{"id":"https://openalex.org/W2869298098","doi":"https://doi.org/10.1093/bioinformatics/bty582","title":"Computational analysis of kinase inhibitor selectivity using structural knowledge","display_name":"Computational analysis of kinase inhibitor selectivity using structural knowledge","publication_year":2018,"publication_date":"2018-07-06","ids":{"openalex":"https://openalex.org/W2869298098","doi":"https://doi.org/10.1093/bioinformatics/bty582","mag":"2869298098","pmid":"https://pubmed.ncbi.nlm.nih.gov/29985971"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/bty582","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bty582","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/35/2/235/27496949/bty582.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/35/2/235/27496949/bty582.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033871757","display_name":"Yu-Chen Lo","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yu-Chen Lo","raw_affiliation_strings":["Department of Bioengineering, Stanford, CA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Stanford, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102959085","display_name":"Tianyun Liu","orcid":"https://orcid.org/0000-0003-4912-383X"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tianyun Liu","raw_affiliation_strings":["Department of Bioengineering, Stanford, CA, USA","Department of Genetics, Stanford University, Stanford, CA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Stanford, CA, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Genetics, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024509581","display_name":"Kari M. Morrissey","orcid":"https://orcid.org/0000-0001-9025-4036"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kari M Morrissey","raw_affiliation_strings":["Department of Clinical Pharmacology, South San Francisco, CA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, South San Francisco, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059479187","display_name":"Satoko Kakiuchi-Kiyota","orcid":"https://orcid.org/0000-0002-4028-8817"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Satoko Kakiuchi-Kiyota","raw_affiliation_strings":["Department of Safety Assessment, South San Francisco, CA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Safety Assessment, South San Francisco, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103080014","display_name":"Adam R. Johnson","orcid":"https://orcid.org/0000-0003-1459-4236"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adam R Johnson","raw_affiliation_strings":["Biochemical and Cellular Pharmacology, South San Francisco, CA, USA"],"affiliations":[{"raw_affiliation_string":"Biochemical and Cellular Pharmacology, South San Francisco, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047272417","display_name":"Fabio Broccatelli","orcid":"https://orcid.org/0000-0002-0724-9752"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fabio Broccatelli","raw_affiliation_strings":["Department of Drug Metabolism and Pharmacokinetic, Genentech Inc., South San Francisco, CA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Drug Metabolism and Pharmacokinetic, Genentech Inc., South San Francisco, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037369499","display_name":"Yu Zhong","orcid":"https://orcid.org/0000-0002-9230-6036"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yu Zhong","raw_affiliation_strings":["Department of Safety Assessment, South San Francisco, CA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Safety Assessment, South San Francisco, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018268115","display_name":"Amita Joshi","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amita Joshi","raw_affiliation_strings":["Department of Clinical Pharmacology, South San Francisco, CA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, South San Francisco, CA, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084043782","display_name":"Russ B. Altman","orcid":"https://orcid.org/0000-0003-3859-2905"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Russ B Altman","raw_affiliation_strings":["Department of Bioengineering, Stanford, CA, USA","Department of Genetics, Stanford University, Stanford, CA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Stanford, CA, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Genetics, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5084043782"],"corresponding_institution_ids":["https://openalex.org/I97018004"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":1.6919,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.8762485,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"35","issue":"2","first_page":"235","last_page":"242"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9955000281333923,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9955000281333923,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9904000163078308,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.572780430316925},{"id":"https://openalex.org/keywords/kinase","display_name":"Kinase","score":0.4750271439552307},{"id":"https://openalex.org/keywords/selectivity","display_name":"Selectivity","score":0.4200516939163208},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.418508917093277},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.2658246159553528},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.20159286260604858},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1825885772705078}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.572780430316925},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4750271439552307},{"id":"https://openalex.org/C118792377","wikidata":"https://www.wikidata.org/wiki/Q108584245","display_name":"Selectivity","level":3,"score":0.4200516939163208},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.418508917093277},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2658246159553528},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20159286260604858},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1825885772705078},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000076722","descriptor_name":"Drug Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000076722","descriptor_name":"Drug Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000076722","descriptor_name":"Drug Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/bty582","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bty582","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/35/2/235/27496949/bty582.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:29985971","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29985971","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:europepmc.org:5910387","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6330000","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/bty582","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bty582","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/35/2/235/27496949/bty582.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.47999998927116394,"id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G5593774952","display_name":null,"funder_award_id":"GM102365","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5921167663","display_name":null,"funder_award_id":"HL117798","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6411790401","display_name":null,"funder_award_id":"LM05652","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332193","display_name":"Genentech","ror":"https://ror.org/04gndp242"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2869298098.pdf","grobid_xml":"https://content.openalex.org/works/W2869298098.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1543963511","https://openalex.org/W1964837805","https://openalex.org/W1967194754","https://openalex.org/W1974903851","https://openalex.org/W1979767649","https://openalex.org/W1983782238","https://openalex.org/W1984364760","https://openalex.org/W1988212011","https://openalex.org/W1993438476","https://openalex.org/W1993976538","https://openalex.org/W1995808589","https://openalex.org/W1998028009","https://openalex.org/W2001097406","https://openalex.org/W2006436808","https://openalex.org/W2014582878","https://openalex.org/W2015015957","https://openalex.org/W2016602387","https://openalex.org/W2019523557","https://openalex.org/W2020257412","https://openalex.org/W2020450593","https://openalex.org/W2030205108","https://openalex.org/W2037947892","https://openalex.org/W2039782788","https://openalex.org/W2045192688","https://openalex.org/W2052201526","https://openalex.org/W2053106209","https://openalex.org/W2065283382","https://openalex.org/W2072582769","https://openalex.org/W2086286404","https://openalex.org/W2093615982","https://openalex.org/W2096993465","https://openalex.org/W2100772783","https://openalex.org/W2108042184","https://openalex.org/W2108285390","https://openalex.org/W2124955716","https://openalex.org/W2129747161","https://openalex.org/W2138675533","https://openalex.org/W2142702787","https://openalex.org/W2152265294","https://openalex.org/W2158315886","https://openalex.org/W2169363650","https://openalex.org/W2259381440","https://openalex.org/W2288765870","https://openalex.org/W2329648702","https://openalex.org/W2339666810","https://openalex.org/W2416046665","https://openalex.org/W2575507470","https://openalex.org/W2744129621","https://openalex.org/W2750674172","https://openalex.org/W2920332650","https://openalex.org/W4236708157"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2748952813","https://openalex.org/W1586206203","https://openalex.org/W2619424135","https://openalex.org/W2114451818","https://openalex.org/W2033566589","https://openalex.org/W2951237352","https://openalex.org/W2006471881","https://openalex.org/W2074571151","https://openalex.org/W2036143465"],"abstract_inverted_index":{"Supplementary":[0],"data":[1],"are":[2],"available":[3],"at":[4],"Bioinformatics":[5],"online.":[6]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
