{"id":"https://openalex.org/W2952872001","doi":"https://doi.org/10.1093/bioinformatics/btz167","title":"VIMCO: variational inference for multiple correlated outcomes in genome-wide association studies","display_name":"VIMCO: variational inference for multiple correlated outcomes in genome-wide association studies","publication_year":2019,"publication_date":"2019-03-08","ids":{"openalex":"https://openalex.org/W2952872001","doi":"https://doi.org/10.1093/bioinformatics/btz167","mag":"2952872001","pmid":"https://pubmed.ncbi.nlm.nih.gov/30851102"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btz167","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btz167","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/35/19/3693/48976393/bioinformatics_35_19_3693.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/35/19/3693/48976393/bioinformatics_35_19_3693.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043964499","display_name":"Xingjie Shi","orcid":"https://orcid.org/0000-0002-9866-8599"},"institutions":[{"id":"https://openalex.org/I137056471","display_name":"Nanjing University of Finance and Economics","ror":"https://ror.org/031y8am81","country_code":"CN","type":"education","lineage":["https://openalex.org/I137056471"]},{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]}],"countries":["CN","SG"],"is_corresponding":false,"raw_author_name":"Xingjie Shi","raw_affiliation_strings":["Centre for Quantitative Medicine, Duke-NUS Medical School , Singapore","Department of Statistics, Nanjing University of Finance and Economics , Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Quantitative Medicine, Duke-NUS Medical School , Singapore","institution_ids":["https://openalex.org/I4210126319"]},{"raw_affiliation_string":"Department of Statistics, Nanjing University of Finance and Economics , Nanjing, China","institution_ids":["https://openalex.org/I137056471"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080185313","display_name":"Yuling Jiao","orcid":"https://orcid.org/0000-0003-2762-0421"},"institutions":[{"id":"https://openalex.org/I158934434","display_name":"Zhongnan University of Economics and Law","ror":"https://ror.org/04yqxxq63","country_code":"CN","type":"education","lineage":["https://openalex.org/I158934434"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuling Jiao","raw_affiliation_strings":["School of Statistics and Mathematics, Zhongnan University of Economics and Law , Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Statistics and Mathematics, Zhongnan University of Economics and Law , Wuhan, China","institution_ids":["https://openalex.org/I158934434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101757671","display_name":"Yi Yang","orcid":"https://orcid.org/0000-0003-1665-5258"},"institutions":[{"id":"https://openalex.org/I181679659","display_name":"Shanghai University of Finance and Economics","ror":"https://ror.org/00wtvfq62","country_code":"CN","type":"education","lineage":["https://openalex.org/I181679659"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Yang","raw_affiliation_strings":["School of Statistics and Management, Shanghai University of Finance and Economics , Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Statistics and Management, Shanghai University of Finance and Economics , Shanghai, China","institution_ids":["https://openalex.org/I181679659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032933669","display_name":"Ching\u2010Yu Cheng","orcid":"https://orcid.org/0000-0003-0655-885X"},"institutions":[{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Ching-Yu Cheng","raw_affiliation_strings":["Centre for Quantitative Medicine, Duke-NUS Medical School , Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Quantitative Medicine, Duke-NUS Medical School , Singapore","institution_ids":["https://openalex.org/I4210126319"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029104097","display_name":"Can Yang","orcid":"https://orcid.org/0000-0002-4407-3055"},"institutions":[{"id":"https://openalex.org/I200769079","display_name":"Hong Kong University of Science and Technology","ror":"https://ror.org/00q4vv597","country_code":"HK","type":"education","lineage":["https://openalex.org/I200769079"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Can Yang","raw_affiliation_strings":["Department of Mathematics, Hong Kong University of Science and Technology , Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics, Hong Kong University of Science and Technology , Hong Kong","institution_ids":["https://openalex.org/I200769079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085230597","display_name":"Xinyi Lin","orcid":"https://orcid.org/0000-0002-7209-6588"},"institutions":[{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Xinyi Lin","raw_affiliation_strings":["Centre for Quantitative Medicine, Duke-NUS Medical School , Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Quantitative Medicine, Duke-NUS Medical School , Singapore","institution_ids":["https://openalex.org/I4210126319"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033553707","display_name":"Jin Liu","orcid":"https://orcid.org/0000-0002-5707-2078"},"institutions":[{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Jin Liu","raw_affiliation_strings":["Centre for Quantitative Medicine, Duke-NUS Medical School , Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Quantitative Medicine, Duke-NUS Medical School , Singapore","institution_ids":["https://openalex.org/I4210126319"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5033553707","https://openalex.org/A5085230597"],"corresponding_institution_ids":["https://openalex.org/I4210126319"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":1.9326,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.86301639,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"35","issue":"19","first_page":"3693","last_page":"3700"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9835000038146973,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9835000038146973,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10845","display_name":"Advanced Causal Inference Techniques","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"Genome-wide association study","score":0.8402359485626221},{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.7489466667175293},{"id":"https://openalex.org/keywords/trait","display_name":"Trait","score":0.7107514142990112},{"id":"https://openalex.org/keywords/genetic-association","display_name":"Genetic association","score":0.6082227826118469},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5538854002952576},{"id":"https://openalex.org/keywords/statistical-power","display_name":"Statistical power","score":0.5052483677864075},{"id":"https://openalex.org/keywords/statistical-inference","display_name":"Statistical inference","score":0.4500305652618408},{"id":"https://openalex.org/keywords/quantitative-trait-locus","display_name":"Quantitative trait locus","score":0.44782838225364685},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.36130446195602417},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.35412371158599854},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3531802296638489},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.33654630184173584},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.2530127465724945},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.24441072344779968},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1937870979309082},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.15951570868492126},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1303217113018036},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.12553730607032776}],"concepts":[{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.8402359485626221},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.7489466667175293},{"id":"https://openalex.org/C106934330","wikidata":"https://www.wikidata.org/wiki/Q1971873","display_name":"Trait","level":2,"score":0.7107514142990112},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.6082227826118469},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5538854002952576},{"id":"https://openalex.org/C96608239","wikidata":"https://www.wikidata.org/wiki/Q1199823","display_name":"Statistical power","level":2,"score":0.5052483677864075},{"id":"https://openalex.org/C134261354","wikidata":"https://www.wikidata.org/wiki/Q938438","display_name":"Statistical inference","level":2,"score":0.4500305652618408},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.44782838225364685},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.36130446195602417},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.35412371158599854},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3531802296638489},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33654630184173584},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.2530127465724945},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.24441072344779968},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1937870979309082},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.15951570868492126},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1303217113018036},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.12553730607032776},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056426","descriptor_name":"Genetic Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056426","descriptor_name":"Genetic Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056426","descriptor_name":"Genetic Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/bioinformatics/btz167","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btz167","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/35/19/3693/48976393/bioinformatics_35_19_3693.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:30851102","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30851102","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:repository.hkust.edu.hk:1783.1-96655","is_oa":false,"landing_page_url":"http://www.scopus.com/record/display.url?eid=2-s2.0-85072710917&origin=inward","pdf_url":null,"source":{"id":"https://openalex.org/S4306401796","display_name":"Rare & Special e-Zone (The Hong Kong University of Science and Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I200769079","host_organization_name":"Hong Kong University of Science and Technology","host_organization_lineage":["https://openalex.org/I200769079"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:repository.ust.hk:1783.1-96655","is_oa":false,"landing_page_url":"http://repository.ust.hk/ir/Record/1783.1-96655","pdf_url":null,"source":{"id":"https://openalex.org/S4306401796","display_name":"Rare & Special e-Zone (The Hong Kong University of Science and Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I200769079","host_organization_name":"Hong Kong University of Science and Technology","host_organization_lineage":["https://openalex.org/I200769079"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btz167","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btz167","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/35/19/3693/48976393/bioinformatics_35_19_3693.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1332731600","display_name":null,"funder_award_id":"-T2-2-006","funder_id":"https://openalex.org/F4320320751","funder_display_name":"Ministry of Education - Singapore"},{"id":"https://openalex.org/G1407052651","display_name":null,"funder_award_id":"MOE2018-T2-1-046,","funder_id":"https://openalex.org/F4320320751","funder_display_name":"Ministry of Education - Singapore"},{"id":"https://openalex.org/G1847970444","display_name":null,"funder_award_id":"R-913-200-098-263","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2342870495","display_name":null,"funder_award_id":"AcRF\u2010Tier2","funder_id":"https://openalex.org/F4320320751","funder_display_name":"Ministry of Education - Singapore"},{"id":"https://openalex.org/G4071393848","display_name":null,"funder_award_id":"MOE2016-T2-2-029","funder_id":"https://openalex.org/F4320320751","funder_display_name":"Ministry of Education - Singapore"},{"id":"https://openalex.org/G4749961416","display_name":null,"funder_award_id":"22302815","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4956433258","display_name":null,"funder_award_id":"-T2-2-029","funder_id":"https://openalex.org/F4320320751","funder_display_name":"Ministry of Education - Singapore"},{"id":"https://openalex.org/G5037888388","display_name":null,"funder_award_id":"12301417","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5041092483","display_name":null,"funder_award_id":"MOE2018-T2-1-046","funder_id":"https://openalex.org/F4320316262","funder_display_name":"Duke-NUS Medical School"},{"id":"https://openalex.org/G51031675","display_name":"\u521b\u65b0\u5982\u4f55\u5f00\u653e\uff1a\u57fa\u4e8e\u7ec4\u7ec7\u63a7\u5236\u7684\u7814\u7a76","funder_award_id":"71472023","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5295298011","display_name":null,"funder_award_id":"71501089","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5350014937","display_name":null,"funder_award_id":"MOE2018-T2-2-006","funder_id":"https://openalex.org/F4320316262","funder_display_name":"Duke-NUS Medical School"},{"id":"https://openalex.org/G6027846787","display_name":null,"funder_award_id":"R-913-200-098-263","funder_id":"https://openalex.org/F4320316262","funder_display_name":"Duke-NUS Medical School"},{"id":"https://openalex.org/G663580435","display_name":null,"funder_award_id":"MOE2016-T2-2-029","funder_id":"https://openalex.org/F4320316262","funder_display_name":"Duke-NUS Medical School"},{"id":"https://openalex.org/G6854926366","display_name":null,"funder_award_id":"Tier 2","funder_id":"https://openalex.org/F4320320751","funder_display_name":"Ministry of Education - Singapore"},{"id":"https://openalex.org/G7241363003","display_name":null,"funder_award_id":"MOE2018","funder_id":"https://openalex.org/F4320320751","funder_display_name":"Ministry of Education - Singapore"},{"id":"https://openalex.org/G7386810869","display_name":null,"funder_award_id":"-T2-1-046","funder_id":"https://openalex.org/F4320320751","funder_display_name":"Ministry of Education - Singapore"},{"id":"https://openalex.org/G7807350344","display_name":null,"funder_award_id":"R-913-200-127-263","funder_id":"https://openalex.org/F4320316262","funder_display_name":"Duke-NUS Medical School"},{"id":"https://openalex.org/G8150694097","display_name":null,"funder_award_id":"11501579","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8761887456","display_name":null,"funder_award_id":"MOE2018-T2-2-006","funder_id":"https://openalex.org/F4320320751","funder_display_name":"Ministry of Education - Singapore"},{"id":"https://openalex.org/G8941465409","display_name":null,"funder_award_id":"12316116","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320316262","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098"},{"id":"https://openalex.org/F4320320751","display_name":"Ministry of Education - Singapore","ror":"https://ror.org/01kcva023"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320331617","display_name":"National Supercomputing Centre Singapore","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2952872001.pdf","grobid_xml":"https://content.openalex.org/works/W2952872001.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1483883706","https://openalex.org/W1663973292","https://openalex.org/W1952660301","https://openalex.org/W1976587387","https://openalex.org/W1980168725","https://openalex.org/W1996299724","https://openalex.org/W2033151532","https://openalex.org/W2071759640","https://openalex.org/W2081531193","https://openalex.org/W2102241087","https://openalex.org/W2103551323","https://openalex.org/W2151292542","https://openalex.org/W2161633633","https://openalex.org/W2166045927","https://openalex.org/W2170264612","https://openalex.org/W2225156818","https://openalex.org/W2411251289","https://openalex.org/W2523336485","https://openalex.org/W2951993085","https://openalex.org/W3101380508","https://openalex.org/W4212863985","https://openalex.org/W7075646083"],"related_works":["https://openalex.org/W4320000477","https://openalex.org/W4285079098","https://openalex.org/W4319077693","https://openalex.org/W4311569799","https://openalex.org/W1976587387","https://openalex.org/W2124120985","https://openalex.org/W4319736502","https://openalex.org/W2912090477","https://openalex.org/W2884396629","https://openalex.org/W2952872001"],"abstract_inverted_index":{"MOTIVATION:":[0],"In":[1],"genome-wide":[2],"association":[3],"studies":[4,156,167],"(GWASs)":[5],"where":[6],"multiple":[7,50,142,150,184],"correlated":[8,187],"traits":[9,21,67,185,194],"have":[10],"been":[11],"measured":[12],"on":[13,74,91,123],"participants,":[14],"a":[15,30,45,57,100,111,137],"joint":[16,46,138],"analysis":[17,32,48,140,171,180],"strategy,":[18],"whereby":[19],"the":[20,66,76,83,92,105,125,132,149,183,193],"are":[22,35,186,195,213],"analyzed":[23],"jointly,":[24],"can":[25,204],"improve":[26],"statistical":[27,176],"power":[28,177],"over":[29,178],"single-trait":[31,179],"strategy.":[33],"There":[34],"two":[36,163],"questions":[37],"of":[38,65,141],"interest":[39],"to":[40,98,161],"be":[41,205],"addressed":[42],"when":[43,135,182,192],"conducting":[44],"GWAS":[47,139],"with":[49,63,82,131],"traits.":[51,151],"The":[52,70,165,201],"first":[53,93],"question":[54,72],"examines":[55],"whether":[56],"genetic":[58,84,133],"loci":[59],"is":[60,80,129],"significantly":[61],"associated":[62,81,130],"any":[64],"being":[68],"tested.":[69],"second":[71,106],"focuses":[73,122],"identifying":[75,124],"specific":[77,126],"trait(s)":[78],"that":[79,103,121,128,173],"loci.":[85],"Since":[86],"existing":[87],"methods":[88],"primarily":[89],"focus":[90],"question,":[94],"this":[95],"article":[96],"seeks":[97],"provide":[99],"complementary":[101],"method":[102],"addresses":[104],"question.":[107],"RESULTS:":[108],"We":[109,152],"propose":[110],"novel":[112],"method,":[113],"Variational":[114],"Inference":[115],"for":[116,146],"Multiple":[117],"Correlated":[118],"Outcomes":[119],"(VIMCO)":[120],"trait":[127],"loci,":[134],"performing":[136],"traits,":[143],"while":[144],"accounting":[145],"correlation":[147],"among":[148],"performed":[153],"extensive":[154],"numerical":[155,166],"and":[157,168,188],"also":[158],"applied":[159],"VIMCO":[160,174,202],"analyze":[162],"datasets.":[164],"real":[169],"data":[170,212],"demonstrate":[172],"improves":[175],"strategies":[181],"has":[189],"comparable":[190],"performance":[191],"not":[196],"correlated.":[197],"AVAILABILITY":[198],"AND":[199],"IMPLEMENTATION:":[200],"software":[203],"downloaded":[206],"from:":[207],"https://github.com/XingjieShi/VIMCO.":[208],"SUPPLEMENTARY":[209],"INFORMATION:":[210],"Supplementary":[211],"available":[214],"at":[215],"Bioinformatics":[216],"online.":[217]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4}],"updated_date":"2026-08-01T09:00:35.917206","created_date":"2025-10-10T00:00:00"}