{"id":"https://openalex.org/W2912041567","doi":"https://doi.org/10.1093/bioinformatics/btz109","title":"Driver network as a biomarker: systematic integration and network modeling of multi-omics data to derive driver signaling pathways for drug combination prediction","display_name":"Driver network as a biomarker: systematic integration and network modeling of multi-omics data to derive driver signaling pathways for drug combination prediction","publication_year":2019,"publication_date":"2019-02-15","ids":{"openalex":"https://openalex.org/W2912041567","doi":"https://doi.org/10.1093/bioinformatics/btz109","mag":"2912041567","pmid":"https://pubmed.ncbi.nlm.nih.gov/30768150"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btz109","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btz109","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1093/bioinformatics/btz109","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056075825","display_name":"Lei Huang","orcid":"https://orcid.org/0000-0002-0322-6078"},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210109259","display_name":"Methodist Hospital","ror":"https://ror.org/01r5p9y80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802827176","https://openalex.org/I4210109259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lei Huang","raw_affiliation_strings":["Department of Systems Medicine and Bioengineering, Houston Methodist Research Institute, Weill Cornell Medicine of Cornell University , Houston, TX, USA","Houston Methodist Hospital, Houston Methodist Cancer Center , Houston, TX, USA"],"affiliations":[{"raw_affiliation_string":"Department of Systems Medicine and Bioengineering, Houston Methodist Research Institute, Weill Cornell Medicine of Cornell University , Houston, TX, USA","institution_ids":["https://openalex.org/I4210109259","https://openalex.org/I1295876152","https://openalex.org/I205783295"]},{"raw_affiliation_string":"Houston Methodist Hospital, Houston Methodist Cancer Center , Houston, TX, USA","institution_ids":["https://openalex.org/I4210109259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031325751","display_name":"David Brunell","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Brunell","raw_affiliation_strings":["Center for Clinical and Translational Cancer Research, Texas A&M Health Sciences Center, Institute of Biosciences and Technology , Houston, TX, USA"],"affiliations":[{"raw_affiliation_string":"Center for Clinical and Translational Cancer Research, Texas A&M Health Sciences Center, Institute of Biosciences and Technology , Houston, TX, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079659253","display_name":"Clifford Stephan","orcid":"https://orcid.org/0000-0003-0657-6484"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Clifford Stephan","raw_affiliation_strings":["Center for Clinical and Translational Cancer Research, Texas A&M Health Sciences Center, Institute of Biosciences and Technology , Houston, TX, USA"],"affiliations":[{"raw_affiliation_string":"Center for Clinical and Translational Cancer Research, Texas A&M Health Sciences Center, Institute of Biosciences and Technology , Houston, TX, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087107452","display_name":"James J. Mancuso","orcid":"https://orcid.org/0000-0001-5776-8617"},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210109259","display_name":"Methodist Hospital","ror":"https://ror.org/01r5p9y80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802827176","https://openalex.org/I4210109259"]},{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Mancuso","raw_affiliation_strings":["Department of Systems Medicine and Bioengineering, Houston Methodist Research Institute, Weill Cornell Medicine of Cornell University , Houston, TX, USA"],"affiliations":[{"raw_affiliation_string":"Department of Systems Medicine and Bioengineering, Houston Methodist Research Institute, Weill Cornell Medicine of Cornell University , Houston, TX, USA","institution_ids":["https://openalex.org/I4210109259","https://openalex.org/I1295876152","https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071285426","display_name":"Xiaohui Yu","orcid":"https://orcid.org/0000-0001-8170-2327"},"institutions":[{"id":"https://openalex.org/I4210109259","display_name":"Methodist Hospital","ror":"https://ror.org/01r5p9y80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802827176","https://openalex.org/I4210109259"]},{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaohui Yu","raw_affiliation_strings":["Department of Systems Medicine and Bioengineering, Houston Methodist Research Institute, Weill Cornell Medicine of Cornell University , Houston, TX, USA"],"affiliations":[{"raw_affiliation_string":"Department of Systems Medicine and Bioengineering, Houston Methodist Research Institute, Weill Cornell Medicine of Cornell University , Houston, TX, USA","institution_ids":["https://openalex.org/I4210109259","https://openalex.org/I1295876152","https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101847545","display_name":"Bin He","orcid":"https://orcid.org/0000-0001-8674-5430"},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210109259","display_name":"Methodist Hospital","ror":"https://ror.org/01r5p9y80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802827176","https://openalex.org/I4210109259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bin He","raw_affiliation_strings":["Department of Medicine, Weill Cornell Medicine of Cornell University , New York, NY, USA","Department of Urology, Immunobiology & Transplant Science Center, Houston Methodist Cancer Center, Houston Methodist Hospital , Houston, TX, USA"],"affiliations":[{"raw_affiliation_string":"Department of Medicine, Weill Cornell Medicine of Cornell University , New York, NY, USA","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Department of Urology, Immunobiology & Transplant Science Center, Houston Methodist Cancer Center, Houston Methodist Hospital , Houston, TX, USA","institution_ids":["https://openalex.org/I4210109259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042000405","display_name":"Timothy C. Thompson","orcid":"https://orcid.org/0000-0003-1424-3831"},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"funder","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy C Thompson","raw_affiliation_strings":["Division of Cancer Medicine, Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center , Houston, TX, USA"],"affiliations":[{"raw_affiliation_string":"Division of Cancer Medicine, Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center , Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105167216","display_name":"Ralph Zinner","orcid":"https://orcid.org/0009-0009-6812-5540"},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ralph Zinner","raw_affiliation_strings":["Department of Medical Oncology, Thomas Jefferson University , Philadelphia, PA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Thomas Jefferson University , Philadelphia, PA, USA","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029369969","display_name":"Jeri Kim","orcid":"https://orcid.org/0000-0001-6254-7755"},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"funder","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeri Kim","raw_affiliation_strings":["Division of Cancer Medicine, Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center , Houston, TX, USA"],"affiliations":[{"raw_affiliation_string":"Division of Cancer Medicine, Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center , Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080527709","display_name":"Peter J. Davies","orcid":"https://orcid.org/0000-0003-0770-2796"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter Davies","raw_affiliation_strings":["Center for Clinical and Translational Cancer Research, Texas A&M Health Sciences Center, Institute of Biosciences and Technology , Houston, TX, USA"],"affiliations":[{"raw_affiliation_string":"Center for Clinical and Translational Cancer Research, Texas A&M Health Sciences Center, Institute of Biosciences and Technology , Houston, TX, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015077092","display_name":"Stephen T.C. Wong","orcid":"https://orcid.org/0000-0001-9188-6502"},"institutions":[{"id":"https://openalex.org/I4210109259","display_name":"Methodist Hospital","ror":"https://ror.org/01r5p9y80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802827176","https://openalex.org/I4210109259"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stephen T C Wong","raw_affiliation_strings":["Department of Systems Medicine and Bioengineering, Houston Methodist Research Institute, Weill Cornell Medicine of Cornell University , Houston, TX, USA","Houston Methodist Hospital, Houston Methodist Cancer Center , Houston, TX, USA"],"affiliations":[{"raw_affiliation_string":"Department of Systems Medicine and Bioengineering, Houston Methodist Research Institute, Weill Cornell Medicine of Cornell University , Houston, TX, USA","institution_ids":["https://openalex.org/I4210109259","https://openalex.org/I1295876152","https://openalex.org/I205783295"]},{"raw_affiliation_string":"Houston Methodist Hospital, Houston Methodist Cancer Center , Houston, TX, USA","institution_ids":["https://openalex.org/I4210109259"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5015077092"],"corresponding_institution_ids":["https://openalex.org/I1295876152","https://openalex.org/I205783295","https://openalex.org/I4210109259"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":4.2618,"has_fulltext":false,"cited_by_count":74,"citation_normalized_percentile":{"value":0.95255761,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"35","issue":"19","first_page":"3709","last_page":"3717"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9904999732971191,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.5734747648239136},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5516303181648254},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.47849172353744507},{"id":"https://openalex.org/keywords/pharmacogenomics","display_name":"Pharmacogenomics","score":0.4226863980293274},{"id":"https://openalex.org/keywords/personalized-medicine","display_name":"Personalized medicine","score":0.41968047618865967},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.41385650634765625},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.4126240015029907},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3424566388130188},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3269241452217102},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2354905605316162},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1360311210155487},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.09449443221092224}],"concepts":[{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.5734747648239136},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5516303181648254},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.47849172353744507},{"id":"https://openalex.org/C170734499","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenomics","level":2,"score":0.4226863980293274},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.41968047618865967},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.41385650634765625},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.4126240015029907},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3424566388130188},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3269241452217102},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2354905605316162},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1360311210155487},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.09449443221092224},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btz109","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btz109","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:30768150","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30768150","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:europepmc.org:5733262","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6761967","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btz109","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btz109","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6100000143051147}],"awards":[{"id":"https://openalex.org/G5404764012","display_name":null,"funder_award_id":"RSG-13\u2013061\u201301-TBE","funder_id":"https://openalex.org/F4320306095","funder_display_name":"American Cancer Society"},{"id":"https://openalex.org/G7620910368","display_name":null,"funder_award_id":"RP110532","funder_id":"https://openalex.org/F4320308129","funder_display_name":"Cancer Prevention and Research Institute of Texas"}],"funders":[{"id":"https://openalex.org/F4320306095","display_name":"American Cancer Society","ror":"https://ror.org/02e463172"},{"id":"https://openalex.org/F4320308129","display_name":"Cancer Prevention and Research Institute of Texas","ror":"https://ror.org/0003xa228"},{"id":"https://openalex.org/F4320309422","display_name":"John S. Dunn Foundation","ror":"https://ror.org/03yhprz62"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1546436101","https://openalex.org/W1970770088","https://openalex.org/W1985264867","https://openalex.org/W1994676913","https://openalex.org/W1995996719","https://openalex.org/W1997476230","https://openalex.org/W2009720434","https://openalex.org/W2013053580","https://openalex.org/W2015136221","https://openalex.org/W2018518196","https://openalex.org/W2018740272","https://openalex.org/W2034537627","https://openalex.org/W2036291018","https://openalex.org/W2036654087","https://openalex.org/W2043058822","https://openalex.org/W2053473615","https://openalex.org/W2053609837","https://openalex.org/W2054768549","https://openalex.org/W2061061337","https://openalex.org/W2061136308","https://openalex.org/W2078241670","https://openalex.org/W2087955215","https://openalex.org/W2098983774","https://openalex.org/W2107468161","https://openalex.org/W2111094216","https://openalex.org/W2116566535","https://openalex.org/W2119412782","https://openalex.org/W2129925362","https://openalex.org/W2130460526","https://openalex.org/W2134640949","https://openalex.org/W2134814468","https://openalex.org/W2138427043","https://openalex.org/W2139923932","https://openalex.org/W2140334822","https://openalex.org/W2144370915","https://openalex.org/W2157852151","https://openalex.org/W2160095931","https://openalex.org/W2165232124","https://openalex.org/W2165863045","https://openalex.org/W2262087934","https://openalex.org/W2322391851","https://openalex.org/W2775061087","https://openalex.org/W6632702381","https://openalex.org/W6660015955","https://openalex.org/W6680243710"],"related_works":["https://openalex.org/W4226103442","https://openalex.org/W4394833375","https://openalex.org/W2999563835","https://openalex.org/W2068142083","https://openalex.org/W2581299237","https://openalex.org/W2159063798","https://openalex.org/W2071084184","https://openalex.org/W2121123734","https://openalex.org/W4394834418","https://openalex.org/W2470631360"],"abstract_inverted_index":{"Supplementary":[0],"data":[1],"are":[2],"available":[3],"at":[4],"Bioinformatics":[5],"online.":[6]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}