{"id":"https://openalex.org/W2891585877","doi":"https://doi.org/10.1093/bioinformatics/bty751","title":"Improving protein function prediction using protein sequence and GO-term similarities","display_name":"Improving protein function prediction using protein sequence and GO-term similarities","publication_year":2018,"publication_date":"2018-08-29","ids":{"openalex":"https://openalex.org/W2891585877","doi":"https://doi.org/10.1093/bioinformatics/bty751","mag":"2891585877","pmid":"https://pubmed.ncbi.nlm.nih.gov/30169569"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/bty751","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bty751","pdf_url":"https://watermark.silverchair.com/bty751.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAswwggLIBgkqhkiG9w0BBwagggK5MIICtQIBADCCAq4GCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQM3RRNVSfI1RRbX36MAgEQgIICfxHv_1Aeeolr6ycblRmRnKyW0yRTuEDF9P4M_IaNVV1cSmAmb5RFiSmqTcGrPFCfrF36VSkXY_gUKodIz6VI_SXvTC-EiGIdSg1SEO7OhOlBFqZDuENSpVcHcPrGXa4CbWNRnLl3Fr7T1i2TGzu4ZvD0DEY6krv07sET3vOhaWUrxVgtapOzFeIRD4WISTYyLIYem92j9c__lJ1ucP63BluBM1K6DNv6G0UoRK-j0upS0f8lnViIO-myZAZ7fXjg2jIBynG5icjb0pK-L8ULxLJbohFRyaFg9rkAQBFHzwNodKzWeIYtPuyHg-d19oibGfANLLbL68v2UorxAUeX0M_qJZGmuiKpQRlOP5zo3iTqvbKR1tJn5xtnHJeGHoGzujgg-loQtjZkYM94x9sao-TaIETdk5IeYJe88lh9JEd5nDt-7KNy1GnB424-p5VvlPWnLBmNHYm2wLllEVlCA1P1jr4vmi8BOG1t_Rmnd1KvETFX2JehD2UGUILCbR-mNouHZoIOamIY4eeBHuVD2XQmw4Ff1CsU_N8BfJsdAubRUN1iqJVprGhMH399hkz24jUvJ2chJAioJhJAaZvoxfyuRCDisK5BAsODm7WC7Wn62Aa7f-bhGVBN4Ic7civexIpMm77hBTwmdzPCUruzHerl5gBf8iffROWRkd9dc806CO2uU-3HyJR8QAL_CILq9mYNuceZLeRiVa4fv7HcL1nQdHt7N-N4Eii6tWeLfwLrOlI4Xo6iZn0ClJcXBgbWDTmRc1Yfw0GMyDKRaQpVQpjX_xz2MJZwv5rggod3wy8vnbWwgOa6DnCZoJLbSF9KCe5xfkJO6Gu98exwoFrSwg","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://watermark.silverchair.com/bty751.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAswwggLIBgkqhkiG9w0BBwagggK5MIICtQIBADCCAq4GCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQM3RRNVSfI1RRbX36MAgEQgIICfxHv_1Aeeolr6ycblRmRnKyW0yRTuEDF9P4M_IaNVV1cSmAmb5RFiSmqTcGrPFCfrF36VSkXY_gUKodIz6VI_SXvTC-EiGIdSg1SEO7OhOlBFqZDuENSpVcHcPrGXa4CbWNRnLl3Fr7T1i2TGzu4ZvD0DEY6krv07sET3vOhaWUrxVgtapOzFeIRD4WISTYyLIYem92j9c__lJ1ucP63BluBM1K6DNv6G0UoRK-j0upS0f8lnViIO-myZAZ7fXjg2jIBynG5icjb0pK-L8ULxLJbohFRyaFg9rkAQBFHzwNodKzWeIYtPuyHg-d19oibGfANLLbL68v2UorxAUeX0M_qJZGmuiKpQRlOP5zo3iTqvbKR1tJn5xtnHJeGHoGzujgg-loQtjZkYM94x9sao-TaIETdk5IeYJe88lh9JEd5nDt-7KNy1GnB424-p5VvlPWnLBmNHYm2wLllEVlCA1P1jr4vmi8BOG1t_Rmnd1KvETFX2JehD2UGUILCbR-mNouHZoIOamIY4eeBHuVD2XQmw4Ff1CsU_N8BfJsdAubRUN1iqJVprGhMH399hkz24jUvJ2chJAioJhJAaZvoxfyuRCDisK5BAsODm7WC7Wn62Aa7f-bhGVBN4Ic7civexIpMm77hBTwmdzPCUruzHerl5gBf8iffROWRkd9dc806CO2uU-3HyJR8QAL_CILq9mYNuceZLeRiVa4fv7HcL1nQdHt7N-N4Eii6tWeLfwLrOlI4Xo6iZn0ClJcXBgbWDTmRc1Yfw0GMyDKRaQpVQpjX_xz2MJZwv5rggod3wy8vnbWwgOa6DnCZoJLbSF9KCe5xfkJO6Gu98exwoFrSwg","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050761197","display_name":"Stavros Makrodimitris","orcid":"https://orcid.org/0000-0002-3111-4268"},"institutions":[{"id":"https://openalex.org/I4210128465","display_name":"KeyGene (Netherlands)","ror":"https://ror.org/02zz2nb17","country_code":"NL","type":"company","lineage":["https://openalex.org/I4210128465"]},{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Stavros Makrodimitris","raw_affiliation_strings":["Department of Bioinformatics, Keygene N.V., Wageningen, The Netherlands","Department of Intelligent Systems, Delft Bioinformatics Lab, Delft University of Technology, Delft, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-3111-4268","affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Keygene N.V., Wageningen, The Netherlands","institution_ids":["https://openalex.org/I4210128465"]},{"raw_affiliation_string":"Department of Intelligent Systems, Delft Bioinformatics Lab, Delft University of Technology, Delft, The Netherlands","institution_ids":["https://openalex.org/I98358874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038211775","display_name":"Roeland C. H. J. van Ham","orcid":"https://orcid.org/0000-0003-2295-4991"},"institutions":[{"id":"https://openalex.org/I4210128465","display_name":"KeyGene (Netherlands)","ror":"https://ror.org/02zz2nb17","country_code":"NL","type":"company","lineage":["https://openalex.org/I4210128465"]},{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Roeland C H J van Ham","raw_affiliation_strings":["Department of Bioinformatics, Keygene N.V., Wageningen, The Netherlands","Department of Intelligent Systems, Delft Bioinformatics Lab, Delft University of Technology, Delft, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Keygene N.V., Wageningen, The Netherlands","institution_ids":["https://openalex.org/I4210128465"]},{"raw_affiliation_string":"Department of Intelligent Systems, Delft Bioinformatics Lab, Delft University of Technology, Delft, The Netherlands","institution_ids":["https://openalex.org/I98358874"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052699801","display_name":"Marcel Reinders","orcid":"https://orcid.org/0000-0002-1148-1562"},"institutions":[{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Marcel J T Reinders","raw_affiliation_strings":["Department of Intelligent Systems, Delft Bioinformatics Lab, Delft University of Technology, Delft, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Intelligent Systems, Delft Bioinformatics Lab, Delft University of Technology, Delft, The Netherlands","institution_ids":["https://openalex.org/I98358874"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5050761197"],"corresponding_institution_ids":["https://openalex.org/I4210128465","https://openalex.org/I98358874"],"apc_list":{"value":3989,"currency":"USD","value_usd":3989},"apc_paid":{"value":3989,"currency":"USD","value_usd":3989},"fwci":1.5715,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.83567311,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"35","issue":"7","first_page":"1116","last_page":"1124"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.4027999937534332,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.4027999937534332,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.36970001459121704,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.18889999389648438,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/term","display_name":"Term (time)","score":0.6892712712287903},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5713822245597839},{"id":"https://openalex.org/keywords/protein-function-prediction","display_name":"Protein function prediction","score":0.5687363147735596},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.5359495282173157},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.466470330953598},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4588592052459717},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.38026484847068787},{"id":"https://openalex.org/keywords/protein-function","display_name":"Protein function","score":0.3492000102996826},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.27438461780548096},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.21444439888000488},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.081820547580719},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.06309890747070312}],"concepts":[{"id":"https://openalex.org/C61797465","wikidata":"https://www.wikidata.org/wiki/Q1188986","display_name":"Term (time)","level":2,"score":0.6892712712287903},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5713822245597839},{"id":"https://openalex.org/C207060522","wikidata":"https://www.wikidata.org/wiki/Q7251473","display_name":"Protein function prediction","level":4,"score":0.5687363147735596},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.5359495282173157},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.466470330953598},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4588592052459717},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.38026484847068787},{"id":"https://openalex.org/C2986374874","wikidata":"https://www.wikidata.org/wiki/Q8054","display_name":"Protein function","level":3,"score":0.3492000102996826},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27438461780548096},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21444439888000488},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.081820547580719},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.06309890747070312},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058977","descriptor_name":"Molecular Sequence Annotation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058977","descriptor_name":"Molecular Sequence Annotation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058977","descriptor_name":"Molecular Sequence Annotation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063990","descriptor_name":"Gene Ontology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063990","descriptor_name":"Gene Ontology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063990","descriptor_name":"Gene Ontology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1093/bioinformatics/bty751","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bty751","pdf_url":"https://watermark.silverchair.com/bty751.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAswwggLIBgkqhkiG9w0BBwagggK5MIICtQIBADCCAq4GCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQM3RRNVSfI1RRbX36MAgEQgIICfxHv_1Aeeolr6ycblRmRnKyW0yRTuEDF9P4M_IaNVV1cSmAmb5RFiSmqTcGrPFCfrF36VSkXY_gUKodIz6VI_SXvTC-EiGIdSg1SEO7OhOlBFqZDuENSpVcHcPrGXa4CbWNRnLl3Fr7T1i2TGzu4ZvD0DEY6krv07sET3vOhaWUrxVgtapOzFeIRD4WISTYyLIYem92j9c__lJ1ucP63BluBM1K6DNv6G0UoRK-j0upS0f8lnViIO-myZAZ7fXjg2jIBynG5icjb0pK-L8ULxLJbohFRyaFg9rkAQBFHzwNodKzWeIYtPuyHg-d19oibGfANLLbL68v2UorxAUeX0M_qJZGmuiKpQRlOP5zo3iTqvbKR1tJn5xtnHJeGHoGzujgg-loQtjZkYM94x9sao-TaIETdk5IeYJe88lh9JEd5nDt-7KNy1GnB424-p5VvlPWnLBmNHYm2wLllEVlCA1P1jr4vmi8BOG1t_Rmnd1KvETFX2JehD2UGUILCbR-mNouHZoIOamIY4eeBHuVD2XQmw4Ff1CsU_N8BfJsdAubRUN1iqJVprGhMH399hkz24jUvJ2chJAioJhJAaZvoxfyuRCDisK5BAsODm7WC7Wn62Aa7f-bhGVBN4Ic7civexIpMm77hBTwmdzPCUruzHerl5gBf8iffROWRkd9dc806CO2uU-3HyJR8QAL_CILq9mYNuceZLeRiVa4fv7HcL1nQdHt7N-N4Eii6tWeLfwLrOlI4Xo6iZn0ClJcXBgbWDTmRc1Yfw0GMyDKRaQpVQpjX_xz2MJZwv5rggod3wy8vnbWwgOa6DnCZoJLbSF9KCe5xfkJO6Gu98exwoFrSwg","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:30169569","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30169569","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5438747","is_oa":false,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6449755","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6449755","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6449755","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:tudelft.nl:uuid:92fc6a4a-bac1-4ed2-99df-293a477e1717","is_oa":false,"landing_page_url":"http://resolver.tudelft.nl/uuid:92fc6a4a-bac1-4ed2-99df-293a477e1717","pdf_url":null,"source":{"id":"https://openalex.org/S4306400906","display_name":"Research Repository (Delft University of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I98358874","host_organization_name":"Delft University of Technology","host_organization_lineage":["https://openalex.org/I98358874"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/bty751","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bty751","pdf_url":"https://watermark.silverchair.com/bty751.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAswwggLIBgkqhkiG9w0BBwagggK5MIICtQIBADCCAq4GCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQM3RRNVSfI1RRbX36MAgEQgIICfxHv_1Aeeolr6ycblRmRnKyW0yRTuEDF9P4M_IaNVV1cSmAmb5RFiSmqTcGrPFCfrF36VSkXY_gUKodIz6VI_SXvTC-EiGIdSg1SEO7OhOlBFqZDuENSpVcHcPrGXa4CbWNRnLl3Fr7T1i2TGzu4ZvD0DEY6krv07sET3vOhaWUrxVgtapOzFeIRD4WISTYyLIYem92j9c__lJ1ucP63BluBM1K6DNv6G0UoRK-j0upS0f8lnViIO-myZAZ7fXjg2jIBynG5icjb0pK-L8ULxLJbohFRyaFg9rkAQBFHzwNodKzWeIYtPuyHg-d19oibGfANLLbL68v2UorxAUeX0M_qJZGmuiKpQRlOP5zo3iTqvbKR1tJn5xtnHJeGHoGzujgg-loQtjZkYM94x9sao-TaIETdk5IeYJe88lh9JEd5nDt-7KNy1GnB424-p5VvlPWnLBmNHYm2wLllEVlCA1P1jr4vmi8BOG1t_Rmnd1KvETFX2JehD2UGUILCbR-mNouHZoIOamIY4eeBHuVD2XQmw4Ff1CsU_N8BfJsdAubRUN1iqJVprGhMH399hkz24jUvJ2chJAioJhJAaZvoxfyuRCDisK5BAsODm7WC7Wn62Aa7f-bhGVBN4Ic7civexIpMm77hBTwmdzPCUruzHerl5gBf8iffROWRkd9dc806CO2uU-3HyJR8QAL_CILq9mYNuceZLeRiVa4fv7HcL1nQdHt7N-N4Eii6tWeLfwLrOlI4Xo6iZn0ClJcXBgbWDTmRc1Yfw0GMyDKRaQpVQpjX_xz2MJZwv5rggod3wy8vnbWwgOa6DnCZoJLbSF9KCe5xfkJO6Gu98exwoFrSwg","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2891585877.pdf"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W46659105","https://openalex.org/W1144107824","https://openalex.org/W1663797894","https://openalex.org/W1705245392","https://openalex.org/W1967542092","https://openalex.org/W1973163442","https://openalex.org/W1973714307","https://openalex.org/W2027869746","https://openalex.org/W2035832348","https://openalex.org/W2045156863","https://openalex.org/W2047606947","https://openalex.org/W2054118996","https://openalex.org/W2060148724","https://openalex.org/W2063291945","https://openalex.org/W2063345857","https://openalex.org/W2084168100","https://openalex.org/W2094124219","https://openalex.org/W2095691234","https://openalex.org/W2098432760","https://openalex.org/W2102814386","https://openalex.org/W2103017472","https://openalex.org/W2108256858","https://openalex.org/W2115119296","https://openalex.org/W2117486996","https://openalex.org/W2120930809","https://openalex.org/W2124735751","https://openalex.org/W2125282516","https://openalex.org/W2140735973","https://openalex.org/W2150563191","https://openalex.org/W2161955763","https://openalex.org/W2162813650","https://openalex.org/W2168118433","https://openalex.org/W2168662600","https://openalex.org/W2227395312","https://openalex.org/W2520368209","https://openalex.org/W2562531153","https://openalex.org/W2565684071","https://openalex.org/W2612647668","https://openalex.org/W2615066396","https://openalex.org/W2763133603","https://openalex.org/W2952508945","https://openalex.org/W3144805566","https://openalex.org/W6659677874","https://openalex.org/W6678337835","https://openalex.org/W6764172607"],"related_works":["https://openalex.org/W2094822546","https://openalex.org/W4388708026","https://openalex.org/W1969080446","https://openalex.org/W3108941781","https://openalex.org/W1578069856","https://openalex.org/W2134206588","https://openalex.org/W2084200259","https://openalex.org/W2065993463","https://openalex.org/W2401071219","https://openalex.org/W2554237979"],"abstract_inverted_index":{"MOTIVATION:":[0],"Most":[1],"automatic":[2],"functional":[3],"annotation":[4],"methods":[5,190],"assign":[6],"Gene":[7],"Ontology":[8],"(GO)":[9],"terms":[10,38,57,75,192],"to":[11,40,45,62,69,88,100],"proteins":[12,23,93,159,174],"based":[13,114,123],"on":[14,115,124,156,172],"annotations":[15],"of":[16,73,103,118,127,145,149,163,193],"highly":[17],"similar":[18,27],"proteins.":[19,106],"We":[20,60,91,107,129],"advocate":[21],"that":[22,24,85,131,176],"are":[25,28,212],"less":[26],"still":[29],"informative.":[30],"Also,":[31],"despite":[32],"their":[33],"simplicity":[34],"and":[35,76,121,188],"structure,":[36],"GO":[37,74],"seem":[39],"be":[41],"hard":[42],"for":[43,201],"computers":[44],"learn,":[46],"in":[47,180,191],"particular":[48],"the":[49,55,71,116,119,142,161,177,202],"Biological":[50],"Process":[51],"ontology,":[52],"which":[53],"has":[54],"most":[56],"(>29":[58],"000).":[59],"propose":[61],"use":[63],"Label-Space":[64],"Dimensionality":[65],"Reduction":[66],"(LSDR)":[67],"techniques":[68],"exploit":[70],"redundancy":[72],"transform":[77],"them":[78],"into":[79],"a":[80,95,101,183],"more":[81],"compact":[82],"latent":[83],"representation":[84,179],"is":[86,204],"easier":[87],"predict.":[89],"RESULTS:":[90],"compare":[92],"using":[94],"sequence":[96],"similarity":[97,126],"profile":[98],"(SSP)":[99],"set":[102],"annotated":[104],"training":[105],"introduce":[108],"two":[109],"new":[110],"LSDR":[111,133,166],"methods,":[112,134],"one":[113,122],"structure":[117],"GO,":[120],"semantic":[125],"terms.":[128],"show":[130,175],"these":[132],"as":[135,137],"well":[136],"three":[138],"existing":[139],"ones,":[140],"improve":[141],"Critical":[143],"Assessment":[144],"Functional":[146],"Annotation":[147],"performance":[148],"several":[150],"function":[151],"prediction":[152],"algorithms.":[153],"Cross-validation":[154],"experiments":[155,171,203],"Arabidopsis":[157],"thaliana":[158],"pinpoint":[160],"superiority":[162],"our":[164],"GO-aware":[165],"over":[167],"generic":[168],"LSDR.":[169],"Our":[170],"A.thaliana":[173],"SSP":[178],"combination":[181],"with":[182],"kNN":[184],"classifier":[185],"outperforms":[186],"state-of-the-art":[187],"baseline":[189],"cross-validated":[194],"F-measure.":[195],"AVAILABILITY":[196],"AND":[197],"IMPLEMENTATION:":[198],"Source":[199],"code":[200],"available":[205,213],"at":[206,214],"https://github.com/stamakro/SSP-LSDR.":[207],"SUPPLEMENTARY":[208],"INFORMATION:":[209],"Supplementary":[210],"data":[211],"Bioinformatics":[215],"online.":[216]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":7}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2025-10-10T00:00:00"}
