{"id":"https://openalex.org/W2954496204","doi":"https://doi.org/10.1093/bioinformatics/btz527","title":"A helical lock and key model of polyproline II conformation with SH3","display_name":"A helical lock and key model of polyproline II conformation with SH3","publication_year":2019,"publication_date":"2019-06-25","ids":{"openalex":"https://openalex.org/W2954496204","doi":"https://doi.org/10.1093/bioinformatics/btz527","mag":"2954496204","pmid":"https://pubmed.ncbi.nlm.nih.gov/31250908"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btz527","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btz527","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089800773","display_name":"Tomer Meirson","orcid":"https://orcid.org/0000-0002-5011-5477"},"institutions":[{"id":"https://openalex.org/I13955877","display_name":"Bar-Ilan University","ror":"https://ror.org/03kgsv495","country_code":"IL","type":"education","lineage":["https://openalex.org/I13955877"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Tomer Meirson","raw_affiliation_strings":["Drug Discovery Laboratory, The Azrieli Faculty of Medicine , Safed 1589, Israel","Laboratory of Cell Migration and Invasion, The Azrieli Faculty of Medicine, Bar-Ilan University , Safed 1589, Israel"],"affiliations":[{"raw_affiliation_string":"Drug Discovery Laboratory, The Azrieli Faculty of Medicine , Safed 1589, Israel","institution_ids":[]},{"raw_affiliation_string":"Laboratory of Cell Migration and Invasion, The Azrieli Faculty of Medicine, Bar-Ilan University , Safed 1589, Israel","institution_ids":["https://openalex.org/I13955877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037839310","display_name":"David Bomze","orcid":"https://orcid.org/0000-0003-2958-7055"},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"David Bomze","raw_affiliation_strings":["Sackler Faculty of Medicine, Tel Aviv University , Tel Aviv 39040, Israel"],"affiliations":[{"raw_affiliation_string":"Sackler Faculty of Medicine, Tel Aviv University , Tel Aviv 39040, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059518057","display_name":"Liron Kahlon","orcid":null},"institutions":[{"id":"https://openalex.org/I13955877","display_name":"Bar-Ilan University","ror":"https://ror.org/03kgsv495","country_code":"IL","type":"education","lineage":["https://openalex.org/I13955877"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Liron Kahlon","raw_affiliation_strings":["The Azrieli Faculty of Medicine, Bar-Ilan University , Safed 1589, Israel"],"affiliations":[{"raw_affiliation_string":"The Azrieli Faculty of Medicine, Bar-Ilan University , Safed 1589, Israel","institution_ids":["https://openalex.org/I13955877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042353099","display_name":"Hava Gil-Henn","orcid":"https://orcid.org/0000-0003-4064-0478"},"institutions":[{"id":"https://openalex.org/I13955877","display_name":"Bar-Ilan University","ror":"https://ror.org/03kgsv495","country_code":"IL","type":"education","lineage":["https://openalex.org/I13955877"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Hava Gil-Henn","raw_affiliation_strings":["Laboratory of Cell Migration and Invasion, The Azrieli Faculty of Medicine, Bar-Ilan University , Safed 1589, Israel"],"affiliations":[{"raw_affiliation_string":"Laboratory of Cell Migration and Invasion, The Azrieli Faculty of Medicine, Bar-Ilan University , Safed 1589, Israel","institution_ids":["https://openalex.org/I13955877"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001115009","display_name":"Abraham O. Samson","orcid":"https://orcid.org/0000-0001-7436-3515"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Abraham O Samson","raw_affiliation_strings":["Drug Discovery Laboratory, The Azrieli Faculty of Medicine , Safed 1589, Israel"],"affiliations":[{"raw_affiliation_string":"Drug Discovery Laboratory, The Azrieli Faculty of Medicine , Safed 1589, Israel","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5089800773"],"corresponding_institution_ids":["https://openalex.org/I13955877"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":0.5966,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.66443944,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"36","issue":"1","first_page":"154","last_page":"159"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polyproline-helix","display_name":"Polyproline helix","score":0.9653500318527222},{"id":"https://openalex.org/keywords/lock","display_name":"Lock (firearm)","score":0.9248641729354858},{"id":"https://openalex.org/keywords/key","display_name":"Key (lock)","score":0.7629667520523071},{"id":"https://openalex.org/keywords/sh3-domain","display_name":"SH3 domain","score":0.46122461557388306},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.43802610039711},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3100661039352417},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.140985369682312},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.10403361916542053},{"id":"https://openalex.org/keywords/peptide","display_name":"Peptide","score":0.0856069028377533},{"id":"https://openalex.org/keywords/computer-security","display_name":"Computer security","score":0.08276093006134033}],"concepts":[{"id":"https://openalex.org/C109300003","wikidata":"https://www.wikidata.org/wiki/Q4384651","display_name":"Polyproline helix","level":3,"score":0.9653500318527222},{"id":"https://openalex.org/C174839445","wikidata":"https://www.wikidata.org/wiki/Q1134386","display_name":"Lock (firearm)","level":2,"score":0.9248641729354858},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.7629667520523071},{"id":"https://openalex.org/C196347352","wikidata":"https://www.wikidata.org/wiki/Q24771787","display_name":"SH3 domain","level":4,"score":0.46122461557388306},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.43802610039711},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3100661039352417},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.140985369682312},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10403361916542053},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.0856069028377533},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.08276093006134033},{"id":"https://openalex.org/C108636557","wikidata":"https://www.wikidata.org/wiki/Q21109354","display_name":"Proto-oncogene tyrosine-protein kinase Src","level":3,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018909","descriptor_name":"src Homology Domains","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018909","descriptor_name":"src Homology Domains","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018909","descriptor_name":"src Homology Domains","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btz527","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btz527","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:31250908","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31250908","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2630405909","display_name":null,"funder_award_id":"1462/17","funder_id":"https://openalex.org/F4320322252","funder_display_name":"Israel Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320320191","display_name":"Foulkes Foundation","ror":"https://ror.org/03hvqcb43"},{"id":"https://openalex.org/F4320322252","display_name":"Israel Science Foundation","ror":"https://ror.org/04sazxf24"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1819031394","https://openalex.org/W1892578325","https://openalex.org/W1913862483","https://openalex.org/W1964538907","https://openalex.org/W1970676151","https://openalex.org/W1972172786","https://openalex.org/W1975282060","https://openalex.org/W1990516841","https://openalex.org/W1997828001","https://openalex.org/W2012745859","https://openalex.org/W2021226373","https://openalex.org/W2030138948","https://openalex.org/W2032997139","https://openalex.org/W2037130336","https://openalex.org/W2061636592","https://openalex.org/W2073306537","https://openalex.org/W2075622623","https://openalex.org/W2083753880","https://openalex.org/W2091849418","https://openalex.org/W2098208486","https://openalex.org/W2102115661","https://openalex.org/W2107532817","https://openalex.org/W2107942874","https://openalex.org/W2114299741","https://openalex.org/W2115726565","https://openalex.org/W2118567914","https://openalex.org/W2132926880","https://openalex.org/W2134373577","https://openalex.org/W2134557029","https://openalex.org/W2150900888","https://openalex.org/W2152733195","https://openalex.org/W2154319440","https://openalex.org/W2158133029","https://openalex.org/W2163705284","https://openalex.org/W2277097906","https://openalex.org/W2412506411","https://openalex.org/W2587048992","https://openalex.org/W2737196618","https://openalex.org/W2750589052","https://openalex.org/W2782784538"],"related_works":["https://openalex.org/W2093878568","https://openalex.org/W2037130336","https://openalex.org/W1967448808","https://openalex.org/W1990516841","https://openalex.org/W2520573750","https://openalex.org/W2954496204","https://openalex.org/W2413449995","https://openalex.org/W1969403795","https://openalex.org/W2740239690","https://openalex.org/W2225543639"],"abstract_inverted_index":{"Supplementary":[0],"data":[1],"are":[2],"available":[3],"at":[4],"Bioinformatics":[5],"online.":[6]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}