{"id":"https://openalex.org/W2137690465","doi":"https://doi.org/10.1093/database/bas034","title":"Dr. PIAS 2.0: an update of a database of predicted druggable protein\u2013protein interactions","display_name":"Dr. PIAS 2.0: an update of a database of predicted druggable protein\u2013protein interactions","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2137690465","doi":"https://doi.org/10.1093/database/bas034","mag":"2137690465","pmid":"https://pubmed.ncbi.nlm.nih.gov/23060433"},"language":"en","primary_location":{"id":"doi:10.1093/database/bas034","is_oa":true,"landing_page_url":"https://doi.org/10.1093/database/bas034","pdf_url":"https://academic.oup.com/database/article-pdf/doi/10.1093/database/bas034/16728808/bas034.pdf","source":{"id":"https://openalex.org/S4210201630","display_name":"Database","issn_l":"1758-0463","issn":["1758-0463"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Database","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/database/article-pdf/doi/10.1093/database/bas034/16728808/bas034.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014933879","display_name":"Nobuyoshi Sugaya","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nobuyoshi Sugaya","raw_affiliation_strings":["Drug Discovery Department, Research & Development Division, PharmaDesign, Inc., Hatchobori 2-19-8, Chuo-ku, Tokyo 104-0032, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Discovery Department, Research & Development Division, PharmaDesign, Inc., Hatchobori 2-19-8, Chuo-ku, Tokyo 104-0032, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108771559","display_name":"Satoru Kanai","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Satoru Kanai","raw_affiliation_strings":["Drug Discovery Department, Research & Development Division, PharmaDesign, Inc., Hatchobori 2-19-8, Chuo-ku, Tokyo 104-0032, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Discovery Department, Research & Development Division, PharmaDesign, Inc., Hatchobori 2-19-8, Chuo-ku, Tokyo 104-0032, Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105687279","display_name":"Toshio Furuya","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Toshio Furuya","raw_affiliation_strings":["Drug Discovery Department, Research & Development Division, PharmaDesign, Inc., Hatchobori 2-19-8, Chuo-ku, Tokyo 104-0032, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Discovery Department, Research & Development Division, PharmaDesign, Inc., Hatchobori 2-19-8, Chuo-ku, Tokyo 104-0032, Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1415,"currency":"GBP","value_usd":1735},"apc_paid":{"value":1415,"currency":"GBP","value_usd":1735},"fwci":3.8204,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.93749139,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"2012","issue":null,"first_page":"bas034","last_page":"bas034"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/druggability","display_name":"Druggability","score":0.9679141044616699},{"id":"https://openalex.org/keywords/support-vector-machine","display_name":"Support vector machine","score":0.4986143112182617},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.49215835332870483},{"id":"https://openalex.org/keywords/interactome","display_name":"Interactome","score":0.482302188873291},{"id":"https://openalex.org/keywords/naive-bayes-classifier","display_name":"Naive Bayes classifier","score":0.47520193457603455},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.34046506881713867},{"id":"https://openalex.org/keywords/database","display_name":"Database","score":0.3365514278411865},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.32384204864501953},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.18201297521591187},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.1701873540878296}],"concepts":[{"id":"https://openalex.org/C10679952","wikidata":"https://www.wikidata.org/wiki/Q5308937","display_name":"Druggability","level":3,"score":0.9679141044616699},{"id":"https://openalex.org/C12267149","wikidata":"https://www.wikidata.org/wiki/Q282453","display_name":"Support vector machine","level":2,"score":0.4986143112182617},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.49215835332870483},{"id":"https://openalex.org/C9760119","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interactome","level":3,"score":0.482302188873291},{"id":"https://openalex.org/C52001869","wikidata":"https://www.wikidata.org/wiki/Q812530","display_name":"Naive Bayes classifier","level":3,"score":0.47520193457603455},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.34046506881713867},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.3365514278411865},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.32384204864501953},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18201297521591187},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.1701873540878296},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/database/bas034","is_oa":true,"landing_page_url":"https://doi.org/10.1093/database/bas034","pdf_url":"https://academic.oup.com/database/article-pdf/doi/10.1093/database/bas034/16728808/bas034.pdf","source":{"id":"https://openalex.org/S4210201630","display_name":"Database","issn_l":"1758-0463","issn":["1758-0463"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Database","raw_type":"journal-article"},{"id":"pmid:23060433","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23060433","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Database : the journal of biological databases and curation","raw_type":null},{"id":"pmh:oai:europepmc.org:2463768","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3468816","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/database/bas034","is_oa":true,"landing_page_url":"https://doi.org/10.1093/database/bas034","pdf_url":"https://academic.oup.com/database/article-pdf/doi/10.1093/database/bas034/16728808/bas034.pdf","source":{"id":"https://openalex.org/S4210201630","display_name":"Database","issn_l":"1758-0463","issn":["1758-0463"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Database","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2137690465.pdf","grobid_xml":"https://content.openalex.org/works/W2137690465.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1975118394","https://openalex.org/W1980543403","https://openalex.org/W1981824495","https://openalex.org/W1983248350","https://openalex.org/W1989684700","https://openalex.org/W2003516452","https://openalex.org/W2036884070","https://openalex.org/W2040581784","https://openalex.org/W2056169996","https://openalex.org/W2083441741","https://openalex.org/W2099754222","https://openalex.org/W2101181377","https://openalex.org/W2102791444","https://openalex.org/W2107580398","https://openalex.org/W2109175855","https://openalex.org/W2114801649","https://openalex.org/W2119470100","https://openalex.org/W2122863289","https://openalex.org/W2123280311","https://openalex.org/W2167398093","https://openalex.org/W2170915616","https://openalex.org/W2915108429","https://openalex.org/W4255855797","https://openalex.org/W6644222004","https://openalex.org/W6645609094","https://openalex.org/W6645915804","https://openalex.org/W6646301475","https://openalex.org/W6647887226","https://openalex.org/W6659566044","https://openalex.org/W6660456452","https://openalex.org/W6664487494","https://openalex.org/W6671680176","https://openalex.org/W6675345267","https://openalex.org/W6675478566","https://openalex.org/W6675482811","https://openalex.org/W6676058677","https://openalex.org/W6676583583","https://openalex.org/W6677233027","https://openalex.org/W6677959988","https://openalex.org/W6678767738","https://openalex.org/W6684536113","https://openalex.org/W6685304552","https://openalex.org/W6758954927"],"related_works":["https://openalex.org/W4292634579","https://openalex.org/W2556855892","https://openalex.org/W4214810602","https://openalex.org/W2523769397","https://openalex.org/W2000687555","https://openalex.org/W2259552966","https://openalex.org/W2158546283","https://openalex.org/W2255897055","https://openalex.org/W2423211199","https://openalex.org/W2198001326"],"abstract_inverted_index":{"Druggable":[0],"Protein-protein":[1],"Interaction":[2],"Assessment":[3],"System":[4],"(Dr.":[5],"PIAS)":[6],"is":[7,90,139],"a":[8,128],"database":[9],"of":[10,27,72,85,98,101,130],"druggable":[11,102,115,125],"protein-protein":[12],"interactions":[13],"(PPIs)":[14],"predicted":[15,114],"by":[16],"our":[17,55,73],"support":[18],"vector":[19],"machine":[20],"(SVM)-based":[21],"method.":[22],"Since":[23],"the":[24,50,69,79,83,95,121],"first":[25],"publication":[26],"this":[28],"database,":[29],"Dr.":[30,117,136],"PIAS":[31,118,137],"has":[32],"been":[33,41,64],"updated":[34],"to":[35,46],"version":[36],"2.0.":[37],"PPI":[38],"data":[39,132],"have":[40,63,93],"increased":[42],"considerably,":[43],"from":[44,127],"71,500":[45],"83,324":[47],"entries.":[48],"As":[49],"new":[51],"positive":[52],"instances":[53],"in":[54,76],"method,":[56],"4":[57],"PPIs":[58,87,126],"and":[59,88],"10":[60],"tertiary":[61],"structures":[62,89],"added.":[65],"This":[66],"addition":[67],"increases":[68],"prediction":[70],"accuracy":[71],"SVM":[74],"classifier":[75],"comparison":[77],"with":[78],"previous":[80],"classifier,":[81],"despite":[82],"number":[84],"added":[86],"small.":[91],"We":[92],"introduced":[94],"novel":[96],"concept":[97],"'similar":[99],"positives'":[100],"PPIs,":[103],"which":[104],"will":[105,119],"help":[106],"researchers":[107],"discover":[108],"small":[109],"compounds":[110],"that":[111],"can":[112],"inhibit":[113],"PPIs.":[116],"aid":[120],"effective":[122],"search":[123],"for":[124],"mine":[129],"interactome":[131],"being":[133],"rapidly":[134],"accumulated.":[135],"2.0":[138],"available":[140],"at":[141],"http://www.drpias.net.":[142]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":2}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}