{"id":"https://openalex.org/W2971233697","doi":"https://doi.org/10.1093/bioinformatics/btz672","title":"Tissue-specific deconvolution of immune cell composition by integrating bulk and single-cell transcriptomes","display_name":"Tissue-specific deconvolution of immune cell composition by integrating bulk and single-cell transcriptomes","publication_year":2019,"publication_date":"2019-08-22","ids":{"openalex":"https://openalex.org/W2971233697","doi":"https://doi.org/10.1093/bioinformatics/btz672","mag":"2971233697","pmid":"https://pubmed.ncbi.nlm.nih.gov/31504185"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btz672","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btz672","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/36/3/819/32369638/btz672.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/36/3/819/32369638/btz672.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100368261","display_name":"Ziyi Chen","orcid":"https://orcid.org/0000-0001-9870-4361"},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210122727","display_name":"Suzhou Institute of Systems Medicine","ror":"https://ror.org/02szepc22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210122727","https://openalex.org/I4210141683"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ziyi Chen","raw_affiliation_strings":["Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100005, China","Suzhou Institute of Systems Medicine , Suzhou 215123, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100005, China","institution_ids":["https://openalex.org/I200296433"]},{"raw_affiliation_string":"Suzhou Institute of Systems Medicine , Suzhou 215123, China","institution_ids":["https://openalex.org/I4210122727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002473889","display_name":"Chengyang Ji","orcid":"https://orcid.org/0000-0001-9258-5453"},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210122727","display_name":"Suzhou Institute of Systems Medicine","ror":"https://ror.org/02szepc22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210122727","https://openalex.org/I4210141683"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chengyang Ji","raw_affiliation_strings":["Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100005, China","Suzhou Institute of Systems Medicine , Suzhou 215123, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100005, China","institution_ids":["https://openalex.org/I200296433"]},{"raw_affiliation_string":"Suzhou Institute of Systems Medicine , Suzhou 215123, China","institution_ids":["https://openalex.org/I4210122727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100752201","display_name":"Qin Shen","orcid":"https://orcid.org/0000-0002-9000-494X"},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210122727","display_name":"Suzhou Institute of Systems Medicine","ror":"https://ror.org/02szepc22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210122727","https://openalex.org/I4210141683"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qin Shen","raw_affiliation_strings":["Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100005, China","Suzhou Institute of Systems Medicine , Suzhou 215123, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100005, China","institution_ids":["https://openalex.org/I200296433"]},{"raw_affiliation_string":"Suzhou Institute of Systems Medicine , Suzhou 215123, China","institution_ids":["https://openalex.org/I4210122727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042289560","display_name":"Wei Liu","orcid":"https://orcid.org/0000-0003-0436-1797"},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210122727","display_name":"Suzhou Institute of Systems Medicine","ror":"https://ror.org/02szepc22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210122727","https://openalex.org/I4210141683"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Liu","raw_affiliation_strings":["Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100005, China","Suzhou Institute of Systems Medicine , Suzhou 215123, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100005, China","institution_ids":["https://openalex.org/I200296433"]},{"raw_affiliation_string":"Suzhou Institute of Systems Medicine , Suzhou 215123, China","institution_ids":["https://openalex.org/I4210122727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015951538","display_name":"F. Xiao\u2010Feng Qin","orcid":"https://orcid.org/0000-0002-5395-0304"},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210122727","display_name":"Suzhou Institute of Systems Medicine","ror":"https://ror.org/02szepc22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210122727","https://openalex.org/I4210141683"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"F Xiao-Feng Qin","raw_affiliation_strings":["Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100005, China","Suzhou Institute of Systems Medicine , Suzhou 215123, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100005, China","institution_ids":["https://openalex.org/I200296433"]},{"raw_affiliation_string":"Suzhou Institute of Systems Medicine , Suzhou 215123, China","institution_ids":["https://openalex.org/I4210122727"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047692460","display_name":"Aiping Wu","orcid":"https://orcid.org/0000-0002-5869-651X"},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210122727","display_name":"Suzhou Institute of Systems Medicine","ror":"https://ror.org/02szepc22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210122727","https://openalex.org/I4210141683"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Aiping Wu","raw_affiliation_strings":["Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100005, China","Suzhou Institute of Systems Medicine , Suzhou 215123, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100005, China","institution_ids":["https://openalex.org/I200296433"]},{"raw_affiliation_string":"Suzhou Institute of Systems Medicine , Suzhou 215123, China","institution_ids":["https://openalex.org/I4210122727"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5047692460"],"corresponding_institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210122727"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":0.6833,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.67622097,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"36","issue":"3","first_page":"819","last_page":"827"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.7398073673248291},{"id":"https://openalex.org/keywords/deconvolution","display_name":"Deconvolution","score":0.7256829738616943},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.6281107664108276},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5386263132095337},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.49012574553489685},{"id":"https://openalex.org/keywords/signature","display_name":"Signature (topology)","score":0.4445026218891144},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4286803901195526},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.41978222131729126},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.34014713764190674},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3107554614543915},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.21543437242507935},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.15849652886390686},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.12971842288970947}],"concepts":[{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.7398073673248291},{"id":"https://openalex.org/C174576160","wikidata":"https://www.wikidata.org/wiki/Q1183700","display_name":"Deconvolution","level":2,"score":0.7256829738616943},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6281107664108276},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5386263132095337},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49012574553489685},{"id":"https://openalex.org/C2779696439","wikidata":"https://www.wikidata.org/wiki/Q7512811","display_name":"Signature (topology)","level":2,"score":0.4445026218891144},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4286803901195526},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.41978222131729126},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.34014713764190674},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3107554614543915},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.21543437242507935},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15849652886390686},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.12971842288970947},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btz672","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btz672","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/36/3/819/32369638/btz672.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:31504185","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31504185","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btz672","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btz672","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/36/3/819/32369638/btz672.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1345243867","display_name":null,"funder_award_id":"2016\u2010I2M\u20101\u2010005","funder_id":"https://openalex.org/F4320323137","funder_display_name":"Chinese Academy of Medical Sciences"},{"id":"https://openalex.org/G2863489447","display_name":null,"funder_award_id":"BK20161245","funder_id":"https://openalex.org/F4320322769","funder_display_name":"Natural Science Foundation of Jiangsu Province"},{"id":"https://openalex.org/G3562381884","display_name":null,"funder_award_id":"201900004","funder_id":"https://openalex.org/F4320326873","funder_display_name":"National Laboratory of Pattern Recognition"},{"id":"https://openalex.org/G4636497604","display_name":null,"funder_award_id":"2016-I2M-1-005","funder_id":"https://openalex.org/F4320336738","funder_display_name":"Chinese Academy of Medical Sciences Initiative for Innovative Medicine"},{"id":"https://openalex.org/G5822758853","display_name":null,"funder_award_id":"2018RC310022","funder_id":"https://openalex.org/F4320323137","funder_display_name":"Chinese Academy of Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320321605","display_name":"Government of Jiangsu Province","ror":"https://ror.org/004svx814"},{"id":"https://openalex.org/F4320322769","display_name":"Natural Science Foundation of Jiangsu Province","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320323137","display_name":"Chinese Academy of Medical Sciences","ror":"https://ror.org/03cve4549"},{"id":"https://openalex.org/F4320326873","display_name":"National Laboratory of Pattern Recognition","ror":null},{"id":"https://openalex.org/F4320336738","display_name":"Chinese Academy of Medical Sciences Initiative for Innovative Medicine","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2971233697.pdf","grobid_xml":"https://content.openalex.org/works/W2971233697.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1985987855","https://openalex.org/W2027508640","https://openalex.org/W2028426093","https://openalex.org/W2090384073","https://openalex.org/W2104950932","https://openalex.org/W2105064756","https://openalex.org/W2126811287","https://openalex.org/W2137526110","https://openalex.org/W2290890702","https://openalex.org/W2301038687","https://openalex.org/W2432712296","https://openalex.org/W2506892818","https://openalex.org/W2507880739","https://openalex.org/W2579440183","https://openalex.org/W2599073119","https://openalex.org/W2788348358","https://openalex.org/W2788357641","https://openalex.org/W2794480084","https://openalex.org/W2803613017","https://openalex.org/W2894687190","https://openalex.org/W2895908547","https://openalex.org/W2899588238","https://openalex.org/W2921330004","https://openalex.org/W2942610007","https://openalex.org/W2950779253","https://openalex.org/W2952001873"],"related_works":["https://openalex.org/W2009966535","https://openalex.org/W2102579905","https://openalex.org/W4247273247","https://openalex.org/W1971124177","https://openalex.org/W3089353767","https://openalex.org/W3097825150","https://openalex.org/W3146618441","https://openalex.org/W2513916811","https://openalex.org/W4213265720","https://openalex.org/W2131160279"],"abstract_inverted_index":{"MOTIVATION:":[0],"Many":[1],"methods":[2,19],"have":[3,48],"been":[4],"developed":[5],"to":[6,83,115,167],"estimate":[7],"immune":[8,30,39,103,123,142,193,209],"cell":[9,31,69,143,194,210],"composition":[10],"from":[11,73,110],"tissue":[12,35,107,122,141,150,206],"transcriptomes.":[13],"One":[14],"common":[15],"characteristic":[16],"of":[17,28,78,95,102,121,134,181,186,192],"these":[18,187],"is":[20],"that":[21,33,54,89,165],"they":[22,46],"are":[23,41,90,226],"trained":[24],"using":[25],"a":[26,155,168,201],"set":[27],"general":[29,56,79,170],"transcriptomes":[32],"ignores":[34],"specificities.":[36],"However,":[37],"as":[38,92,148],"cells":[40,104],"localized":[42],"in":[43,105,140,158,162,173],"different":[44,74,128,197],"tissues,":[45],"may":[47,59],"distinct":[49],"expression":[50,81,119],"profiles.":[51],"Hence,":[52],"calculations":[53],"use":[55],"signature":[57,80,86,138,152,171,216],"matrices":[58,88,217],"hinder":[60],"the":[61,93,96,100,117,132,149,174,178,184],"deconvolution":[62,97,175],"accuracy.":[63],"RESULTS:":[64],"This":[65],"study":[66],"used":[67,91,114],"single":[68],"RNA-sequencing":[70],"(scRNA-Seq)":[71],"data":[72,112,145,188,225],"mouse":[75],"tissues":[76,164,198],"instead":[77],"values":[82],"generate":[84],"tissue-specific":[85],"gene":[87,129],"input":[94],"model.":[98,176],"First,":[99],"transcriptome":[101],"each":[106],"was":[108,160],"extracted":[109],"scRNA-Seq":[111,144,182],"and":[113],"construct":[116],"entire":[118],"matrix":[120,172],"cells.":[124],"Then,":[125],"after":[126],"comparing":[127],"selection":[130],"strategies,":[131],"expressions":[133],"162":[135],"seq-ImmuCC":[136],"derived":[137],"genes":[139],"were":[146,218],"regarded":[147],"specific":[151],"matrices.":[153],"Finally,":[154],"modest":[156],"improvement":[157],"performance":[159],"observed":[161],"multiple":[163],"refer":[166],"traditional":[169],"With":[177],"fast":[179],"accumulation":[180],"data,":[183],"introduction":[185],"into":[189],"an":[190],"estimation":[191],"compositions":[195],"for":[196,204,208],"will":[199],"open":[200],"new":[202],"window":[203],"avoiding":[205],"bias":[207],"expression.":[211],"AVAILABILITY":[212],"AND":[213],"IMPLEMENTATION:":[214],"The":[215],"available":[219,227],"at":[220,228],"https://github.com/wuaipinglab/ImmuCC/tree/master/tissue_immucc/SignatureMatrix).":[221],"SUPPLEMENTARY":[222],"INFORMATION:":[223],"Supplementary":[224],"Bioinformatics":[229],"online.":[230]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":2}],"updated_date":"2026-08-01T09:00:35.917206","created_date":"2025-10-10T00:00:00"}