{"id":"https://openalex.org/W3000337788","doi":"https://doi.org/10.1093/bioinformatics/btz973","title":"Fast zero-inflated negative binomial mixed modeling approach for analyzing longitudinal metagenomics data","display_name":"Fast zero-inflated negative binomial mixed modeling approach for analyzing longitudinal metagenomics data","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W3000337788","doi":"https://doi.org/10.1093/bioinformatics/btz973","mag":"3000337788","pmid":"https://pubmed.ncbi.nlm.nih.gov/31904815"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btz973","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btz973","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100393363","display_name":"Xinyan Zhang","orcid":"https://orcid.org/0000-0002-8274-8711"},"institutions":[{"id":"https://openalex.org/I39815113","display_name":"Georgia Southern University","ror":"https://ror.org/04agmb972","country_code":"US","type":"education","lineage":["https://openalex.org/I39815113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xinyan Zhang","raw_affiliation_strings":["Department of Biostatistics, Jiann-Ping Hsu College of Public Health, Georgia Southern University , Statesboro, GA 30458, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Jiann-Ping Hsu College of Public Health, Georgia Southern University , Statesboro, GA 30458, USA","institution_ids":["https://openalex.org/I39815113"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086059667","display_name":"Nengjun Yi","orcid":"https://orcid.org/0000-0001-5857-5868"},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nengjun Yi","raw_affiliation_strings":["Department of Biostatistics, University of Alabama at Birmingham , Birmingham, AL 35294, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, University of Alabama at Birmingham , Birmingham, AL 35294, USA","institution_ids":["https://openalex.org/I32389192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5086059667"],"corresponding_institution_ids":["https://openalex.org/I32389192"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":2.7341,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.91137457,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"36","issue":"8","first_page":"2345","last_page":"2351"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9923999905586243,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.978600025177002,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/count-data","display_name":"Count data","score":0.7440555095672607},{"id":"https://openalex.org/keywords/metagenomics","display_name":"Metagenomics","score":0.729305624961853},{"id":"https://openalex.org/keywords/negative-binomial-distribution","display_name":"Negative binomial distribution","score":0.6731610298156738},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5854659676551819},{"id":"https://openalex.org/keywords/generalized-linear-mixed-model","display_name":"Generalized linear mixed model","score":0.5076104402542114},{"id":"https://openalex.org/keywords/mixed-model","display_name":"Mixed model","score":0.49877357482910156},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.44113969802856445},{"id":"https://openalex.org/keywords/r-package","display_name":"R package","score":0.4320818781852722},{"id":"https://openalex.org/keywords/multinomial-distribution","display_name":"Multinomial distribution","score":0.4118730127811432},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.31546759605407715},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.22297197580337524},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.2170526385307312},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.17755335569381714}],"concepts":[{"id":"https://openalex.org/C33643355","wikidata":"https://www.wikidata.org/wiki/Q5176731","display_name":"Count data","level":3,"score":0.7440555095672607},{"id":"https://openalex.org/C15151743","wikidata":"https://www.wikidata.org/wiki/Q903778","display_name":"Metagenomics","level":3,"score":0.729305624961853},{"id":"https://openalex.org/C199335787","wikidata":"https://www.wikidata.org/wiki/Q743364","display_name":"Negative binomial distribution","level":3,"score":0.6731610298156738},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5854659676551819},{"id":"https://openalex.org/C153720581","wikidata":"https://www.wikidata.org/wiki/Q5532490","display_name":"Generalized linear mixed model","level":2,"score":0.5076104402542114},{"id":"https://openalex.org/C16012445","wikidata":"https://www.wikidata.org/wiki/Q1501135","display_name":"Mixed model","level":2,"score":0.49877357482910156},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.44113969802856445},{"id":"https://openalex.org/C2984074130","wikidata":"https://www.wikidata.org/wiki/Q73539779","display_name":"R package","level":2,"score":0.4320818781852722},{"id":"https://openalex.org/C192065140","wikidata":"https://www.wikidata.org/wiki/Q1147928","display_name":"Multinomial distribution","level":2,"score":0.4118730127811432},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.31546759605407715},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.22297197580337524},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.2170526385307312},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17755335569381714},{"id":"https://openalex.org/C459310","wikidata":"https://www.wikidata.org/wiki/Q117801","display_name":"Computational science","level":1,"score":0.0},{"id":"https://openalex.org/C100906024","wikidata":"https://www.wikidata.org/wiki/Q205692","display_name":"Poisson distribution","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012336","descriptor_name":"RNA, Ribosomal, 16S","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012336","descriptor_name":"RNA, Ribosomal, 16S","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012336","descriptor_name":"RNA, Ribosomal, 16S","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054892","descriptor_name":"Metagenome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054892","descriptor_name":"Metagenome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054892","descriptor_name":"Metagenome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056186","descriptor_name":"Metagenomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056186","descriptor_name":"Metagenomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056186","descriptor_name":"Metagenomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btz973","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btz973","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:31904815","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31904815","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1496933752","https://openalex.org/W1513618424","https://openalex.org/W1565240145","https://openalex.org/W1587094587","https://openalex.org/W1644145788","https://openalex.org/W1908906771","https://openalex.org/W1968578768","https://openalex.org/W2003412530","https://openalex.org/W2010916289","https://openalex.org/W2014581807","https://openalex.org/W2030714357","https://openalex.org/W2032579367","https://openalex.org/W2034875436","https://openalex.org/W2054680137","https://openalex.org/W2072997280","https://openalex.org/W2092696502","https://openalex.org/W2100318919","https://openalex.org/W2110518014","https://openalex.org/W2112577424","https://openalex.org/W2154065358","https://openalex.org/W2155988679","https://openalex.org/W2156591001","https://openalex.org/W2340748026","https://openalex.org/W2343597029","https://openalex.org/W2398800349","https://openalex.org/W2507058334","https://openalex.org/W2509481846","https://openalex.org/W2567421046","https://openalex.org/W2593643174","https://openalex.org/W2624135745","https://openalex.org/W2734475592","https://openalex.org/W2782323684","https://openalex.org/W2786358356","https://openalex.org/W2883762818","https://openalex.org/W2951361249","https://openalex.org/W2952200190","https://openalex.org/W3122992882","https://openalex.org/W4206439534","https://openalex.org/W4239130026"],"related_works":["https://openalex.org/W4307324678","https://openalex.org/W1994299254","https://openalex.org/W2021312236","https://openalex.org/W2186257539","https://openalex.org/W2895736713","https://openalex.org/W2477652392","https://openalex.org/W1551599973","https://openalex.org/W4388295412","https://openalex.org/W2356286374","https://openalex.org/W9882299"],"abstract_inverted_index":{"Supplementary":[0],"data":[1],"are":[2],"available":[3],"at":[4],"Bioinformatics":[5],"online.":[6]},"counts_by_year":[{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":4}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}