{"id":"https://openalex.org/W2889157692","doi":"https://doi.org/10.1093/bioinformatics/bty763","title":"Drug Gene Budger (DGB): an application for ranking drugs to modulate a specific gene based on transcriptomic signatures","display_name":"Drug Gene Budger (DGB): an application for ranking drugs to modulate a specific gene based on transcriptomic signatures","publication_year":2018,"publication_date":"2018-08-30","ids":{"openalex":"https://openalex.org/W2889157692","doi":"https://doi.org/10.1093/bioinformatics/bty763","mag":"2889157692","pmid":"https://pubmed.ncbi.nlm.nih.gov/30169739"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/bty763","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bty763","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100784336","display_name":"Zichen Wang","orcid":"https://orcid.org/0000-0002-1415-1286"},"institutions":[{"id":"https://openalex.org/I178645029","display_name":"Illumina (United States)","ror":"https://ror.org/05k34t975","country_code":"US","type":"company","lineage":["https://openalex.org/I178645029"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zichen Wang","raw_affiliation_strings":["Department of Pharmacological Sciences, BD2K-LINCS Data Coordination and Integration Center, Knowledge Management Center for Illuminating the Druggable Genome, Mount Sinai Center for Bioinformatics, Icahn 10 School of Medicine at Mount Sinai, New York, NY, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacological Sciences, BD2K-LINCS Data Coordination and Integration Center, Knowledge Management Center for Illuminating the Druggable Genome, Mount Sinai Center for Bioinformatics, Icahn 10 School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320","https://openalex.org/I178645029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024472014","display_name":"Edward He","orcid":null},"institutions":[{"id":"https://openalex.org/I178645029","display_name":"Illumina (United States)","ror":"https://ror.org/05k34t975","country_code":"US","type":"company","lineage":["https://openalex.org/I178645029"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward He","raw_affiliation_strings":["Department of Pharmacological Sciences, BD2K-LINCS Data Coordination and Integration Center, Knowledge Management Center for Illuminating the Druggable Genome, Mount Sinai Center for Bioinformatics, Icahn 10 School of Medicine at Mount Sinai, New York, NY, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacological Sciences, BD2K-LINCS Data Coordination and Integration Center, Knowledge Management Center for Illuminating the Druggable Genome, Mount Sinai Center for Bioinformatics, Icahn 10 School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320","https://openalex.org/I178645029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035046647","display_name":"Kevin Sani","orcid":null},"institutions":[{"id":"https://openalex.org/I178645029","display_name":"Illumina (United States)","ror":"https://ror.org/05k34t975","country_code":"US","type":"company","lineage":["https://openalex.org/I178645029"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin Sani","raw_affiliation_strings":["Department of Pharmacological Sciences, BD2K-LINCS Data Coordination and Integration Center, Knowledge Management Center for Illuminating the Druggable Genome, Mount Sinai Center for Bioinformatics, Icahn 10 School of Medicine at Mount Sinai, New York, NY, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacological Sciences, BD2K-LINCS Data Coordination and Integration Center, Knowledge Management Center for Illuminating the Druggable Genome, Mount Sinai Center for Bioinformatics, Icahn 10 School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320","https://openalex.org/I178645029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033965639","display_name":"Kathleen M. Jagodnik","orcid":"https://orcid.org/0000-0002-2755-2097"},"institutions":[{"id":"https://openalex.org/I178645029","display_name":"Illumina (United States)","ror":"https://ror.org/05k34t975","country_code":"US","type":"company","lineage":["https://openalex.org/I178645029"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathleen M Jagodnik","raw_affiliation_strings":["Department of Pharmacological Sciences, BD2K-LINCS Data Coordination and Integration Center, Knowledge Management Center for Illuminating the Druggable Genome, Mount Sinai Center for Bioinformatics, Icahn 10 School of Medicine at Mount Sinai, New York, NY, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacological Sciences, BD2K-LINCS Data Coordination and Integration Center, Knowledge Management Center for Illuminating the Druggable Genome, Mount Sinai Center for Bioinformatics, Icahn 10 School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320","https://openalex.org/I178645029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015142107","display_name":"Moshe C. Silverstein","orcid":"https://orcid.org/0000-0001-7050-6267"},"institutions":[{"id":"https://openalex.org/I178645029","display_name":"Illumina (United States)","ror":"https://ror.org/05k34t975","country_code":"US","type":"company","lineage":["https://openalex.org/I178645029"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Moshe C Silverstein","raw_affiliation_strings":["Department of Pharmacological Sciences, BD2K-LINCS Data Coordination and Integration Center, Knowledge Management Center for Illuminating the Druggable Genome, Mount Sinai Center for Bioinformatics, Icahn 10 School of Medicine at Mount Sinai, New York, NY, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacological Sciences, BD2K-LINCS Data Coordination and Integration Center, Knowledge Management Center for Illuminating the Druggable Genome, Mount Sinai Center for Bioinformatics, Icahn 10 School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320","https://openalex.org/I178645029"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032951414","display_name":"Avi Ma\u2019ayan","orcid":"https://orcid.org/0000-0002-6904-1017"},"institutions":[{"id":"https://openalex.org/I178645029","display_name":"Illumina (United States)","ror":"https://ror.org/05k34t975","country_code":"US","type":"company","lineage":["https://openalex.org/I178645029"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Avi Ma\u2019ayan","raw_affiliation_strings":["Department of Pharmacological Sciences, BD2K-LINCS Data Coordination and Integration Center, Knowledge Management Center for Illuminating the Druggable Genome, Mount Sinai Center for Bioinformatics, Icahn 10 School of Medicine at Mount Sinai, New York, NY, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacological Sciences, BD2K-LINCS Data Coordination and Integration Center, Knowledge Management Center for Illuminating the Druggable Genome, Mount Sinai Center for Bioinformatics, Icahn 10 School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320","https://openalex.org/I178645029"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5032951414"],"corresponding_institution_ids":["https://openalex.org/I178645029","https://openalex.org/I98704320"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":4.0608,"has_fulltext":false,"cited_by_count":49,"citation_normalized_percentile":{"value":0.94831587,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"35","issue":"7","first_page":"1247","last_page":"1248"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9890999794006348,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.6700972318649292},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.6095997095108032},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6084461808204651},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.6013885140419006},{"id":"https://openalex.org/keywords/ranking","display_name":"Ranking (information retrieval)","score":0.5299801826477051},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4398573040962219},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.35563698410987854},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3461248576641083},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.31699663400650024},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.2905440926551819},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.24854916334152222},{"id":"https://openalex.org/keywords/information-retrieval","display_name":"Information retrieval","score":0.1156759262084961}],"concepts":[{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6700972318649292},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6095997095108032},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6084461808204651},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6013885140419006},{"id":"https://openalex.org/C189430467","wikidata":"https://www.wikidata.org/wiki/Q7293293","display_name":"Ranking (information retrieval)","level":2,"score":0.5299801826477051},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4398573040962219},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.35563698410987854},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3461248576641083},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.31699663400650024},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2905440926551819},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.24854916334152222},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.1156759262084961}],"mesh":[{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040421","descriptor_name":"Cell Phone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040421","descriptor_name":"Cell Phone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040421","descriptor_name":"Cell Phone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D063731","descriptor_name":"Mobile Applications","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063731","descriptor_name":"Mobile Applications","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063731","descriptor_name":"Mobile Applications","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/bty763","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bty763","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:30169739","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30169739","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:europepmc.org:6057925","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6449747","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4099999964237213}],"awards":[{"id":"https://openalex.org/G1142117526","display_name":null,"funder_award_id":"U24CA224260","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2777337649","display_name":null,"funder_award_id":"U54HL127624","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7335327132","display_name":null,"funder_award_id":"HL127624","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8190715374","display_name":null,"funder_award_id":"OT3OD025467","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W2018518196","https://openalex.org/W2107665951","https://openalex.org/W2121604817","https://openalex.org/W2146512944","https://openalex.org/W2169353806","https://openalex.org/W2524066112","https://openalex.org/W2612467560","https://openalex.org/W2804408552"],"related_works":["https://openalex.org/W2399513595","https://openalex.org/W4388386498","https://openalex.org/W2028462563","https://openalex.org/W2982720988","https://openalex.org/W3150324899","https://openalex.org/W4392059188","https://openalex.org/W4388725868","https://openalex.org/W2104762330","https://openalex.org/W4379374180","https://openalex.org/W2523545060"],"abstract_inverted_index":{"Supplementary":[0],"data":[1],"are":[2],"available":[3],"at":[4],"Bioinformatics":[5],"online.":[6]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":3}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}