{"id":"https://openalex.org/W2911539447","doi":"https://doi.org/10.1093/bioinformatics/btz066","title":"Batch-normalization of cerebellar and medulloblastoma gene expression datasets utilizing empirically defined negative control genes","display_name":"Batch-normalization of cerebellar and medulloblastoma gene expression datasets utilizing empirically defined negative control genes","publication_year":2019,"publication_date":"2019-01-30","ids":{"openalex":"https://openalex.org/W2911539447","doi":"https://doi.org/10.1093/bioinformatics/btz066","mag":"2911539447","pmid":"https://pubmed.ncbi.nlm.nih.gov/30715209"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btz066","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btz066","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/35/18/3357/30024517/btz066.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/35/18/3357/30024517/btz066.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063999480","display_name":"Holger Weishaupt","orcid":"https://orcid.org/0000-0002-0364-2709"},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Holger Weishaupt","raw_affiliation_strings":["Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Rudbeck Laboratory, Uppsala University , Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Rudbeck Laboratory, Uppsala University , Uppsala, Sweden","institution_ids":["https://openalex.org/I2800139495","https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025962179","display_name":"Patrik Johansson","orcid":"https://orcid.org/0000-0002-9907-117X"},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Patrik Johansson","raw_affiliation_strings":["Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Rudbeck Laboratory, Uppsala University , Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Rudbeck Laboratory, Uppsala University , Uppsala, Sweden","institution_ids":["https://openalex.org/I2800139495","https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072951694","display_name":"Anders Sundstr\u00f6m","orcid":"https://orcid.org/0000-0003-3942-6271"},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Anders Sundstr\u00f6m","raw_affiliation_strings":["Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Rudbeck Laboratory, Uppsala University , Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Rudbeck Laboratory, Uppsala University , Uppsala, Sweden","institution_ids":["https://openalex.org/I2800139495","https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038083124","display_name":"Zelmina Lubovac-Pilav","orcid":"https://orcid.org/0000-0001-6427-0315"},"institutions":[{"id":"https://openalex.org/I205158640","display_name":"University of Sk\u00f6vde","ror":"https://ror.org/051mrsz47","country_code":"SE","type":"education","lineage":["https://openalex.org/I205158640"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Zelmina Lubovac-Pilav","raw_affiliation_strings":["Division for Biology and Bioinformatics, School of Bioscience, The Systems Biology Research Centre, University of Sk\u00f6vde , Sk\u00f6vde, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division for Biology and Bioinformatics, School of Bioscience, The Systems Biology Research Centre, University of Sk\u00f6vde , Sk\u00f6vde, Sweden","institution_ids":["https://openalex.org/I205158640"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056458463","display_name":"Bj\u00f6rn Olsson","orcid":"https://orcid.org/0000-0001-6254-4335"},"institutions":[{"id":"https://openalex.org/I205158640","display_name":"University of Sk\u00f6vde","ror":"https://ror.org/051mrsz47","country_code":"SE","type":"education","lineage":["https://openalex.org/I205158640"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Bj\u00f6rn Olsson","raw_affiliation_strings":["Division for Biology and Bioinformatics, School of Bioscience, The Systems Biology Research Centre, University of Sk\u00f6vde , Sk\u00f6vde, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division for Biology and Bioinformatics, School of Bioscience, The Systems Biology Research Centre, University of Sk\u00f6vde , Sk\u00f6vde, Sweden","institution_ids":["https://openalex.org/I205158640"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051667380","display_name":"Sven Nelander","orcid":"https://orcid.org/0000-0003-1758-1262"},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Sven Nelander","raw_affiliation_strings":["Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Rudbeck Laboratory, Uppsala University , Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Rudbeck Laboratory, Uppsala University , Uppsala, Sweden","institution_ids":["https://openalex.org/I2800139495","https://openalex.org/I123387679"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068758660","display_name":"Fredrik J. Swartling","orcid":"https://orcid.org/0000-0002-8460-4367"},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Fredrik J Swartling","raw_affiliation_strings":["Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Rudbeck Laboratory, Uppsala University , Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Rudbeck Laboratory, Uppsala University , Uppsala, Sweden","institution_ids":["https://openalex.org/I2800139495","https://openalex.org/I123387679"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5063999480","https://openalex.org/A5068758660"],"corresponding_institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2800139495"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":2856,"currency":"EUR","value_usd":3080},"fwci":3.7594,"has_fulltext":true,"cited_by_count":78,"citation_normalized_percentile":{"value":0.94233334,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"35","issue":"18","first_page":"3357","last_page":"3364"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.3993000090122223,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.3993000090122223,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.3695000112056732,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.017500000074505806,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/medulloblastoma","display_name":"Medulloblastoma","score":0.7997572422027588},{"id":"https://openalex.org/keywords/normalization","display_name":"Normalization (sociology)","score":0.7797856330871582},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.6334314942359924},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4696822762489319},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4489337205886841},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.44161680340766907},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.4331303536891937},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.345139741897583}],"concepts":[{"id":"https://openalex.org/C2780789225","wikidata":"https://www.wikidata.org/wiki/Q1333608","display_name":"Medulloblastoma","level":2,"score":0.7997572422027588},{"id":"https://openalex.org/C136886441","wikidata":"https://www.wikidata.org/wiki/Q926129","display_name":"Normalization (sociology)","level":2,"score":0.7797856330871582},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6334314942359924},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4696822762489319},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4489337205886841},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.44161680340766907},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4331303536891937},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.345139741897583},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C19165224","wikidata":"https://www.wikidata.org/wiki/Q23404","display_name":"Anthropology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002528","descriptor_name":"Cerebellar Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002528","descriptor_name":"Cerebellar Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002528","descriptor_name":"Cerebellar Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002528","descriptor_name":"Cerebellar Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008527","descriptor_name":"Medulloblastoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008527","descriptor_name":"Medulloblastoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008527","descriptor_name":"Medulloblastoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008527","descriptor_name":"Medulloblastoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1093/bioinformatics/btz066","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btz066","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/35/18/3357/30024517/btz066.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:30715209","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30715209","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:DiVA.org:his-16769","is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-16769","pdf_url":null,"source":{"id":"https://openalex.org/S4306401029","display_name":"University Library of Sk\u00f6vde (University of Sk\u00f6vde)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205158640","host_organization_name":"University of Sk\u00f6vde","host_organization_lineage":["https://openalex.org/I205158640"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"pmh:oai:DiVA.org:uu-395689","is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-395689","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article in journal"},{"id":"pmh:oai:pubmedcentral.nih.gov:6748729","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6748729","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btz066","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btz066","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/35/18/3357/30024517/btz066.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6399999856948853,"display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G5972191337","display_name":"Molecularly defined models of human childhood brain tumors","funder_award_id":"640275","funder_id":"https://openalex.org/F4320338335","funder_display_name":"H2020 European Research Council"}],"funders":[{"id":"https://openalex.org/F4320321491","display_name":"Cancerfonden","ror":"https://ror.org/0527jb766"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320323766","display_name":"Barncancerfonden","ror":"https://ror.org/05072yv34"},{"id":"https://openalex.org/F4320338335","display_name":"H2020 European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2911539447.pdf","grobid_xml":"https://content.openalex.org/works/W2911539447.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1503789718","https://openalex.org/W1560814177","https://openalex.org/W1963740134","https://openalex.org/W1974625077","https://openalex.org/W1986849266","https://openalex.org/W1996409634","https://openalex.org/W2004456850","https://openalex.org/W2008083733","https://openalex.org/W2009405916","https://openalex.org/W2062533676","https://openalex.org/W2070095707","https://openalex.org/W2082080058","https://openalex.org/W2087224762","https://openalex.org/W2097626332","https://openalex.org/W2107665951","https://openalex.org/W2112741367","https://openalex.org/W2113253187","https://openalex.org/W2115003883","https://openalex.org/W2116650193","https://openalex.org/W2118124054","https://openalex.org/W2127643721","https://openalex.org/W2140213125","https://openalex.org/W2143290174","https://openalex.org/W2146712834","https://openalex.org/W2147013674","https://openalex.org/W2153398041","https://openalex.org/W2161535481","https://openalex.org/W2166549811","https://openalex.org/W2169030185","https://openalex.org/W2169353806","https://openalex.org/W2266806088","https://openalex.org/W2337433062","https://openalex.org/W2606710299","https://openalex.org/W2618958001","https://openalex.org/W2624094894","https://openalex.org/W2626440326","https://openalex.org/W2737542366","https://openalex.org/W6693419381"],"related_works":["https://openalex.org/W3094500874","https://openalex.org/W4303033928","https://openalex.org/W2374080520","https://openalex.org/W2062443378","https://openalex.org/W3099410057","https://openalex.org/W2803323662","https://openalex.org/W3032874291","https://openalex.org/W2005057264","https://openalex.org/W2363156284","https://openalex.org/W2415025170"],"abstract_inverted_index":{"MOTIVATION:":[0],"Medulloblastoma":[1],"(MB)":[2],"is":[3,186],"a":[4,93,103,118,124],"brain":[5,77],"cancer":[6],"predominantly":[7],"arising":[8],"in":[9,35,167],"children.":[10],"Roughly":[11],"70%":[12],"of":[13,51,87,105,117,120,128,144,148,154,170],"patients":[14],"are":[15,209],"cured":[16],"today,":[17],"but":[18,33],"survivors":[19],"often":[20,34],"suffer":[21],"from":[22],"severe":[23],"sequelae.":[24],"MB":[25,73,129,171],"has":[26],"been":[27],"extensively":[28],"studied":[29],"by":[30,172],"molecular":[31],"profiling,":[32],"small":[36],"and":[37,44,74,102,130,146,195],"scattered":[38],"cohorts.":[39],"To":[40,79],"improve":[41,164],"cure":[42],"rates":[43],"reduce":[45],"treatment":[46],"side":[47],"effects,":[48,82,122],"accurate":[49,142],"integration":[50,143],"such":[52],"data":[53,145,185,208],"to":[54,107],"increase":[55],"analytical":[56],"power":[57],"will":[58,137,163],"be":[59,138,197],"important,":[60],"if":[61],"not":[62],"essential.":[63],"RESULTS:":[64],"We":[65,157],"have":[66],"integrated":[67,161],"23":[68],"transcription":[69],"datasets,":[70],"spanning":[71],"1350":[72],"291":[75],"normal":[76,149],"samples.":[78],"remove":[80],"batch":[81,121],"we":[83],"combined":[84],"the":[85,115,160,168,189,200],"Removal":[86],"Unwanted":[88],"Variation":[89],"(RUV)":[90],"method":[91],"with":[92],"novel":[94],"pipeline":[95],"for":[96,141,152],"determining":[97],"empirical":[98],"negative":[99],"control":[100],"genes":[101],"panel":[104],"metrics":[106],"evaluate":[108],"normalization":[109],"performance.":[110],"The":[111,134,182],"documented":[112],"approach":[113],"enabled":[114],"removal":[116],"majority":[119],"producing":[123],"large-scale,":[125],"integrative":[126],"dataset":[127,162],"cerebellar":[131],"expression":[132,177,184],"data.":[133],"proposed":[135],"strategy":[136],"broadly":[139],"applicable":[140],"incorporation":[147],"reference":[150],"samples":[151],"studies":[153],"various":[155],"diseases.":[156],"hope":[158],"that":[159],"current":[165],"research":[166],"field":[169],"allowing":[173],"more":[174],"large-scale":[175],"gene":[176],"analyses.":[178],"AVAILABILITY":[179],"AND":[180],"IMPLEMENTATION:":[181],"RUV-normalized":[183],"available":[187,210],"through":[188],"Gene":[190],"Expression":[191],"Omnibus":[192],"(GEO;":[193],"https://www.ncbi.nlm.nih.gov/geo/)":[194],"can":[196],"accessed":[198],"via":[199],"GSE":[201],"series":[202],"number":[203],"GSE124814.":[204],"SUPPLEMENTARY":[205],"INFORMATION:":[206],"Supplementary":[207],"at":[211],"Bioinformatics":[212],"online.":[213]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":22},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}