{"id":"https://openalex.org/W2979986977","doi":"https://doi.org/10.1093/bioinformatics/btz773","title":"SOLart: a structure-based method to predict protein solubility and aggregation","display_name":"SOLart: a structure-based method to predict protein solubility and aggregation","publication_year":2019,"publication_date":"2019-10-08","ids":{"openalex":"https://openalex.org/W2979986977","doi":"https://doi.org/10.1093/bioinformatics/btz773","mag":"2979986977","pmid":"https://pubmed.ncbi.nlm.nih.gov/31603466"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btz773","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btz773","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/36/5/1445/32794024/btz773.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/36/5/1445/32794024/btz773.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027816412","display_name":"Qingzhen Hou","orcid":"https://orcid.org/0000-0002-7655-0899"},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Qingzhen Hou","raw_affiliation_strings":["Computational Biology and Bioinformatics, Universit\u00e9 Libre de Bruxelles , Avenue Roosevelt 50, 1050 Brussels, Belgium","Interuniversity Institute of Bioinformatics in Brussels , Boulevard du Triomphe, 1050 Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biology and Bioinformatics, Universit\u00e9 Libre de Bruxelles , Avenue Roosevelt 50, 1050 Brussels, Belgium","institution_ids":["https://openalex.org/I132053463"]},{"raw_affiliation_string":"Interuniversity Institute of Bioinformatics in Brussels , Boulevard du Triomphe, 1050 Brussels, Belgium","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037585501","display_name":"Jean Marc Kwasigroch","orcid":null},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jean Marc Kwasigroch","raw_affiliation_strings":["Computational Biology and Bioinformatics, Universit\u00e9 Libre de Bruxelles , Avenue Roosevelt 50, 1050 Brussels, Belgium","Interuniversity Institute of Bioinformatics in Brussels , Boulevard du Triomphe, 1050 Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biology and Bioinformatics, Universit\u00e9 Libre de Bruxelles , Avenue Roosevelt 50, 1050 Brussels, Belgium","institution_ids":["https://openalex.org/I132053463"]},{"raw_affiliation_string":"Interuniversity Institute of Bioinformatics in Brussels , Boulevard du Triomphe, 1050 Brussels, Belgium","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073330873","display_name":"Marianne Rooman","orcid":"https://orcid.org/0000-0002-3810-7802"},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Marianne Rooman","raw_affiliation_strings":["Computational Biology and Bioinformatics, Universit\u00e9 Libre de Bruxelles , Avenue Roosevelt 50, 1050 Brussels, Belgium","Interuniversity Institute of Bioinformatics in Brussels , Boulevard du Triomphe, 1050 Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biology and Bioinformatics, Universit\u00e9 Libre de Bruxelles , Avenue Roosevelt 50, 1050 Brussels, Belgium","institution_ids":["https://openalex.org/I132053463"]},{"raw_affiliation_string":"Interuniversity Institute of Bioinformatics in Brussels , Boulevard du Triomphe, 1050 Brussels, Belgium","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085366265","display_name":"Fabrizio Pucci","orcid":"https://orcid.org/0000-0003-2916-022X"},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]},{"id":"https://openalex.org/I171892758","display_name":"Forschungszentrum J\u00fclich","ror":"https://ror.org/02nv7yv05","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I171892758"]},{"id":"https://openalex.org/I4210113364","display_name":"John von Neumann Institute for Computing","ror":"https://ror.org/02zmk8084","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I1305996414","https://openalex.org/I1305996414","https://openalex.org/I169556180","https://openalex.org/I171892758","https://openalex.org/I2801876189","https://openalex.org/I4210113364"]}],"countries":["BE","DE"],"is_corresponding":false,"raw_author_name":"Fabrizio Pucci","raw_affiliation_strings":["Computational Biology and Bioinformatics, Universit\u00e9 Libre de Bruxelles , Avenue Roosevelt 50, 1050 Brussels, Belgium","Interuniversity Institute of Bioinformatics in Brussels , Boulevard du Triomphe, 1050 Brussels, Belgium","John von Neumann Institute for Computing , J\u00fclich Supercomputer Centre, Forschungszentrum J\u00fclich, 52428 J\u00fclich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biology and Bioinformatics, Universit\u00e9 Libre de Bruxelles , Avenue Roosevelt 50, 1050 Brussels, Belgium","institution_ids":["https://openalex.org/I132053463"]},{"raw_affiliation_string":"Interuniversity Institute of Bioinformatics in Brussels , Boulevard du Triomphe, 1050 Brussels, Belgium","institution_ids":[]},{"raw_affiliation_string":"John von Neumann Institute for Computing , J\u00fclich Supercomputer Centre, Forschungszentrum J\u00fclich, 52428 J\u00fclich, Germany","institution_ids":["https://openalex.org/I171892758","https://openalex.org/I4210113364"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5073330873"],"corresponding_institution_ids":["https://openalex.org/I132053463"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":2.5807,"has_fulltext":false,"cited_by_count":88,"citation_normalized_percentile":{"value":0.90955089,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"36","issue":"5","first_page":"1445","last_page":"1452"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.41920000314712524,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.41920000314712524,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.1354999989271164,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.10750000178813934,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/solubility","display_name":"Solubility","score":0.6221544742584229},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6175155639648438},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.37797781825065613},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.28611937165260315},{"id":"https://openalex.org/keywords/physical-chemistry","display_name":"Physical chemistry","score":0.09082493185997009},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.08789947628974915}],"concepts":[{"id":"https://openalex.org/C155574463","wikidata":"https://www.wikidata.org/wiki/Q170731","display_name":"Solubility","level":2,"score":0.6221544742584229},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6175155639648438},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.37797781825065613},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.28611937165260315},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.09082493185997009},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08789947628974915}],"mesh":[{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012997","descriptor_name":"Solvents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012997","descriptor_name":"Solvents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012997","descriptor_name":"Solvents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btz773","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btz773","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/36/5/1445/32794024/btz773.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:31603466","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31603466","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:dipot.ulb.ac.be:2013/300304","is_oa":true,"landing_page_url":"http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/300304","pdf_url":null,"source":{"id":"https://openalex.org/S4306401063","display_name":"D\u00e9p\u00f4t institutionnel de l'Universit\u00e9 libre de Bruxelles (Universit\u00e9 Libre de Bruxelles)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I132053463","host_organization_name":"Universit\u00e9 Libre de Bruxelles","host_organization_lineage":["https://openalex.org/I132053463"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics, 36 (5","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btz773","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btz773","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/36/5/1445/32794024/btz773.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321390","display_name":"Fonds De La Recherche Scientifique - FNRS","ror":"https://ror.org/03q83t159"},{"id":"https://openalex.org/F4320333433","display_name":"National Institute of Corrections","ror":null}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2979986977.pdf"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W273955616","https://openalex.org/W1551212125","https://openalex.org/W1582795354","https://openalex.org/W1588724272","https://openalex.org/W1831050183","https://openalex.org/W1949063151","https://openalex.org/W1970756887","https://openalex.org/W1972260684","https://openalex.org/W1972291622","https://openalex.org/W2002559713","https://openalex.org/W2014140912","https://openalex.org/W2015185330","https://openalex.org/W2048537773","https://openalex.org/W2058908275","https://openalex.org/W2067552612","https://openalex.org/W2073758773","https://openalex.org/W2080187647","https://openalex.org/W2083152645","https://openalex.org/W2093861673","https://openalex.org/W2094535327","https://openalex.org/W2102592002","https://openalex.org/W2103083136","https://openalex.org/W2113196743","https://openalex.org/W2119246926","https://openalex.org/W2123863402","https://openalex.org/W2130479394","https://openalex.org/W2133458779","https://openalex.org/W2137433045","https://openalex.org/W2138816428","https://openalex.org/W2151548440","https://openalex.org/W2153153865","https://openalex.org/W2154139219","https://openalex.org/W2156665896","https://openalex.org/W2162780339","https://openalex.org/W2163222586","https://openalex.org/W2164511624","https://openalex.org/W2165186407","https://openalex.org/W2171419407","https://openalex.org/W2171533950","https://openalex.org/W2171698890","https://openalex.org/W2172034373","https://openalex.org/W2255304239","https://openalex.org/W2298358682","https://openalex.org/W2558272290","https://openalex.org/W2585597953","https://openalex.org/W2620185010","https://openalex.org/W2766578745","https://openalex.org/W2783557542","https://openalex.org/W2794004073","https://openalex.org/W2893520080","https://openalex.org/W2943407516","https://openalex.org/W4234714728","https://openalex.org/W6610017368"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W1990608904","https://openalex.org/W1539400370","https://openalex.org/W2007219878","https://openalex.org/W1934224411","https://openalex.org/W1561807720","https://openalex.org/W2005109573","https://openalex.org/W1564792705"],"abstract_inverted_index":{"MOTIVATION:":[0],"The":[1,238],"solubility":[2,15,43,55,126,134,168,218],"of":[3,14,33,40,73,118,170,185,192],"a":[4,17,37,51,110,116,160,196,224],"protein":[5,28,34,80,133],"is":[6,16,50,201,221,228,241],"often":[7],"decisive":[8],"for":[9,54],"its":[10],"proper":[11],"functioning.":[12],"Lack":[13],"major":[18],"bottleneck":[19],"in":[20,26,76,174,181,199],"high-throughput":[21],"structural":[22],"genomic":[23],"studies":[24],"and":[25,30,47,96,99,106,125,166,180,211,214],"high-concentration":[27],"production,":[29],"the":[31,71,131,177],"formation":[32],"aggregates":[35],"causes":[36],"wide":[38],"variety":[39],"diseases.":[41],"Since":[42],"measurements":[44],"are":[45,67,156,250],"time-consuming":[46],"expensive,":[48],"there":[49],"strong":[52],"need":[53],"prediction":[56],"tools.":[57],"RESULTS:":[58],"We":[59,128],"have":[60],"recently":[61],"introduced":[62],"solubility-dependent":[63,89,151],"distance":[64],"potentials":[65,90],"that":[66],"able":[68],"to":[69,142,230],"unravel":[70],"role":[72],"residue-residue":[74],"interactions":[75],"promoting":[77],"or":[78],"decreasing":[79],"solubility.":[81],"Here,":[82],"we":[83],"extended":[84],"their":[85],"construction":[86],"by":[87,232],"defining":[88],"based":[91],"on":[92,115,176],"backbone":[93],"torsion":[94],"angles":[95],"solvent":[97],"accessibility,":[98],"integrated":[100],"them,":[101],"together":[102],"with":[103,122,159,208],"other":[104],"structure-":[105],"sequence-based":[107],"features,":[108],"into":[109],"random":[111],"forest":[112],"model":[113],"trained":[114],"set":[117,184],"Escherichia":[119],"coli":[120],"proteins":[121],"experimental":[123,165],"structures":[124],"values.":[127],"thus":[129,205],"obtained":[130],"SOLart":[132,154,203,239],"predictor,":[135],"whose":[136],"most":[137],"informative":[138],"features":[139],"turned":[140],"out":[141],"be":[143,206],"folding":[144],"free":[145],"energy":[146],"differences":[147],"computed":[148],"from":[149],"our":[150],"statistical":[152],"potentials.":[153],"performances":[155],"very":[157],"good,":[158],"Pearson":[161],"correlation":[162],"coefficient":[163],"between":[164],"predicted":[167],"values":[169],"almost":[171],"0.7":[172],"both":[173,209],"cross-validation":[175],"training":[178],"dataset":[179],"an":[182],"independent":[183],"Saccharomyces":[186],"cerevisiae":[187],"proteins.":[188],"On":[189],"test":[190],"sets":[191],"modeled":[193],"structures,":[194,213],"only":[195],"limited":[197],"drop":[198],"performance":[200],"observed.":[202],"can":[204],"used":[207],"high-resolution":[210],"low-resolution":[212],"clearly":[215],"outperforms":[216],"state-of-art":[217],"predictors.":[219],"It":[220],"available":[222,243,251],"through":[223],"user-friendly":[225],"webserver,":[226],"which":[227],"easy":[229],"use":[231],"non-expert":[233],"scientists.":[234],"AVAILABILITY":[235],"AND":[236],"IMPLEMENTATION:":[237],"webserver":[240],"freely":[242],"at":[244,252],"http://babylone.ulb.ac.be/SOLART/.":[245],"SUPPLEMENTARY":[246],"INFORMATION:":[247],"Supplementary":[248],"data":[249],"Bioinformatics":[253],"online.":[254]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":18},{"year":2024,"cited_by_count":15},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":2}],"updated_date":"2026-07-30T17:31:21.811387","created_date":"2025-10-10T00:00:00"}