{"id":"https://openalex.org/W2952126842","doi":"https://doi.org/10.1093/bioinformatics/btz464","title":"DNN-Dom: predicting protein domain boundary from sequence alone by deep neural network","display_name":"DNN-Dom: predicting protein domain boundary from sequence alone by deep neural network","publication_year":2019,"publication_date":"2019-06-05","ids":{"openalex":"https://openalex.org/W2952126842","doi":"https://doi.org/10.1093/bioinformatics/btz464","mag":"2952126842","pmid":"https://pubmed.ncbi.nlm.nih.gov/31197306"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btz464","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btz464","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044355742","display_name":"Qiang Shi","orcid":"https://orcid.org/0000-0001-6655-3116"},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiang Shi","raw_affiliation_strings":["School of Software Engineering and College of Life Science & Technology, Huazhong University of Science and Technology , Wuhan 430074, China"],"affiliations":[{"raw_affiliation_string":"School of Software Engineering and College of Life Science & Technology, Huazhong University of Science and Technology , Wuhan 430074, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021694898","display_name":"Weiya Chen","orcid":"https://orcid.org/0000-0002-6523-5578"},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weiya Chen","raw_affiliation_strings":["School of Software Engineering and College of Life Science & Technology, Huazhong University of Science and Technology , Wuhan 430074, China"],"affiliations":[{"raw_affiliation_string":"School of Software Engineering and College of Life Science & Technology, Huazhong University of Science and Technology , Wuhan 430074, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039367742","display_name":"Siqi Huang","orcid":"https://orcid.org/0000-0003-0097-9813"},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Siqi Huang","raw_affiliation_strings":["School of Software Engineering and College of Life Science & Technology, Huazhong University of Science and Technology , Wuhan 430074, China"],"affiliations":[{"raw_affiliation_string":"School of Software Engineering and College of Life Science & Technology, Huazhong University of Science and Technology , Wuhan 430074, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053709457","display_name":"Fanglin Jin","orcid":null},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fanglin Jin","raw_affiliation_strings":["School of Software Engineering and College of Life Science & Technology, Huazhong University of Science and Technology , Wuhan 430074, China"],"affiliations":[{"raw_affiliation_string":"School of Software Engineering and College of Life Science & Technology, Huazhong University of Science and Technology , Wuhan 430074, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102384197","display_name":"Yinghao Dong","orcid":null},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yinghao Dong","raw_affiliation_strings":["School of Software Engineering and College of Life Science & Technology, Huazhong University of Science and Technology , Wuhan 430074, China"],"affiliations":[{"raw_affiliation_string":"School of Software Engineering and College of Life Science & Technology, Huazhong University of Science and Technology , Wuhan 430074, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029045124","display_name":"Yan Wang","orcid":"https://orcid.org/0000-0002-9003-8680"},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yan Wang","raw_affiliation_strings":["School of Software Engineering and College of Life Science & Technology, Huazhong University of Science and Technology , Wuhan 430074, China"],"affiliations":[{"raw_affiliation_string":"School of Software Engineering and College of Life Science & Technology, Huazhong University of Science and Technology , Wuhan 430074, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062775403","display_name":"Zhidong Xue","orcid":"https://orcid.org/0000-0003-3559-0867"},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhidong Xue","raw_affiliation_strings":["School of Software Engineering and College of Life Science & Technology, Huazhong University of Science and Technology , Wuhan 430074, China"],"affiliations":[{"raw_affiliation_string":"School of Software Engineering and College of Life Science & Technology, Huazhong University of Science and Technology , Wuhan 430074, China","institution_ids":["https://openalex.org/I47720641"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5029045124","https://openalex.org/A5062775403"],"corresponding_institution_ids":["https://openalex.org/I47720641"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":1.5342,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.82967083,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"35","issue":"24","first_page":"5128","last_page":"5136"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9955000281333923,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9955000281333923,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9930999875068665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9864000082015991,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.765067458152771},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.699914813041687},{"id":"https://openalex.org/keywords/domain","display_name":"Domain (mathematical analysis)","score":0.6718524694442749},{"id":"https://openalex.org/keywords/convolutional-neural-network","display_name":"Convolutional neural network","score":0.6694580912590027},{"id":"https://openalex.org/keywords/boundary","display_name":"Boundary (topology)","score":0.6600399017333984},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.6488234400749207},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.6166393756866455},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.5924649238586426},{"id":"https://openalex.org/keywords/random-forest","display_name":"Random forest","score":0.5118445754051208},{"id":"https://openalex.org/keywords/range","display_name":"Range (aeronautics)","score":0.46002334356307983},{"id":"https://openalex.org/keywords/support-vector-machine","display_name":"Support vector machine","score":0.41652894020080566},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.4149358868598938},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3657165765762329},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3404301702976227},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.09065663814544678},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.07916447520256042}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.765067458152771},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.699914813041687},{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.6718524694442749},{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.6694580912590027},{"id":"https://openalex.org/C62354387","wikidata":"https://www.wikidata.org/wiki/Q875399","display_name":"Boundary (topology)","level":2,"score":0.6600399017333984},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.6488234400749207},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.6166393756866455},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.5924649238586426},{"id":"https://openalex.org/C169258074","wikidata":"https://www.wikidata.org/wiki/Q245748","display_name":"Random forest","level":2,"score":0.5118445754051208},{"id":"https://openalex.org/C204323151","wikidata":"https://www.wikidata.org/wiki/Q905424","display_name":"Range (aeronautics)","level":2,"score":0.46002334356307983},{"id":"https://openalex.org/C12267149","wikidata":"https://www.wikidata.org/wiki/Q282453","display_name":"Support vector machine","level":2,"score":0.41652894020080566},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4149358868598938},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3657165765762329},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3404301702976227},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.09065663814544678},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.07916447520256042},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C146978453","wikidata":"https://www.wikidata.org/wiki/Q3798668","display_name":"Aerospace engineering","level":1,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btz464","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btz464","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:31197306","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31197306","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Life in Land","id":"https://metadata.un.org/sdg/15","score":0.6100000143051147}],"awards":[{"id":"https://openalex.org/G1397402559","display_name":null,"funder_award_id":"2017KFYXJJ225","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G2406816347","display_name":null,"funder_award_id":"71771098","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7012408336","display_name":null,"funder_award_id":"61772217","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8689648819","display_name":null,"funder_award_id":"2016YXMS104","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W1494809085","https://openalex.org/W1871676704","https://openalex.org/W1968697272","https://openalex.org/W1973262365","https://openalex.org/W1976005460","https://openalex.org/W1987468852","https://openalex.org/W1993796017","https://openalex.org/W1994001097","https://openalex.org/W1996150123","https://openalex.org/W2027446338","https://openalex.org/W2045088722","https://openalex.org/W2049690299","https://openalex.org/W2050135038","https://openalex.org/W2055118532","https://openalex.org/W2059136964","https://openalex.org/W2077515504","https://openalex.org/W2092182190","https://openalex.org/W2097606916","https://openalex.org/W2102588875","https://openalex.org/W2104703176","https://openalex.org/W2111374837","https://openalex.org/W2116772258","https://openalex.org/W2116827999","https://openalex.org/W2119542589","https://openalex.org/W2119902292","https://openalex.org/W2120804283","https://openalex.org/W2125501682","https://openalex.org/W2129834345","https://openalex.org/W2130647858","https://openalex.org/W2131474431","https://openalex.org/W2138116388","https://openalex.org/W2147526198","https://openalex.org/W2149548330","https://openalex.org/W2152059523","https://openalex.org/W2154205489","https://openalex.org/W2155144535","https://openalex.org/W2157190239","https://openalex.org/W2160121621","https://openalex.org/W2160649303","https://openalex.org/W2167308484","https://openalex.org/W2168195002","https://openalex.org/W2510934692","https://openalex.org/W2558272290","https://openalex.org/W2566370974","https://openalex.org/W2567587907","https://openalex.org/W2579272540","https://openalex.org/W2607268717","https://openalex.org/W2613997260","https://openalex.org/W2730472814","https://openalex.org/W2754293187","https://openalex.org/W2766352633","https://openalex.org/W2791848964","https://openalex.org/W2889498145","https://openalex.org/W2890911678","https://openalex.org/W2949867299","https://openalex.org/W2950463913","https://openalex.org/W2951621517","https://openalex.org/W2963457143","https://openalex.org/W4252991110","https://openalex.org/W6686288242","https://openalex.org/W6731867162"],"related_works":["https://openalex.org/W4200112873","https://openalex.org/W2955796858","https://openalex.org/W4224941037","https://openalex.org/W2004826645","https://openalex.org/W4226493464","https://openalex.org/W4312417841","https://openalex.org/W3135818052","https://openalex.org/W4372048956","https://openalex.org/W3193565141","https://openalex.org/W3133861977"],"abstract_inverted_index":{"Supplementary":[0],"data":[1],"are":[2],"available":[3],"at":[4],"Bioinformatics":[5],"online.":[6]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}