{"id":"https://openalex.org/W2980281204","doi":"https://doi.org/10.1093/bioinformatics/btz758","title":"Single-sample landscape entropy reveals the imminent phase transition during disease progression","display_name":"Single-sample landscape entropy reveals the imminent phase transition during disease progression","publication_year":2019,"publication_date":"2019-10-08","ids":{"openalex":"https://openalex.org/W2980281204","doi":"https://doi.org/10.1093/bioinformatics/btz758","mag":"2980281204","pmid":"https://pubmed.ncbi.nlm.nih.gov/31598632"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btz758","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btz758","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/36/5/1522/32794031/btz758.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/36/5/1522/32794031/btz758.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100448485","display_name":"Rui Liu","orcid":"https://orcid.org/0000-0002-4547-8695"},"institutions":[{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui Liu","raw_affiliation_strings":["School of Mathematics, South China University of Technology , Guangzhou 510640, China"],"affiliations":[{"raw_affiliation_string":"School of Mathematics, South China University of Technology , Guangzhou 510640, China","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100326679","display_name":"Pei Chen","orcid":"https://orcid.org/0000-0002-2017-576X"},"institutions":[{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Pei Chen","raw_affiliation_strings":["School of Mathematics, South China University of Technology , Guangzhou 510640, China"],"affiliations":[{"raw_affiliation_string":"School of Mathematics, South China University of Technology , Guangzhou 510640, China","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012283696","display_name":"Luonan Chen","orcid":"https://orcid.org/0000-0002-3960-0068"},"institutions":[{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]},{"id":"https://openalex.org/I4210121447","display_name":"Center for Excellence in Molecular Cell Science","ror":"https://ror.org/02rrdvm96","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210121447"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210164150","display_name":"Shanghai Center for Brain Science and Brain-Inspired Technology","ror":"https://ror.org/0551a0y31","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210164150"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Luonan Chen","raw_affiliation_strings":["Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences , Kunming 650223, China","Key Laboratory of Systems Biology, Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences , Shanghai 200031, China","Shanghai Research Center for Brain Science and Brain-Inspired Intelligence , Shanghai 201210, China"],"affiliations":[{"raw_affiliation_string":"Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences , Kunming 650223, China","institution_ids":["https://openalex.org/I19820366"]},{"raw_affiliation_string":"Key Laboratory of Systems Biology, Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences , Shanghai 200031, China","institution_ids":["https://openalex.org/I4210121447","https://openalex.org/I19820366","https://openalex.org/I4210106477"]},{"raw_affiliation_string":"Shanghai Research Center for Brain Science and Brain-Inspired Intelligence , Shanghai 201210, China","institution_ids":["https://openalex.org/I4210164150"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5012283696","https://openalex.org/A5100326679"],"corresponding_institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477","https://openalex.org/I4210121447","https://openalex.org/I4210164150","https://openalex.org/I90610280"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":4.5386,"has_fulltext":false,"cited_by_count":95,"citation_normalized_percentile":{"value":0.95744387,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"36","issue":"5","first_page":"1522","last_page":"1532"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9829999804496765,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/entropy","display_name":"Entropy (arrow of time)","score":0.5349423289299011},{"id":"https://openalex.org/keywords/statistical-physics","display_name":"Statistical physics","score":0.4944624900817871},{"id":"https://openalex.org/keywords/sample","display_name":"Sample (material)","score":0.49263912439346313},{"id":"https://openalex.org/keywords/sample-entropy","display_name":"Sample entropy","score":0.4640457034111023},{"id":"https://openalex.org/keywords/phase-transition","display_name":"Phase transition","score":0.4514707922935486},{"id":"https://openalex.org/keywords/transition","display_name":"Transition (genetics)","score":0.41966792941093445},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.38016462326049805},{"id":"https://openalex.org/keywords/econometrics","display_name":"Econometrics","score":0.3347194194793701},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.3271852731704712},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3224886953830719},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.30111613869667053},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.2314228117465973},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.20552626252174377},{"id":"https://openalex.org/keywords/chromatography","display_name":"Chromatography","score":0.16548454761505127},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.16120001673698425},{"id":"https://openalex.org/keywords/thermodynamics","display_name":"Thermodynamics","score":0.13971680402755737}],"concepts":[{"id":"https://openalex.org/C106301342","wikidata":"https://www.wikidata.org/wiki/Q4117933","display_name":"Entropy (arrow of time)","level":2,"score":0.5349423289299011},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.4944624900817871},{"id":"https://openalex.org/C198531522","wikidata":"https://www.wikidata.org/wiki/Q485146","display_name":"Sample (material)","level":2,"score":0.49263912439346313},{"id":"https://openalex.org/C66696666","wikidata":"https://www.wikidata.org/wiki/Q17105612","display_name":"Sample entropy","level":3,"score":0.4640457034111023},{"id":"https://openalex.org/C149288129","wikidata":"https://www.wikidata.org/wiki/Q185357","display_name":"Phase transition","level":2,"score":0.4514707922935486},{"id":"https://openalex.org/C194232998","wikidata":"https://www.wikidata.org/wiki/Q1606712","display_name":"Transition (genetics)","level":3,"score":0.41966792941093445},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.38016462326049805},{"id":"https://openalex.org/C149782125","wikidata":"https://www.wikidata.org/wiki/Q160039","display_name":"Econometrics","level":1,"score":0.3347194194793701},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3271852731704712},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3224886953830719},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30111613869667053},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2314228117465973},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.20552626252174377},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.16548454761505127},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16120001673698425},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.13971680402755737},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019277","descriptor_name":"Entropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019277","descriptor_name":"Entropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019277","descriptor_name":"Entropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btz758","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btz758","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/36/5/1522/32794031/btz758.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:31598632","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31598632","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btz758","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btz758","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/36/5/1522/32794031/btz758.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7400000095367432,"display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G1007789424","display_name":null,"funder_award_id":"2017YFA0505500","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G1031434965","display_name":null,"funder_award_id":"31930022","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4102960347","display_name":null,"funder_award_id":"31771476","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4635834956","display_name":null,"funder_award_id":"11901203","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5314434045","display_name":null,"funder_award_id":"11771152","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6949819384","display_name":null,"funder_award_id":"2019MS111","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G7159030997","display_name":null,"funder_award_id":"2019B151502062","funder_id":"https://openalex.org/F4320337111","funder_display_name":"Basic and Applied Basic Research Foundation of Guangdong Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null},{"id":"https://openalex.org/F4320337111","display_name":"Basic and Applied Basic Research Foundation of Guangdong Province","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2980281204.pdf","grobid_xml":"https://content.openalex.org/works/W2980281204.grobid-xml"},"referenced_works_count":79,"referenced_works":["https://openalex.org/W600438518","https://openalex.org/W1601070508","https://openalex.org/W1616468580","https://openalex.org/W1892363833","https://openalex.org/W1965890236","https://openalex.org/W1966469380","https://openalex.org/W1973979344","https://openalex.org/W1976752649","https://openalex.org/W1983082314","https://openalex.org/W1983577042","https://openalex.org/W1989105287","https://openalex.org/W1998443306","https://openalex.org/W2007599495","https://openalex.org/W2007885262","https://openalex.org/W2008405927","https://openalex.org/W2014693052","https://openalex.org/W2026576172","https://openalex.org/W2029018130","https://openalex.org/W2030083295","https://openalex.org/W2033561829","https://openalex.org/W2035471593","https://openalex.org/W2040264938","https://openalex.org/W2040401976","https://openalex.org/W2040565342","https://openalex.org/W2050000965","https://openalex.org/W2055235218","https://openalex.org/W2068784631","https://openalex.org/W2075080759","https://openalex.org/W2086116383","https://openalex.org/W2086411786","https://openalex.org/W2089491174","https://openalex.org/W2092180337","https://openalex.org/W2096173332","https://openalex.org/W2100139538","https://openalex.org/W2103017472","https://openalex.org/W2106927126","https://openalex.org/W2116199452","https://openalex.org/W2120510384","https://openalex.org/W2134759932","https://openalex.org/W2134964552","https://openalex.org/W2136861086","https://openalex.org/W2138835511","https://openalex.org/W2151098810","https://openalex.org/W2154349465","https://openalex.org/W2156262303","https://openalex.org/W2159482845","https://openalex.org/W2167279877","https://openalex.org/W2167874269","https://openalex.org/W2169401708","https://openalex.org/W2171653202","https://openalex.org/W2335527355","https://openalex.org/W2344677018","https://openalex.org/W2401833807","https://openalex.org/W2417285541","https://openalex.org/W2417365772","https://openalex.org/W2462400394","https://openalex.org/W2475189158","https://openalex.org/W2508622936","https://openalex.org/W2547691837","https://openalex.org/W2556756273","https://openalex.org/W2557530941","https://openalex.org/W2570396690","https://openalex.org/W2570629027","https://openalex.org/W2631063318","https://openalex.org/W2728974037","https://openalex.org/W2754346778","https://openalex.org/W2765174715","https://openalex.org/W2800948866","https://openalex.org/W2896741302","https://openalex.org/W2899397884","https://openalex.org/W2907471989","https://openalex.org/W2952938648","https://openalex.org/W4235383396","https://openalex.org/W4294216483","https://openalex.org/W6673579618","https://openalex.org/W6684587864","https://openalex.org/W6716620241","https://openalex.org/W6744313548","https://openalex.org/W6755613812"],"related_works":["https://openalex.org/W2165375209","https://openalex.org/W3088843374","https://openalex.org/W2076258781","https://openalex.org/W2050076996","https://openalex.org/W229760109","https://openalex.org/W2093589470","https://openalex.org/W2006708776","https://openalex.org/W2415751681","https://openalex.org/W2889925888","https://openalex.org/W2022287597"],"abstract_inverted_index":{"Supplementary":[0],"data":[1],"are":[2],"available":[3],"at":[4],"Bioinformatics":[5],"online.":[6]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":24},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":18}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}
