{"id":"https://openalex.org/W2962028921","doi":"https://doi.org/10.1093/bioinformatics/btz355","title":"Collaborative intra-tumor heterogeneity detection","display_name":"Collaborative intra-tumor heterogeneity detection","publication_year":2019,"publication_date":"2019-05-24","ids":{"openalex":"https://openalex.org/W2962028921","doi":"https://doi.org/10.1093/bioinformatics/btz355","mag":"2962028921","pmid":"https://pubmed.ncbi.nlm.nih.gov/31510674"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btz355","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btz355","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/35/14/i379/28913717/btz355.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/35/14/i379/28913717/btz355.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066797978","display_name":"Sahand Khakabimamaghani","orcid":"https://orcid.org/0000-0002-5178-0188"},"institutions":[{"id":"https://openalex.org/I18014758","display_name":"Simon Fraser University","ror":"https://ror.org/0213rcc28","country_code":"CA","type":"education","lineage":["https://openalex.org/I18014758"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Sahand Khakabimamaghani","raw_affiliation_strings":["School of Computing Science, Simon Fraser University, Burnaby, BC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computing Science, Simon Fraser University, Burnaby, BC","institution_ids":["https://openalex.org/I18014758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045683675","display_name":"Salem Maliki\u0107","orcid":"https://orcid.org/0000-0002-4215-5655"},"institutions":[{"id":"https://openalex.org/I18014758","display_name":"Simon Fraser University","ror":"https://ror.org/0213rcc28","country_code":"CA","type":"education","lineage":["https://openalex.org/I18014758"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Salem Malikic","raw_affiliation_strings":["School of Computing Science, Simon Fraser University, Burnaby, BC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computing Science, Simon Fraser University, Burnaby, BC","institution_ids":["https://openalex.org/I18014758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083623568","display_name":"Jeffrey Tang","orcid":"https://orcid.org/0000-0002-5633-6123"},"institutions":[{"id":"https://openalex.org/I18014758","display_name":"Simon Fraser University","ror":"https://ror.org/0213rcc28","country_code":"CA","type":"education","lineage":["https://openalex.org/I18014758"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jeffrey Tang","raw_affiliation_strings":["Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC","institution_ids":["https://openalex.org/I18014758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085340125","display_name":"Dujian Ding","orcid":null},"institutions":[{"id":"https://openalex.org/I18014758","display_name":"Simon Fraser University","ror":"https://ror.org/0213rcc28","country_code":"CA","type":"education","lineage":["https://openalex.org/I18014758"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Dujian Ding","raw_affiliation_strings":["School of Computing Science, Simon Fraser University, Burnaby, BC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computing Science, Simon Fraser University, Burnaby, BC","institution_ids":["https://openalex.org/I18014758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081644676","display_name":"Ryan D. Morin","orcid":"https://orcid.org/0000-0003-2932-7800"},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]},{"id":"https://openalex.org/I18014758","display_name":"Simon Fraser University","ror":"https://ror.org/0213rcc28","country_code":"CA","type":"education","lineage":["https://openalex.org/I18014758"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ryan Morin","raw_affiliation_strings":["Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC","Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, BC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC","institution_ids":["https://openalex.org/I18014758"]},{"raw_affiliation_string":"Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, BC","institution_ids":["https://openalex.org/I1289530486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065939739","display_name":"Leonid Chindelevitch","orcid":"https://orcid.org/0000-0002-6619-6013"},"institutions":[{"id":"https://openalex.org/I18014758","display_name":"Simon Fraser University","ror":"https://ror.org/0213rcc28","country_code":"CA","type":"education","lineage":["https://openalex.org/I18014758"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Leonid Chindelevitch","raw_affiliation_strings":["School of Computing Science, Simon Fraser University, Burnaby, BC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computing Science, Simon Fraser University, Burnaby, BC","institution_ids":["https://openalex.org/I18014758"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018267399","display_name":"Martin Ester","orcid":"https://orcid.org/0000-0001-7732-2815"},"institutions":[{"id":"https://openalex.org/I18014758","display_name":"Simon Fraser University","ror":"https://ror.org/0213rcc28","country_code":"CA","type":"education","lineage":["https://openalex.org/I18014758"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Martin Ester","raw_affiliation_strings":["School of Computing Science, Simon Fraser University, Burnaby, BC","Vancouver Prostate Centre, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computing Science, Simon Fraser University, Burnaby, BC","institution_ids":["https://openalex.org/I18014758"]},{"raw_affiliation_string":"Vancouver Prostate Centre, Vancouver, BC, Canada","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5018267399"],"corresponding_institution_ids":["https://openalex.org/I18014758"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":0.6859,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.63663995,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"35","issue":"14","first_page":"i379","last_page":"i388"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.8632000088691711,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.8632000088691711,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13664","display_name":"Genome Rearrangement Algorithms","score":0.03519999980926514,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.029500000178813934,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7286689281463623},{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.6408959627151489},{"id":"https://openalex.org/keywords/phylogenetic-tree","display_name":"Phylogenetic tree","score":0.6240105032920837},{"id":"https://openalex.org/keywords/deconvolution","display_name":"Deconvolution","score":0.5577916502952576},{"id":"https://openalex.org/keywords/source-code","display_name":"Source code","score":0.556065559387207},{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.425869882106781},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4194289445877075},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.34155935049057007},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.34048736095428467},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.32844066619873047},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.25225216150283813},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.23858362436294556},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1118268072605133},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.10502919554710388}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7286689281463623},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.6408959627151489},{"id":"https://openalex.org/C193252679","wikidata":"https://www.wikidata.org/wiki/Q242125","display_name":"Phylogenetic tree","level":3,"score":0.6240105032920837},{"id":"https://openalex.org/C174576160","wikidata":"https://www.wikidata.org/wiki/Q1183700","display_name":"Deconvolution","level":2,"score":0.5577916502952576},{"id":"https://openalex.org/C43126263","wikidata":"https://www.wikidata.org/wiki/Q128751","display_name":"Source code","level":2,"score":0.556065559387207},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.425869882106781},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4194289445877075},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.34155935049057007},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.34048736095428467},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.32844066619873047},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25225216150283813},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.23858362436294556},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1118268072605133},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10502919554710388},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017421","descriptor_name":"Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017421","descriptor_name":"Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017421","descriptor_name":"Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/bioinformatics/btz355","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btz355","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/35/14/i379/28913717/btz355.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:31510674","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31510674","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:europepmc.org:5588738","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6612880","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:spiral.imperial.ac.uk:10044/1/86911","is_oa":true,"landing_page_url":"http://hdl.handle.net/10044/1/86911","pdf_url":null,"source":{"id":"https://openalex.org/S4306401396","display_name":"Spiral (Imperial College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I47508984","host_organization_name":"Imperial College London","host_organization_lineage":["https://openalex.org/I47508984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"i388","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btz355","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btz355","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/35/14/i379/28913717/btz355.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5799999833106995,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2962028921.pdf"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1826483772","https://openalex.org/W1984853417","https://openalex.org/W2002295829","https://openalex.org/W2015182193","https://openalex.org/W2084829134","https://openalex.org/W2092660685","https://openalex.org/W2101354849","https://openalex.org/W2106036365","https://openalex.org/W2111874706","https://openalex.org/W2114095872","https://openalex.org/W2122392334","https://openalex.org/W2144847592","https://openalex.org/W2150073600","https://openalex.org/W2166815431","https://openalex.org/W2167278498","https://openalex.org/W2233432342","https://openalex.org/W2253465175","https://openalex.org/W2340974016","https://openalex.org/W2346273585","https://openalex.org/W2558715006","https://openalex.org/W2570688054","https://openalex.org/W2754025713","https://openalex.org/W2756005140","https://openalex.org/W2888094747","https://openalex.org/W2891700678","https://openalex.org/W2896479296","https://openalex.org/W2949688529","https://openalex.org/W2980515223","https://openalex.org/W3004647847","https://openalex.org/W6638305113"],"related_works":["https://openalex.org/W4251527294","https://openalex.org/W3090782779","https://openalex.org/W4296701479","https://openalex.org/W4231036715","https://openalex.org/W3149087629","https://openalex.org/W2032074591","https://openalex.org/W1986156575","https://openalex.org/W4242983818","https://openalex.org/W2970288912","https://openalex.org/W1966302070"],"abstract_inverted_index":{"MOTIVATION:":[0],"Despite":[1],"the":[2,12,17,24,33,36,54,66,87,91,123,136,146,178],"remarkable":[3],"advances":[4],"in":[5,11,62],"sequencing":[6,42,107],"and":[7,14,65,85,114,140,181],"computational":[8],"techniques,":[9],"noise":[10],"data":[13,43,108],"complexity":[15],"of":[16,23,35,40,44,48,53,57,90,112,149,154],"underlying":[18],"biological":[19],"mechanisms":[20],"render":[21],"deconvolution":[22],"phylogenetic":[25,55,147],"relationships":[26],"between":[27,127],"cancer":[28],"mutations":[29,58],"difficult.":[30],"Besides":[31],"that,":[32],"majority":[34],"existing":[37,67,92,179],"datasets":[38],"consist":[39],"bulk":[41],"single":[45],"tumor":[46,116],"sample":[47],"an":[49,131,158],"individual.":[50],"Accurate":[51],"inference":[52],"order":[56],"is":[59,194],"particularly":[60],"challenging":[61],"these":[63,77],"cases":[64],"methods":[68,80],"are":[69,81,175],"faced":[70],"with":[71,169,177],"several":[72],"theoretical":[73],"limitations.":[74],"To":[75],"overcome":[76],"limitations,":[78],"new":[79],"required":[82],"for":[83,101,109,118,144,192],"integrating":[84],"harnessing":[86],"full":[88],"potential":[89],"data.":[93],"RESULTS:":[94],"We":[95],"introduce":[96],"a":[97,110,170],"method":[98],"called":[99],"Hintra":[100,105,134,193],"intra-tumor":[102],"heterogeneity":[103],"detection.":[104],"integrates":[106],"cohort":[111],"tumors":[113],"infers":[115],"phylogeny":[117],"each":[119],"individual":[120,150],"based":[121],"on":[122],"evolutionary":[124,138],"information":[125,143],"shared":[126],"different":[128],"tumors.":[129,151],"Through":[130],"iterative":[132],"process,":[133],"learns":[135],"repeating":[137],"patterns":[139],"uses":[141],"this":[142],"resolving":[145],"ambiguities":[148],"The":[152,166,189],"results":[153,168],"synthetic":[155],"experiments":[156],"show":[157],"improved":[159],"performance":[160],"compared":[161],"to":[162],"two":[163],"state-of-the-art":[164],"methods.":[165],"experimental":[167],"recent":[171],"Breast":[172],"Cancer":[173],"dataset":[174],"consistent":[176],"knowledge":[180],"provide":[182],"potentially":[183],"interesting":[184],"findings.":[185],"AVAILABILITY":[186],"AND":[187],"IMPLEMENTATION:":[188],"source":[190],"code":[191],"available":[195],"at":[196],"https://github.com/sahandk/HINTRA.":[197]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5}],"updated_date":"2026-05-22T06:13:13.366637","created_date":"2025-10-10T00:00:00"}