{"id":"https://openalex.org/W2890070664","doi":"https://doi.org/10.1093/bioinformatics/bty557","title":"Quantitative trait loci identification for brain endophenotypes via new additive model with random networks","display_name":"Quantitative trait loci identification for brain endophenotypes via new additive model with random networks","publication_year":2018,"publication_date":"2018-07-07","ids":{"openalex":"https://openalex.org/W2890070664","doi":"https://doi.org/10.1093/bioinformatics/bty557","mag":"2890070664","pmid":"https://pubmed.ncbi.nlm.nih.gov/30423101"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/bty557","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bty557","pdf_url":"https://watermark.silverchair.com/bty557.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAsAwggK8BgkqhkiG9w0BBwagggKtMIICqQIBADCCAqIGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMi-c1SmPqGZOG7cm5AgEQgIICcxoNXCS7kGqSO7arHkjVlIFg1AtiOXcK4BxYOwE7dpslk17IxXxog7GdJtTN1m0-VOuCmwn9hsFPqJcvGgJFxtYo7sIBZKi9XHbvIpXWGY-XI5ao2uOg_2kQtpIszl7wmAfSw9kakeuQEEkeN9ZEZZWW1wJQjedKEKo1iH7Nfu3dviJtiHTG-eWd9rRi2eMoaUQVk4oFHEhM8Xt_6FDIE5Pskq5Ty3RoHPUgcxXgHTzAl_NqDpe1CXH-H9VxjeQBkEjsO5zAE30LsA4KNq5eJN4lop1KU0fzc1_kyf-JWdTrF-fPk0Om2SnLSLjprxYPkHs02qtBukNv8ClUn53nQxTcqaoKDAHU47p78fQ97IcA64SVhvh9wPitK6rtMXP_f4lInwPGvosbMgxSCYU72-H3cktibwbHMGq5oeblj9SpykjHwYF_vzorr4OdD26-tCjuuHBB7UlH-bpLbYW-KCfxMNN0AlX1oMNPUKteFaG9YI2CNmsm82KYwQFvh_jLiEHIXCw-6EmdS_ViJh9PjTyY0gOFz7z1bCFeOI9_q1gyNLXT73tPV0N2IPdhU4TO43Q3i0ABgUPeBxXgVRDiLWNVxOV8OOFNpVWi7liVNcqecC8wOwpzYmwQpCDYJOSMq8ImYnKhbtqCFpOfK6aHfjEvoYbn1R-FTvUr9dtg-9o64NsJXgBvKyrEMoWoiusx57-N37AsaHAU0vbuJjsnmWOwOasZeZNTHT37hGeWw_yfYkNA07feyxRXFFniP8UyF4XyyMjPAcY5EFytCcCt-LRbBt-dRGCMAdmNDg0CRmq1FjUaGofGbuxRd1Dl0Uz5gRDLMA","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://watermark.silverchair.com/bty557.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAsAwggK8BgkqhkiG9w0BBwagggKtMIICqQIBADCCAqIGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMi-c1SmPqGZOG7cm5AgEQgIICcxoNXCS7kGqSO7arHkjVlIFg1AtiOXcK4BxYOwE7dpslk17IxXxog7GdJtTN1m0-VOuCmwn9hsFPqJcvGgJFxtYo7sIBZKi9XHbvIpXWGY-XI5ao2uOg_2kQtpIszl7wmAfSw9kakeuQEEkeN9ZEZZWW1wJQjedKEKo1iH7Nfu3dviJtiHTG-eWd9rRi2eMoaUQVk4oFHEhM8Xt_6FDIE5Pskq5Ty3RoHPUgcxXgHTzAl_NqDpe1CXH-H9VxjeQBkEjsO5zAE30LsA4KNq5eJN4lop1KU0fzc1_kyf-JWdTrF-fPk0Om2SnLSLjprxYPkHs02qtBukNv8ClUn53nQxTcqaoKDAHU47p78fQ97IcA64SVhvh9wPitK6rtMXP_f4lInwPGvosbMgxSCYU72-H3cktibwbHMGq5oeblj9SpykjHwYF_vzorr4OdD26-tCjuuHBB7UlH-bpLbYW-KCfxMNN0AlX1oMNPUKteFaG9YI2CNmsm82KYwQFvh_jLiEHIXCw-6EmdS_ViJh9PjTyY0gOFz7z1bCFeOI9_q1gyNLXT73tPV0N2IPdhU4TO43Q3i0ABgUPeBxXgVRDiLWNVxOV8OOFNpVWi7liVNcqecC8wOwpzYmwQpCDYJOSMq8ImYnKhbtqCFpOfK6aHfjEvoYbn1R-FTvUr9dtg-9o64NsJXgBvKyrEMoWoiusx57-N37AsaHAU0vbuJjsnmWOwOasZeZNTHT37hGeWw_yfYkNA07feyxRXFFniP8UyF4XyyMjPAcY5EFytCcCt-LRbBt-dRGCMAdmNDg0CRmq1FjUaGofGbuxRd1Dl0Uz5gRDLMA","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100713981","display_name":"Xiaoqian Wang","orcid":"https://orcid.org/0000-0002-4424-6024"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoqian Wang","raw_affiliation_strings":["Electrical and Computer Engineering, University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Electrical and Computer Engineering, University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072429814","display_name":"Hong Chen","orcid":"https://orcid.org/0000-0002-8848-282X"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hong Chen","raw_affiliation_strings":["Electrical and Computer Engineering, University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Electrical and Computer Engineering, University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103218500","display_name":"Jingwen Yan","orcid":"https://orcid.org/0000-0001-9066-4908"},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":null,"type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jingwen Yan","raw_affiliation_strings":["Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I55769427","https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087302585","display_name":"Kwangsik Nho","orcid":"https://orcid.org/0000-0002-7624-3872"},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":null,"type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kwangsik Nho","raw_affiliation_strings":["Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I55769427","https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018610871","display_name":"Shannon L. Risacher","orcid":"https://orcid.org/0000-0002-3304-7943"},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":null,"type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shannon L Risacher","raw_affiliation_strings":["Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I55769427","https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026257338","display_name":"Andrew J. Saykin","orcid":"https://orcid.org/0000-0002-1376-8532"},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":null,"type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew J Saykin","raw_affiliation_strings":["Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I55769427","https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100333320","display_name":"Li Shen","orcid":"https://orcid.org/0000-0002-5443-0503"},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li Shen","raw_affiliation_strings":["Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060016795","display_name":"Heng Huang","orcid":"https://orcid.org/0000-0002-3483-8333"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Heng Huang","raw_affiliation_strings":["Electrical and Computer Engineering, University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Electrical and Computer Engineering, University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":null,"display_name":"for the ADNI","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"for the ADNI","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5060016795"],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":0.5376,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.73360989,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"34","issue":"17","first_page":"i866","last_page":"i874"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.39989998936653137,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.39989998936653137,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.3391000032424927,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.0414000004529953,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endophenotype","display_name":"Endophenotype","score":0.9374191761016846},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5946993231773376},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.4898967146873474},{"id":"https://openalex.org/keywords/quantitative-trait-locus","display_name":"Quantitative trait locus","score":0.48619669675827026},{"id":"https://openalex.org/keywords/linear-model","display_name":"Linear model","score":0.46627098321914673},{"id":"https://openalex.org/keywords/neuroimaging","display_name":"Neuroimaging","score":0.4616609215736389},{"id":"https://openalex.org/keywords/trait","display_name":"Trait","score":0.44472751021385193},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4073665738105774},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3527553081512451},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.29574650526046753},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2810364365577698},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.24679046869277954},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.14556527137756348},{"id":"https://openalex.org/keywords/cognition","display_name":"Cognition","score":0.11481574177742004}],"concepts":[{"id":"https://openalex.org/C187869287","wikidata":"https://www.wikidata.org/wiki/Q2032061","display_name":"Endophenotype","level":3,"score":0.9374191761016846},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5946993231773376},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.4898967146873474},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.48619669675827026},{"id":"https://openalex.org/C163175372","wikidata":"https://www.wikidata.org/wiki/Q3339222","display_name":"Linear model","level":2,"score":0.46627098321914673},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.4616609215736389},{"id":"https://openalex.org/C106934330","wikidata":"https://www.wikidata.org/wiki/Q1971873","display_name":"Trait","level":2,"score":0.44472751021385193},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4073665738105774},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3527553081512451},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.29574650526046753},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2810364365577698},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24679046869277954},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.14556527137756348},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.11481574177742004},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058068","descriptor_name":"Endophenotypes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058068","descriptor_name":"Endophenotypes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058068","descriptor_name":"Endophenotypes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058068","descriptor_name":"Endophenotypes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058068","descriptor_name":"Endophenotypes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058068","descriptor_name":"Endophenotypes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1093/bioinformatics/bty557","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bty557","pdf_url":"https://watermark.silverchair.com/bty557.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAsAwggK8BgkqhkiG9w0BBwagggKtMIICqQIBADCCAqIGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMi-c1SmPqGZOG7cm5AgEQgIICcxoNXCS7kGqSO7arHkjVlIFg1AtiOXcK4BxYOwE7dpslk17IxXxog7GdJtTN1m0-VOuCmwn9hsFPqJcvGgJFxtYo7sIBZKi9XHbvIpXWGY-XI5ao2uOg_2kQtpIszl7wmAfSw9kakeuQEEkeN9ZEZZWW1wJQjedKEKo1iH7Nfu3dviJtiHTG-eWd9rRi2eMoaUQVk4oFHEhM8Xt_6FDIE5Pskq5Ty3RoHPUgcxXgHTzAl_NqDpe1CXH-H9VxjeQBkEjsO5zAE30LsA4KNq5eJN4lop1KU0fzc1_kyf-JWdTrF-fPk0Om2SnLSLjprxYPkHs02qtBukNv8ClUn53nQxTcqaoKDAHU47p78fQ97IcA64SVhvh9wPitK6rtMXP_f4lInwPGvosbMgxSCYU72-H3cktibwbHMGq5oeblj9SpykjHwYF_vzorr4OdD26-tCjuuHBB7UlH-bpLbYW-KCfxMNN0AlX1oMNPUKteFaG9YI2CNmsm82KYwQFvh_jLiEHIXCw-6EmdS_ViJh9PjTyY0gOFz7z1bCFeOI9_q1gyNLXT73tPV0N2IPdhU4TO43Q3i0ABgUPeBxXgVRDiLWNVxOV8OOFNpVWi7liVNcqecC8wOwpzYmwQpCDYJOSMq8ImYnKhbtqCFpOfK6aHfjEvoYbn1R-FTvUr9dtg-9o64NsJXgBvKyrEMoWoiusx57-N37AsaHAU0vbuJjsnmWOwOasZeZNTHT37hGeWw_yfYkNA07feyxRXFFniP8UyF4XyyMjPAcY5EFytCcCt-LRbBt-dRGCMAdmNDg0CRmq1FjUaGofGbuxRd1Dl0Uz5gRDLMA","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:30423101","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30423101","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:europepmc.org:5675862","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6129276","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:iu.tind.io:1349","is_oa":false,"landing_page_url":"http://iu.tind.io/record/1349","pdf_url":null,"source":{"id":"https://openalex.org/S4306402656","display_name":"IUScholarWorks Open (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://iu.tind.io/record/1349","raw_type":"Text"},{"id":"pmh:oai:scholarworks.indianapolis.iu.edu:1805/21583","is_oa":false,"landing_page_url":"https://hdl.handle.net/1805/21583","pdf_url":null,"source":{"id":"https://openalex.org/S4306400987","display_name":"IUScholarWorks (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PMC","raw_type":"Article"},{"id":"pmh:oai:scholarworks.iupui.edu:1805/21583","is_oa":false,"landing_page_url":"http://hdl.handle.net/1805/21583","pdf_url":null,"source":{"id":"https://openalex.org/S4306400987","display_name":"IUScholarWorks (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PMC","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/bty557","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bty557","pdf_url":"https://watermark.silverchair.com/bty557.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAsAwggK8BgkqhkiG9w0BBwagggKtMIICqQIBADCCAqIGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMi-c1SmPqGZOG7cm5AgEQgIICcxoNXCS7kGqSO7arHkjVlIFg1AtiOXcK4BxYOwE7dpslk17IxXxog7GdJtTN1m0-VOuCmwn9hsFPqJcvGgJFxtYo7sIBZKi9XHbvIpXWGY-XI5ao2uOg_2kQtpIszl7wmAfSw9kakeuQEEkeN9ZEZZWW1wJQjedKEKo1iH7Nfu3dviJtiHTG-eWd9rRi2eMoaUQVk4oFHEhM8Xt_6FDIE5Pskq5Ty3RoHPUgcxXgHTzAl_NqDpe1CXH-H9VxjeQBkEjsO5zAE30LsA4KNq5eJN4lop1KU0fzc1_kyf-JWdTrF-fPk0Om2SnLSLjprxYPkHs02qtBukNv8ClUn53nQxTcqaoKDAHU47p78fQ97IcA64SVhvh9wPitK6rtMXP_f4lInwPGvosbMgxSCYU72-H3cktibwbHMGq5oeblj9SpykjHwYF_vzorr4OdD26-tCjuuHBB7UlH-bpLbYW-KCfxMNN0AlX1oMNPUKteFaG9YI2CNmsm82KYwQFvh_jLiEHIXCw-6EmdS_ViJh9PjTyY0gOFz7z1bCFeOI9_q1gyNLXT73tPV0N2IPdhU4TO43Q3i0ABgUPeBxXgVRDiLWNVxOV8OOFNpVWi7liVNcqecC8wOwpzYmwQpCDYJOSMq8ImYnKhbtqCFpOfK6aHfjEvoYbn1R-FTvUr9dtg-9o64NsJXgBvKyrEMoWoiusx57-N37AsaHAU0vbuJjsnmWOwOasZeZNTHT37hGeWw_yfYkNA07feyxRXFFniP8UyF4XyyMjPAcY5EFytCcCt-LRbBt-dRGCMAdmNDg0CRmq1FjUaGofGbuxRd1Dl0Uz5gRDLMA","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G103556449","display_name":null,"funder_award_id":"11671161","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3559141165","display_name":null,"funder_award_id":"DBI 1356628","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G37673707","display_name":null,"funder_award_id":"IIS 1619308","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G4558216502","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5796066727","display_name":null,"funder_award_id":"R01 LM011360","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7136375676","display_name":null,"funder_award_id":"IIS 1344152","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7619289898","display_name":null,"funder_award_id":"IIS-1117335","funder_id":"https://openalex.org/F4320310174","funder_display_name":"University of Pittsburgh"},{"id":"https://openalex.org/G7762013212","display_name":null,"funder_award_id":"IIS 1633753","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G942013628","display_name":null,"funder_award_id":"IIS 1302675","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320309370","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10"},{"id":"https://openalex.org/F4320310174","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320338487","display_name":"DoD Alzheimer's Disease Neuroimaging Initiative","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W597932189","https://openalex.org/W1488505114","https://openalex.org/W1979804471","https://openalex.org/W1986278072","https://openalex.org/W1987470211","https://openalex.org/W2004293194","https://openalex.org/W2007044705","https://openalex.org/W2017079501","https://openalex.org/W2021950004","https://openalex.org/W2047278710","https://openalex.org/W2058402854","https://openalex.org/W2058880763","https://openalex.org/W2068179693","https://openalex.org/W2069552222","https://openalex.org/W2092007765","https://openalex.org/W2096192437","https://openalex.org/W2102117809","https://openalex.org/W2106403755","https://openalex.org/W2107199945","https://openalex.org/W2119679926","https://openalex.org/W2119848633","https://openalex.org/W2130994442","https://openalex.org/W2135046866","https://openalex.org/W2135315105","https://openalex.org/W2147303334","https://openalex.org/W2147958782","https://openalex.org/W2154865814","https://openalex.org/W2155910151","https://openalex.org/W2159242834","https://openalex.org/W2160972508","https://openalex.org/W2163013660","https://openalex.org/W2164303459","https://openalex.org/W2166348468","https://openalex.org/W2166501262","https://openalex.org/W2523905666","https://openalex.org/W2538894230","https://openalex.org/W2602024037","https://openalex.org/W2606567126","https://openalex.org/W2725150247","https://openalex.org/W2770415971","https://openalex.org/W4213220085","https://openalex.org/W4245558064","https://openalex.org/W6629275658","https://openalex.org/W6678945949","https://openalex.org/W6683090604","https://openalex.org/W6736312915","https://openalex.org/W6746293615"],"related_works":["https://openalex.org/W2495861132","https://openalex.org/W3140386247","https://openalex.org/W2913571226","https://openalex.org/W2131171966","https://openalex.org/W2506162896","https://openalex.org/W2077427362","https://openalex.org/W4206746115","https://openalex.org/W2324271132","https://openalex.org/W1893909712","https://openalex.org/W2952386651"],"abstract_inverted_index":{"Motivation:":[0],"The":[1],"identification":[2],"of":[3,13,70,76,97,135,145,214],"quantitative":[4],"trait":[5],"loci":[6],"(QTL)":[7],"is":[8,81,85,138,183,189,227],"critical":[9],"to":[10,29,67,87,93,111,130],"the":[11,26,30,46,54,58,68,71,74,89,95,113,132,142,146,160,165,193,201,211],"study":[12,36],"causal":[14],"relationships":[15],"between":[16,48,116],"genetic":[17],"variations":[18],"and":[19,53,99,118,175,195,223],"disease":[20],"abnormalities.":[21],"We":[22],"focus":[23],"on":[24,78,185,200],"identifying":[25,218],"QTLs":[27,77],"associated":[28],"brain":[31,55,79,119],"endophenotypes":[32,56,80,120],"in":[33,121],"imaging":[34],"genomics":[35],"for":[37,141,164,192,217],"Alzheimer's":[38,122,204],"Disease":[39,205],"(AD).":[40],"Existing":[41],"research":[42],"works":[43],"mainly":[44],"depict":[45],"association":[47],"single":[49],"nucleotide":[50],"polymorphisms":[51],"(SNPs)":[52],"via":[57],"linear":[59],"methods,":[60],"which":[61,188],"may":[62],"introduce":[63],"high":[64],"bias":[65],"due":[66],"simplicity":[69],"models.":[72],"Since":[73],"influence":[75,134],"quite":[82],"complex,":[83],"it":[84],"desired":[86],"design":[88],"appropriate":[90,191],"non-linear":[91,114,133],"models":[92],"investigate":[94],"associations":[96,115],"genotypes":[98],"endophenotypes.":[100],"Results:":[101],"In":[102],"this":[103],"paper,":[104],"we":[105,158],"propose":[106],"a":[107],"new":[108],"additive":[109],"model":[110,125],"learn":[112],"SNPs":[117],"disease.":[123],"Our":[124],"can":[126],"be":[127],"flexibly":[128],"employed":[129],"explain":[131],"QTLs,":[136],"thus":[137],"more":[139,190],"adaptive":[140],"complex":[143],"distribution":[144],"high-throughput":[147,194],"biological":[148,197,219],"data.":[149,198],"Meanwhile,":[150],"as":[151],"an":[152],"important":[153],"computational":[154],"learning":[155],"theory":[156],"contribution,":[157],"provide":[159],"generalization":[161],"error":[162,181],"analysis":[163,172],"proposed":[166],"approach.":[167],"Unlike":[168],"most":[169],"previous":[170],"theoretical":[171],"under":[173],"independent":[174],"identically":[176],"distributed":[177],"samples":[178],"assumption,":[179],"our":[180,215],"bound":[182],"based":[184],"m-dependent":[186],"observations,":[187],"noisy":[196],"Experiments":[199],"data":[202],"from":[203],"Neuroimaging":[206],"Initiative":[207],"(ADNI)":[208],"cohort":[209],"demonstrate":[210],"promising":[212],"performance":[213],"approach":[216],"meaningful":[220],"SNPs.":[221],"Availability":[222],"implementation:":[224],"An":[225],"executable":[226],"available":[228],"at":[229],"https://github.com/littleq1991/additive_FNNRW.":[230]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1}],"updated_date":"2026-06-02T09:04:35.204637","created_date":"2025-10-10T00:00:00"}