new":[143,203],"module":[144],"curate":[146],"information.":[148],"As":[149],"well,":[150],"show":[152],"how":[153],"integration":[155],"connect":[157],"phenotypes":[158],"diseases.":[160],"This":[161,211],"leveraged":[165],"information":[167],"about":[168],"toxic":[169],"endpoints":[170],"important":[171],"help":[176,201],"develop":[177],"testable":[178],"hypotheses":[179],"drug-disease":[181],"events.":[182],"The":[183],"availability":[184],"these":[186],"detailed,":[187],"contextualized,":[188],"high-quality":[189],"from":[192],"seven":[193],"decades'":[194],"worth":[195],"scientific":[198],"literature":[199],"should":[200],"facilitate":[202],"mechanistic":[204],"screening":[205],"assays":[206],"compound":[209],"survival.":[210],"unique":[212],"partnership":[213],"demonstrates":[214],"importance":[216],"resource":[218],"sharing":[219],"private":[225],"entities":[226],"underscores":[228],"complementary":[230],"needs":[231],"science":[236],"communities.":[239],"URL:":[241],"http://ctdbase.org/":[242]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":20},{"year":2016,"cited_by_count":19},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":7}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}