{"id":"https://openalex.org/W2984021089","doi":"https://doi.org/10.1093/bioinformatics/btz851","title":"Somatic selection distinguishes oncogenes and tumor suppressor genes","display_name":"Somatic selection distinguishes oncogenes and tumor suppressor genes","publication_year":2019,"publication_date":"2019-11-12","ids":{"openalex":"https://openalex.org/W2984021089","doi":"https://doi.org/10.1093/bioinformatics/btz851","mag":"2984021089","pmid":"https://pubmed.ncbi.nlm.nih.gov/32176769"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btz851","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btz851","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/36/6/1712/36089211/btz851.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/36/6/1712/36089211/btz851.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008660778","display_name":"Pramod Bharadwaj Chandrashekar","orcid":"https://orcid.org/0000-0002-0175-0423"},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pramod Chandrashekar","raw_affiliation_strings":["Center for Personalized Diagnostics, Biodesign Institute, Arizona State University , Tempe, AZ, 85281, USA","College of Health Solutions, Arizona State University , Phoenix, AZ, 85004, USA"],"raw_orcid":"https://orcid.org/0000-0002-0175-0423","affiliations":[{"raw_affiliation_string":"Center for Personalized Diagnostics, Biodesign Institute, Arizona State University , Tempe, AZ, 85281, USA","institution_ids":["https://openalex.org/I55732556"]},{"raw_affiliation_string":"College of Health Solutions, Arizona State University , Phoenix, AZ, 85004, USA","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007752758","display_name":"Navid Ahmadinejad","orcid":"https://orcid.org/0000-0001-8584-0890"},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Navid Ahmadinejad","raw_affiliation_strings":["Center for Personalized Diagnostics, Biodesign Institute, Arizona State University , Tempe, AZ, 85281, USA","College of Health Solutions, Arizona State University , Phoenix, AZ, 85004, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Personalized Diagnostics, Biodesign Institute, Arizona State University , Tempe, AZ, 85281, USA","institution_ids":["https://openalex.org/I55732556"]},{"raw_affiliation_string":"College of Health Solutions, Arizona State University , Phoenix, AZ, 85004, USA","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100704433","display_name":"Junwen Wang","orcid":"https://orcid.org/0000-0002-4432-4707"},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]},{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junwen Wang","raw_affiliation_strings":["College of Health Solutions, Arizona State University , Phoenix, AZ, 85004, USA","Department of Health Sciences Research & Center for Individualized Medicine , Mayo Clinic Arizona, Scottsdale, AZ, 85259, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Health Solutions, Arizona State University , Phoenix, AZ, 85004, USA","institution_ids":["https://openalex.org/I55732556"]},{"raw_affiliation_string":"Department of Health Sciences Research & Center for Individualized Medicine , Mayo Clinic Arizona, Scottsdale, AZ, 85259, USA","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101740053","display_name":"Aleksandar Sekuli\u0107","orcid":"https://orcid.org/0000-0002-1323-3220"},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aleksandar Sekulic","raw_affiliation_strings":["Department of Health Sciences Research & Center for Individualized Medicine , Mayo Clinic Arizona, Scottsdale, AZ, 85259, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Sciences Research & Center for Individualized Medicine , Mayo Clinic Arizona, Scottsdale, AZ, 85259, USA","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112904477","display_name":"Jan B. Egan","orcid":"https://orcid.org/0000-0002-2155-3099"},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jan B Egan","raw_affiliation_strings":["Department of Health Sciences Research & Center for Individualized Medicine , Mayo Clinic Arizona, Scottsdale, AZ, 85259, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Sciences Research & Center for Individualized Medicine , Mayo Clinic Arizona, Scottsdale, AZ, 85259, USA","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022178171","display_name":"Yan W. Asmann","orcid":"https://orcid.org/0000-0002-8896-2647"},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yan W Asmann","raw_affiliation_strings":["Department of Health Sciences Research, Mayo Clinic Florida , Jacksonville, AZ, 32224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Sciences Research, Mayo Clinic Florida , Jacksonville, AZ, 32224, USA","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100680948","display_name":"Sudhir Kumar","orcid":"https://orcid.org/0000-0002-9918-8212"},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sudhir Kumar","raw_affiliation_strings":["Department of Biology, Temple University , Philadelphia, PA, 19122, USA","Institute for Genomics and Evolutionary Medicine, Temple University , Philadelphia, PA, 19122, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Temple University , Philadelphia, PA, 19122, USA","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Institute for Genomics and Evolutionary Medicine, Temple University , Philadelphia, PA, 19122, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062132898","display_name":"Carlo C. Maley","orcid":"https://orcid.org/0000-0002-0745-7076"},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlo Maley","raw_affiliation_strings":["Center for Personalized Diagnostics, Biodesign Institute, Arizona State University , Tempe, AZ, 85281, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Personalized Diagnostics, Biodesign Institute, Arizona State University , Tempe, AZ, 85281, USA","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100418924","display_name":"Li Liu","orcid":"https://orcid.org/0000-0003-4002-7497"},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]},{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Li Liu","raw_affiliation_strings":["Center for Personalized Diagnostics, Biodesign Institute, Arizona State University , Tempe, AZ, 85281, USA","College of Health Solutions, Arizona State University , Phoenix, AZ, 85004, USA","Department of Health Sciences Research & Center for Individualized Medicine , Mayo Clinic Arizona, Scottsdale, AZ, 85259, USA"],"raw_orcid":"https://orcid.org/0000-0003-4002-7497","affiliations":[{"raw_affiliation_string":"Center for Personalized Diagnostics, Biodesign Institute, Arizona State University , Tempe, AZ, 85281, USA","institution_ids":["https://openalex.org/I55732556"]},{"raw_affiliation_string":"College of Health Solutions, Arizona State University , Phoenix, AZ, 85004, USA","institution_ids":["https://openalex.org/I55732556"]},{"raw_affiliation_string":"Department of Health Sciences Research & Center for Individualized Medicine , Mayo Clinic Arizona, Scottsdale, AZ, 85259, USA","institution_ids":["https://openalex.org/I4210125099"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5100418924"],"corresponding_institution_ids":["https://openalex.org/I4210125099","https://openalex.org/I55732556"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":1.4694,"has_fulltext":false,"cited_by_count":50,"citation_normalized_percentile":{"value":0.80200928,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"36","issue":"6","first_page":"1712","last_page":"1717"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.46970000863075256,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.46970000863075256,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.34119999408721924,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.01720000058412552,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.731785774230957},{"id":"https://openalex.org/keywords/suppressor","display_name":"Suppressor","score":0.6944186687469482},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.6035820841789246},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5881521701812744},{"id":"https://openalex.org/keywords/somatic-cell","display_name":"Somatic cell","score":0.5276345610618591},{"id":"https://openalex.org/keywords/selection","display_name":"Selection (genetic algorithm)","score":0.5191892385482788},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4861414134502411},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.47680923342704773},{"id":"https://openalex.org/keywords/negative-selection","display_name":"Negative selection","score":0.46041518449783325},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.433489590883255},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.21858826279640198},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.1767115592956543},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.05920088291168213}],"concepts":[{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.731785774230957},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.6944186687469482},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6035820841789246},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5881521701812744},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.5276345610618591},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.5191892385482788},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4861414134502411},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47680923342704773},{"id":"https://openalex.org/C7386963","wikidata":"https://www.wikidata.org/wiki/Q3954859","display_name":"Negative selection","level":4,"score":0.46041518449783325},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.433489590883255},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.21858826279640198},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.1767115592956543},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.05920088291168213},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009857","descriptor_name":"Oncogenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009857","descriptor_name":"Oncogenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009857","descriptor_name":"Oncogenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016147","descriptor_name":"Genes, Tumor Suppressor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016147","descriptor_name":"Genes, Tumor Suppressor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016147","descriptor_name":"Genes, Tumor Suppressor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1093/bioinformatics/btz851","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btz851","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/36/6/1712/36089211/btz851.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:32176769","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32176769","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:7703750","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7703750","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:scholarshare.temple.edu:20.500.12613/4523","is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.12613/4523","pdf_url":null,"source":{"id":"https://openalex.org/S4306402624","display_name":"TUScholarShare (Temple University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I84392919","host_organization_name":"Temple University","host_organization_lineage":["https://openalex.org/I84392919"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btz851","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btz851","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/36/6/1712/36089211/btz851.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1569974698","display_name":null,"funder_award_id":"U54CA217376","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2804744938","display_name":null,"funder_award_id":"LM012487","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G636439097","display_name":null,"funder_award_id":"R01 CA140657","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6883517829","display_name":null,"funder_award_id":"R01 LM012487","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"},{"id":"https://openalex.org/G7599057251","display_name":null,"funder_award_id":"U54 CA217376","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8509518165","display_name":null,"funder_award_id":"R01 LM013385","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"}],"funders":[{"id":"https://openalex.org/F4320306335","display_name":"Flinn Foundation","ror":"https://ror.org/058qtek75"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337372","display_name":"U.S. National Library of Medicine","ror":"https://ror.org/0060t0j89"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2984021089.pdf"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1566258855","https://openalex.org/W1837617056","https://openalex.org/W1956577542","https://openalex.org/W1963558982","https://openalex.org/W1973701942","https://openalex.org/W1979115864","https://openalex.org/W2034269086","https://openalex.org/W2043565416","https://openalex.org/W2044433401","https://openalex.org/W2045164090","https://openalex.org/W2045641296","https://openalex.org/W2051620527","https://openalex.org/W2066841033","https://openalex.org/W2073302269","https://openalex.org/W2126547130","https://openalex.org/W2128016314","https://openalex.org/W2131761857","https://openalex.org/W2145617244","https://openalex.org/W2152024278","https://openalex.org/W2158485828","https://openalex.org/W2160578982","https://openalex.org/W2259572413","https://openalex.org/W2260951263","https://openalex.org/W2413084977","https://openalex.org/W2439991713","https://openalex.org/W2472102520","https://openalex.org/W2557187647","https://openalex.org/W2589262995","https://openalex.org/W2591757282","https://openalex.org/W2608502938","https://openalex.org/W2624281239","https://openalex.org/W2734327577","https://openalex.org/W2734649221","https://openalex.org/W2743205823","https://openalex.org/W2795073885","https://openalex.org/W2796408191","https://openalex.org/W2894573839","https://openalex.org/W2906802315","https://openalex.org/W2952767051","https://openalex.org/W2956135855","https://openalex.org/W2966169904","https://openalex.org/W2973658374","https://openalex.org/W6638600212"],"related_works":["https://openalex.org/W2060908277","https://openalex.org/W2048083752","https://openalex.org/W2438531772","https://openalex.org/W1992103432","https://openalex.org/W81105053","https://openalex.org/W4251027247","https://openalex.org/W1881137434","https://openalex.org/W2046743283","https://openalex.org/W3021321537","https://openalex.org/W2081894066"],"abstract_inverted_index":{"MOTIVATION:":[0],"Functions":[1],"of":[2,52,66,69,139,167],"cancer":[3,23,45,131,145],"driver":[4,46],"genes":[5,19],"vary":[6],"substantially":[7],"across":[8],"tissues":[9],"and":[10,17,31,54,64,79,98,129],"organs.":[11],"Distinguishing":[12],"passenger":[13,76],"genes,":[14,47,77],"oncogenes":[15],"(OGs)":[16],"tumor-suppressor":[18],"(TSGs)":[20],"for":[21,27,49,75],"each":[22],"type":[24],"is":[25,171,180],"critical":[26],"understanding":[28],"tumor":[29,125],"biology":[30],"identifying":[32],"clinically":[33],"actionable":[34],"targets.":[35],"Although":[36],"many":[37],"computational":[38],"tools":[39],"are":[40,56,72,188],"available":[41,172,181,189],"to":[42,95,122],"predict":[43],"putative":[44],"resources":[48],"context-aware":[50],"classifications":[51],"OGs":[53,78,97,141],"TSGs":[55,99],"limited.":[57],"RESULTS:":[58],"We":[59],"show":[60],"that":[61],"the":[62,168],"direction":[63],"magnitude":[65],"somatic":[67],"selection":[68,92,107],"protein-coding":[70],"mutations":[71],"significantly":[73],"different":[74,154],"TSGs.":[80],"Based":[81],"on":[82],"these":[83],"patterns,":[84],"we":[85,147],"develop":[86],"a":[87,101,111],"new":[88],"method":[89],"(genes":[90],"under":[91,106],"in":[93,100,108,153,158],"tumors)":[94],"discover":[96],"cancer-type":[102],"specific":[103],"manner.":[104],"Genes":[105],"tumors":[109],"shows":[110],"high":[112,134],"accuracy":[113],"(92%)":[114],"when":[115],"evaluated":[116],"via":[117],"strict":[118],"cross-validations.":[119],"Its":[120],"application":[121],"10":[123],"172":[124],"exomes":[126],"found":[127,148],"known":[128],"novel":[130],"drivers":[132],"with":[133,177],"tissue-specificities.":[135],"In":[136],"11":[137],"out":[138],"13":[140],"shared":[142],"among":[143],"multiple":[144],"types,":[146],"functional":[149],"domains":[150],"selectively":[151],"engaged":[152],"cancers,":[155],"suggesting":[156],"differences":[157],"disease":[159],"mechanisms.":[160],"AVAILABILITY":[161],"AND":[162],"IMPLEMENTATION:":[163],"An":[164],"R":[165],"implementation":[166],"GUST":[169],"algorithm":[170],"at":[173,182,190],"https://github.com/liliulab/gust.":[174],"A":[175],"database":[176],"pre-computed":[178],"results":[179],"https://liliulab.shinyapps.io/gust.":[183],"SUPPLEMENTARY":[184],"INFORMATION:":[185],"Supplementary":[186],"data":[187],"Bioinformatics":[191],"online.":[192]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5}],"updated_date":"2026-06-24T13:16:06.693445","created_date":"2025-10-10T00:00:00"}