{"id":"https://openalex.org/W2920646405","doi":"https://doi.org/10.1093/bioinformatics/btz138","title":"<i>deTS</i> : tissue-specific enrichment analysis to decode tissue specificity","display_name":"<i>deTS</i> : tissue-specific enrichment analysis to decode tissue specificity","publication_year":2019,"publication_date":"2019-02-26","ids":{"openalex":"https://openalex.org/W2920646405","doi":"https://doi.org/10.1093/bioinformatics/btz138","mag":"2920646405","pmid":"https://pubmed.ncbi.nlm.nih.gov/30824912"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btz138","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btz138","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6761978","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074004648","display_name":"Guangsheng Pei","orcid":"https://orcid.org/0000-0003-1804-7598"},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guangsheng Pei","raw_affiliation_strings":["School of Biomedical Informatics, Center for Precision Health, The University of Texas Health Science Center at Houston , Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Informatics, Center for Precision Health, The University of Texas Health Science Center at Houston , Houston, TX, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043473632","display_name":"Yulin Dai","orcid":"https://orcid.org/0000-0003-1874-7893"},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yulin Dai","raw_affiliation_strings":["School of Biomedical Informatics, Center for Precision Health, The University of Texas Health Science Center at Houston , Houston, TX, USA"],"raw_orcid":"https://orcid.org/0000-0003-1874-7893","affiliations":[{"raw_affiliation_string":"School of Biomedical Informatics, Center for Precision Health, The University of Texas Health Science Center at Houston , Houston, TX, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006688612","display_name":"Zhongming Zhao","orcid":"https://orcid.org/0000-0002-3477-0914"},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zhongming Zhao","raw_affiliation_strings":["Department of Biomedical Informatics, Vanderbilt University Medical Center , Nashville, TN, USA","Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston , Houston, TX, USA","School of Biomedical Informatics, Center for Precision Health, The University of Texas Health Science Center at Houston , Houston, TX, USA"],"raw_orcid":"https://orcid.org/0000-0002-3477-0914","affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, Vanderbilt University Medical Center , Nashville, TN, USA","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston , Houston, TX, USA","institution_ids":["https://openalex.org/I919571938"]},{"raw_affiliation_string":"School of Biomedical Informatics, Center for Precision Health, The University of Texas Health Science Center at Houston , Houston, TX, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056121087","display_name":"Peilin Jia","orcid":"https://orcid.org/0000-0003-4523-4153"},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peilin Jia","raw_affiliation_strings":["School of Biomedical Informatics, Center for Precision Health, The University of Texas Health Science Center at Houston , Houston, TX, USA"],"raw_orcid":"https://orcid.org/0000-0003-4523-4153","affiliations":[{"raw_affiliation_string":"School of Biomedical Informatics, Center for Precision Health, The University of Texas Health Science Center at Houston , Houston, TX, USA","institution_ids":["https://openalex.org/I919571938"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5006688612","https://openalex.org/A5056121087"],"corresponding_institution_ids":["https://openalex.org/I901861585","https://openalex.org/I919571938"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":6.4381,"has_fulltext":false,"cited_by_count":85,"citation_normalized_percentile":{"value":0.97040713,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"35","issue":"19","first_page":"3842","last_page":"3845"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.8776000142097473,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.8776000142097473,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.07329999655485153,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.022700000554323196,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4616599678993225}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4616599678993225}],"mesh":[{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btz138","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btz138","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:30824912","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30824912","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:6761978","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6761978","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6761978","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6761978","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G174454136","display_name":null,"funder_award_id":"R01LM012806","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G431924609","display_name":"UTHealth Cancer Genomics Core (UTHealth CGC)","funder_award_id":"RP180734","funder_id":"https://openalex.org/F4320308129","funder_display_name":"Cancer Prevention and Research Institute of Texas"},{"id":"https://openalex.org/G5651236485","display_name":null,"funder_award_id":"R01 LM012806","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"}],"funders":[{"id":"https://openalex.org/F4320308129","display_name":"Cancer Prevention and Research Institute of Texas","ror":"https://ror.org/0003xa228"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337372","display_name":"U.S. National Library of Medicine","ror":"https://ror.org/0060t0j89"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1904407543","https://openalex.org/W1963740134","https://openalex.org/W2018838463","https://openalex.org/W2032714982","https://openalex.org/W2039153962","https://openalex.org/W2045017910","https://openalex.org/W2047783882","https://openalex.org/W2095521407","https://openalex.org/W2101357408","https://openalex.org/W2112848098","https://openalex.org/W2115779804","https://openalex.org/W2115801316","https://openalex.org/W2137716527","https://openalex.org/W2139852278","https://openalex.org/W2148643094","https://openalex.org/W2152799367","https://openalex.org/W2158485828","https://openalex.org/W2159422401","https://openalex.org/W2337404315","https://openalex.org/W2346626662","https://openalex.org/W2635658300","https://openalex.org/W2738082385","https://openalex.org/W2745116209","https://openalex.org/W2952673268","https://openalex.org/W2953357410"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W4391913857","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4396696052"],"abstract_inverted_index":{"MOTIVATION:":[0],"Diseases":[1],"and":[2,28,53,59,77,106],"traits":[3],"are":[4,12,51,113],"under":[5],"dynamic":[6],"tissue-specific":[7,41,57],"regulation.":[8],"However,":[9],"heterogeneous":[10],"tissues":[11,90],"often":[13],"collected":[14],"in":[15,22],"biomedical":[16],"studies,":[17],"which":[18],"reduce":[19],"the":[20,23,87],"power":[21],"identification":[24],"of":[25,63,66],"disease-associated":[26],"variants":[27],"gene":[29],"expression":[30,79],"profiles.":[31],"RESULTS:":[32],"We":[33],"present":[34],"deTS,":[35],"an":[36],"R":[37],"package,":[38],"to":[39],"conduct":[40],"enrichment":[42,61],"analysis":[43],"with":[44],"two":[45],"built-in":[46],"reference":[47],"panels.":[48],"Statistical":[49],"methods":[50],"developed":[52],"implemented":[54],"for":[55,60,91,99],"detecting":[56],"genes":[58],"test":[62],"different":[64],"forms":[65],"query":[67,93],"data.":[68],"Our":[69],"applications":[70],"using":[71],"multi-trait":[72],"genome-wide":[73],"association":[74],"studies":[75],"data":[76,80,112],"cancer":[78],"showed":[81],"that":[82],"deTS":[83],"could":[84],"effectively":[85],"identify":[86],"most":[88],"relevant":[89],"each":[92],"trait":[94],"or":[95],"sample,":[96],"providing":[97],"insights":[98],"future":[100],"studies.":[101],"AVAILABILITY":[102],"AND":[103],"IMPLEMENTATION:":[104],"https://github.com/bsml320/deTS":[105],"CRAN":[107],"https://cran.r-project.org/web/packages/deTS/.":[108],"SUPPLEMENTARY":[109],"INFORMATION:":[110],"Supplementary":[111],"available":[114],"at":[115],"Bioinformatics":[116],"online.":[117]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1}],"updated_date":"2026-07-15T18:14:33.161393","created_date":"2019-03-11T00:00:00"}