{"id":"https://openalex.org/W4292633637","doi":"https://doi.org/10.1093/database/baac072","title":"Phosprof: pathway analysis database of drug response based on phosphorylation activity measurements","display_name":"Phosprof: pathway analysis database of drug response based on phosphorylation activity measurements","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4292633637","doi":"https://doi.org/10.1093/database/baac072","pmid":"https://pubmed.ncbi.nlm.nih.gov/35994309"},"language":"en","primary_location":{"id":"doi:10.1093/database/baac072","is_oa":true,"landing_page_url":"https://doi.org/10.1093/database/baac072","pdf_url":"https://academic.oup.com/database/article-pdf/doi/10.1093/database/baac072/45494336/baac072.pdf","source":{"id":"https://openalex.org/S4210201630","display_name":"Database","issn_l":"1758-0463","issn":["1758-0463"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Database","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/database/article-pdf/doi/10.1093/database/baac072/45494336/baac072.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026872938","display_name":"Harumi Kagiwada","orcid":"https://orcid.org/0000-0002-1228-2629"},"institutions":[{"id":"https://openalex.org/I73613424","display_name":"National Institute of Advanced Industrial Science and Technology","ror":"https://ror.org/01703db54","country_code":"JP","type":"government","lineage":["https://openalex.org/I73613424"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Harumi Kagiwada","raw_affiliation_strings":["Cellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology , 2-4-7, Aomi Koto-ku, Tokyo, Japan"],"raw_orcid":"https://orcid.org/0000-0002-1228-2629","affiliations":[{"raw_affiliation_string":"Cellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology , 2-4-7, Aomi Koto-ku, Tokyo, Japan","institution_ids":["https://openalex.org/I73613424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040706344","display_name":"Chie Motono","orcid":"https://orcid.org/0000-0002-5835-9273"},"institutions":[{"id":"https://openalex.org/I150744194","display_name":"Waseda University","ror":"https://ror.org/00ntfnx83","country_code":"JP","type":"education","lineage":["https://openalex.org/I150744194"]},{"id":"https://openalex.org/I73613424","display_name":"National Institute of Advanced Industrial Science and Technology","ror":"https://ror.org/01703db54","country_code":"JP","type":"government","lineage":["https://openalex.org/I73613424"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Chie Motono","raw_affiliation_strings":["AIST-Waseda University Computational Bio Big-Data Open Innovation Laboratory (CBBD-OIL) , 3-4-1, Okubo Shinjuku-ku, Tokyo 169-8555, Japan","Cellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology , 2-4-7, Aomi Koto-ku, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AIST-Waseda University Computational Bio Big-Data Open Innovation Laboratory (CBBD-OIL) , 3-4-1, Okubo Shinjuku-ku, Tokyo 169-8555, Japan","institution_ids":["https://openalex.org/I150744194"]},{"raw_affiliation_string":"Cellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology , 2-4-7, Aomi Koto-ku, Tokyo, Japan","institution_ids":["https://openalex.org/I73613424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045840721","display_name":"Katsuhisa Horimoto","orcid":"https://orcid.org/0000-0002-8328-6694"},"institutions":[{"id":"https://openalex.org/I73613424","display_name":"National Institute of Advanced Industrial Science and Technology","ror":"https://ror.org/01703db54","country_code":"JP","type":"government","lineage":["https://openalex.org/I73613424"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsuhisa Horimoto","raw_affiliation_strings":["Artificial Intelligence Research Center, National Institute of Advanced Industrial Science and Technology , 2-4-7, Aomi Koto-ku, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Artificial Intelligence Research Center, National Institute of Advanced Industrial Science and Technology , 2-4-7, Aomi Koto-ku, Tokyo, Japan","institution_ids":["https://openalex.org/I73613424"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076215084","display_name":"Kazuhiko Fukui","orcid":"https://orcid.org/0000-0002-2482-8481"},"institutions":[{"id":"https://openalex.org/I150744194","display_name":"Waseda University","ror":"https://ror.org/00ntfnx83","country_code":"JP","type":"education","lineage":["https://openalex.org/I150744194"]},{"id":"https://openalex.org/I73613424","display_name":"National Institute of Advanced Industrial Science and Technology","ror":"https://ror.org/01703db54","country_code":"JP","type":"government","lineage":["https://openalex.org/I73613424"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kazuhiko Fukui","raw_affiliation_strings":["AIST-Waseda University Computational Bio Big-Data Open Innovation Laboratory (CBBD-OIL) , 3-4-1, Okubo Shinjuku-ku, Tokyo 169-8555, Japan","Cellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology , 2-4-7, Aomi Koto-ku, Tokyo, Japan"],"raw_orcid":"https://orcid.org/0000-0002-2482-8481","affiliations":[{"raw_affiliation_string":"AIST-Waseda University Computational Bio Big-Data Open Innovation Laboratory (CBBD-OIL) , 3-4-1, Okubo Shinjuku-ku, Tokyo 169-8555, Japan","institution_ids":["https://openalex.org/I150744194"]},{"raw_affiliation_string":"Cellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology , 2-4-7, Aomi Koto-ku, Tokyo, Japan","institution_ids":["https://openalex.org/I73613424"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5026872938","https://openalex.org/A5076215084"],"corresponding_institution_ids":["https://openalex.org/I150744194","https://openalex.org/I73613424"],"apc_list":{"value":1415,"currency":"GBP","value_usd":1735},"apc_paid":{"value":1415,"currency":"GBP","value_usd":1735},"fwci":0.2653,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.55330082,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"2022","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.37279999256134033,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.37279999256134033,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.13369999825954437,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.11140000075101852,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phosphorylation","display_name":"Phosphorylation","score":0.8446794748306274},{"id":"https://openalex.org/keywords/protein-phosphorylation","display_name":"Protein phosphorylation","score":0.596747100353241},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.5504268407821655},{"id":"https://openalex.org/keywords/kinase","display_name":"Kinase","score":0.5449182391166687},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.48205170035362244},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.47282254695892334},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.4520364999771118},{"id":"https://openalex.org/keywords/database","display_name":"Database","score":0.42995545268058777},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3954451382160187},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3088262379169464},{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"Protein kinase A","score":0.24705064296722412},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.24068203568458557},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.21490809321403503},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.20270752906799316}],"concepts":[{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.8446794748306274},{"id":"https://openalex.org/C87325107","wikidata":"https://www.wikidata.org/wiki/Q7251493","display_name":"Protein phosphorylation","level":4,"score":0.596747100353241},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5504268407821655},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5449182391166687},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.48205170035362244},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.47282254695892334},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4520364999771118},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.42995545268058777},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3954451382160187},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3088262379169464},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.24705064296722412},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.24068203568458557},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21490809321403503},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.20270752906799316}],"mesh":[{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/database/baac072","is_oa":true,"landing_page_url":"https://doi.org/10.1093/database/baac072","pdf_url":"https://academic.oup.com/database/article-pdf/doi/10.1093/database/baac072/45494336/baac072.pdf","source":{"id":"https://openalex.org/S4210201630","display_name":"Database","issn_l":"1758-0463","issn":["1758-0463"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Database","raw_type":"journal-article"},{"id":"pmid:35994309","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35994309","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Database : the journal of biological databases and curation","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:9394491","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9394491","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Database (Oxford)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/database/baac072","is_oa":true,"landing_page_url":"https://doi.org/10.1093/database/baac072","pdf_url":"https://academic.oup.com/database/article-pdf/doi/10.1093/database/baac072/45494336/baac072.pdf","source":{"id":"https://openalex.org/S4210201630","display_name":"Database","issn_l":"1758-0463","issn":["1758-0463"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Database","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7200000286102295,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G6920561814","display_name":null,"funder_award_id":"21ae0101074s0203","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"}],"funders":[{"id":"https://openalex.org/F4320311405","display_name":"Japan Agency for Medical Research and Development","ror":"https://ror.org/004rtk039"},{"id":"https://openalex.org/F4320334789","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4292633637.pdf","grobid_xml":"https://content.openalex.org/works/W4292633637.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1639582946","https://openalex.org/W1679250118","https://openalex.org/W1989277387","https://openalex.org/W2030205108","https://openalex.org/W2033269165","https://openalex.org/W2042794231","https://openalex.org/W2043274355","https://openalex.org/W2059499441","https://openalex.org/W2084072056","https://openalex.org/W2091091775","https://openalex.org/W2100755177","https://openalex.org/W2105869859","https://openalex.org/W2106647330","https://openalex.org/W2106932520","https://openalex.org/W2110095004","https://openalex.org/W2110841878","https://openalex.org/W2112380414","https://openalex.org/W2130479394","https://openalex.org/W2133667940","https://openalex.org/W2155521690","https://openalex.org/W2170285778","https://openalex.org/W2270314129","https://openalex.org/W2766762767","https://openalex.org/W2998799567","https://openalex.org/W3000059924","https://openalex.org/W3004747635","https://openalex.org/W3038811185","https://openalex.org/W3097145107","https://openalex.org/W3152110994","https://openalex.org/W3159719254","https://openalex.org/W3173484879","https://openalex.org/W4233698560","https://openalex.org/W6637397027","https://openalex.org/W6682755346","https://openalex.org/W6684902706","https://openalex.org/W6693882756"],"related_works":["https://openalex.org/W2051108283","https://openalex.org/W2352214813","https://openalex.org/W1964515703","https://openalex.org/W2491608603","https://openalex.org/W941583161","https://openalex.org/W2505862120","https://openalex.org/W1576619789","https://openalex.org/W4223412920","https://openalex.org/W1973530967","https://openalex.org/W4362623556"],"abstract_inverted_index":{"Protein":[0],"phosphorylation":[1,60,73,96,167],"plays":[2],"a":[3,88,134],"fundamental":[4],"role":[5],"in":[6,35,118,164],"many":[7],"cellular":[8],"processes.":[9],"Proteins":[10],"are":[11,177],"phosphorylated":[12,106],"by":[13,126,168],"kinases,":[14],"which":[15],"have":[16,32],"been":[17],"studied":[18],"as":[19,133],"drug":[20,92,142,162],"targets":[21],"for":[22,138,158],"the":[23,115,127,151,170],"treatment":[24],"of":[25,51,62,91,161,166],"various":[26,171],"diseases,":[27],"particularly":[28],"cancer.":[29],"Because":[30],"kinases":[31],"multiple":[33],"roles":[34],"interconnected":[36],"molecular":[37,148],"pathways,":[38],"their":[39,147],"specific":[40],"regulation":[41],"is":[42,99],"required":[43],"to":[44,101],"enhance":[45],"beneficial":[46],"and":[47,64,81,121],"reduce":[48],"adversarial":[49],"effects":[50],"drugs.":[52,71,129,153],"Using":[53],"our":[54],"previously":[55],"developed":[56],"platform,":[57],"we":[58,85],"measured":[59],"profiles":[61,74],"MCF7":[63],"K562":[65],"cells":[66],"treated":[67],"with":[68,150],"94":[69,152],"clinical":[70],"These":[72],"can":[75,155],"provide":[76],"insights":[77],"into":[78],"pathway":[79,110],"activities":[80],"biological":[82],"functions.":[83],"Here,":[84],"introduce":[86],"Phosprof,":[87],"novel":[89],"database":[90],"response":[93],"based":[94,145],"on":[95,109,114,146],"activity.":[97],"Phosprof":[98,154],"able":[100],"present":[102],"up-":[103],"or":[104,140],"downregulated":[105],"signature":[107],"proteins":[108],"maps,":[111],"significant":[112],"pathways":[113,124],"hierarchal":[116],"tree":[117],"signal":[119],"transduction":[120],"commonly":[122],"perturbed":[123],"affected":[125],"selected":[128],"It":[130],"also":[131],"serves":[132],"useful":[135],"web":[136],"interface":[137],"new":[139],"known":[141],"profile":[143],"search":[144],"similarity":[149],"be":[156],"helpful":[157],"further":[159],"investigation":[160],"responses":[163],"terms":[165],"utilizing":[169],"approved":[172],"drugs":[173],"whose":[174],"target":[175],"phenotypes":[176],"known.":[178],"DATABASE":[179],"URL:":[180],"https://phosprof.medals.jp/.":[181]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-08-09T07:27:16.801131","created_date":"2025-10-10T00:00:00"}